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1. 发明申请

WO2009121556A1 SAMPLE HOLDER AND METHOD OF USING THE SAME 审中-公开
标题翻译：样品保持器及其使用方法
公开(公告)号：WO2009121556A1
公开(公告)日：2009-10-08
申请号：PCT/EP2009/002333
申请日：2009-03-31
申请人： ESE GMBH , HABERSTROH, Klaus , FAULSTICH, Konrad
发明人： HABERSTROH, Klaus , FAULSTICH, Konrad
IPC分类号： B01L3/00 , G01N21/03 , G01N21/27 , G01N21/64 , G01N35/10
CPC分类号： G01N21/03 , B01L3/50857 , B01L3/5088 , B01L2200/142 , B01L2300/04 , B01L2300/0822 , B01L2300/0861 , B01L2300/161 , G01N21/25 , G01N21/278 , G01N21/64 , G01N21/76 , G01N35/00029 , G01N2021/0325 , G01N2021/0346 , G01N2021/035 , G02B21/34
摘要： A sample holder, such as a microscope slide, is provided in the form of a card-shaped substrate or plate, preferably for use in an analytical reader. The sample holder comprises at least one hole, preferably a plurality of holes, for receiving a sample to be analyzed. The at least one hole extends completely through the substrate and is sized such that the sample is held within the at least one hole by means of the surface tension of the sample against the force of gravity. Optionally the substrate comprises a first upper substrate and a second lower substrate that together embed a porous membrane. As a further option the sample holder comprises a first cover attached to the top side of the first upper substrate and/or a second cover attached to the bottom side of the second lower substrate. Moreover a method for using such a sample holder in an analytical reader is provided, comprising the steps of: filling the at least one hole of the sample holder with a sample and reagent mixture; inserting the sample holder in the analytical reader; and analyzing the sample and reagent mixture in the at least one hole of the sample holder with the analytical reader.
摘要翻译：样品架（例如显微镜载玻片）以卡形基板或板的形式提供，优选用于分析读取器。样品架包括用于接收待分析样品的至少一个孔，优选多个孔。所述至少一个孔完全延伸穿过基底，并且其尺寸设计成使得样品通过样品的表面张力抵抗重力而保持在至少一个孔内。可选地，基底包括一起嵌入多孔膜的第一上基底和第二下基底。作为另一选择，样品架包括附接到第一上基板的顶侧的第一盖和/或附接到第二下基板的底侧的第二盖。此外，提供了一种在分析读取器中使用这种样品保持器的方法，包括以下步骤：用样品和试剂混合物填充样品架的至少一个孔; 将样品架插入分析读数器; 并用分析读取器分析样品架的至少一个孔中的样品和试剂混合物。

2. 发明申请

WO2006044841A2 FLUID PROCESSING DEVICE INCLUDING SIZE-CHANGING BARRIER 审中-公开
标题翻译：包括尺寸变化障碍物的流体加工装置
公开(公告)号：WO2006044841A2
公开(公告)日：2006-04-27
申请号：PCT/US2005/037338
申请日：2005-10-18
申请人： APPLERA CORPORATION , BANERJEE, Debjyoti , ULMANELLA, Umberto , FAULSTICH, Konrad , LAU, Aldrich, N., K. , XIE, Jun
发明人： BANERJEE, Debjyoti , ULMANELLA, Umberto , FAULSTICH, Konrad , LAU, Aldrich, N., K. , XIE, Jun
IPC分类号： B01L3/00
CPC分类号： F16K99/0001 , B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0415 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0661 , B01L2400/0677 , B01L2400/0683 , B01L2400/082 , B01L2400/084 , B01L2400/086 , F16K99/003 , F16K99/0036 , F16K99/0057 , F16K2099/0084 , Y10S422/901 , Y10T137/0318 , Y10T137/0324 , Y10T137/1624 , Y10T137/1812 , Y10T137/2191 , Y10T137/8376 , Y10T137/8593 , Y10T137/85978 , Y10T436/143333 , Y10T436/2575
摘要： A diagnostic device is provided that includes a plurality of retainment regions interconnected through at least one fluid processing passageway or separated by at least one barrier. A fluid flow modulator can be provided in the fluid processing passageway if a fluid processing passageway is provided. The barrier and/or fluid flow modulator can comprise a polysaccharide, a derivative of a polysaccharide, or a combination thereof. For example, the barrier can comprise a chitosan material.
摘要翻译：提供了诊断装置，其包括通过至少一个流体处理通道互连或由至少一个屏障隔开的多个保持区域。如果提供流体处理通道，流体流动调节器可以设置在流体处理通道中。阻隔和/或流体流动调节器可以包含多糖，多糖的衍生物或其组合。例如，阻挡层可以包含壳聚糖材料。

