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1. 发明申请

WO2008140584A3 SECOND HARMONIC IMAGING NANOPROBES AND TECHNIQUES FOR USE THEREOF 审中-公开
标题翻译：第二谐波成像纳米微粒及其使用技术
公开(公告)号：WO2008140584A3
公开(公告)日：2009-01-08
申请号：PCT/US2007085407
申请日：2007-11-21
申请人： CALIFORNIA INST OF TECHN , PANTAZIS PERIKLIS , PSALTIS DEMETRI , HONG JOHN , PU YE , FRASER SCOTT E
发明人： PANTAZIS PERIKLIS , PSALTIS DEMETRI , HONG JOHN , PU YE , FRASER SCOTT E
IPC分类号： G01N21/00
CPC分类号： G01N33/483 , A61B5/0075 , A61K49/0002 , B82Y5/00 , B82Y15/00 , B82Y20/00 , G01N21/636 , G02F1/37 , G06K9/00134
摘要： Second harmonic nanoprobes for imaging biological samples and a method of using such probes to monitor the dynamics of biological process using a field resonance enhanced second harmonic (FRESH) technique are provided. The second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystals that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy for in vivo imaging of biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging.
摘要翻译：提供了用于成像生物样品的二次谐波纳米探针和使用这种探针来监测使用场共振增强二次谐波（FRESH）技术的生物过程的动力学的方法。二次谐波产生（SHG）纳米探针由不具有反转对称性的各种纳米晶体组成，因此能够产生二次谐波信号，然后可以通过传统的双光子显微镜检测生物过程的体内成像，结构如细胞信号传导，神经成像，蛋白质构象探索，DNA构象探索，基因转录，细胞中的病毒感染和复制，蛋白质动力学，肿瘤成像和癌症治疗评估和诊断以及光学成像中的定量。

2. 发明申请

WO2008127432A3 METHOD OF NONLINEAR HARMONIC HOLOGRAPHY 审中-公开
标题翻译：非线性谐波全息法的方法
公开(公告)号：WO2008127432A3
公开(公告)日：2008-12-11
申请号：PCT/US2007085409
申请日：2007-11-21
申请人： CALIFORNIA INST OF TECHN , PU YE , PSALTIS DEMETRI
发明人： PU YE , PSALTIS DEMETRI
IPC分类号： G03H1/00
CPC分类号： G01N21/636 , B82Y20/00 , G01N21/453 , G01N21/658 , G01N2021/653 , G02B5/32 , G03H1/0465 , G03H2001/0447 , G03H2210/62 , G03H2210/63 , G03H2222/33 , G03H2223/26 , G03H2240/56
摘要： A harmonic holography (H2) technique and system that combines holography and nonlinear optics that enables holographic recording of 3D images with femtosecond framing time are provided. The H2 technique records holograms with second harmonic (SH) signals scattered off specialized nanocrystals that are functionalized to label specific protein or other biomolecules in a living organism. The capability of generating second harmonic radiations is specific to materials with noncentrosymmetric crystalline structures only, and ?® vanishes for all other types of materials. Therefore, a sharp contrast is formed when particles of noncentrosymmetric structures are dispersed in a medium of other species, pumped at a fundamental frequency, and imaged at the second harmonic frequency. The new scheme described herein provides a sound basis for a new type of contrast microscopy with enormous potential in molecular biomedical imaging.
摘要翻译：提供了一种组合全息和非线性光学的谐波全息（H2）技术和系统，可以实现3D图像与飞秒成帧时间的全息记录。 H2技术记录具有二次谐波（SH）信号的全息图，散射专门的纳米晶体，其被功能化以标记生物体中的特定蛋白质或其他生物分子。产生二次谐波辐射的能力仅限于具有非中心对称结晶结构的材料，而对于所有其他类型的材料，？®消失。因此，当非中心对称结构的颗粒分散在其他物质的介质中，以基频泵浦并且以二次谐波频率成像时，形成明显的对比。本文描述的新方案为分子生物医学成像中具有巨大潜力的新型对比显微镜提供了良好的基础。

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