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1. 发明申请

WO1995010508A1 OXAZOLINONE DERIVATIVE HAVING INTRACELLULAR PHOSPHOLIPASE A2 INHIBITOR ACTIVITY 审中-公开
标题翻译：具有细胞内磷脂酶A2抑制剂活性的奥沙罗宁衍生物
公开(公告)号：WO1995010508A1
公开(公告)日：1995-04-20
申请号：PCT/JP1994001716
申请日：1994-10-13
申请人： SHIONOGI & CO., LTD. , OHTANI, Mitsuaki , KATO, Toshiyuki
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07D263/38
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D263/22 , C07D263/38 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： A compound represented by general formula (I), and having an intracellular phospholipase A2 inhibitor activity, and a composition containing the same, wherein a and b represent each a carbon atom and the bond -- between the atoms a and b represents either a single or a double bond; X represents hydrogen, optionallysubstituted aryl, heteroaryl or aralkyl; Y represents hydrogen, optionally substituted aryl, aralkyl, carboxyl or a functional group related thereto; and Z represents hydrogen, optionally substituted alkyl, alkenyl, alkynyl, aralkyl, arylalkenyl, heteroarylalkyl, heteroarylalkenyl, aryloxyalkyl, aralkyloxyalkyl, arylcarbonylalkyl, arylsulfonylalkyl, heteroarylsulfonylalkyl, aminoalkyl, carboxyalkyl or a functional group related thereto, alkyloxycarbonyl, aralkyloxycarbonyl, arylcarbonyl, alkylsulfonyl, arylsulfonyl or heteroarylsulfonyl; provided the case where X, Y and Z represent simultaneously hydrogen atoms is excluded.
摘要翻译：由通式（I）表示的具有细胞内磷脂酶A2抑制剂活性的化合物和含有该化合物的组合物，其中a和b各自表示碳原子和原子之间的键 - a和b表示单键或双键; X表示氢，任选取代的芳基，杂芳基或芳烷基; Y表示氢，任选取代的芳基，芳烷基，羧基或与其相关的官能团; 芳基烷基，芳基磺酰基烷基，杂芳基磺酰基烷基，氨基烷基，羧基烷基或与其有关的官能团，烷氧基羰基，芳烷氧基羰基，芳基羰基，烷基磺酰基，芳基磺酰基或杂芳基磺酰基; 只要X，Y和Z同时表示氢原子排除的情况。

2. 发明申请

WO1991005765A1 PROCESS FOR PREPARING SULFONAMIDE DERIVATIVE OF NORBORNANE 审中-公开
标题翻译：制备NORBORNANE的磺酰胺衍生物的方法
公开(公告)号：WO1991005765A1
公开(公告)日：1991-05-02
申请号：PCT/JP1990001330
申请日：1990-10-16
申请人： SHIONOGI & CO., LTD. , OHTANI, Mitsuaki , MATSUURA, Takaharu , HAMADA, Yoshinori , SHINOMOTO, Shoji
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07C311/20
CPC分类号： C07D493/08 , C07C311/20
摘要： A process for preparing a sulfonamide derivative of a norbornane represented by formula (I), (wherein R' represents optionally protected CH2OH or COOH; R2 represents optionally substituted phenyl; and Y represents oxygen or optionally substituted methylene), which comprises treating under Hofmann rearrangement reaction conditions a norbornane carboxamide represented by formula (II), (wherein R represents optionally protected CH¿2?OH or COOR?1, R1¿ represents hydrogen or an ester-forming group; and Y is as defined above); and reacting the resultant compound with a sulfonyl halide represented by formula (III), (wherein R2 is as defined above; and X represents a halogen).

