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1. 发明申请

WO2012119114A3 E-PETRI DISHES, DEVICES, AND SYSTEMS 审中-公开
公开(公告)号：WO2012119114A3
公开(公告)日：2012-09-07
申请号：PCT/US2012/027575
申请日：2012-03-02
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , ZHENG, Guoan , YANG, Samuel , LEE, Seung Ah , PANG, Shuo , YANG, Changhuei
发明人： ZHENG, Guoan , YANG, Samuel , LEE, Seung Ah , PANG, Shuo , YANG, Changhuei
IPC分类号： H01J37/22 , H01J37/244
摘要： An e-Petri dish comprising a transparent layer having a specimen surface and a light detector configured to sample a sequence of sub-pixel shifted projection images of a specimen located on the specimen surface. The sub-pixel shifted projection images associated with light from a plurality of illumination angles provided by an illumination source.

2. 发明申请

WO2012058233A2 SCANNING PROJECTIVE LENSLESS MICROSCOPE SYSTEM 审中-公开
标题翻译：扫描投影无线显微镜系统
公开(公告)号：WO2012058233A2
公开(公告)日：2012-05-03
申请号：PCT/US2011057735
申请日：2011-10-25
申请人： CALIFORNIA INST OF TECHN , ZHENG GUOAN , YANG SAMUEL , LEE SEUNG AH , YANG CHANGHUEI
发明人： ZHENG GUOAN , YANG SAMUEL , LEE SEUNG AH , YANG CHANGHUEI
IPC分类号： G01B9/04 , G01N21/00 , G02B21/00
CPC分类号： H04N7/183 , G02B21/0008 , G02B21/06 , G02B21/367 , G03H2001/0447
摘要： A scanning projective lensless microscope device comprises a specimen surface, a scanning illumination source with a light element, a light detector outside the specimen surface, and a processor. The scanning illumination source scans the light element to a plurality of scanning locations to provide illumination to an object on the specimen surface. The light detector samples a sequence of sub-pixel shifted projection object images corresponding to the plurality of scanning locations. The processor constructs a high resolution image of the object based on the sequence of sub-pixel shifted projection images and a motion vector of the projections at a plane of interest.
摘要翻译：一种扫描投影镜头无显微镜装置，包括一个样品表面，一个带有光元件的扫描照明源，在样品表面外部的光检测器和一个处理器。扫描照明源将光元件扫描到多个扫描位置以向样品表面上的物体提供照明。光检测器对与多个扫描位置对应的子像素偏移投影对象图像序列进行采样。处理器基于子像素移位的投影图像的序列和感兴趣的平面上的投影的运动矢量来构建对象的高分辨率图像。

3. 发明申请

WO2011060101A3 TURBIDITY SUPPRESSION BY OPTICAL PHASE CONJUGATION USING A SPATIAL LIGHT MODULATOR 审中-公开
标题翻译：用光调制器实现光学相位共轭抑制浊度
公开(公告)号：WO2011060101A3
公开(公告)日：2011-11-24
申请号：PCT/US2010056274
申请日：2010-11-10
申请人： CALIFORNIA INST OF TECHN , YANG CHANGHUEI , CUI MENG
发明人： YANG CHANGHUEI , CUI MENG
IPC分类号： G01N15/06 , G01N21/59 , G01N33/483
CPC分类号： G02B21/0056 , A61B5/0059 , A61B5/0066 , G01N21/1717 , G01N21/4795 , G01N21/6456 , G01N2021/1708 , G01N2021/1727 , G02B21/00 , G02B21/0004 , G02B21/0068 , G02B21/0092 , Y10T29/49826
摘要： A detector of light transmitted through a turbid medium, comprising: one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include (1) a sensor for detecting input light that has been transmitted through the turbid medium and inputted on the sensor; and (2) a spatial light modulator (SLM) for outputting, in response to the input light detected by the sensor, output light that is an optical phase conjugate of the input light.
摘要翻译： 1.一种透过混浊介质的光的检测器，包括：一个或多个数字光学相位共轭（DOPC）装置，其中所述DOPC装置包括（1）传感器，用于检测已经透过混浊介质并输入到传感器; （2）空间光调制器（SLM），用于响应于传感器检测到的输入光输出作为输入光的光学相位共轭的输出光。