3. 发明申请

WO0125479A3 FLUORESCENT MULTIPLEX-SEQUENCING 审中-公开
标题翻译：荧光多重测序
公开(公告)号：WO0125479A3
公开(公告)日：2002-06-20
申请号：PCT/EP0009763
申请日：2000-10-05
申请人： EUROP LAB MOLEKULARBIOLOG , ANSORGE WILHELM , BENES VLADIMIR , STEGEMANN JOSEF , VENTZKI ROBERT , WURMBACH ELISA , FAULSTICH KONRAD
发明人： ANSORGE WILHELM , BENES VLADIMIR , STEGEMANN JOSEF , VENTZKI ROBERT , WURMBACH ELISA , FAULSTICH KONRAD
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2565/125 , C12Q2565/102 , C12Q2563/107
摘要： The invention relates to a method for analysing nucleic acids which were created in a nucleic acid sequencing reaction, in particular, in an enzymatic sequencing reaction, using fluorescent dyes as markers.
摘要翻译：本发明涉及用于核酸在核酸测序反应的分析的方法，特别是在酶促测序反应，产生了使用荧光染料作为标签。

4. 发明申请

WO2009127424A3 FLUORESCENCE STANDARD, AND THE USE THEREOF 审中-公开
标题翻译：荧光标准品及其使用
公开(公告)号：WO2009127424A3
公开(公告)日：2009-12-10
申请号：PCT/EP2009002830
申请日：2009-04-17
申请人： ESE GMBH , HABERSTROH KLAUS , FAULSTICH KONRAD
发明人： HABERSTROH KLAUS , FAULSTICH KONRAD
IPC分类号： G01N21/27 , B01L3/00 , G01J1/58 , G01K11/32 , G01N21/64 , G01N23/223 , G01T1/36
CPC分类号： G01N21/278 , B01L3/50857 , B01L3/5088 , B01L2200/148 , B01L2300/0822 , B01L2300/0829 , G01K11/14 , G01N1/28 , G01N21/6452 , G01N2001/2893 , G01N2015/1018 , G01T1/362 , Y10T436/10
摘要： The invention relates to fluorescence standards, and particularly to fluorescence standards for calibrating optical detectors. According to the invention a fluorescent mineral, or mixtures of minerals, are utilized for use as a fluorescence standard. The fluorescent mineral can be a naturally occurring mineral, or a synthetically produced mineral. Preferred fluorescent minerals for use as fluorescent standards are corundum, fluorite, turquoise, amber, zirconium, zoisite, iolithe, or cordierite, respectively, spinel, topaz, calcium fluorite, sphalerite, calcite, apatite, scheelite, or tungsten, respectively, willemite, feldspar, sodalite, a uranium mineral, an Al3+ containing mineral, and particularly ruby and sapphire. A sample plate (10) for receiving a fluorescent mineral (12b, 14b) or a substance containing a fluorescent mineral is likewise disclosed.
摘要翻译：本发明涉及一种荧光标准，特别是荧光标准，用于校准光检测器。根据本发明的矿物的荧光矿物质或混合物用于用作荧光标准。荧光矿物可以是天然存在的矿物或合成的矿物质。优选的荧光矿物质用作荧光标准是刚玉，萤石，绿松石，琥珀，锆，Zoisit，Iolith或堇青石，尖晶石，黄玉，Calciumfluorit，闪锌矿或闪锌矿，方解石或方解石，磷灰石，白钨矿或通·斯通，硅锌矿，长石，方钠石，铀矿物中，Al 3+含有矿物，更具体红宝石和蓝宝石。的样品板（10），用于接收至少一种样品包含荧光矿物（12B，14B），或包含荧光矿物质的物质也被公开。

