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1. 发明申请

WO2017074936A1 BONE VOID FILLER HAVING CALCIUM COATINGS 审中-公开
标题翻译：具有钙涂层的骨填充物
公开(公告)号：WO2017074936A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/058663
申请日：2016-10-25
申请人： WARSAW ORTHOPEDIC, INC.
发明人： MCKAY, William F.
IPC分类号： A61F2/28 , A61L27/44 , A61L27/54
CPC分类号： A61L27/365 , A61L27/025 , A61L27/10 , A61L27/18 , A61L27/24 , A61L27/427 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , A61L2300/406 , A61L2300/604 , A61L2300/62 , A61L2430/02 , C08L89/06
摘要： A bone void filler material is provided for sustained release of a therapeutic agent. The bone void filler material comprising a biodegradable matrix having ceramic cement beads comprising calcium sulfate, and ceramic particles disposed within the matrix. The ceramic cement beads are loaded with the therapeutic agent to cause sustained release of the therapeutic agent. Methods of use are also disclosed.
摘要翻译：提供骨空隙填充材料用于缓释治疗剂。所述骨空隙填充材料包含具有包含硫酸钙的陶瓷水泥珠和置于所述基质内的陶瓷颗粒的生物可降解基质。陶瓷水泥珠装载治疗剂以引起治疗剂的持续释放。还公开了使用方法。

2. 发明申请

WO2017011854A1 PROCESS FOR PRINTING 3D TISSUE CULTURE MODELS 审中-公开
标题翻译：打印3D组织文化模型的过程
公开(公告)号：WO2017011854A1
公开(公告)日：2017-01-26
申请号：PCT/AU2016/000258
申请日：2016-07-21
申请人： INVENTIA LIFE SCIENCE PTY LTD
发明人： O'MAHONY, Aidan Patrick , UTAMA, Robert Hadinoto , FIFE, Christopher Michael , ATAPATTU, Lakmali , RIBEIRO, Julio Cesar Caldeira
IPC分类号： C12N5/02 , A61L27/52
CPC分类号： A61L27/52 , A61L27/20 , A61L2300/62 , A61L2300/64 , C12N5/0062 , C08L5/04
摘要： A process for producing a 3D tissue culture model by (a) printing a drop of bio-ink to a substrate; (b) printing a drop of activator to the drop of bio-ink to form a hydrogel droplet; (c) repeating steps (a) and (b) in any order to form a hydrogel mold adapted to receive a drop containing cells; (d) printing a drop containing cells to the hydrogel mold; and (e) repeating steps (a) and (b) in any order to form a 3D tissue culture model comprising the cells encapsulated in the hydrogel mold.
摘要翻译：一种通过（a）将一滴生物油墨印刷到基底上来生产3D组织培养模型的方法; （b）将一滴活化剂印刷到生物油墨滴上以形成水凝胶液滴; （c）以任何顺序重复步骤（a）和（b）以形成适于接收含有细胞的液滴的水凝胶模具; （d）将含有细胞的液滴印刷到水凝胶模具上; 和（e）以任何顺序重复步骤（a）和（b）以形成包含封装在水凝胶模具中的细胞的3D组织培养模型。