4. 发明申请

WO2019168556A1 ULTRASOUND MODULATING OPTICAL TOMOGRAPHY USING REDUCED LASER PULSE DURATION 审中-公开
公开(公告)号：WO2019168556A1
公开(公告)日：2019-09-06
申请号：PCT/US2018/041334
申请日：2018-07-09
申请人： HI LLC , MARBLESTONE, Adam , YANG, Changhuei
发明人： MARBLESTONE, Adam , YANG, Changhuei , ALFORD, Jamu
IPC分类号： A61B5/00 , A61B5/1455
摘要： Sample light is delivered into the anatomical structure having a target voxel, whereby a portion of the sample light passing through the target voxel is scattered by the anatomical structure as signal light, and another portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light that is combined with the signal light to create a sample light pattern. Reference light is combined with the sample light pattern to generate an interference light pattern, such that the signal light and the reference light are combined in a heterodyne manner. Ultrasound is delivered into the target voxel, such that the signal light is frequency shifted by the ultrasound. The ultrasound and the sample light are pulsed in synchrony, such that at least one pulse of the sample light has a combined duration less than a pulse width of the ultrasound.

5. 发明申请

WO2012119094A3 LIGHT GUIDED PIXEL 审中-公开
公开(公告)号：WO2012119094A3
公开(公告)日：2012-09-07
申请号：PCT/US2012/027522
申请日：2012-03-02
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , LEE, Seung Ah , ZHENG, Guoan , JUDKEWITZ, Benjamin , PANG, Shuo , WU, Jigang , YANG, Changhuei
发明人： LEE, Seung Ah , ZHENG, Guoan , JUDKEWITZ, Benjamin , PANG, Shuo , WU, Jigang , YANG, Changhuei
IPC分类号： G02B6/42 , G02B6/10
摘要： A light guided pixel having a guide layer and a light detector layer. The guide layer has a light guide. The light detector layer has a light detecting element that receives light channeled by the light guide. The light guide may include a filter for channeling emissions to the light detecting element.

6. 发明申请

WO2011119678A3 SUPER RESOLUTION OPTOFLUIDIC MICROSCOPES FOR 2D AND 3D IMAGING 审中-公开
标题翻译：超分辨率光学显微镜2D和3D成像
公开(公告)号：WO2011119678A3
公开(公告)日：2012-02-02
申请号：PCT/US2011029542
申请日：2011-03-23
申请人： CALIFORNIA INST OF TECHN , ZHENG GUOAN , YANG CHANGHUEI , YANG SAMUEL , LEE SEUNG AH
发明人： ZHENG GUOAN , YANG CHANGHUEI , YANG SAMUEL , LEE SEUNG AH
IPC分类号： G01N21/49 , G01N35/00 , G02B21/32
CPC分类号： H04N5/349 , G01N15/147 , G01N15/1484 , G02B21/0008 , G02B21/36 , G06T3/4053
摘要： A super resolution optofluidic microscope device comprises a body defining a fluid channel having a longitudinal axis and includes a surface layer proximal the fluid channel. The surface layer has a two-dimensional light detector array configured to receive light passing through the fluid channel and sample a sequence of subpixel shifted projection frames as an object moves through the fluid channel. The super resolution optofluidic microscope device further comprises a processor in electronic communication with the two-dimensional light detector array. The processor is configured to generate a high resolution image of the object using a super resolution algorithm, and based on the sequence of subpixel shifted projection frames and a motion vector of the object.
摘要翻译：超分辨率光流体显微镜装置包括限定具有纵向轴线的流体通道的主体并且包括靠近流体通道的表面层。表面层具有二维光检测器阵列，其构造成当物体移动通过流体通道时，接收通过流体通道的光并采样一系列子像素偏移的投影框。超分辨率光流体显微镜装置还包括与二维光检测器阵列电子通信的处理器。处理器被配置为使用超分辨率算法，并且基于子像素偏移的投影帧的序列和对象的运动矢量来生成对象的高分辨率图像。