5. 发明申请

WO2009127424A2 FLUORESZENZSTANDARDS UND DEREN VERWENDUNG 审中-公开
标题翻译：荧光标准品及其使用
公开(公告)号：WO2009127424A2
公开(公告)日：2009-10-22
申请号：PCT/EP2009/002830
申请日：2009-04-17
申请人： ESE GMBH , HABERSTROH, Klaus , FAULSTICH, Konrad
发明人： HABERSTROH, Klaus , FAULSTICH, Konrad
IPC分类号： G01N21/27 , G01N21/64 , B01L3/00 , G01J1/58 , G01T1/36
CPC分类号： G01N21/278 , B01L3/50857 , B01L3/5088 , B01L2200/148 , B01L2300/0822 , B01L2300/0829 , G01K11/14 , G01N1/28 , G01N21/6452 , G01N2001/2893 , G01N2015/1018 , G01T1/362 , Y10T436/10
摘要： Die Erfindung betrifft Fluoreszenzstandards und insbesondere Fluoreszenzstandards zur Kalibrierung optischer Detektoren. Erfindungsgemäß wird ein fluoreszierendes Mineral oder Mischungen von Mineralien zur Verwendung als Fluoreszenzstandard eingesetzt. Bei dem fluoreszierenden Mineral kann es sich um ein natürlich vorkommendes Mineral oder um ein synthetisch hergestelltes Mineral handeln. Bevorzugte fluoreszierende Minerale zur Verwendung als Fluoreszenzstandards sind Korund, Fluorit, Türkis, Bernstein, Zirkon, Zoisit, Iolith bzw. Cordierit, Spinell, Topas, Calciumfluorit, Sphalerit bzw. Zinkblende, Calcit bzw. Kalkspat, Apatit, Scheelit bzw. Tungstein, Willemit, Feldspate, Sodalith, ein Uran-Mineral, ein Al 3+ enthaltendes Mineral und insbesondere Rubin und Saphir.
摘要翻译：本发明涉及一种荧光标准，特别是荧光标准，用于校准光检测器。根据本发明的矿物的荧光矿物质或混合物用于用作荧光标准。荧光矿物可以是天然存在的矿物或合成的矿物质。优选的荧光矿物质用作荧光标准是刚玉，萤石，绿松石，琥珀，锆，Zoisit，Iolith或堇青石，尖晶石，黄玉，Calciumfluorit，闪锌矿或闪锌矿，方解石或方解石，磷灰石，白钨矿或通·斯通，硅锌矿，长石，方钠石，铀矿物中，Al 3+含有矿物，特别是红宝石和蓝宝石。

6. 发明申请

WO2006081479A3 SAMPLE PREPARATION DEVICES AND METHODS 审中-公开
标题翻译：样品制备装置和方法
公开(公告)号：WO2006081479A3
公开(公告)日：2009-06-04
申请号：PCT/US2006003061
申请日：2006-01-27
申请人： APPLERA CORP , FAULSTICH KONRAD , VAN CAMP JOHN R , VANN CHARLES S
发明人： FAULSTICH KONRAD , VAN CAMP JOHN R , VANN CHARLES S
IPC分类号： C12N1/06
CPC分类号： C12N1/066 , B01L3/502 , B01L2300/0681 , B01L2400/0478 , B01L2400/0605 , C12N1/06 , G01N2001/4088
摘要： A method and device for preparing biological samples includes lysing the microorganisms, and collecting a desired biological material.
摘要翻译：用于制备生物样品的方法和装置包括裂解微生物并收集所需的生物材料。

