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1. 发明申请

WO2009022246A1 SENSOR ARRAY FOR SPR-BASED DETECTION. 审中-公开
标题翻译：传感器阵列进行基于SPR的检测。
公开(公告)号：WO2009022246A1
公开(公告)日：2009-02-19
申请号：PCT/IB2008/053029
申请日：2008-07-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , MUSKENS, Otto L. , GOMEZ RIVAS, Jaime , VAN DIJK, Erik, M. H. P. , KLUNDER, Derk J.W.
发明人： MUSKENS, Otto L. , GOMEZ RIVAS, Jaime , VAN DIJK, Erik, M. H. P. , KLUNDER, Derk J.W.
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , G01N2021/258
摘要： The invention relates to a sensor array for detecting the presence of a target, where a target is detected based on a detection of a surface plasmon resonance (SPR). The sensor array (30) comprises a carrier substrate (31), and a plurality of nano-sized particles (32) disposed on the carrier substrate. The surface plasmon resonance (SPR) for each of the nano-sized particles is correlated to a structural parameter of the nano-sized particles or group of nano-sized particles. The structural parameter and thereby the surface plasmon resonance is varied in a pre-defined way in at least a first area of the carrier substrate. The target is detected based on detecting intensity variations in the radiation resulting from the sensor array, the intensity variations being correlated to the pre-defined variation in the structural parameter. In embodiments, the sensor array may be a bio-sensor for the detection of bio-molecules.
摘要翻译：本发明涉及一种用于检测靶的存在的传感器阵列，其中基于表面等离子体共振（SPR）的检测来检测目标。传感器阵列（30）包括载体衬底（31）和设置在载体衬底上的多个纳米尺寸颗粒（32）。每个纳米尺寸颗粒的表面等离子体共振（SPR）与纳米尺寸颗粒或纳米尺寸颗粒组的结构参数相关。结构参数以及由此的表面等离子体共振在载体衬底的至少第一区域中以预定义的方式变化。基于检测由传感器阵列产生的辐射的强度变化来检测目标，强度变化与结构参数中的预定变化相关。在实施例中，传感器阵列可以是用于检测生物分子的生物传感器。

2. 发明申请

WO2007072293A2 BIOSENSOR WITH ONE-DIMENSIONAL SUB-DIFFRACTION-LIMITED APERTURES COMPOSED OF A GRID AND A POLARIZER 审中-公开
标题翻译：具有一个网格和一个偏振器的一维亚衍射极限孔径生物传感器
公开(公告)号：WO2007072293A2
公开(公告)日：2007-06-28
申请号：PCT/IB2006/054750
申请日：2006-12-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , U.S. PHILIPS CORPORATION , VAN HERPEN, Maarten , BROER, Dirk J. , PEETERS, Emiel , KLUNDER, Derk J.W. , STAPERT, Hendrik R.
发明人： VAN HERPEN, Maarten , BROER, Dirk J. , PEETERS, Emiel , KLUNDER, Derk J.W. , STAPERT, Hendrik R.
IPC分类号： G01N21/00
CPC分类号： G01N21/648 , Y10T436/11
摘要： A method and sensor for the detection of luminescence radiation generated by at least one luminophore is disclosed. In the context of the present invention the biosensor comprises a grid (120) defined as arrays of apertures with the apertures having a first dimension below and a second dimension above the diffraction limit of the excitation light (102) in a medium, a polarizer (115), and luminophores (117) positioned in a volume selected from the group consisting of: the volume inside the apertures of the grid (120), the volume in between the array of slits (120) and the polarizer (115) and a volume that extends into the polarizer (115), wherein the grid (120) providing a transmission axis extending in a first direction and the polarizer (115) providing a transmission axis extending in a second direction, the first direction and the second direction being substantially perpendicular with respect to each other, wherein the excitation radiation (102) is polarized such that it is substantially suppressed by one of the at least one grid (120) and polarizer (115) and substantially not suppressed by the other of the at least one grid (120) and polarizer (115).
摘要翻译：公开了一种用于检测由至少一个发光体产生的发光辐射的方法和传感器。在本发明的上下文中，生物传感器包括被限定为孔阵列的网格（120），其中孔径具有在介质中的激发光（102）的衍射极限以下的第一维度和第二维度，偏振器（（120）的体积，狭缝阵列（120）和偏振器（115）之间的体积以及一个或多个发光体（117），所述发光体（117）位于从由以下各项组成的组中选择的体积中：其中所述栅格（120）提供在第一方向上延伸的透射轴并且所述偏振器（115）提供在第二方向上延伸的透射轴，所述第一方向和所述第二方向基本上是相对于彼此垂直，其中所述激发辐射（102）被极化，使得所述激发辐射（102）基本上被所述至少一个栅格（120）和偏振器（115）中的一个抑制并且基本上不被所述o 至少一个格栅（120）和偏振器（115）的一部分。

3. 发明申请

WO2009083884A1 MICROELECTRONIC SENSOR DEVICE. 审中-公开
标题翻译：微电子传感器装置。
公开(公告)号：WO2009083884A1
公开(公告)日：2009-07-09
申请号：PCT/IB2008/055417
申请日：2008-12-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KLUNDER, Derk J.W.
发明人： KLUNDER, Derk J.W.
IPC分类号： G01N21/64 , G01N21/55
CPC分类号： G01N21/553 , G01N21/648
摘要： The invention concerns an optical device for providing evanescent radiation, in response to incident radiation, in a detection volume for containing a target component in a medium, the detection volume having at least one in-plane dimension (W1) smaller than a diffraction limit. The diffraction limit is defined by the radiation wavelength and the medium. The evanescent radiation is provided by aperture defining structures having a smallest in plane aperture dimension W1 smaller than the diffraction limit. The detection volume is provided between said aperture defining structures. The aperture defining structures in addition define a largest in plane aperture dimension W2; wherein said largest in plane aperture dimension is larger than the diffraction limit. A source is provided for emitting a beam of radiation having a wavelength incident at the optical device and having a direction of incidence non parallel to an out of plane normal direction, for providing evanescent radiation in the detection volume, in response to the radiation incident at the optical device. The plane of incidence is parallel to the largest in plane aperture dimension.
摘要翻译：本发明涉及一种光学装置，用于响应于入射辐射，在用于在介质中容纳目标成分的检测体积中提供ev逝辐射，所述检测体积具有小于衍射极限的至少一个面内尺寸（W1）。衍射极限由辐射波长和介质决定。 ev逝辐射由具有小于衍射极限的最小平面孔径尺寸W1的孔限定结构提供。检测体积设置在所述孔限定结构之间。孔限定结构另外限定最大的平面孔尺寸W2; 其中所述最大的平面孔径尺寸大于衍射极限。提供源，用于发射具有入射在光学装置处的波长并具有不平行于外部平面法线方向的入射方向的辐射束，用于响应于入射在...的辐射而在检测体积中提供渐逝辐射光学装置。入射平面平行于最大的平面孔径尺寸。

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