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1. 发明申请

WO0125779A2 ELECTROPHORESIS DEVICE FOR ANALYSING LABELLED MOLECULES, IN PARTICULAR, BIOLOGICAL MOLECULES 审中-公开
标题翻译：电泳仪用于分析标记的分子，尤其是生物分子
公开(公告)号：WO0125779A2
公开(公告)日：2001-04-12
申请号：PCT/EP0009777
申请日：2000-10-05
申请人： EUROP LAB MOLEKULARBIOLOG , ANSORGE WILHELM , STEGEMANN JOSEF , VENTZKI ROBERT , SCHWAGER CHRISTIAN
发明人： ANSORGE WILHELM , STEGEMANN JOSEF , VENTZKI ROBERT , SCHWAGER CHRISTIAN
IPC分类号： G01N21/64 , G01N27/447
CPC分类号： G01N27/44782 , G01N21/6428 , G01N27/44721 , G01N27/44726
摘要： The invention relates to an electrophoresis device (10) for analysing molecules labelled with fluorescent markers, in particular, biological molecules. According to one aspect of the invention, said device is suitable for resolving at least four different fluorescent markers independently of one another using a detector field assigned to each marker, according to the respective gel electrophoresis lane and the respective fluorescent marker. To this end, spectral filters are balanced with one another with regard to their spectral selectivity, the fluorescent markers are balanced with one another with regard to their spectral absorption and emission selectivity and the wavelengths of the laser beams (60, 62, 64, 66) which are used to excite the fluorescent markers are balanced with one another in a corresponding manner.
摘要翻译：本发明涉及一种电泳装置（10），用于分析荧光标记物标记的分子，即根据本发明的一个方面通过一个分别相关联的检测器阵列的装置每个凝胶电泳后适于彼此独立地至少四种不同的荧光标记物尤其是生物分子和荧光标记物的各自的幅材检测溶解。为了这个目的，光谱滤光器相对于它的光谱选择性，在它们的光谱吸收和发射选择性方面的荧光标记物和激光光束的用于激发荧光标记物的波长（60，62，64，66），其适于以相应的方式彼此连接。

2. 发明申请

WO0125479A3 FLUORESCENT MULTIPLEX-SEQUENCING 审中-公开
标题翻译：荧光多重测序
公开(公告)号：WO0125479A3
公开(公告)日：2002-06-20
申请号：PCT/EP0009763
申请日：2000-10-05
申请人： EUROP LAB MOLEKULARBIOLOG , ANSORGE WILHELM , BENES VLADIMIR , STEGEMANN JOSEF , VENTZKI ROBERT , WURMBACH ELISA , FAULSTICH KONRAD
发明人： ANSORGE WILHELM , BENES VLADIMIR , STEGEMANN JOSEF , VENTZKI ROBERT , WURMBACH ELISA , FAULSTICH KONRAD
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2565/125 , C12Q2565/102 , C12Q2563/107
摘要： The invention relates to a method for analysing nucleic acids which were created in a nucleic acid sequencing reaction, in particular, in an enzymatic sequencing reaction, using fluorescent dyes as markers.
摘要翻译：本发明涉及用于核酸在核酸测序反应的分析的方法，特别是在酶促测序反应，产生了使用荧光染料作为标签。