7. 发明申请

WO2007011946A2 DETECTION OF NUCLEIC ACID AMPLIFICATION 审中-公开
标题翻译：检测核酸扩增
公开(公告)号：WO2007011946A2
公开(公告)日：2007-01-25
申请号：PCT/US2006/027872
申请日：2006-07-17
申请人： APPLERA CORPORATION , AIVAZACHVILI, Vissarion , SCABOO, Kristian, M. , LAU, Aldrich, N.K. , FAULSTICH, Konrad , EASON, Robert, G. , VAN CAMP, John, R. , LIU, Timothy, Z.
发明人： AIVAZACHVILI, Vissarion , SCABOO, Kristian, M. , LAU, Aldrich, N.K. , FAULSTICH, Konrad , EASON, Robert, G. , VAN CAMP, John, R. , LIU, Timothy, Z.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6823 , B01L3/5027 , B01L7/525 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/1844 , B01L2300/185 , B01L2300/1872 , B01L2300/1894 , B01L2400/0418 , C12Q1/6825 , C12Q2565/607 , C12Q2563/131 , C12Q2565/629 , C12Q2531/113 , C12Q2521/301 , C12Q2523/107
摘要： Methods for detecting a target polynucleotide sequences are provided that utilize a probe having a target-complementary segment and a detectable tag. By cleaving the detectable tab and associating the tag with a tag complement coupled to an electrode, an electrochemical signal can be detected that is related to the presence of the tag:tag complement complex.
摘要翻译：提供了检测靶多核苷酸序列的方法，其利用具有靶互补区段和可检测标签的探针。通过切割可检测的标签并将标签与耦合到电极的标签补体相关联，可以检测与标签：标签补体复合物的存在相关的电化学信号。

8. 发明申请

WO2006076650A2 COMPOSITIONS, METHODS, AND KITS FOR SELECTIVE AMPLIFICATION OF NUCLEIC ACIDS 审中-公开
标题翻译：用于选择性放大核酸的组合物，方法和试剂盒
公开(公告)号：WO2006076650A2
公开(公告)日：2006-07-20
申请号：PCT/US2006/001360
申请日：2006-01-12
申请人： APPLERA CORPORATION , AIVAZACHVILI, Vissarion , FAULSTICH, Konrad , TRAN, Tony
发明人： AIVAZACHVILI, Vissarion , FAULSTICH, Konrad , TRAN, Tony
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6844 , C12Q1/6853 , Y02A50/54 , C12Q2525/307 , C12Q2531/125 , C12Q2525/117 , C12Q2561/125 , C12Q2537/143
摘要： The current teachings are directed to compositions, methods, and kits for selectively amplifying and for detecting target sequences. In some embodiments, a circularizable probe and/or a probe pair are disclosed for selectively amplifying target sequences. Methods for selectively amplifying target sequences are also disclosed, as are methods for detecting selectively amplified target sequences. Certain embodiments of the disclosed methods comprise a circularizable probe, a probe pair, comprising a first probe and a second probe, or both. In certain embodiments, a multiplicity of different circularizable probes, a multiplicity of different probe sets, or a multiplicity of different circularizable probes and a multiplicity of different probe sets are provided to selectively amplify or to detect a multiplicity of different target sequences, typically in a multiplex reaction. According to certain disclosed methods, surrogates of the target sequences are selectively amplified, including without limitation ligated probes, first amplification products, second amplification products, or combinations thereof. In some embodiments, selectively amplified target sequences or their surrogates are detected, directly or indirectly, indicating the presence of the corresponding target sequence. Kits to facilitate the performance of the disclosed methods are also provided.
摘要翻译：目前的教导涉及用于选择性扩增和检测靶序列的组合物，方法和试剂盒。在一些实施方案中，公开了可圆化探针和/或探针对，用于选择性扩增靶序列。还公开了选择性扩增靶序列的方法，以及用于检测选择性扩增的靶序列的方法。所公开方法的某些实施方案包括可圆化的探针，包括第一探针和第二探针的探针对，或两者。在某些实施方案中，提供多个不同的可圆化探针，多个不同的探针组或多个不同的可环化探针和多个不同的探针组，以选择性地扩增或检测多种不同靶序列，通常在多重反应。根据某些公开的方法，选择性扩增靶序列的替代物，包括但不限于连接的探针，第一扩增产物，第二扩增产物或其组合。在一些实施方案中，直接或间接检测选择性扩增的靶序列或其替代物，表明存在相应的靶序列。还提供了用于促进所公开方法的性能的套件。

