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1. 发明申请

WO2011152834A1 COHERENT ANTI-STOKES RAMAN HOLOGRAPHY 审中-公开
标题翻译：相关的反倾销拉曼全息图
公开(公告)号：WO2011152834A1
公开(公告)日：2011-12-08
申请号：PCT/US2010/037440
申请日：2010-06-04
申请人： THE PENN STATE RESEARCH FOUNDATION , LIU, Zhiwen , SHI, Kebin , PSALTIS, Demetri , XU, Qian
发明人： LIU, Zhiwen , SHI, Kebin , PSALTIS, Demetri , XU, Qian
IPC分类号： G01J3/44 , G02B5/32
CPC分类号： G01J3/44 , G01N21/65 , G01N2021/653 , G02B21/0004 , G02B21/086 , G02B21/14 , G03H1/0005 , G03H1/02 , G03H1/04 , G03H1/0443 , G03H1/0866 , G03H2001/0212 , G03H2001/0445 , G03H2001/0447 , G03H2222/10
摘要： Apparatus and methods of four wave mixing (FWM) holography are described, including illuminating a sample with a first beam, a second beam, and a third beam, and combining the generated FWM signal with a reference beam at a imaging device to obtain holographic image data. In some examples, the first and second beams may be provided by a single pump-probe beam. The third beam may be a Stokes beam or an anti-Stokes beam. A representative example is coherent anti-Stokes Raman holography (CARS holography), which includes illuminating a sample with a pump/probe beam and a Stokes beam to obtain a CARS signal from the sample; and combining the CARS signal with a reference beam to obtain a CARS hologram.
摘要翻译：描述了四波混合（FWM）全息术的装置和方法，包括用第一光束，第二光束和第三光束照射样本，并将所产生的FWM信号与成像装置处的参考光束组合以获得全息图像数据。在一些示例中，第一和第二梁可以由单个泵 - 探针梁提供。第三光束可以是斯托克斯光束或反斯托克斯光束。一个典型的例子是相干反斯托克斯拉曼全息术（CARS holography），其包括用泵/探针光束和斯托克斯光束照射样品以从样品获得CARS信号; 并将CARS信号与参考光束组合以获得CARS全息图。

2. 发明申请

WO2008140584A3 SECOND HARMONIC IMAGING NANOPROBES AND TECHNIQUES FOR USE THEREOF 审中-公开
标题翻译：第二谐波成像纳米微粒及其使用技术
公开(公告)号：WO2008140584A3
公开(公告)日：2009-01-08
申请号：PCT/US2007085407
申请日：2007-11-21
申请人： CALIFORNIA INST OF TECHN , PANTAZIS PERIKLIS , PSALTIS DEMETRI , HONG JOHN , PU YE , FRASER SCOTT E
发明人： PANTAZIS PERIKLIS , PSALTIS DEMETRI , HONG JOHN , PU YE , FRASER SCOTT E
IPC分类号： G01N21/00
CPC分类号： G01N33/483 , A61B5/0075 , A61K49/0002 , B82Y5/00 , B82Y15/00 , B82Y20/00 , G01N21/636 , G02F1/37 , G06K9/00134
摘要： Second harmonic nanoprobes for imaging biological samples and a method of using such probes to monitor the dynamics of biological process using a field resonance enhanced second harmonic (FRESH) technique are provided. The second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.
摘要翻译：提供了用于成像生物样品的二次谐波纳米探针和使用这种探针来监测使用场共振增强二次谐波（FRESH）技术的生物过程的动力学的方法。二次谐波产生（SHG）纳米探针由不具有反转对称性的各种纳米晶体组成，因此能够产生二次谐波信号，然后可以通过传统的双光子显微镜检测生物过程的体内成像，结构如细胞信号传导，神经成像，蛋白质构象探索，DNA构象探索，基因转录，细胞中的病毒感染和复制，蛋白质动力学，肿瘤成像和癌症治疗评估和诊断以及光学成像中的定量。

