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1. 发明申请

WO2012092504A3 NANOPARTICLE AND SURFACE-MODIFIED PARTICULATE COATINGS, COATED BALLOONS, AND METHODS THEREFORE 审中-公开
公开(公告)号：WO2012092504A3
公开(公告)日：2012-07-05
申请号：PCT/US2011/067921
申请日：2011-12-29
申请人： MICELL TECHNOLOGIES, INC. , MCCLAIN, James, B. , TAYLOR, Charles, Douglas , ZANI, Brett, G. , KIORPES, Timothy, Charles
发明人： MCCLAIN, James, B. , TAYLOR, Charles, Douglas , ZANI, Brett, G. , KIORPES, Timothy, Charles
IPC分类号： A61K9/14
摘要： Devices, coatings, and methods therefore comprise a medical device for delivering nanoparticles of an active agent to a treatment site. A coating on the medical device comprises active agent nanoparticles, which delivers coating to the treatment site and releases active agent nanoparticles into the treatment site over at least one day. A coating may comprise a polymer, a surfactant, and the nanoparticles. The coating may be prepared by forming a nanoemulsion. A coating may comprise encapsulated active agent nanoparticles which comprise active agent nanoparticles encapsulated in a polymer. The coating may have a positive surface charge. The coating may deliver active agent nanoparticles into the treatment site over at least about one day. The coating may be formed of a surfactant and nanoparticles mixture. The active agent nanoparticles may be deposited on the medical device using electrostatic capture.

2. 发明申请

WO2011133655A1 STENTS AND OTHER DEVICES HAVING EXTRACELLULAR MATRIX COATING 审中-公开
标题翻译： STENTS和其他具有细胞基质涂层的设备
公开(公告)号：WO2011133655A1
公开(公告)日：2011-10-27
申请号：PCT/US2011/033225
申请日：2011-04-20
申请人： MICELL TECHNOLOGIES, INC. , MCCLAIN, James, B. , BENVENUTO, Arthur, J.
发明人： MCCLAIN, James, B. , BENVENUTO, Arthur, J.
IPC分类号： A61F2/02
CPC分类号： A61L31/16 , A61L31/10 , A61L31/148 , A61L2300/30 , A61L2300/62 , A61L2420/02 , A61L2420/08 , C09D167/04
摘要： Provided herein are devices comprising a stent; and a coating on said stent comprising a polymer and an active agent, wherein the active agent comprises at least one of: extracellular matrix and an extracellular matrix component. Provided herein are methods of preparing a device comprising a stent and a coating on said stent; said method comprising: providing a stent; and forming a plurality of layers on said stent; wherein the coating comprises a polymer and at least one of said layers comprises one or more active agents; wherein at least a portion of the active agent comprises at least one of extracellular matrix and an extracellular matrix component.
摘要翻译：本文提供了包括支架的装置; 以及所述支架上的包含聚合物和活性剂的涂层，其中所述活性剂包括细胞外基质和细胞外基质组分中的至少一种。本文提供了制备包括支架和在所述支架上的涂层的装置的方法; 所述方法包括：提供支架; 并在所述支架上形成多个层; 其中所述涂层包含聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中所述活性剂的至少一部分包含细胞外基质和细胞外基质组分中的至少一种。

3. 发明申请

WO2010120552A3 COATED STENTS 审中-公开
标题翻译：涂层手套
公开(公告)号：WO2010120552A3
公开(公告)日：2011-03-31
申请号：PCT/US2010029494
申请日：2010-03-31
申请人： MICELL TECHNOLOGIES INC , TAYLOR DOUGLAS , MCCLAIN JAMES B
发明人： TAYLOR DOUGLAS , MCCLAIN JAMES B
IPC分类号： A61F2/82 , A61L27/04 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58
CPC分类号： A61L31/10 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61L31/16 , C08L67/04
摘要： Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
摘要翻译：本文提供了一种涂覆的冠状动脉支架，包括：a。支架; 湾沉积在所述支架上以形成所述冠状动脉支架的多个层; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

