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1. 发明申请

WO2016057427A1 NANOTUBE TRANS-MEMBRANE CHANNELS MIMICKING BIOLOGICAL PORINS 审中-公开
公开(公告)号：WO2016057427A1
公开(公告)日：2016-04-14
申请号：PCT/US2015/054084
申请日：2015-10-05
申请人： LAWRENCE LIVERMORE NATIONAL SECURITY, LLC , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , UNIVERSIDAD DEL PAÍS VASCO , GENG, Jia , ZHANG, Jianfei , FROLOV, Vadim
发明人： GENG, Jia , ZHANG, Jianfei , FROLOV, Vadim , NOY, Aleksandr
IPC分类号： C01B31/02 , C01B21/064 , C01G39/06 , A61K47/48 , A61K51/02 , C12Q1/68
CPC分类号： A61K47/02 , A01N25/04 , A61K9/0092 , A61K9/1272 , B01J13/08 , B01J13/20 , B01J13/203 , B82Y5/00 , B82Y15/00 , B82Y40/00 , C01B21/064 , C01B32/17 , C01B32/172 , C01B32/174 , C01B32/176 , C01B2202/02 , C01B2202/34 , C01B2202/36 , C01G39/06 , C01P2004/04 , C01P2004/13 , C12Q1/6825 , C12Q1/6869 , G01N27/44791 , Y10S977/746 , Y10S977/75 , Y10S977/847 , Y10S977/907 , Y10S977/915 , Y10S977/924 , C12Q2565/631
摘要： Provided herein is a nanopore structure, which in one aspect is a "carbon nanotube porin", that comprises a short nanotube with an associated lipid coating. Also disclosed are compositions and methods enabling the preparation of such nanotube/lipid complexes. Further disclosed is a method for therapeutics delivery that involves a drug delivery agent comprising a liposome with a NT loaded with a therapeutic agent, introducing the therapeutic agent into a cell or a tissue or an organism; and subsequent release of the therapeutic agents into a cell.
摘要翻译：本文提供纳米孔结构，其一方面是“碳纳米管孔蛋白”，其包含具有相关脂质涂层的短纳米管。还公开了能够制备这种纳米管/脂质复合物的组合物和方法。进一步公开的是一种治疗剂递送的方法，其涉及含有负载有治疗剂的NT的脂质体的药物递送剂，将治疗剂引入细胞或组织或生物体中; 并随后将治疗剂释放到细胞中。

2. 发明申请

WO2009111788A2 SENSOR ELECTRODE AND METHOD FOR THE ELECTROCHEMICAL DETECTION OF NUCLEOTIDES 审中-公开
标题翻译：传感器电极和电化学检测核子的方法
公开(公告)号：WO2009111788A2
公开(公告)日：2009-09-11
申请号：PCT/US2009/036547
申请日：2009-03-09
申请人： THE CURATORS OF THE UNIVERSITY OF MISSOURI , CARSON, Charles, A. , LI, Hao , YU, Qingsong
发明人： CARSON, Charles, A. , LI, Hao , YU, Qingsong
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： G01N27/3278 , B82Y5/00 , B82Y15/00 , C12Q1/6825 , Y10S977/924
摘要： A sensor electrode for the detection of nucleotides in a biological sample is described. The sensitivity of the electrode is enhanced by the nanostructured sensor architecture that increases the available surface area of the electrode. The electrode detects nucleotides using standard electrochemical methods.
摘要翻译：描述了用于检测生物样品中核苷酸的传感器电极。通过增加电极的可用表面积的纳米结构传感器架构来增强电极的灵敏度。电极使用标准电化学方法检测核苷酸。

3. 发明申请

WO2002102504A2 THE PRODUCTION OF MOLECULAR ARRAYS 审中-公开
标题翻译：分子阵列的生产
公开(公告)号：WO2002102504A2
公开(公告)日：2002-12-27
申请号：PCT/GB2002/002727
申请日：2002-06-13
申请人： IMPERIAL COLLEGE INNOVATIONS LTD. , KORCHEV, Yuri, Evgenievich , KLENERMAN, David , ABELL, Christopher , YING, Liming , BRUCKBAUER, Andreas
发明人： KORCHEV, Yuri, Evgenievich , KLENERMAN, David , ABELL, Christopher , YING, Liming , BRUCKBAUER, Andreas
IPC分类号： B01J19/00
CPC分类号： B01J19/0046 , B01J2219/00364 , B01J2219/00371 , B01J2219/00533 , B01J2219/00576 , B01J2219/00608 , B01J2219/00612 , B01J2219/00637 , B01J2219/00722 , B01J2219/00725 , G01Q80/00 , Y10S977/924
摘要： A method for the production of an array of molecules immobilised on a substrate, comprises the deposition of the molecules from a micropipette containing them, onto the substrate, in a liquid environment, wherein the distance of the micropipette from the substrate is controlled in response to the ion current in the liquid. This method is particularly suitable for the deposition of biological molecules.
摘要翻译：用于制备固定在基底上的分子阵列的方法包括在液体环境中将分子从含有它们的微量移液管沉积到基底上，其中微量移液管与基底的距离响应于液体中的离子电流。该方法特别适用于沉积生物分子。