3. 发明申请

WO0040952A3 DEVICE FOR THE PRECISION ROTATION OF SAMPLES 审中-公开
标题翻译：精密样本轮换
公开(公告)号：WO0040952A3
公开(公告)日：2001-10-18
申请号：PCT/EP0000088
申请日：2000-01-07
申请人： EUROP LAB MOLEKULARBIOLOG , CIPRIANI FLORENT , CASTAGNA JEAN CHARLES
发明人： CIPRIANI FLORENT , CASTAGNA JEAN CHARLES
IPC分类号： G21K1/06 , G01N23/20 , G01N23/22 , H05H7/00
CPC分类号： G01N23/20016 , H05H7/00
摘要： The invention relates to a device for the precision rotation of samples, which device is mounted on a diffractometer and used notably for X-ray or synchrotron radiation diffraction experiments. Said device comprises: a centering element (26) which is held at one end of a motor-driven rotating shaft (22) and can be displaced in a plane orthogonal to the axis of rotation of the rotating shaft (22); a sample holder (30) which is fixed to or formed as a single piece with the centering element (26) and holds a sample (32) substantially centrally in relation to the axis of rotation in an X-ray or synchrotron radiation beam (S); and at least one micrometric finger (36) which is arranged in the area of the centering element (26) and by means of a micrometric finger drive device can be positioned orthogonally to the axis of rotation of the rotating shaft (22).
摘要翻译：所以建议上的衍射仪，特别是对于X射线或同步加速器散射实验，样品装置包括一个旋转精度：a。在马达驱动的旋转轴（22）的一个端部保持并在旋转轴（22）的水平移动的定心元件的旋转轴线正交（26 ）; 定心元件中的一个（26）附接或与之整体样品用于在X射线或同步加速器辐射束（S）保持的样品（32）的大致中央，以旋转轴保持器（30）; 在可以由测微手指驱动装置正交被定位于旋转轴（22）的旋转轴线定心元件（26）微米的手指（36）的区域中布置的至少一个。

4. 发明申请

WO9925732A3 DESIGN OF COILED-COIL DIMER DERIVED ANTAGONISTS OF 4-HELIX BUNDLE CYTOKINE SPECIFIC RECEPTORS 审中-公开
标题翻译： 4螺旋组织细胞因子特异性受体的线圈二极体衍生拮抗剂的设计
公开(公告)号：WO9925732A3
公开(公告)日：1999-09-02
申请号：PCT/EP9807286
申请日：1998-11-13
申请人： EUROP LAB MOLEKULARBIOLOG , DOMINGUES HELENA , CREGUT DAVID , SEBALD WALTER , OSCHKINAT HARTMUT , SERRANO LUIS
发明人： DOMINGUES HELENA , CREGUT DAVID , SEBALD WALTER , OSCHKINAT HARTMUT , SERRANO LUIS
IPC分类号： A61K38/00 , A61K38/20 , C07K14/395 , C07K14/54
CPC分类号： C07K14/5406 , A61K38/00 , C07K14/395 , C07K2319/00 , Y10S514/826 , Y10S514/885
摘要： The design of antagonists of 4-helix bundle cytokine specific receptors, mimetic peptides that are able to act as such antagonists and their use as pharmaceutical agents is disclosed.
摘要翻译：公开了4螺旋束细胞因子特异性受体的拮抗剂的设计，能够作为这种拮抗剂的模拟肽及其作为药剂的用途。

5. 发明申请

WO2004065929A3 SILICONE/GRAPHITE SAMPLE HOLDER 审中-公开
标题翻译：硅胶/石墨样品瓶
公开(公告)号：WO2004065929A3
公开(公告)日：2005-09-09
申请号：PCT/EP2004000313
申请日：2004-01-16
申请人： EUROP LAB MOLEKULARBIOLOG , FRANZ THOMAS
发明人： FRANZ THOMAS
IPC分类号： G01N1/00 , H01J49/04
CPC分类号： H01J49/04
摘要： The present invention relates to a sample holder for a mass spectrometer onto which a mixture of silicone and graphite is applied.
摘要翻译：本发明涉及一种用于质谱仪的样品架，其上涂有硅树脂和石墨的混合物。