3. 发明申请

WO2016061419A1 PROGRAMMABLE LIQUID, GEL AND BIOHYBRID COMPARTMENTS AND METHODS OF USE 审中-公开
标题翻译：可编程液体，凝胶和生物橡胶间隔和使用方法
公开(公告)号：WO2016061419A1
公开(公告)日：2016-04-21
申请号：PCT/US2015/055836
申请日：2015-10-15
申请人： DUKE UNIVERSITY
发明人： LOPEZ, Gabriel, P. , SIMON, Joseph, R. , CARROLL, Nick, J. , CHILKOTI, Ashutosh
IPC分类号： C08J3/12 , C07K14/78 , C07K19/00 , C12M3/00 , A61L33/06 , A61K47/30
CPC分类号： B01J13/06 , A61K9/146 , A61K38/39 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/62 , B01J2/00 , B01J2/06 , C07K14/78 , C07K19/00 , C12M23/20
摘要： Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a mixture of components to induce a phase separation point of a first component, and maintaining stimulation at the phase separation point to form a coacervate domain of the first component within each of the droplets to form the liquid coacervate particles. The self-assembled nano, meso, micro and macro liquid coacervate particles and related coated substrates can have utility in drug delivery, bioanalytical systems, controlled cell culture, tissue engineering, biomanufacturing and drug discovery.
摘要翻译：提供了纳米至微米级的液体凝聚颗粒。通过包括刺激含有一种或多种组分混合物的液滴的群体以诱导第一组分的相分离点并在相分离点保持刺激以形成第一组分的凝聚区的方法产生液体凝聚颗粒每个液滴中的组分以形成液体凝聚颗粒。自组装的纳米，中观，微观和宏观液体凝聚颗粒和相关的涂层底物可用于药物递送，生物分析系统，受控细胞培养，组织工程，生物制造和药物发现。

4. 发明申请

WO2016049404A1 SUBSTRATES COMPRISING MALODOR REDUCTION COMPOSITIONS 审中-公开
标题翻译：包含恶性降解组合物的基质
公开(公告)号：WO2016049404A1
公开(公告)日：2016-03-31
申请号：PCT/US2015/052119
申请日：2015-09-25
申请人： THE PROCTER & GAMBLE COMPANY
发明人： FRANKENBACH, Gayle, Marie , HOLLINGSHEAD, Judith, Ann , HORENZIAK, Steven, Anthony
IPC分类号： A61K8/35 , C11B9/00
CPC分类号： C11D3/0068 , A61K8/11 , A61K8/31 , A61K8/33 , A61K8/34 , A61K8/342 , A61K8/35 , A61K8/36 , A61K8/361 , A61K8/368 , A61K8/37 , A61K8/4926 , A61K8/494 , A61K8/4966 , A61K8/4973 , A61K8/498 , A61K8/58 , A61K8/731 , A61K8/8152 , A61K2800/56 , A61K2800/592 , A61K2800/5922 , A61L2/18 , A61L9/01 , A61L9/012 , A61L9/03 , A61L9/122 , A61L9/127 , A61L15/20 , A61L15/28 , A61L15/46 , A61L2209/21 , A61L2300/62 , A61Q5/02 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/10 , B01J20/24 , C08K5/0008 , C11B9/0015 , C11B9/0019 , C11B9/003 , C11B9/0034 , C11B9/0038 , C11B9/0042 , C11B9/0049 , C11B9/0053 , C11B9/0061 , C11B9/0076 , C11B9/008 , C11B9/0092 , C11D3/001 , C11D3/184 , C11D3/2034 , C11D3/2068 , C11D3/2072 , C11D3/2079 , C11D3/2093 , C11D3/2096 , C11D3/222 , C11D3/30 , C11D3/43 , C11D3/50 , C11D3/505 , C11D11/0017 , C11D17/0043 , C11D17/042 , C11D17/047 , C11D17/06 , D06B1/02 , G06F17/10 , G06F17/11 , G06F17/5018 , G06F19/701 , G06F19/705 , G06Q99/00
摘要： The present invention relates to substrates comprising malodor reduction compositions and methods of making and using such substrates. Such malodor reduction compositions do not unduely interfere with the scent of the perfumed or unperfumed substrates comprising such malodor reduction compositions and the perfumed or unperfumed situs that is treated with such substrates.
摘要翻译：本发明涉及包含恶臭还原组合物的基质和制备和使用这些底物的方法。这种恶臭还原组合物不会不适当地干扰包含这种恶臭减少组合物的加香或未消光底物的气味，以及用这种底物处理的加香或不起泡的部位。