3. 发明申请

WO1997027174A1 SULFONATED AMINO ACID DERIVATIVES AND METALLOPROTEINASE INHIBITORS CONTAINING THE SAME 审中-公开
标题翻译：含有氨基酸的氨基酸衍生物和含有其的金属蛋白酶抑制剂
公开(公告)号：WO1997027174A1
公开(公告)日：1997-07-31
申请号：PCT/JP1997000126
申请日：1997-01-22
申请人： SHIONOGI & CO., LTD. , WATANABE, Fumihiko , TSUZUKI, Hiroshige , OHTANI, Mitsuaki
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07C311/00
CPC分类号： C07D213/54 , C07C311/06 , C07C311/13 , C07C311/19 , C07C311/29 , C07C311/32 , C07C311/42 , C07C311/46 , C07C311/47 , C07C311/49 , C07C323/62 , C07C323/67 , C07D209/20 , C07D209/42 , C07D213/55 , C07D213/81 , C07D213/82 , C07D235/16 , C07D241/24 , C07D257/04 , C07D261/18 , C07D277/30 , C07D277/64 , C07D333/34 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds having a metalloproteinase inhibitory activity, represented by general formula (I), optically active isomers thereof, or pharmacologically acceptable salts thereof, or hydrates of these.
摘要翻译：具有由通式（I）表示的金属蛋白酶抑制活性的化合物，其光学活性异构体或其药理学上可接受的盐或它们的水合物。

4. 发明申请

WO1996003120A1 INDENE sPLA2 INHIBITORS 审中-公开
标题翻译： INDENE sPLA2抑制剂
公开(公告)号：WO1996003120A1
公开(公告)日：1996-02-08
申请号：PCT/US1995009246
申请日：1995-07-20
申请人： ELI LILLY AND COMPANY , SHIONOGI & CO., LTD. , DILLARD, Robert, D. , HAGISHITA, Sanji , OHTANI, Mitsuaki
发明人： ELI LILLY AND COMPANY , SHIONOGI & CO., LTD.
IPC分类号： A61K31/10
CPC分类号： C07F9/3882 , C07C45/46 , C07C45/65 , C07C49/755 , C07C59/64 , C07C59/72 , C07C69/734 , C07C235/32 , C07C2602/08
摘要： A class of novel indene-1-functional compounds is disclosed together with the use of such indene compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock. The compounds are indene-1-acetamides, indene-1-acetic acid hydrazides, and indene-1-glyoxylamides.
摘要翻译：公开了一类新颖的茚-1-功能化合物以及使用这样的茚化合物来抑制sPLA2介导的脂肪酸释放来治疗诸如败血性休克的病症。化合物是茚-1-乙酰胺，茚-1-乙酸酰肼和茚-1-乙醛酰胺。

5. 发明申请

WO2010014794A1 BENZOIMIDAZOLE DERIVATIVES AND GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING THE SAME 审中-公开
标题翻译：苯并咪唑衍生物和含有其的GLYCOGEN SYNTHASE激酶3激酶抑制剂
公开(公告)号：WO2010014794A1
公开(公告)日：2010-02-04
申请号：PCT/US2009/052225
申请日：2009-07-30
申请人： ONCOTHERAPY SCIENCE, INC. , OHTANI, Mitsuaki , MATSUO, Yo , LI, Yingfu , WALKER, Joel, R. , JENKINS, David, M. , AHMED, Feryan , OHSAWA, Ryuji , HISADA, Shoji
发明人： OHTANI, Mitsuaki , MATSUO, Yo , LI, Yingfu , WALKER, Joel, R. , JENKINS, David, M. , AHMED, Feryan , OHSAWA, Ryuji , HISADA, Shoji
IPC分类号： A01N43/30
CPC分类号： C07D409/04 , C07D235/18 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Benzoimidazole Derivatives are provided. The compounds of the present invention are useful for Glycogen Synthase Kinase-3 Beta Inhibitors.
摘要翻译：提供苯并咪唑衍生物。本发明的化合物可用于糖原合酶激酶-3β抑制剂。