4. 发明申请

WO2008052000A3 HOLDER FOR ELECTRICALLY CHARGING A SUBSTRATE DURING COATING 审中-公开
标题翻译：用于在涂覆期间对基板进行电充电的保持器
公开(公告)号：WO2008052000A3
公开(公告)日：2008-06-26
申请号：PCT/US2007082275
申请日：2007-10-23
申请人： MICELL TECHNOLOGIES INC , MCCLAIN JAMES B , TAYLOR DOUG , DICKINSON ED , WORM STEVE
发明人： MCCLAIN JAMES B , TAYLOR DOUG , DICKINSON ED , WORM STEVE
IPC分类号： B05D1/04
CPC分类号： B05B5/0533 , A61L31/10 , B05B5/082 , B05B13/0207 , B05C13/025
摘要： A stent holder for mounting and electrically charging a stent during coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. An assembly for supporting and electrically charging a stent during the coating of the stent using dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A chamber for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles, the particles comprising inert polymers, pharmaceutical or biological agents, is provided. A method for creating an electrical field around a stent and for supporting, electrically charging, and exposing the stent to dry particles comprising inert polymers, pharmaceutical or biological agents is provided.
摘要翻译：提供了一种支架保持器，用于在使用干颗粒涂覆支架期间安装和充电支架，所述颗粒包含惰性聚合物，药物或生物制剂。提供了在使用干颗粒涂覆支架期间支撑和给支架充电的组件，所述颗粒包含惰性聚合物，药物或生物制剂。提供了用于在支架周围产生电场并用于支撑，充电和暴露支架以干燥颗粒的腔室，所述颗粒包含惰性聚合物，药物或生物制剂。提供了用于在支架周围产生电场并用于支撑，充电和暴露支架以干燥包含惰性聚合物，药物或生物制剂的颗粒的方法。

5. 发明申请

WO2005072095A2 METHOD OF TREATING MICROELECTRONIC SUBSTRATES 审中-公开
标题翻译：微电子基板处理方法
公开(公告)号：WO2005072095A2
公开(公告)日：2005-08-11
申请号：PCT/US2004/042001
申请日：2004-12-15
申请人： MICELL TECHNOLOGIES, INC. , DEYOUNG, James, P. , MCCLAIN, James, B. , GROSS, Stephen, M. , TAYLOR, Doug , WAGNER, Mark, I. , BRAINARD, David
发明人： DEYOUNG, James, P. , MCCLAIN, James, B. , GROSS, Stephen, M. , TAYLOR, Doug , WAGNER, Mark, I. , BRAINARD, David
IPC分类号： H01L21/288 , H01L21/3205 , H01L21/4763 , H01L21/768 , H01L23/48 , H01L23/52 , H01L29/40
CPC分类号： H01L21/32051 , H01L21/283 , H01L21/288 , H01L21/76814 , H01L21/76843 , H01L21/76871
摘要： A method of treating a dielectric surface portion of a semiconductor substrate, comprising the steps of: (a) providing a semiconductor substrate having a dielectric surface portion; and then (b) treating said dielectric surface portion with a coating reagent, the coating reagent comprising a reactive group coupled to a coordinating group, with the coordinating group having a metal bound thereto, so that the metal is deposited on the dielectric surface portion to produce a surface portion treated with a metal.
摘要翻译：一种处理半导体衬底的电介质表面部分的方法，包括以下步骤：（a）提供具有电介质表面部分的半导体衬底; 然后（b）用涂层试剂处理所述电介质表面部分，所述涂覆试剂包含与配位基团偶联的反应基团，所述配位基团与其结合金属，使得金属沉积在电介质表面部分上产生用金属处理的表面部分。

6. 发明申请

WO2004070776A2 METHODS FOR TRANSFERRING SUPERCRITICAL FLUIDS IN MICROELECTRONIC AND OTHER INDUSTRIAL PROCESSES 审中-公开
标题翻译：在微电子和其他工业过程中传输超临界流体的方法
公开(公告)号：WO2004070776A2
公开(公告)日：2004-08-19
申请号：PCT/US2003/040155
申请日：2003-12-08
申请人： MICELL TECHNOLOGIES, INC. , MCCLAIN, James, B. , DEYOUNG, James, P. , GROSS, Stephen, M. , WAGNER, Mark, I.
发明人： MCCLAIN, James, B. , DEYOUNG, James, P. , GROSS, Stephen, M. , WAGNER, Mark, I.
IPC分类号： H01L
CPC分类号： B08B7/0021 , B05D1/18 , B05D2401/90 , H01L21/02063 , H01L21/02101 , H01L21/67017 , H01L21/67028 , Y10T137/0324
摘要： A method of displacing a supercritical fluid from a pressure vessel (e.g., in a microelectronic manufacturing process), comprises the steps of: providing an enclosed pressure vessel containing a first supercritical fluid (said supercritical fluid preferably comprising carbon dioxide); adding a second fluid (typically also a supercritical fluid) to said vessel, with said second fluid being added at a pressure greater than the pressure of the first supercritical fluid, and with said second fluid having a density less than that of the first supercritical fluid; forming an interface between the first supercritical fluid and the second fluid; and displacing at least a portion of the first supercritical fluid from the vessel with the pressure of the second, preferably fluid while maintaining the interface therebetween.
摘要翻译：从压力容器（例如，微电子制造工艺）中移出超临界流体的方法包括以下步骤：提供包含第一超临界流体（所述超临界流体优选包含二氧化碳）的封闭压力容器; 向所述容器中加入第二流体（通常也是超临界流体），其中所述第二流体以大于第一超临界流体的压力的压力加入，并且所述第二流体的密度小于第一超临界流体的密度 ; 在所述第一超临界流体和所述第二流体之间形成界面; 并且使第二超临界流体的至少一部分与第二流体（优选流体）的压力从容器移位，同时保持其间的界面。

