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1. 发明申请

WO2012149185A2 METHOD OF CHANGING FLUID FLOW BY USING AN OPTICAL BEAM 审中-公开
标题翻译：使用光束改变流体流动的方法
公开(公告)号：WO2012149185A2
公开(公告)日：2012-11-01
申请号：PCT/US2012/035250
申请日：2012-04-26
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY , LOU, Janet, W. , VILLARRUEL, Carl, A. , SCHERMER, Ross
发明人： LOU, Janet, W. , VILLARRUEL, Carl, A. , SCHERMER, Ross
IPC分类号： G01N35/08 , G01N1/10
CPC分类号： G01N21/00 , B01L3/502776 , B01L2300/0816 , B01L2300/1861 , B01L2300/1872 , B01L2400/0442 , B01L2400/0487 , G01N15/1404 , G01N15/1484 , G01N2015/1413 , G01N2015/149 , Y10T137/0391 , Y10T137/206 , Y10T137/2076 , Y10T137/2196
摘要： The application of an optical beam redirects sheathed micro-fluidic flow without direct interaction with the sample. The hydrodynamic properties of the sheath are locally modified due to optical absorption and heating, resulting in a spatial shift of the sample flow. The technique can result in up to 100 μιη shift at peak flow velocities of 19 mm/sec.
摘要翻译：光束的应用重新定向了与样品直接相互作用的护套微流体流。由于光学吸收和加热，护套的流体动力学特性被局部改进，导致样品流动的空间偏移。该技术可以达到100μ？在峰值流速为19毫米/秒的位移。

2. 发明申请

WO2008125927A2 MICROFLUIDIC SYSTEM WITH ACTUATORS 审中-公开
标题翻译：具有执行器的微流控系统
公开(公告)号：WO2008125927A2
公开(公告)日：2008-10-23
申请号：PCT/IB2007/055104
申请日：2007-12-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , GILLIES, Murray, F. , DEN TOONDER, Jacob, M., J. , PONJEE, Marc, W., G. , JOHNSON, Mark, T.
发明人： GILLIES, Murray, F. , DEN TOONDER, Jacob, M., J. , PONJEE, Marc, W., G. , JOHNSON, Mark, T.
CPC分类号： B01F13/0059 , B01F13/0091 , B01L3/50273 , B01L3/502792 , B01L7/52 , B01L7/54 , B01L2300/0819 , B01L2300/089 , B01L2300/1822 , B01L2300/1827 , B01L2300/1872 , B01L2400/0484 , B01L2400/0633 , B01L2400/0688 , F04B19/006 , F04B19/24 , F04D33/00
摘要： The invention relates to microfluidic system (100), particularly a biosensor, for manipulating a sample in a sample chamber (1). The device comprises at least one actuator (10) that reversibly changes its spatial configuration if it is heated and/or cooled. The actuator (10) may particularly be arranged adjacent to an associated heating element (20) of a 5 heating array that is used to establish a predetermined spatial and/or temporal temperature profile in the sample chamber (1). The configuration change of the actuator (10) can be used to move the sample fluid or to control its passage through fluid channels. A plurality of actuators (10) may optionally be provided that undergo their configuration changes at different temperatures, particularly temperatures within a range that is passed during a 10 reaction like PCR.
摘要翻译：本发明涉及用于操纵样品室（1）中的样品的微流体系统（100），特别是生物传感器。该装置包括至少一个致动器（10），其如果被加热和/或冷却则可逆地改变其空间构造。致动器（10）可以特别地布置成与用于在样品室（1）中建立预定空间和/或时间温度分布的5个加热阵列的相关联的加热元件（20）相邻。致动器（10）的配置变化可用于移动样品流体或控制其通过流体通道。可以任选地提供多个致动器（10），其在不同温度，特别是在10反应期间通过的范围内的温度（如PCR）中进行其配置变化。

3. 发明申请

WO2007072417A3 INK JET DEVICE FOR THE POSITIONING OF A SUBSTANCE ONTO A SUBSTRATE, METHOD FOR THE POSITIONING OF A SUBSTANCE ONTO A SUBSTRATE AND USE OF AN INK JET DEVICE 审中-公开
标题翻译：用于将物质定位到基底上的墨水装置，用于将物质定位到基底上的方法和使用喷墨装置
公开(公告)号：WO2007072417A3
公开(公告)日：2007-10-18
申请号：PCT/IB2006054942
申请日：2006-12-19
申请人： KONINKL PHILIPS ELECTRONICS NV , VERBEEK ROY G F A , SCHROEDERS RICHARD J M , KOLESNYCHENKO ALEKSEY
发明人： VERBEEK ROY G F A , SCHROEDERS RICHARD J M , KOLESNYCHENKO ALEKSEY
IPC分类号： B41J3/28 , B01L3/00 , B41J3/407
CPC分类号： B41J3/28 , B01J19/0046 , B01J2219/0036 , B01J2219/00378 , B01J2219/00495 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00662 , B01J2219/00677 , B01J2219/00689 , B01J2219/00722 , B01J2219/00725 , B01L3/0268 , B01L2300/0819 , B01L2300/1872 , B41J3/407
摘要： The invention provides an ink jet device for the positioning of a substance onto a substrate, the device comprising at least a print head comprising a nozzle provided to eject a droplet comprising the substance, the ink jet device further comprising at least one heating element arranged such that the substrate can be heated prior to, during and/or after the landing of a droplet on the substrate.
摘要翻译：本发明提供了一种用于将物质定位到基底上的喷墨装置，该装置至少包括一个打印头，该打印头包括一个喷嘴，喷嘴被设置成喷射包括该物质的液滴，该喷墨装置还包括至少一个这样的加热元件衬底可以在液滴在衬底上着落之前，期间和/或之后被加热。