6. 发明申请

WO1993012075A1 HYDROXAMIC ACID DERIVATIVE BASED ON AROMATIC SULFONAMIDE 审中-公开
标题翻译：基于芳香磺酰胺的羟基酸衍生物
公开(公告)号：WO1993012075A1
公开(公告)日：1993-06-24
申请号：PCT/JP1992001593
申请日：1992-12-07
申请人： SHIONOGI & CO., LTD. , OHTANI, Mitsuaki , ARITA, Hitoshi , SUGITA, Kenji , MATSUURA, Takaharu , SHIRAHASE, Kazuhiro
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07C259/06
CPC分类号： C07C311/19 , C07C59/64 , C07C259/06 , C07C271/28 , C07C311/08 , C07C311/21 , C07C311/29 , C07D209/18
摘要： A novel hydroxamic acid derivative containing a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof as the active ingredient, which has activities of inhibiting cell growth, vascularization, etc.. It has activities of inhibiting hemangioendothelial cell growth and the development of a lymphocyte adhesion factor, and detransformation by ras gene, thus inhibiting cell growth and being efficacious against inflammation and tumor.

7. 发明申请

WO1993001157A1 PHOSPHOLIPASE A2 INHIBITOR 审中-公开
标题翻译：磷脂酶A2抑制剂
公开(公告)号：WO1993001157A1
公开(公告)日：1993-01-21
申请号：PCT/JP1992000802
申请日：1992-06-24
申请人： SHIONOGI & CO., LTD. , OHTANI, Mitsuaki , MATSUTANI, Shigeru , YOSHIDA, Tadashi , TANAKA, Kazushige , FUJII, Yasuhiko , SHIRAHASE, Kazuhiro
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07C69/00
CPC分类号： C07D493/10 , C07C69/90 , C07C69/92 , C07C229/36 , C07C271/22 , C07C317/44 , C07C323/62 , C07D309/38
摘要： A novel thielocin derivative having a phospholipase A2 inhibitory activity, represented by general formula (I), or a salt thereof, wherein R1 to R8 represent each independently hydrogen, lower alkyl, lower alkoxy, hydroxy or halogen; E¿1? and E2 represent each independently hydrogen or an ester residue; m and n represent each independently an integer of 0 to 4; and -Y- represents a divalent group selected among those represented by the following formulae -CH2CH2-, -CH=CH-, (II), (III), (IV), (V), (VI), (VII).

8. 发明申请

WO1997005135A1 PYRROLIDINE DERIVATIVES HAVING PHOSPHOLIPASE A2 INHIBITORY ACTIVITY 审中-公开
标题翻译：具有磷脂酶A2抑制活性的吡咯烷衍生物
公开(公告)号：WO1997005135A1
公开(公告)日：1997-02-13
申请号：PCT/JP1996002079
申请日：1996-07-25
申请人： SHIONOGI & CO., LTD. , OHTANI, Mitsuaki , KATO, Toshiyuki , WATANABE, Fumihiko , SENO, Kaoru
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07D417/12
CPC分类号： C07D417/12 , C07D417/14
摘要： Compound represented by general formula I or pharmaceutically acceptable salts or hydrates thereof, having the activity of inhibiting the production of prostaglandin E2 by inhibiting intracellular phospholipase A2.
摘要翻译：具有通过抑制细胞内磷脂酶A2抑制前列腺素E2产生的活性的通式I或其药学上可接受的盐或水合物所代表的化合物。