7. 发明申请

WO0157303A9 METHODS FOR CARBON DIOXIDE DRY CLEANING WITH INTEGRATED DISTRIBUTION 审中-公开
标题翻译：用于二氧化碳干燥清洗与一体化分布的方法
公开(公告)号：WO0157303A9
公开(公告)日：2002-10-31
申请号：PCT/US0103545
申请日：2001-02-01
申请人： MICELL TECHNOLOGIES INC , MCCLAIN JAMES B , ROMACK TIMOTHY J , DEYOUNG JAMES P , LIENHART R BRADLEY , DESIMONE JOSEPH M , HUGGINS KENNETH L
发明人： MCCLAIN JAMES B , ROMACK TIMOTHY J , DEYOUNG JAMES P , LIENHART R BRADLEY , DESIMONE JOSEPH M , HUGGINS KENNETH L
IPC分类号： D06L1/02 , D06L1/04 , D06L1/08 , D06L1/10
CPC分类号： D06L1/02
摘要： The present invention provides a dry cleaning process that facilitates distribution of detergent and solvent and (optionally) facilitates recovery of cleaning by-products in conjunction with the cleaning of articles at a dry cleaning facility. The proces comprises the steps of: (a) receiving from a source a dry cleaning solvent at the dry cleaning facility, the solvent consisting essentially of carbon dioxide; (b) receiving a concentrated detergent formulation (preferably a liquid formulation) at the cleaning facility; (c) accepting from customers soiled articles to be cleaned at the cleaning facility; (d) mixing the dry cleaning solvent and the concentrated detergent formulation to provide a dry cleaning formulation comprised of from 30 or 40 to 99 percent by weight of carbon dioxide solvent; (e) cleaning the articles in a cleaning apparatus to produce cleaned articles; (f) at least periodically distilling the dry cleaning formulation to produce a still residue comprising surfactant and soil; and then (g) returning the cleaned articles to the customers. Optionally but preferably, the process further comprises the step of: (h) returning the still residue to a waste collector or reprocessor for suitable disposal.
摘要翻译：本发明提供了一种便于洗涤剂和溶剂的分配的干洗方法，并且（任选地）便于在干洗设施处清洁物品的同时回收清洁副产物。方法包括以下步骤：（a）在干洗设备处从干燥清洁设备处获得干洗溶剂，所述溶剂基本上由二氧化碳组成; （b）在清洁设施处接收浓缩洗涤剂配制剂（优选液体制剂）; （c）客户接受在清洁设施上清洁的污物; （d）混合干洗溶剂和浓缩洗涤剂配方以提供由30或40至99重量％的二氧化碳溶剂组成的干洗制剂; （e）清洁清洁设备中的物品以产生清洁物品; （f）至少定期蒸馏干洗制剂以产生包含表面活性剂和土壤的残余物; 然后（g）将清洁的物品送回顾客。可选地，但优选地，该方法还包括以下步骤：（h）将残余物返回到废物收集器或再处理器以进行适当处置。