5. 发明申请

WO2016033011A1 GASTROINTESTINAL DEVICE WITH ASSOCIATED COMMENSAL MICROBES 审中-公开
标题翻译：具有相关联的通用微波的气体装置
公开(公告)号：WO2016033011A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/046650
申请日：2015-08-25
申请人： ELWHA LLC
发明人： BANGERA, Mahalaxmi Gita , DUNCAN, William David , HYDE, Roderick A. , KINDSVOGEL, Wayne R. , SWEENEY, Elizabeth A.
IPC分类号： A61F2/00 , A61F2/04
CPC分类号： A61F5/0076 , A61F2/04 , A61F2002/045 , A61F2210/0004 , A61F2210/0057 , A61F2210/0076 , A61F2220/0016 , A61F2240/001 , A61K35/74 , A61K35/741 , A61K35/745 , A61K35/747 , A61K38/168 , A61K2035/115 , A61L27/54 , A61L29/08 , A61L29/148 , A61L29/16 , A61L31/005 , A61L31/048 , A61L31/06 , A61L31/10 , A61L31/145 , A61L31/148 , A61L31/16 , A61L2300/252 , A61L2300/604 , A61L2300/62 , A61L2420/02 , A61L2420/06
摘要： A gastrointestinal device and methods of manufacturing said gastrointestinal device are described and include a flexible tubular structure including an inner surface and an outer surface, a plurality of at least one type of commensal microbe associated with at least a portion of at least one of the inner surface and the outer surface, and a proximal end and a distal end, the proximal end and the distal end forming a flow conduit through the flexible tubular structure; and at least one anchor structure including one or more gastric wall-engaging components configured to engage a wall of the gastrointestinal tract of the subject.S
摘要翻译：描述了胃肠装置和制造所述胃肠装置的方法，并且包括包括内表面和外表面的柔性管状结构，多个至少一种类型的共生微生物，其与至少一个内部表面和外表面，以及近端和远端，近端和远端形成通过柔性管状结构的流动管道; 以及包括一个或多个胃壁接合部件的至少一个锚结构，所述胃壁接合部件配置成接合受试者的胃肠道的壁。

6. 发明申请

WO2015048344A2 SILK/PLATELET COMPOSITION AND USE THEREOF 审中-公开
标题翻译： SILK / PLATELET组合物及其用途
公开(公告)号：WO2015048344A2
公开(公告)日：2015-04-02
申请号：PCT/US2014/057541
申请日：2014-09-25
申请人： TUFTS UNIVERSITY
发明人： PALLOTTA, Isabella , KLUGE, Jonathan , BALDUINI, Alessandra , KAPLAN, David L.
IPC分类号： A61L27/00
CPC分类号： A61L27/3604 , A61K8/042 , A61K8/64 , A61K8/66 , A61K8/983 , A61K8/987 , A61K9/0014 , A61K9/0019 , A61K9/06 , A61K35/19 , A61K35/63 , A61K35/64 , A61K38/18 , A61K38/4833 , A61K2800/5922 , A61L27/3616 , A61L27/52 , A61L27/54 , A61L27/58 , A61L2300/412 , A61L2300/414 , A61L2300/418 , A61L2300/45 , A61L2300/604 , A61L2300/62 , A61Q7/00 , A61Q19/08
摘要： The present disclosure relates generally to silk fibroin and unlysed platelet compositions. The compositions are useful for a variety of medical uses such as wound healing or repair and soft tissue repair or augmentation.
摘要翻译：本公开内容一般涉及丝素蛋白和未絮凝的血小板组合物。该组合物可用于多种医疗用途，例如伤口愈合或修复以及软组织修复或增大。