3. 发明申请

WO2004019004A9 AN ARSENIC METER 审中-公开
标题翻译：一台砷测量仪
公开(公告)号：WO2004019004A9
公开(公告)日：2004-05-27
申请号：PCT/US0326484
申请日：2003-08-21
申请人： UNIV COLUMBIA , VAN GEEN ALEXANDER , PERONA PIETRO , MOSER CHRISTOPHE , PSALTIS DEMETRI
发明人： VAN GEEN ALEXANDER , PERONA PIETRO , MOSER CHRISTOPHE , PSALTIS DEMETRI
IPC分类号： G01J3/02 , G01J3/10 , G01J3/42 , G01N21/27 , G01N21/35 , G01N21/78 , G01N33/18 , G01J3/46 , G01N21/25
CPC分类号： G01N33/182 , G01J3/02 , G01J3/0272 , G01J3/0283 , G01J3/0286 , G01J3/108 , G01J3/42 , G01N21/274 , G01N21/276 , G01N21/31 , G01N21/3577 , G01N21/78 , G01N2021/1751
摘要： A field test-kit for analyzing arsenic concentration in water samples incudes a portable infrared beam photometer for measuring light absorbance in aqueous specimens. An infrared ligth emittng diode (120A, 120B) is configured to direct a beam of light through a specimen. A photodetecotr diode (130A, 130B) measures the intensity of light passing through the specimen. The photodetector (130A, 130B) output voltages relate to the light absorbed in the specimen and are displayed on a LCD (160) screen. To test for arsenic, molybdenum-blue color complexes. The light absorbance of a specimen with both arsenates and phosphates bound in molybdenum-blue color complexes is compared to that of a reference specimen in which phosphates but not arsenates are bound and converted. A quantitative value for the arsenic concentration in the water sample is determined from the differential light absorbance of the two specimens.
摘要翻译：用于分析水样中砷浓度的现场测试工具包包括用于测量水样中光吸收的便携式红外光度计。红外线发射二极管（120A，120B）被配置为引导光束通过样本。光探测器二极管（130A，130B）测量穿过样本的光的强度。光电探测器（130A，130B）的输出电压与样本中吸收的光有关并显示在LCD（160）屏幕上。测试砷，钼蓝色复合物。将砷酸盐和磷酸盐结合在钼 - 蓝色配合物中的样品的光吸收与与其中磷酸盐而非砷酸盐结合并转化的参考样品进行比较。水样中砷浓度的定量值由两个样品的差示吸光度确定。

4. 发明申请

WO1997001133A1 MULTIPLEXED HOLOGRAM COPYING SYSTEM AND METHOD 审中-公开
标题翻译：多功能复印系统和方法
公开(公告)号：WO1997001133A1
公开(公告)日：1997-01-09
申请号：PCT/US1996010410
申请日：1996-06-21
申请人： HOLOPLEX , MOK, Fai, H. , QIAO, Yong , ZHOU, Gan , PSALTIS, Demetri
发明人： HOLOPLEX
IPC分类号： G03H01/16
CPC分类号： G11B7/28 , G03H1/0248 , G03H1/202 , G03H1/26 , G03H1/265 , G03H2001/2675 , G11B7/0065 , G11B7/127
摘要： A system of reproducing multiplexed holographic information from one master medium (100, 300, 400, 500, 600, 720) to another replicate medium (200, 310, 410, 510, 610, 730) simultaneously reads out the information from all multiplexed master holograms within the master medium, and records it onto the replicate medium. The replica has different phase and amplitude distributions from the master medium containing a plurality of multiplexed holograms (420, 520) though both the replica and the master contain the identical holographic information of the original objects.
摘要翻译：将多路复用全息信息从一个主介质（100,300,400,500,600,720）再现到另一个复制介质（200,310,410,510,610,730）的系统同时从所有多路复用主机读出信息在主介质中的全息图，并将其记录在复制介质上。复制品具有与包含多个多路复用全息图（420,520）的主介质不同的相位和幅度分布，尽管副本和主机都包含原始对象的相同全息信息。

5. 发明申请

WO2012114164A1 LIGHT FILTER AND METHOD FOR USING SUCH FILTER 审中-公开
标题翻译：光过滤器和使用这种过滤器的方法
公开(公告)号：WO2012114164A1
公开(公告)日：2012-08-30
申请号：PCT/IB2011/054217
申请日：2011-09-26
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) , VASDEKIS, Andreas , CUENNET, Julien , PSALTIS, Demetri
发明人： VASDEKIS, Andreas , CUENNET, Julien , PSALTIS, Demetri
IPC分类号： G02B5/30 , G02B26/02 , G02F1/133 , G02F1/139
CPC分类号： G02B26/02 , G02B5/3016 , G02B5/3083 , G02F1/116 , G02F1/1393 , G02F2203/055
摘要： The invention concerns a light filter comprising a plate defined by a length along a direction x, a width along a direction y and a height along a direction z; said plate including at least one chamber containing Liquid Crystals (LC) molecules and which is oriented substantially along a direction parallel to the xy, xz or yz-plane; said filter furthermore being adapted to let a flow be present or temporally and spatially modified within said chamber, wherein said LC molecules are oriented along a first direction in the absence of said flow and along second direction when said flow is present, resulting thus in the emergence or modification of a birefringence. The invention also relates to a method for using this light filter.
摘要翻译：本发明涉及一种光过滤器，其包括由沿着方向x的长度，沿着y方向的宽度和沿着z方向的高度限定的板; 所述板包括至少一个包含液晶（LC）分子的室，并且其基本上沿着平行于xy，xz或yz平面的方向取向; 所述过滤器还适于使流动在所述室内存在或在时间和空间上被修改，其中所述LC分子在没有所述流动的情况下沿着第一方向定向，并且当所述流动存在时沿着第二方向定向，从而导致出现或修改双折射。本发明还涉及一种使用该滤光器的方法。