8. 发明申请

WO0231253A3 DEVICE AND PROCESS FOR DRY-CLEANING PROCESS USING CARBON DIOXIDE AND A DIVIDED PRESSURE VESSEL 审中-公开
标题翻译：使用二氧化碳和分压压力容器进行干燥清洗工艺的装置和方法
公开(公告)号：WO0231253A3
公开(公告)日：2002-08-01
申请号：PCT/US0131507
申请日：2001-10-10
申请人： MICELL TECHNOLOGIES INC , WORM STEVE L , DEYOUNG JAMES P , MCCLAIN JAMES B , BRAINARD DAVID E
发明人： WORM STEVE L , DEYOUNG JAMES P , MCCLAIN JAMES B , BRAINARD DAVID E
IPC分类号： A23L27/10 , D06F43/00 , D06L1/08 , F17C1/00 , F17C5/00 , F17C7/00
CPC分类号： D06L1/08 , A23L27/11 , D06F43/00 , D06F43/081 , F17C1/00 , F17C1/005 , F17C5/00 , F17C7/00 , F17C2201/0109 , F17C2201/0171 , F17C2201/032 , F17C2201/035 , F17C2201/056 , F17C2203/0643 , F17C2205/0347 , F17C2205/0397 , F17C2221/013 , F17C2221/014 , F17C2221/017 , F17C2221/033 , F17C2221/035 , F17C2227/0157 , F17C2227/0383 , F17C2250/0408 , F17C2265/012 , F17C2270/02 , F17C2270/0518
摘要： Processing systems employing one or more divided pressure vessels (653) are described. These systems may allow for multiple solvent baths each having a different chemical composition to be stored and/or processed in a single pressure vessel (653) while maintaining the different chemical compositions of the multiple solvent baths. Thus, such systems employing one or more divided pressure vessels (653) may provide the improved operational efficiency of a carbon dioxide based system having multiple solvent baths while decreasing the capital costs that may be associated with such systems.
摘要翻译：描述了采用一个或多个分压的压力容器（653）的处理系统。这些系统可以允许具有不同化学组成的多个溶剂浴在单个压力容器（653）中储存和/或加工，同时保持多个溶剂浴的不同化学组成。因此，采用一个或多个分压的压力容器（653）的这种系统可以提供具有多个溶剂浴的具有二氧化碳的系统的改进的操作效率，同时减少可能与这种系统相关联的资本成本。

9. 发明申请

WO2013025535A1 STENTS HAVING CONTROLLED ELUTION 审中-公开
标题翻译：具有控制力的手柄
公开(公告)号：WO2013025535A1
公开(公告)日：2013-02-21
申请号：PCT/US2012/050408
申请日：2012-08-10
申请人： MICELL TECHNOLOGIES, INC. , McCLAIN, James, B. , TAYLOR, Charles Douglas , CARLYLE, Wenda C.
发明人： McCLAIN, James, B. , TAYLOR, Charles Douglas , CARLYLE, Wenda C.
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61L31/022 , A61L31/024 , A61L31/028 , A61L31/10 , A61L31/148 , A61L2300/416 , A61L2300/63 , C08L67/04
摘要： Provided herein is a device comprising a stent and a coating on the stent; wherein the coating comprises at least one polymer and at least one active agent; wherein at least part of the active agent is in crystalline form.
摘要翻译：本文提供了一种包括支架和支架上的涂层的装置; 其中所述涂层包含至少一种聚合物和至少一种活性剂; 其中至少部分活性剂为结晶形式。

10. 发明申请

WO2013012689A1 DRUG DELIVERY MEDICAL DEVICE 审中-公开
标题翻译：药物递送医疗设备
公开(公告)号：WO2013012689A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/046545
申请日：2012-07-12
申请人： MICELL TECHNOLOGIES, INC. , MCCLAIN, James B. , TAYLOR, Charles Douglas , ZANI, Brett G. , NEET, John , KIORPES, Timothy Charles
发明人： MCCLAIN, James B. , TAYLOR, Charles Douglas , ZANI, Brett G. , NEET, John , KIORPES, Timothy Charles
IPC分类号： A61F2/06
CPC分类号： A61L31/08 , A61B17/12136 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/602 , A61L2420/06 , A61M25/10 , A61M2025/1081 , A61M2210/12 , B05D7/24
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on the substrate, wherein the coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within the coating and on the substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of the medical device in the body of the subject a portion of the pharmaceutical agent and/or active biological agent is delivered at the intervention site along with at least a portion of the polymer and/or a at least a portion of the pharmaceutical carrying agents.
摘要翻译：提供一种涂覆的可植入医疗装置，包括：基底; 以及涂层，其设置在所述基底上，其中所述涂层包含至少一种聚合物和至少一种治疗期望形态的药剂和/或至少一种活性生物剂和任选的一种或多种药物载体; 其中基本上所有的药剂和/或活性生物剂都保留在涂层内和衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将医疗装置部署在受试者体内时一部分药剂和/或活性生物制剂在干预部位与至少一部分聚合物和/或药物载体的至少一部分一起递送。

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