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    • 3. 发明申请
    • APPARATUS AND METHODS FOR PREPARATION OF SUBTANTIALLY UNIFORM EMULSIONS CONTAINING A PARTICLE
    • 用于制备含有颗粒的亚基均匀乳液的装置和方法
    • WO2008144288A8
    • 2009-06-04
    • PCT/US2008063480
    • 2008-06-06
    • APPLERA CORPLAU ALDRICH N KCASSEL JONATHAN MBRIDGHAM JOHN A
    • LAU ALDRICH N KCASSEL JONATHAN MBRIDGHAM JOHN A
    • A61K8/06B01J13/00
    • B01F3/0807B01F5/0475B01F5/0476B01F5/0485B01F13/0059
    • Methods and systems for forming water-in-oil emulsions are described. For example, an apparatus is described which includes: a first compartment containing a plurality of particles dispersed in an aqueous phase; a second compartment containing an oil phase; a porous layer separating the first and second compartments; and a device for applying pressure to the first compartment. A method is described which includes: moving an oil phase relative to a surface of a porous layer while simultaneously forcing an aqueous composition comprising particles through the porous layer and into the flowing dispersion medium thereby forming droplets of the aqueous composition containing particles dispersed in the oil phase. The aqueous composition can include one or more nucleic acid templates and reagents for amplifying the nucleic acids such as PCR reagents. A porous partition is described comprising a first and second major surfaces and at least two straight through pores comprising a cross sectional shape selected from a polygon, an oval, an oblong, a dumbbell, a bowtie and irregular shapes thereof. Aqueous droplets containing an oligonucleotide attached to a particle and reagents can be used as a microreactor for nucleic acid amplification.
    • 描述了形成油包水乳液的方法和系统。 例如,描述了一种装置,其包括:包含分散在水相中的多个颗粒的第一隔室; 含有油相的第二隔室; 分离第一和第二隔室的多孔层; 以及用于向第一隔室施加压力的装置。 描述了一种方法,其包括:相对于多孔层的表面移动油相,同时迫使包含颗粒的水性组合物通过多孔层并进入流动分散介质中,由此形成含有分散在油中的颗粒的含水组合物的液滴 相。 水性组合物可以包括一种或多种核酸模板和用于扩增核酸如PCR试剂的试剂。 描述了一种多孔分隔件,其包括第一和第二主表面和至少两个直通孔,其包括选自多边形,椭圆形,长方形,哑铃,弓形和不规则形状的横截面形状。 含有与粒子连接的寡核苷酸的水滴和试剂可以用作用于核酸扩增的微反应器。
    • 4. 发明申请
    • SURFACE MODIFICATION IN A MANIPULATION CHAMBER
    • 操纵室中的表面修饰
    • WO2007050143A3
    • 2009-05-14
    • PCT/US2006022959
    • 2006-06-13
    • APPLERA CORPLAU ALDRICH N KPHAN HUAN L
    • LAU ALDRICH N KPHAN HUAN L
    • C12M1/34C12M3/00
    • G01N27/305B03C11/00C07K1/26
    • A device for manipulating biological material, the device including at least one electrode and a photoconductive material configured to receive the biological material; and a light source configured to illuminate the photoconductive material so as to modulate an electric field, wherein the electric field is configured to manipulate the biological material; wherein a surface of the at least one electrode and/or the photoconductive material is modified with at least one of a carboxylic moiety, an amino moiety, a poly(ethylene glycol) moiety, a polymer of (poly(ethylene oxide) methyl ether) acrylate, a poly(2-hydroxyethyl (meth)acrylate), a poly(N-vinylpyrrolidone), a poly(N-vinylformamide), a poly(N-vinylformamide) derivative, a poly((meth)acrylamide), and a poly((meth)acrylamide) derivative. Methods for manipulating biological material are also disclosed.
    • 一种用于操纵生物材料的装置,该装置包括至少一个电极和被配置为容纳生物材料的光导材料; 以及光源,被配置为照亮所述光电导材料以调制电场,其中所述电场被配置为操纵所述生物材料; 其中所述至少一个电极和/或光电导材料的表面用羧基部分,氨基部分,聚(乙二醇)部分,(聚(环氧乙烷)甲基醚)的聚合物, 丙烯酸酯,聚(甲基)丙烯酸2-羟乙酯),聚(N-乙烯基吡咯烷酮),聚(N-乙烯基甲酰胺),聚(N-乙烯基甲酰胺)衍生物,聚((甲基)丙烯酰胺) 聚((甲基)丙烯酰胺)衍生物。 还公开了用于操作生物材料的方法。
    • 10. 发明申请
    • SURFACE MODIFICATION IN A MANIPULATION CHAMBER
    • 操纵室中的表面修饰
    • WO2007050143A2
    • 2007-05-03
    • PCT/US2006/022959
    • 2006-06-13
    • APPLERA CORPORATIONLAU, Aldrich, N., K.PHAN, Huan, L.
    • LAU, Aldrich, N., K.PHAN, Huan, L.
    • C07K1/26G01N27/00
    • G01N27/305B03C11/00C07K1/26
    • A device for manipulating biological material, the device including at least one electrode and a photoconductive material configured to receive the biological material; and a light source configured to illuminate the photoconductive material so as to modulate an electric field, wherein the electric field is configured to manipulate the biological material; wherein a surface of the at least one electrode and/or the photoconductive material is modified with at least one of a carboxylic moiety, an amino moiety, a poly(ethylene glycol) moiety, a polymer of (poly(ethylene oxide) methyl ether) acrylate, a poly(2-hydroxyethyl (meth)acrylate), a poly(N-vinylpyrrolidone), a poly(N-vinylformamide), a poly(N-vinylformamide) derivative, a poly((meth)acrylamide), and a poly((meth)acrylamide) derivative. Methods for manipulating biological material are also disclosed.
    • 一种用于操纵生物材料的装置,该装置包括至少一个电极和被配置为容纳生物材料的光导材料; 以及光源,被配置为照亮所述光电导材料以调制电场,其中所述电场被配置为操纵所述生物材料; 其中所述至少一个电极和/或光电导材料的表面用羧基部分,氨基部分,聚(乙二醇)部分,(聚(环氧乙烷)甲基醚)的聚合物, 丙烯酸酯,聚(甲基)丙烯酸2-羟乙酯),聚(N-乙烯基吡咯烷酮),聚(N-乙烯基甲酰胺),聚(N-乙烯基甲酰胺)衍生物,聚((甲基)丙烯酰胺) 聚((甲基)丙烯酰胺)衍生物。 还公开了用于操作生物材料的方法。