4. 发明申请

WO0151665A2 NANOPARTICLES HAVING OLIGONUCLEOTIDES ATTACHED THERETO AND USES THEREFOR 审中-公开
公开(公告)号：WO0151665A2
公开(公告)日：2001-07-19
申请号：PCT/US0101190
申请日：2001-01-12
申请人： NANOSPHERE INC
发明人： MIRKIN CHAD A , LETSINGER ROBERT L , MUCIC ROBERT C , STORHOFF JAMES J , ELGHANIAN ROBERT , TATON THOMAS ANDREW , LI ZHI
IPC分类号： G01N33/53 , B82B1/00 , C07B61/00 , C07H21/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , G01N21/78 , G01N27/04 , G01N33/483 , G01N33/566 , G01N33/58 , G01N37/00
CPC分类号： B82Y30/00 , B01J2219/00274 , B01J2219/005 , B01J2219/00585 , B01J2219/00596 , B01J2219/00603 , B01J2219/00648 , B01J2219/00653 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B82B1/00 , B82Y15/00 , C07B2200/11 , C07H21/00 , C12Q1/6816 , C12Q1/6818 , C12Q1/6825 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6839 , C40B40/00 , C40B40/06 , Y10S977/924 , C12Q2563/155 , C12Q2563/143 , C12Q2537/143 , C12Q2525/197 , C12Q2525/161 , C12Q2565/625 , C12Q2537/125
摘要： The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.

5. 发明申请

WO01021632A1 METHOD FOR NUCLEIC ACID ISOLATION AND KIT 审中-公开
标题翻译：核酸分离和包装方法
公开(公告)号：WO01021632A1
公开(公告)日：2001-03-29
申请号：PCT/US2000/002260
申请日：2000-01-28
IPC分类号： G01N33/48 , C07H21/02 , C07H21/04 , C12N15/09 , C12N15/10 , C12Q1/02 , G01N33/50 , C07H1/08
CPC分类号： C12N15/1006 , Y10S977/924
摘要： The present invention provides a method for isolating nucleic acid from a sample, preferably from a biological sample. This method involves applying the biological sample to a hydrophobic organic polymeric solid phase to selectively trap target nucleic acid and removing nucleic acid with a nonionic surfactant. Another method involves treating a hydrophobic organic polymeric material with a nonionic surfactant, washing the surface, and subsequently contacting the treated solid organic polymeric material with a biological sample to reduce the amount of nucleic acid that binds to the organic polymeric solid phase.
摘要翻译：本发明提供了一种从样品中分离核酸的方法，优选从生物样品中分离核酸。该方法包括将生物样品应用于疏水性有机聚合物固相以选择性捕集靶核酸并用非离子表面活性剂除去核酸。另一种方法包括用非离子表面活性剂处理疏水性有机聚合物材料，洗涤表面，并随后使经处理的固体有机聚合材料与生物样品接触以减少与有机聚合物固相结合的核酸的量。

6. 发明申请

WO00062818A1 DIFFERENTIATION OF MONOCYTES INTO FUNCTIONAL DENDRITIC CELLS 审中-公开
标题翻译：单核细胞在功能性细胞中的分化
公开(公告)号：WO00062818A1
公开(公告)日：2000-10-26
申请号：PCT/US2000/008793
申请日：2000-04-03
IPC分类号： A61K9/16 , A61K9/50 , A61K35/14 , A61K39/00 , A61K41/00 , A61P35/00 , A61P35/02 , A61P37/04 , A61P43/00 , C12N5/02 , C12N5/0784 , A61K48/00 , C12N5/00 , C12N5/10
CPC分类号： A61K41/0066 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , C12N5/0639 , C12N2501/22 , C12N2501/23 , C12N2501/25 , C12N2501/999 , Y10S977/904 , Y10S977/924
摘要： A method for inducing differentiation of monocytes contained in an extracorporeal quantity of a subject's blood into functional dendritic antigen presenting cells is provided. The monocytes are first treated by exposure to physical perturbation, irradiation in the presence of a photoactivatable agent capable of forming photoadducts with cellular DNA components, and/or treatment with a DNA binding agent. The treated monocytes are then incubated for a period of time sufficient to maximize the number of functional dendritic cells in the treated cell population. Functional dendritic cells generated from induced monocytes are incubated together with disease effector agents to enhance the presentation of at least one disease-causing antigen expressed by the disease effector agents. Compositions including dendritic cells derived from induced monocytes and compositions including such dendritic cells incubated with disease effector agents are also provided.
摘要翻译：提供了将体外含有受试者的血液中所含的单核细胞分化为功能性树突状抗原呈递细胞的方法。首先通过暴露于物理扰动，在能够与细胞DNA组分形成光加成物的光活化剂的存在下照射和/或用DNA结合剂处理来处理单核细胞。然后将经处理的单核细胞孵育足以使处理的细胞群体中功能性树突状细胞数量最大化的时间。从诱导的单核细胞产生的功能性树突状细胞与疾病效应剂一起温育以增强由疾病效应剂表达的至少一种致病性抗原的呈递。还提供了包含衍生自诱导的单核细胞的树突状细胞的组合物和包含与疾病效应剂孵育的树突状细胞的组合物。