9. 发明申请

WO1997000853A1 BICYCLIC AMINO DERIVATIVES AND PGD2 ANTAGONIST CONTAINING THE SAME 审中-公开
标题翻译：双相氨基酸衍生物和含有其的PGD2拮抗剂
公开(公告)号：WO1997000853A1
公开(公告)日：1997-01-09
申请号：PCT/JP1996001685
申请日：1996-06-19
申请人： SHIONOGI & CO., LTD. , OHTANI, Mitsuaki , ARIMURA, Akinori , TSURI, Tatsuo , KISHINO, Junji , HONMA, Tsunetoshi
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07C233/52
CPC分类号： C07D213/81 , A61K31/557 , C07C233/52 , C07C233/63 , C07C233/74 , C07C233/81 , C07C233/84 , C07C235/22 , C07C235/36 , C07C235/42 , C07C235/54 , C07C235/84 , C07C237/38 , C07C237/42 , C07C245/08 , C07C251/48 , C07C251/86 , C07C255/57 , C07C271/24 , C07C275/42 , C07C281/14 , C07C309/65 , C07C311/13 , C07C311/20 , C07C311/29 , C07C311/37 , C07C311/43 , C07C311/46 , C07C311/51 , C07C317/44 , C07C323/62 , C07C337/08 , C07C2601/14 , C07C2601/16 , C07C2602/42 , C07C2603/18 , C07D207/34 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/42 , C07D209/88 , C07D213/56 , C07D215/36 , C07D221/12 , C07D231/12 , C07D233/56 , C07D235/06 , C07D249/08 , C07D257/04 , C07D261/18 , C07D263/57 , C07D271/06 , C07D271/107 , C07D275/03 , C07D277/20 , C07D277/56 , C07D279/20 , C07D279/22 , C07D285/06 , C07D285/12 , C07D295/192 , C07D307/68 , C07D307/84 , C07D307/91 , C07D311/12 , C07D311/24 , C07D311/82 , C07D313/14 , C07D317/48 , C07D319/24 , C07D333/18 , C07D333/24 , C07D333/32 , C07D333/34 , C07D333/36 , C07D333/38 , C07D333/62 , C07D333/68 , C07D333/76 , C07D333/78 , C07D337/14 , C07F9/5355
摘要： Compounds of general formula (I), salts thereof or hydrates thereof wherein (a) represents (b) or (c), for example, the compounds (d) and (e), which are useful as a PGD2 antagonist and thus usable in, for example, a remedy for systemic mastocytosis or systemic mast cell activation disorders, a drug for bronchoconstriction, an antiasthmatic, a drug for allergic rhinitis agent, a drug for allergic conjunctivitis, a drug for urticaria, a remedy for ischemia reflow disorders or an antiinflammatory agent. It is particularly useful in the treatment of nasal occlusion.
摘要翻译：通式（I）的化合物，其盐或其水合物，其中（a）代表（b）或（c），例如化合物（d）和（e）），其可用作PGD2拮抗剂，例如，用于系统性肥大细胞增多症或系统性肥大细胞活化障碍的药物，用于支气管收缩的药物，抗哮喘药，用于过敏性鼻炎药物，用于过敏性结膜炎的药物，用于荨麻疹的药物，缺血性回流病症的治疗剂或抗炎剂。它在治疗鼻塞方面特别有用。

10. 发明申请

WO1996003383A1 INDOLIZINE sPLA2 INHIBITORS 审中-公开
标题翻译：推荐sPLA2抑制剂
公开(公告)号：WO1996003383A1
公开(公告)日：1996-02-08
申请号：PCT/US1995009381
申请日：1995-07-20
申请人： ELI LILLY AND COMPANY , SHIONOGI & CO., LTD. , DILLARD, Robert, D. , HAGISHITA, Sanji , OHTANI, Mitsuaki
发明人： ELI LILLY AND COMPANY , SHIONOGI & CO., LTD.
IPC分类号： C07D221/04
CPC分类号： C07D471/04 , C07F9/6561
摘要： A class of novel indolizine-1-functional compounds and indolizine-3-functional compounds is disclosed together with the use of such indolizine compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock. The compounds are indolizine-1-acetamides, indolizine-1-acetic acid hydrazides, indolizine-1-glyoxylamides, indolizine-3-acetamides, indolizine-3-acetic acid hydraxides, and indolizine-3-glyoxylamides.
摘要翻译：公开了一类新的中氮嗪-1-功能化合物和中氮嗪-3-功能化合物，以及使用这种中氮茚化合物来抑制sPLA2介导的脂肪酸释放以治疗诸如败血性休克的病症。所述化合物为中氮茚-1-乙酰胺，中氮茚-1-乙酸酰肼，中氮茚-1-乙醛酰胺，中氮茚-3-乙酰胺，中氮茚-3-乙酸氢氧化物和中氮茚-3-乙醛酰胺。

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