7. 发明申请

WO2011106324A3 NONDIFFRACTING BEAM DETECTION DEVICES FOR THREE-DIMENSIONAL IMAGING 审中-公开
标题翻译：用于三维成像的非衍射光束检测装置
公开(公告)号：WO2011106324A3
公开(公告)日：2011-09-01
申请号：PCT/US2011/025751
申请日：2011-02-22
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , PAVANI, Sri Rama Prasanna , YANG, Changhuei
发明人： PAVANI, Sri Rama Prasanna , YANG, Changhuei
IPC分类号： G01B11/24 , G02B27/22
摘要： Embodiments of the present invention relate a nondiffracting beam detection module for generating three-dimensional image data that has a surface layer having a first surface and a light transmissive region, a microaxicon, and a light detector. The microaxicon receives light through the light transmissive region from outside the first surface and generates one or more detection nondiffracting beams based on the received light. The light detector receives the nondiffracting beams and generates three-dimensional image data associated with an object located outside the first surface based on the one or more detection nondiffracting beams received. In some cases, the light detector can localize a three-dimensional position on the object associated with each detection nondiffracting beam received. In other cases, the light detector can determine perspective projections based on the detection nondiffracting beams received and generates the three-dimensional image data, using tomography, based on the determined perspective projections.
摘要翻译：本发明的实施例涉及一种用于生成三维图像数据的非衍射光束检测模块，该三维图像数据具有具有第一表面和透光区域的表面层，微型轴和光检测器。微米从第一表面的外部通过透光区域接收光，并且基于接收到的光产生一个或多个检测非衍射光束。光检测器接收非衍射光束并基于接收的一个或多个检测非衍射光束产生与位于第一表面外部的对象相关联的三维图像数据。在一些情况下，光检测器可以定位与接收的每个检测非衍射光束相关联的物体上的三维位置。在其他情况下，光检测器可以基于所接收的检测非衍射光束来确定透视投影，并基于所确定的透视投影使用断层摄影来生成三维图像数据。

8. 发明申请

WO2011047053A2 HOLOGRAPHICALLY ILLUMINATED IMAGING DEVICES 审中-公开
标题翻译：全自动照明成像装置
公开(公告)号：WO2011047053A2
公开(公告)日：2011-04-21
申请号：PCT/US2010/052512
申请日：2010-10-13
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , YANG, Changhuei , WU, Jigang , PANG, Shuo
发明人： YANG, Changhuei
IPC分类号： G02B21/00 , G02B27/22 , G02B27/24
CPC分类号： G02B27/106 , G02B5/32 , G02B21/0076 , G02B21/16 , G02B26/004 , G02B26/10 , G02B27/1093 , G02B27/141
摘要： Embodiments of the present invention relate to holographically illuminated imaging devices including a holographic element for transforming an illumination beam into a focal array of light spots, a scanning mechanism for moving an object across one or more light spots in the focal array of light spots, and a light detector for detecting light associated with the focal array of light spots and generating light data associated with the received light.
摘要翻译：本发明的实施例涉及全息照明的成像装置，其包括用于将照明光束变换为光斑的焦点阵列的全息元件，用于沿着光斑的焦点阵列中的一个或多个光点移动物体的扫描机构，以及用于检测与光点的焦点阵列相关联的光并产生与所接收的光相关联的光数据的光检测器。

9. 发明申请

WO2008112416A3 OPTOFLUIDIC MICROSCOPE DEVICE 审中-公开
标题翻译：光学显微镜装置
公开(公告)号：WO2008112416A3
公开(公告)日：2008-11-13
申请号：PCT/US2008054908
申请日：2008-02-25
申请人： CALIFORNIA INST OF TECHN , YANG CHANGHUEI , PSALTIS DEMETRI
发明人： YANG CHANGHUEI , PSALTIS DEMETRI
IPC分类号： G01N21/00 , B32B27/04
CPC分类号： G01N21/6458 , B82Y30/00
摘要： An optofluidic microscope device is disclosed. The device includes a fluid channel having a surface and an object such as a bacterium or virus may flow through the fluid channel. Light transmissive regions of different sizes may be used to image the object.
摘要翻译：公开了一种光流体显微镜装置。该装置包括具有表面的流体通道，诸如细菌或病毒的物体可以流过流体通道。可以使用不同尺寸的透光区域对物体进行成像。

10. 发明申请

WO2007038682A3 PAIRED ANGLED ROTATION SCANNING PROBES AND METHODS OF USE 审中-公开
公开(公告)号：WO2007038682A3
公开(公告)日：2007-04-05
申请号：PCT/US2006/037901
申请日：2006-09-27
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , YANG, Changhuei , WU, Jigang
发明人： YANG, Changhuei , WU, Jigang
IPC分类号： A61B1/07
摘要： Probes, and systems and methods for optically scanning a conical volume in front of a probe, for use with an imaging modality, such as Optical Coherence Tomography (OCT). A probe includes an optical fiber (20) having a proximal end and a distal e and defining an axis, with the proximal end of the optical fiber being proximate a light source, and the distal end having a first angle surface (θ). A refractive lens element (30) is positioned proximate the distal end of the optical fiber. The lens element and the fiber e are both configured to separately rotate about the axis so as to image a conical scan volume when light is provided by the source. Reflected light from a sample under investigation is collected by the fiber and analyzed by an imaging system. Such probes may be v compact, e.g., having a diameter 1 mm or less, and are advantageous for use in minimally invasive surgical procedures.

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