7. 发明申请

WO0014244A3 TREATMENT OF CERVICAL CANCER 审中-公开
标题翻译：治疗宫颈癌
公开(公告)号：WO0014244A3
公开(公告)日：2000-06-02
申请号：PCT/CA9900807
申请日：1999-09-03
申请人： CONNAUGHT LAB , GAJEWCZYK DIANE M , PERSSON ROY , YAO FEI LONG , CAO SHI XIAN , KLEIN MICHEL H , TARTAGLIA JAMES , MOINGEON PHILLIPE , ROVINSKI BENJAMIN
发明人： GAJEWCZYK DIANE M , PERSSON ROY , YAO FEI-LONG , CAO SHI-XIAN , KLEIN MICHEL H , TARTAGLIA JAMES , MOINGEON PHILLIPE , ROVINSKI BENJAMIN
IPC分类号： C12N15/09 , A61B5/026 , A61B5/029 , A61B5/055 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K39/12 , A61K39/245 , A61K39/39 , A61K48/00 , A61P31/20 , A61P35/00 , C07K14/025 , C12N15/37 , G06T7/00 , C12N15/86
CPC分类号： A61B5/055 , A61B5/0263 , A61B5/029 , A61B5/41 , A61K48/00 , A61K2039/51 , A61K2039/53 , C07K14/005 , C12N2710/20022 , C12N2710/20043 , Y10S977/804 , Y10S977/904 , Y10S977/916 , Y10S977/924
摘要： Vectors for DNA immunization against cervical cancer comprise a nucleic acid molecule encoding at least one none-toxic T-cell epitope of the E6 and/or E7 antigens of a strain of human papilloma virus (HPV) associated with cervical cancer, such as HPV-16, and a promoter operatively coupled to the nucleic acid molecule for expression of the nucleic acid molecule in a host to which the vector is administered.
摘要翻译：用于针对宫颈癌的DNA免疫的载体包含编码人宫颈癌相关的人乳头瘤病毒（HPV）株的E6和/或E7抗原的至少一种无毒T-细胞表位的核酸分子，所述HPV- 16和启动子，所述启动子可操作地偶联于核酸分子，用于在施用了载体的宿主中表达核酸分子。

8. 发明申请

WO99045145A1 SCREENING FOR FUNCTIONAL ANTISENSE AGENTS 审中-公开
标题翻译：筛选功能性抗菌剂
公开(公告)号：WO99045145A1
公开(公告)日：1999-09-10
申请号：PCT/GB1999/000631
申请日：1999-03-03
IPC分类号： C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6816 , C12Q1/6837 , Y10S977/924 , C12Q2565/601 , C12Q2563/173 , C12Q2525/207 , C12Q2565/515
摘要： Provided is a method for identifying a functional antisense agent, which method comprises hybridising an RNA with an aligonucleotide probe and measuring in real time the kinetics of hybridisation, wherein the kinetics are measured by either hybridising in the presence of an intercalation dye and recording a change in the spectroscopic properties of the dye as hybridising proceeds, or incorporating a label in either the RNA or the probe, attaching the non-labelled RNA or non-labelled probe to a solid support, generating an evanescent wave in the proximity of the non-labelled RNA or non-labelled probe and recording the increase in a signal generated by interaction of the evanescent wave with the label, as hybridisation proceeds.
摘要翻译：提供了用于鉴定功能性反义剂的方法，该方法包括将RNA与寡核苷酸探针杂交并实时测量杂交的动力学，其中通过在插入染料存在下杂交并记录变化来测量动力学在作为杂交进行的染料的光谱性质中，或在RNA或探针中掺入标记，将未标记的RNA或未标记的探针附着到固体支持物上，标记的RNA或非标记探针，并记录由ev逝波与标记相互作用产生的信号的增加，因为杂交进行。