9. 发明申请

WO2006044896A3 FLUID PROCESSING DEVICE INCLUDING COMPOSITE MATERIAL FLOW MODULATOR 审中-公开
公开(公告)号：WO2006044896A3
公开(公告)日：2006-04-27
申请号：PCT/US2005/037451
申请日：2005-10-18
申请人： APPLERA CORPORATION , FAULSTICH, Konrad , LAU, Aldrich , BANERJEE, Debjyoti , ULMANELLA, Umberto , XIE, Jun
发明人： FAULSTICH, Konrad , LAU, Aldrich , BANERJEE, Debjyoti , ULMANELLA, Umberto , XIE, Jun
IPC分类号： G01N15/06 , G01N33/00 , B01L3/02 , B01L11/00 , B01L3/00
摘要： A fluid processing device is provided that includes a substrate, a plurality of fluid retainment regions formed in or on the substrate, and a barrier at least partially separating two or more of the fluid retainment regions. The barrier includes a mixture of a sequestering material and a reaction component. The reaction component can be at least one of a reactant, a reagent, a catalyst, an initiator, a promoter, a cofactor, an enzyme, a salt, or a combination thereof. The sequestering material can be a porous material, a dissolvable material, or both.

10. 发明申请

WO9953087A3 5'-MODIFIED NUCLEOTIDES AND THE APPLICATION THEREOF IN MOLECULAR BIOLOGY AND MEDICINE 审中-公开
标题翻译： 5'-修饰的核苷酸及其分子生物学和医学中的应用
公开(公告)号：WO9953087A3
公开(公告)日：1999-12-02
申请号：PCT/EP9902320
申请日：1999-04-06
申请人： EUROP LAB MOLEKULARBIOLOG , FAULSTICH KONRAD , ANSORGE WILHELM
发明人： FAULSTICH KONRAD , ANSORGE WILHELM
IPC分类号： C12Q1/68 , A61K31/70 , C07H19/10 , C07H19/20 , C07H21/00
CPC分类号： C12Q1/6869 , C12Q2527/119 , C12Q2527/101 , C12Q2525/113
摘要： The invention relates to 5'-modified nucleotides and nucleic acids containing said nucleotides. The invention also relates to methods for integrating 5'-modified nucleotides in nucleic acids and subsequent localized splitting of the nucleic acids on the 5'-modified monomer structural elements. The inventive methods can be used in nucleic acid sequencing, in the creation of nucleic acid libraries, in the detection of mutations, in the production of carrier-bound nucleic acids and for pharmaceutical purposes.
摘要翻译：本发明涉及5'-修饰的核苷酸和含有这样的核苷酸的核酸。此外，公开了用于掺入5'-修饰的核苷酸为核酸和核酸的5'-修饰的单体单元随后位点特异性切割的方法。这些方法可用于核酸测序，用于生产的核酸文库，用于检测突变，为的载体结合的核酸的制备，以及用于制药目的。

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