6. 发明申请

WO2008112416A3 OPTOFLUIDIC MICROSCOPE DEVICE 审中-公开
标题翻译：光学显微镜装置
公开(公告)号：WO2008112416A3
公开(公告)日：2008-11-13
申请号：PCT/US2008054908
申请日：2008-02-25
申请人： CALIFORNIA INST OF TECHN , YANG CHANGHUEI , PSALTIS DEMETRI
发明人： YANG CHANGHUEI , PSALTIS DEMETRI
IPC分类号： G01N21/00 , B32B27/04
CPC分类号： G01N21/6458 , B82Y30/00
摘要： An optofluidic microscope device is disclosed. The device includes a fluid channel having a surface and an object such as a bacterium or virus may flow through the fluid channel. Light transmissive regions of different sizes may be used to image the object.
摘要翻译：公开了一种光流体显微镜装置。该装置包括具有表面的流体通道，诸如细菌或病毒的物体可以流过流体通道。可以使用不同尺寸的透光区域对物体进行成像。

7. 发明申请

WO2005096741A3 SYSTEM AND METHODS FOR REFRACTIVE AND DIFFRACTIVE VOLUME HOLOGRAPHIC ELEMENTS 审中-公开
标题翻译：用于折射和衍射体积全息图元素的系统和方法
公开(公告)号：WO2005096741A3
公开(公告)日：2007-01-25
申请号：PCT/US2005010809
申请日：2005-03-30
申请人： ONDAX INC , MOSER CHRISTOPHE , HYMEL ART , BUSE KARSTEN , PSALTIS DEMETRI , STECKMAN GREGORY
发明人： MOSER CHRISTOPHE , HYMEL ART , BUSE KARSTEN , PSALTIS DEMETRI , STECKMAN GREGORY
IPC分类号： G02B5/32
CPC分类号： G02B5/32 , H01S5/141
摘要： A laser utilizes feedback from a volume holographic grating integrated in a collimating lens as a wavelength standard to lock the laser output wavelength to its desired value. This feedback is optical, wherein a volume hologram reflection grating is used to generate optical feedback into the laser gain region. Fabrication of the integrated volume hologram grating lens elements is by either first recording the grating in a rectangular parallelepiped of material and then shaping the lens from it, or alternatively by first shaping the material into the desired shape and then recording the grating with the use of an apparatus composed of an optical block within which a cavity is present to accept the lens and index matching fluid.
摘要翻译：激光器利用集成在准直透镜中的体积全息光栅作为波长标准的反馈来将激光输出波长锁定到其期望值。该反馈是光学的，其中使用体积全息图反射光栅来产生到激光增益区域的光学反馈。集成的体积全息图光栅透镜元件的制造是首先将光栅记录在长方体的材料中，然后从其成形透镜，或者通过首先将材料成形为期望的形状，然后使用由光学块组成的装置，其中存在空腔以接收透镜和折射率匹配流体。

8. 发明申请

WO2004019004A3 AN ARSENIC METER 审中-公开
公开(公告)号：WO2004019004A3
公开(公告)日：2004-03-04
申请号：PCT/US2003/026484
申请日：2003-08-21
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , VAN GEEN, Alexander , PERONA, Pietro , MOSER, Christophe , PSALTIS, Demetri
发明人： VAN GEEN, Alexander , PERONA, Pietro , MOSER, Christophe , PSALTIS, Demetri
IPC分类号： G01J03/46
摘要： A field test-kit for analyzing arsenic concentration in water samples incudes a portable infrared beam photometer for measuring light absorbance in aqueous specimens. An infrared ligth emittng diode (120A, 120B) is configured to direct a beam of light through a specimen. A photodetecotr diode (130A, 130B) measures the intensity of light passing through the specimen. The photodetector (130A, 130B) output voltages relate to the light absorbed in the specimen and are displayed on a LCD (160) screen. To test for arsenic, molybdenum-blue color complexes. The light absorbance of a specimen with both arsenates and phosphates bound in molybdenum-blue color complexes is compared to that of a reference specimen in which phosphates but not arsenates are bound and converted. A quantitative value for the arsenic concentration in the water sample is determined from the differential light absorbance of the two specimens.