9. 发明申请

WO9915539A3 PENTOPYRANOSYL NUCLEOSIDE, AND PRODUCTION AND USE OF THE SAME 审中-公开
标题翻译： Pentopyranosylnucleoside，其生产和使用
公开(公告)号：WO9915539A3
公开(公告)日：1999-06-17
申请号：PCT/EP9805997
申请日：1998-09-21
申请人： AVENTIS RES & TECH GMBH & CO , MICULKA CHRISTIAN , WINDHAB NORBERT , BRANDSTETTER TILMANN , BURDINSKI GERHARD
发明人： MICULKA CHRISTIAN , WINDHAB NORBERT , BRANDSTETTER TILMANN , BURDINSKI GERHARD
IPC分类号： C12Q1/68 , A61K49/00 , C07H1/00 , C07H19/04 , C07H19/067 , C07H21/00 , C07K16/00 , G01N33/532
CPC分类号： C07H21/00 , A61K47/549 , A61K49/0013 , C07H19/04 , C07H21/02 , C07H21/04 , G01N33/532 , Y02P20/55 , Y10S977/728 , Y10S977/80 , Y10S977/836 , Y10S977/894 , Y10S977/896 , Y10S977/904 , Y10S977/914 , Y10S977/915 , Y10S977/924 , Y10S977/925
摘要： The invention relates to a pentopyranosyl nucleoside of formula (I) or formula (II), to the production of said pentopyranosyl nucleoside, and to its use for producing a therapeutic agent, a diagnostic agent and/or an electronic component.
摘要翻译：本发明涉及式（I）或式（II），它们的制备和使用用于治疗，诊断和/或电子部件的制备中的pentopyranosylnucleoside。

10. 发明申请

WO99020640A2 HIGH SURFACE DENSITY COVALENT IMMOBILIZATION OF OLIGONUCLEOTIDE MONOLAYERS 审中-公开
标题翻译：高表面密度共价键固定寡核苷酸单链的方法
公开(公告)号：WO99020640A2
公开(公告)日：1999-04-29
申请号：PCT/CA1998/000969
申请日：1998-10-16
IPC分类号： G01N33/53 , B01J20/32 , B32B17/10 , C03C17/30 , C03C17/34 , C07C309/39 , C07F7/12 , C07H21/00 , C07H21/04 , C12M1/00 , C12N15/09 , G01N37/00
CPC分类号： B82Y30/00 , B01J20/3242 , B32B17/10688 , B82Y5/00 , B82Y15/00 , C03C17/30 , C03C17/3405 , C07B2200/11 , C07H21/00 , Y10S977/702 , Y10S977/902 , Y10S977/92 , Y10S977/924 , Y10S977/958
摘要： Oligonucleotides and other biomolecules are immobilized in high density on solid substrates through covalent forces using either a permanent thioether bond, or a chemoselectively reversible disulfide bond to a surface thiol. Substrates which have hydroxyl groups on their surfaces can be first silanized with a trichlorosilane containing 2-20 carbon atoms in its hydrocarbon backbone, terminating in a protected thiol group. The oligonucleotides or other biomolecules are first connected to a tether consisting of a hydrocarbon or polyether chain of 2-20 units in length which terminates in a thiol group. This thiol may be further modified with a halobenzylic-bifunctional water soluble reagent which allows the conjugate to be immobilized onto the surface thiol group by a permanent thioether bond. Alternatively, the oligonucleotide-tether-thiol group can be converted to a pyridyldisulfide functionality which attaches to the surface thiol by a chemoselectively reversible disulfide bond. The permanently bound oligonucleotides are immobilized in high density compared to other types of thiol functionalized silane surface and to the avidin-biotin method.
摘要翻译：本发明涉及在固体基质上通过共价力使用永久硫醚键或化学选择性可转化为表面硫醇的二硫键的高密度寡核苷酸和其他固定生物分子。羟基底物可以首先在它们的烃骨架上用含有2-20个碳原子的三氯硅烷在其表面上进行硅烷化，终止于受保护的硫醇基。首先将寡核苷酸或其他生物分子结合到由长度在2和20个单位之间的烃或聚醚链组成的栓链上，所述单链以巯基终止。然后可以用双官能卤代苄基水溶性试剂修饰该巯基，这使得可以通过永久硫醚键将缀合物固定在表面硫醇基上。根据另一个变体，寡核苷酸 - 连接臂硫醇基团可以转化为吡啶基二硫化物功能，其通过化学选择性可逆的二硫键与表面硫醇结合。与其他类型的官能化硫醇硅烷表面以及抗生物素蛋白 - 生物素方法相比，高密度永久结合的寡核苷酸被固定化。

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