6. 发明申请

WO0056875A9 DETECTION, CLONING AND SEQUENCING OF POLYPEPTIDES WHICH DRIVE THE SUBCELLULAR LOCALIZATION OF PROTEINS 审中-公开
标题翻译：检测，克隆和测序推动蛋白质的细胞定位的多肽
公开(公告)号：WO0056875A9
公开(公告)日：2002-02-28
申请号：PCT/EP0002607
申请日：2000-03-23
申请人： EUROP LAB MOLEKULARBIOLOG , GONZALEZ CAYSTANO , BEJARANO LUIS
发明人： GONZALEZ CAYSTANO , BEJARANO LUIS
IPC分类号： C07K14/435 , C12N15/10 , C12N15/12 , C12N15/62
CPC分类号： C12N15/1051 , C07K2319/00 , C07K2319/60 , C12N15/1086
摘要： The present invention concerns a process for the detection, cloning and/or sequencing of polypeptides or parts thereof, which drive the subcellular localization of a protein containing such polypeptide or part thereof, characterized in that the process comprises the following steps: (a) constructing an expression library of random nucleic acids ligated to a reporter gene and contained in a vector molecule, (b) transfecting a plurality of host cells with the library, (c) screening for the subcellular localization of the expression product of the nucleic acid in the host cells via detection of a signal produced by the reporter gene, (d) cloning such cells where the reporter gene signal is detected in a certain subcellular localization, and (e) cloning and optionally sequencing the nucleic acid insert which encodes the polypeptide or part thereof. Polypeptides, driving the intracellular localization can be used to construct fusion proteins with predetermined intracellular localization.
摘要翻译：本发明涉及用于检测，克隆和/或测序多肽或其部分的方法，其驱动含有此类多肽或其部分的蛋白质的亚细胞定位，其特征在于该方法包括以下步骤：（a）构建连接到报告基因并包含在载体分子中的随机核酸的表达文库，（b）用该文库转染多个宿主细胞，（c）筛选核酸表达产物的亚细胞定位通过检测由报告基因产生的信号的宿主细胞，（d）克隆这样的细胞，其中在某些亚细胞定位中检测到报告基因信号，和（e）克隆和任选测序编码多肽或部分的核酸插入片段它们。驱动细胞内定位的多肽可用于构建具有预定细胞内定位的融合蛋白。

7. 发明申请

WO0046600A3 METHOD OF DETECTING ANALYTES IN A SAMPLE AND SUPPORT FOR THIS PURPOSE 审中-公开
标题翻译：方法分析物在测量探头和测量性载体检测
公开(公告)号：WO0046600A3
公开(公告)日：2001-11-01
申请号：PCT/EP0000876
申请日：2000-02-03
申请人： EUROP LAB MOLEKULARBIOLOG , BECKER PETER , HOERBER HEINRICH
发明人： BECKER PETER , HOERBER HEINRICH
IPC分类号： B01J19/00 , C40B40/06 , G01N33/543 , G01N33/551 , G11B7/013
CPC分类号： G01N33/54366 , B01J19/0046 , B01J2219/00536 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/0063 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , C40B40/06
摘要： The invention relates to a method of detecting analytes in a sample. According to said method, analyte-specific binders (15) are immobilized on a plurality of detection fields (5, 7) on one of the planar faces of a disk-shaped substrate (3). The sample is contacted with said detection fields (5, 7) and the presence or/and the quantity of the analytes (17) to be detected is determined by optically evaluating the detection fields (5, 7). According to the invention, a substrate (3) is used that is produced from an optically transparent material. The detection fields (5, 7) are arranged along at least one spiral line (27) distributed across the substrate (3). After the sample has been contacted with the detection fields (5, 7), a reflecting layer (21) is flatly applied on the substrate (3) on the planar face carrying the detection fields (5, 7). Alternatively, a magnetic read-out of the substrate can be made instead of the optical read-out.
摘要翻译：公开了一种用于在测试样品中检测分析物的方法，其中的圆盘状基板上（3）上的多个检测视野的其平坦侧面的粘合剂（15）中的一个分析物（5，7）被固定在接触的方法，并随后测定试样检测字段（5,7）由所述检测视野的光学评估放置，然后在存在或/和要被检测的分析物的量（17）（5,7）被确定。根据本发明，使用一个由光学透明材料基板（3），其中所述检测区域（5，7）被设置沿所述衬底（3）上的至少一个螺旋线（27）分布的。建立与所述检测区域（5,7），其检测字段（5,7）承载有反射层（21）的平坦侧表面在衬底（3）样品的接触之后提供。可替代地，所述衬底的磁性读出设想代替光学读出。