9. 发明申请

WO2008105914A3 MECHANICALLY TUNABLE ELASTOMERIC OPTOFLUIDIC DISTRIBUTED FEEDBACK DYE LASERS 审中-公开
标题翻译：机械柔性弹性光滑分布式反馈染料激光
公开(公告)号：WO2008105914A3
公开(公告)日：2008-12-18
申请号：PCT/US2007075668
申请日：2007-08-10
申请人： CALIFORNIA INST OF TECHN , LI ZHENYU , PSALTIS DEMETRI , SCHERER AXEL , ZHANG ZHAOYU
发明人： LI ZHENYU , PSALTIS DEMETRI , SCHERER AXEL , ZHANG ZHAOYU
IPC分类号： H01S3/213 , H01S3/094
CPC分类号： H01S3/022 , H01S3/08036 , H01S3/1053 , H01S3/213
摘要： The invention relates to a microfluidic dye laser (100) including a pump light source configured to provide light (107) having a pump light wavelength. The microfluidic dye laser (100) also includes an elastomer substantially optically transparent at the pump light wavelength (107) and at a microfluidic dye laser wavelength. A microfluidic channel (102) configured to accept a iluidic dye is defined in the elastomer. An optical grating (108) is formed in a single mode 3D waveguide in the microfluidic channel (102) in order to provide a single mode microfluidic dye laser light as output in response to illumination with light from the pump light source (107). In another aspect, the invention features a method of tuning a wavelength of a microfluidic dye laser light by mechanically deforming the eiastomeric laser chip to change the grating period in the optical cavity.
摘要翻译：本发明涉及一种微流体染料激光器（100），其包括被配置为提供具有泵浦光波长的光（107）的泵浦光源。微流体染料激光器（100）还包括在泵浦光波长（107）处以微流体染料激光波长基本上光学透明的弹性体。在弹性体中限定了构造成接受液体染料的微流体通道（102）。在微流体通道（102）中的单模3D波导中形成光栅（108），以便响应于来自泵浦光源（107）的光的照明，提供单模微流体染料激光作为输出。在另一方面，本发明的特征在于一种通过机械地使所述激光激光芯片变形以改变光腔中的光栅周期来调谐微流体染料激光的波长的方法。

10. 发明申请

WO2008127432A3 METHOD OF NONLINEAR HARMONIC HOLOGRAPHY 审中-公开
标题翻译：非线性谐波全息法的方法
公开(公告)号：WO2008127432A3
公开(公告)日：2008-12-11
申请号：PCT/US2007085409
申请日：2007-11-21
申请人： CALIFORNIA INST OF TECHN , PU YE , PSALTIS DEMETRI
发明人： PU YE , PSALTIS DEMETRI
IPC分类号： G03H1/00
CPC分类号： G01N21/636 , B82Y20/00 , G01N21/453 , G01N21/658 , G01N2021/653 , G02B5/32 , G03H1/0465 , G03H2001/0447 , G03H2210/62 , G03H2210/63 , G03H2222/33 , G03H2223/26 , G03H2240/56
摘要： A harmonic holography (H2) technique and system that combines holography and nonlinear optics that enables holographic recording of 3D images with femtosecond framing time are provided. The H2 technique records holograms with second harmonic (SH) signals scattered off specialized nanocrystals that are functionalized to label specific protein or other biomolecules in a living organism. The capability of generating second harmonic radiations is specific to materials with noncentrosymmetric crystalline structures only, and ?® vanishes for all other types of materials. Therefore, a sharp contrast is formed when particles of noncentrosymmetric structures are dispersed in a medium of other species, pumped at a fundamental frequency, and imaged at the second harmonic frequency. The new scheme described herein provides a sound basis for a new type of contrast microscopy with enormous potential in molecular biomedical imaging.
摘要翻译：提供了一种组合全息和非线性光学的谐波全息（H2）技术和系统，可以实现3D图像与飞秒成帧时间的全息记录。 H2技术记录具有二次谐波（SH）信号的全息图，散射专门的纳米晶体，其被功能化以标记生物体中的特定蛋白质或其他生物分子。产生二次谐波辐射的能力仅限于具有非中心对称结晶结构的材料，而对于所有其他类型的材料，？®消失。因此，当非中心对称结构的颗粒分散在其他物质的介质中，以基频泵浦并且以二次谐波频率成像时，形成明显的对比。本文描述的新方案为分子生物医学成像中具有巨大潜力的新型对比显微镜提供了良好的基础。

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