7. 发明申请

WO2015002707A1 BONE REGENERATION USING STROMAL VASCULAR FRACTION. PLATELET-DERIVED GROWTH FACTOR-RICH HYDROGEL, THREE DIMENSIONAL PRINTED POLY-EPSILON-CAPROLACTONE SCAFFOLDS 审中-公开
标题翻译：使用结构性血管分裂的骨再生。平板衍生生长因子丰富的水凝胶，三维印刷的聚苯二甲酸乙二醇酯
公开(公告)号：WO2015002707A1
公开(公告)日：2015-01-08
申请号：PCT/US2014/039767
申请日：2014-05-28
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： GRAYSON, Warren , COOK, Colin , HUNG, Ben, P.J. , HURI, Pinar , HUTTON, Daphne, L. , TEMPLE, Joshua
IPC分类号： A61L27/56 , A61L27/52 , A61L27/54 , A61L27/14 , A61F2/28
CPC分类号： A61L27/3847 , A61F2/2803 , A61F2002/2817 , A61F2002/3092 , A61F2002/30962 , A61L27/18 , A61L27/225 , A61L27/3808 , A61L27/3821 , A61L27/3834 , A61L27/3886 , A61L27/3895 , A61L27/48 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/604 , A61L2300/62 , A61L2300/64 , A61L2430/02 , C08L67/04 , C08L89/00
摘要： The presently disclosed subject matter focuses on recapitulating the heterotypic interactions needed to maximize the co-development of vasculature and bone. More particularly, the presently disclosed subject matter explores the potential of cellular aggregation and temporal presentation of factors to induce the cell-cell signaling events required to stimulate ASCs to self-organize into vascularized bone. Further, exogenous PDGF-BB synergizes complex tissue formation in ASC cultures by enhancing vascular stability and osteogenic differentiation. The presently disclosed approach provides a robust protocol to engineer vascularized bone with ASCs in vitro .
摘要翻译：目前公开的主题集中在概述为使脉管系统和骨骼共同发展最大化所需的异型相互作用。更具体地，目前公开的主题探讨了细胞聚集和时间表现的潜在因素，以诱导刺激ASCs自组织成血管化骨所需的细胞信号传递事件。此外，外源性PDGF-BB通过增强血管稳定性和成骨分化来促进ASC培养物中复杂的组织形成。目前公开的方法提供了用于在体外用ASCs工程化血管化骨的鲁棒方案。

8. 发明申请

WO2014123978A3 IMPLANTABLE DEVICES FOR BONE OR JOINT DEFECTS 审中-公开
标题翻译：用于骨或关节缺损的可植入装置
公开(公告)号：WO2014123978A3
公开(公告)日：2014-10-02
申请号：PCT/US2014014832
申请日：2014-02-05
申请人： UNIV UTAH RES FOUND
发明人： BROOKS AMANDA , GRAINGER DAVID , SINCLAIR KRISTOFER D , BROOKS BENJAMIN
IPC分类号： A61F2/28 , A61L27/02 , A61L27/14 , A61L27/54 , A61L27/58
CPC分类号： A61L27/58 , A61K31/7036 , A61L27/26 , A61L27/306 , A61L27/3608 , A61L27/54 , A61L2300/406 , A61L2300/412 , A61L2300/62 , A61L2430/02 , A61L2430/24 , B05D3/002 , B05D2203/00 , B29C67/24 , B29K2001/08 , B29L2031/7532
摘要： In one aspect, the invention provides an implantable device comprising a uniform mixture of components including degradable polymer, inorganic bone particulate either natural or synthetic, a drug, and a soluble microporagen. In some embodiments, the uniform mixture further includes a soluble polymer macroporagen. In some embodiments, the uniform mixture is coated with an immobilized outer porous layer comprising or consisting of synthetic or natural inorganic bone granules. In further aspects, the invention provides an implantable device comprising a composite core of degradable polymer, bone, and a drug, and a coating comprising or consisting of microporous bone overlayer covering the degradable composite core.
摘要翻译：一方面，本发明提供一种可植入装置，其包括均匀的组分混合物，包括可降解聚合物，天然或合成的无机骨颗粒，药物和可溶性微孔。在一些实施方案中，均匀混合物还包含可溶性聚合物大分子。在一些实施方案中，均匀混合物用包含合成或天然无机骨颗粒的固定的外多孔层涂覆。在另外的方面，本发明提供了一种可植入装置，其包含可降解聚合物，骨骼和药物的复合芯，以及包含可复合骨芯的微孔骨覆盖层或由其构成的涂层。