8. 发明申请

WO0046367A2 PROTEIN WITH CELL PROLIFERATION AND CELL DIVISION MODULATING ACTIVITY AND DNA ENCODING SUCH PROTEIN 审中-公开
标题翻译：蛋白质与细胞增殖和细胞分裂调节活性和DNA编码这种蛋白质
公开(公告)号：WO0046367A2
公开(公告)日：2000-08-10
申请号：PCT/EP0000877
申请日：2000-02-03
申请人： EUROP LAB MOLEKULARBIOLOG , FERBY INGVAR MATS , NEBREDA M ANGEL RODRIGUEZ
发明人： FERBY INGVAR MATS , NEBREDA M ANGEL RODRIGUEZ
IPC分类号： G01N33/53 , A61K38/00 , A61K38/17 , A61P15/00 , A61P35/00 , C07K14/46 , C07K14/47 , C07K19/00 , C12N15/09 , C12N15/12 , C12N15/62 , C12Q1/02 , C12Q1/68 , G01N33/50 , G01N33/566 , G01N33/68
CPC分类号： C07K14/463 , A61K38/00 , C12Q1/6876
摘要： A DNA sequence according to the invention contains (a) a sequence as shown in SEQ ID NO.1 or 2; (b) a sequence which encodes the same protein as (a) but is degenerated as a result of the genetic code, (c) a sequence hybridizing under stringent conditions to the sequences of (a) and/or (b), (d) a genomic sequence containing the sequence of (a, b or c) and further containing one or more introns; or (e) a sequence which differs from (a, b, c or d) due to its origin from a different species. A protein according to the invention is encoded by such DNA sequence and can be used for inducing oocyte maturation and/or modulating cell division and/or differentiation and/or proliferation, in a pharmaceutical composition or as diagnostic agent.
摘要翻译：根据本发明的DNA序列包含（a）SEQ ID NO.1或2所示的序列; （b）编码与（a）相同的蛋白质但是由于遗传密码而退化的序列，（c）在严格条件下与（a）和/或（b），（d）的序列杂交的序列）含有（a，b或c）序列并且还含有一个或多个内含子的基因组序列; 或（e）不同于（a，b，c或d）的序列，其来源于不同的物种。根据本发明的蛋白质由这样的DNA序列编码，并且可用于诱导卵母细胞成熟和/或调节药物组合物中或作为诊断剂的细胞分裂和/或分化和/或增殖。