9. 发明申请

WO2014063111A8 DRUG DELIVERY MEDICAL DEVICE 审中-公开
标题翻译：药物交付医疗设备
公开(公告)号：WO2014063111A8
公开(公告)日：2014-05-30
申请号：PCT/US2013065777
申请日：2013-10-18
申请人： MICELL TECHNOLOGIES INC
发明人： MCCLAIN JAMES B , TAYLOR CHARLES DOUGLAS , FAGAN MEAGAN M
IPC分类号： A61L27/00 , A61L31/00
CPC分类号： A61L29/085 , A61L29/16 , A61L2300/62 , A61L2300/63
摘要： A medical device that releases a pharmaceutical agent to a target site is disclosed. The medical device includes a balloon, and a coating on at least a portion of the balloon. The coating includes particles of a pharmaceutical agent. Each particle of the particles of the pharmaceutical agent is at least partially encapsulated in a polymer material. A method of releasing a pharmaceutical agent at a target site is also disclosed. The method includes the steps of providing a device including a balloon, and a coating on at least a portion of the balloon, the coating including particles of a pharmaceutical agent, and each particle of the pharmaceutical agent is at least partially encapsulated in a polymer material; positioning the device to allow the balloon to reach the target site; and inflating the balloon of the device.
摘要翻译：公开了一种将药剂释放到目标部位的医疗装置。该医疗装置包括球囊以及球囊的至少一部分上的涂层。该包衣包括药剂的颗粒。药剂颗粒的每个颗粒至少部分包封在聚合物材料中。还公开了在靶位释放药剂的方法。该方法包括以下步骤：提供包括球囊的装置和在球囊的至少一部分上的涂层，所述涂层包括药剂的颗粒，并且药剂的每个颗粒至少部分地包封在聚合物材料 ; 定位该装置以允许气囊到达目标部位; 并使装置的气球膨胀。

10. 发明申请

WO2014072857A1 TRIGGERABLE COMPOSITIONS FOR TWO-STAGE, CONTROLLED RELEASE OF ACTIVE CHEMISTRY 审中-公开
标题翻译：两级可触发组合物，控制释放活性化学物质
公开(公告)号：WO2014072857A1
公开(公告)日：2014-05-15
申请号：PCT/IB2013/059547
申请日：2013-10-22
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： SONG, Xuedong
IPC分类号： A61L15/20 , A61L15/42 , A61F13/15
CPC分类号： A61K8/44 , A61K8/11 , A61K8/8152 , A61K8/8182 , A61K2800/56 , A61L15/24 , A61L15/44 , A61L15/46 , A61L2300/602 , A61L2300/62 , A61Q19/005 , C08L39/06 , C08L33/12
摘要： A triggerable composition for two-stage, controlled release of a functional active chemical includes an ecapsulation material for encapsulating a betaine ester or betaine ester derivative including a functional active. The encapsulation material is triggerable to release the betaine ester or betaine ester derivative at a first stage upon the occurrence with an environmental stimulus, such as a pH change, an enzymatic change, and a temperature change. The betaine ester or betaine ester derivative of a functional active with at least one hydroxyl group releases the functional active through a hydrolysis reaction upon contact with an aqueous medium.
摘要翻译：用于功能活性化学品的两阶段控制释放的可触发组合物包括用于包封含有功能活性物质的甜菜碱酯或甜菜碱酯衍生物的包封材料。包封材料可触发以在出现时的第一阶段释放甜菜碱酯或甜菜碱酯衍生物，其中环境刺激例如pH变化，酶促变化和温度变化。具有至少一个羟基的官能活性物质的甜菜碱酯或甜菜碱酯衍生物在与水性介质接触时通过水解反应释放功能活性物质。

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