9. 发明申请

WO0036398A2 METHOD AND DEVICES FOR DETECTING OPTICAL PROPERTIES, ESPECIALLY LUMINESCENCE REACTIONS AND REFRACTION BEHAVIOUR OF MOLECULES WHICH ARE DIRECTLY OR INDIRECTLY BOUND ON A SUPPORT 审中-公开
标题翻译：用于测定光学特性，尤其是，发光反应和中断特性的方法和设备，通过载体直接或间接结合分子
公开(公告)号：WO0036398A2
公开(公告)日：2000-06-22
申请号：PCT/DE9903981
申请日：1999-12-14
申请人： DEUTSCHES KREBSFORSCH , EUROP LAB MOLEKULARBIOLOG , POUSTKA ANNEMARIE , BREITLING FRANK , GROSS KARL HEINZ , DUEBEL STEFAN , SAFFRICH RAINER
发明人： POUSTKA ANNEMARIE , BREITLING FRANK , GROSS KARL-HEINZ , DUEBEL STEFAN , SAFFRICH RAINER
IPC分类号： B01J19/00 , C07K1/04 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/64 , G01N21/00
CPC分类号： G01N21/6428 , B01J19/0046 , B01J2219/00378 , B01J2219/00441 , B01J2219/00542 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00711 , B01J2219/00725 , B82Y30/00 , C07K1/047 , C40B40/10 , C40B60/14 , C40B70/00 , G01N21/6454
摘要： According to the method for detecting optical properties, especially luminescence reactions and refraction behaviour of molecules which are directly or indirectly bound on a support, electromagnetic waves, especially laser light, are radiated onto the support. The light that is emitted or refracted by the molecules is then detected by a detector. The detector and the support are moved in relation to each other during and after the radiation of the electromagnetic waves. The support used is especially a transparent support with integrated position markings which can be detected by a detector, especially an optoelectronic scanning system. At least one of the integrated position markings is selected while the support and the detector are being moved in relation to each other or thereafter so that the light that is detected by the detector can be associated with a location on the support. A device for carrying out the method is provided with a detector, especially an optoelectronic scanning system, for detecting the position markings that are integrated in the support.
摘要翻译：在用于检测的光学特性的方法，特别是发光反应和在载体上的直接或间接结合的分子的电磁波的折射行为，尤其是激光，被照射到载体上。检测器检测由分子发射或折射的光。在电磁波检测器和载体的照射期间和之后相对于彼此移动。作为支撑体，一个透明支撑体和具有集成，由检测器检测的，特别是optoeletronischen扫描位置标记在特定使用。这里，集成位置标记中的一个的至少期间或载体和检测器的相对运动之后被读取时，使得检测到的光的分配由所述检测器，以在载体上的位置是可能的。在用于Durchfühnung提供了一种装置的方法中，检测器，特别是用于检测集成在支持位置标记的光电扫描系统。

10. 发明申请

WO0244321A3 RNA INTERFERENCE MEDIATING SMALL RNA MOLECULES 审中-公开
标题翻译： RNA干扰介导小RNA分子
公开(公告)号：WO0244321A3
公开(公告)日：2003-10-23
申请号：PCT/EP0113968
申请日：2001-11-29
申请人： MAX PLANCK GESELLSCHAFT , TUSCHL THOMAS , ELBASHIR SAYDA , LENDECKEL WINFRIED , WILM MATTHIAS , EUROP LAB MOLEKULARBIOLOG
发明人： TUSCHL THOMAS , ELBASHIR SAYDA , LENDECKEL WINFRIED , WILM MATTHIAS
IPC分类号： A01H5/00 , A01K67/027 , A61K9/00 , A61K31/7105 , A61K38/00 , A61K45/00 , A61K48/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07H20060101 , C07H21/00 , C12N20060101 , C12N1/00 , C12N5/10 , C12N15/09 , C12N15/10 , C12N15/113 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/68
CPC分类号： C12N15/113 , A01K2217/075 , A61K9/0019 , A61K38/00 , A61K48/00 , C12N15/1079 , C12N15/111 , C12N2310/14 , C12N2310/321 , C12N2310/53 , C12N2330/30 , C12N2310/3521
摘要： Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are generated by an RNase III-like processing reaction from long dsRNA. Chemically synthesized siRNA duplexes with overhanging 3' ends mediate efficient target RNA cleavage in the lysate, and the cleavage site is located near the center of the region spanned by the guiding siRNA. Furthermore, we provide evidence that the direction of dsRNA processing determines whether sense or antisense target RNA can be cleaved by the produced siRNP complex.
摘要翻译：双链RNA（dsRNA）通过称为RNA干扰（RNAi）的过程在许多生物体中诱导序列特异性转录后基因沉默。使用果蝇体外系统，我们证明19-23短小RNA片段是RNAi的序列特异性介质。通过来自长dsRNA的RNA酶III类加工反应产生短干扰RNA（siRNA）。与突出的3'端的化学合成的siRNA双链体介导裂解物中有效的靶RNA切割，并且切割位点位于由引导siRNA跨越的区域的中心附近。此外，我们提供证据表明dsRNA加工的方向决定了有义或反义的靶RNA是否可以被生成的siRNP复合物切割。

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