4. 发明申请

WO2007005077A1 HEATING ELEMENT FOR A ROTATING MULTIPLEX FLUORESCENCE DETECTION DEVICE 审中-公开
标题翻译：旋转多重荧光检测装置的加热元件
公开(公告)号：WO2007005077A1
公开(公告)日：2007-01-11
申请号：PCT/US2006/010819
申请日：2006-03-24
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： BEDINGHAM, William D., , LUDOWISE, Peter D., , ROBOLE, Barry W.,
IPC分类号： B01L7/00
CPC分类号： G01N21/645 , B01L3/5027 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0806 , B01L2300/1805 , B01L2300/1844 , B01L2300/1872 , G01N21/07 , G01N21/6428 , G01N2021/6419 , G01N2021/6421 , G01N2201/04 , G01N2201/0407 , G01N2201/08 , G01N2201/10 , G01N2201/101
摘要： Techniques are described for the detection of multiple target species in real-time PCR (polymerase chain reaction). For example, a system comprises a data acquisition device and a detection device coupled to the data acquisition device. The detection device includes a rotating disk having a plurality of process chambers having a plurality of species that emit fluorescent light at different wavelengths. The device further includes a plurality of removable optical modules that are optically configured to excite the species and capture fluorescent light emitted by the species at different wavelengths. A fiber optic bundle coupled to the plurality of removable optical modules conveys the fluorescent light from the optical modules to a single detector. The device further includes a heating element for heating one or more process chambers on the disk. In addition, the device may control the flow of fluid in the disk by locating and selectively opening valves separating chambers by heating the valves with a laser.
摘要翻译：描述了用于在实时PCR（聚合酶链式反应）中检测多种靶物种的技术。例如，系统包括数据采集装置和耦合到数据采集装置的检测装置。检测装置包括具有多个处理室的旋转盘，该多个处理室具有发射不同波长的荧光的多种物质。该装置还包括多个可移除的光学模块，其被光学配置为激发物种并捕获由不同波长的物质发射的荧光。耦合到多个可移除光学模块的光纤束将来自光学模块的荧光传送到单个检测器。该装置还包括用于加热盘上的一个或多个处理室的加热元件。此外，该装置可以通过利用激光加热阀来定位和选择性地打开阀分离腔来控制盘中的流体流动。

5. 发明申请

WO2004033099A2 METHODS AND SYSTEMS FOR MULTIPLEXING IR-MEDIATED HEATING ON A MICROCHIP 审中-公开
标题翻译：在微波炉上复合红外介质加热的方法和系统
公开(公告)号：WO2004033099A2
公开(公告)日：2004-04-22
申请号：PCT/US2003/031806
申请日：2003-10-08
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , LANDERS, James, P.
发明人： LANDERS, James, P.
IPC分类号： B01L
CPC分类号： B01L3/5027 , B01L7/52 , B01L7/54 , B01L2200/147 , B01L2300/0803 , B01L2300/0829 , B01L2300/1838 , B01L2300/1844 , B01L2300/1872 , B01L2400/0409 , G01N2035/00415
摘要： The present invention relates to methods and systems for rapid multiplexed heating of a plurality of small volume samples on a microchip. More specifically, the present invention relates to methods and systems for non-contact temperature cycling of the samples using infrared (IR)-mediated heating of small, micro to nanoliter, volume samples, wherein each cycle can be completed in as little as a few seconds. Depending on the system used, the present invention involves a spinning microchip or an immobile microchip having a plurality of micro-heating areas thereon. In the case of the spinning chip, the micro-heating areas are located in a circular configuration on the chip, so the micro-heating areas can be accessed by static heating source(s) by spinning the microchip. In case of the immobile microchip, fiber optics are used to direct radiation from a heating source or multiple heating sources directly to the micro-heating areas on a microchip.
摘要翻译：本发明涉及用于在微芯片上快速复用加热多个小体积样品的方法和系统。更具体地说，本发明涉及使用红外（IR）介导的小的，微至纳升的体积样品的加热样品的非接触温度循环的方法和系统，其中每个循环可以在少至几个秒。根据所使用的系统，本发明涉及一种纺丝微芯片或其上具有多个微加热区域的固定微芯片。在纺丝芯片的情况下，微加热区域位于芯片上的圆形构造中，因此通过旋转微芯片可以通过静态加热源访问微加热区域。在不动的微芯片的情况下，光纤用于将来自加热源或多个加热源的辐射直接引导到微芯片上的微加热区域。

6. 发明申请

WO2003102226A1 IMPROVED DNA AMPLIFICATION APPARATUS AND METHOD 审中-公开
标题翻译：改进的DNA扩增装置和方法
公开(公告)号：WO2003102226A1
公开(公告)日：2003-12-11
申请号：PCT/AU2003/000672
申请日：2003-05-30
申请人： BIO-MOLECULAR HOLDINGS PTY LIMITED , CORBETT, John, Michael , CORBETT, John, Michael, Jr.
发明人： CORBETT, John, Michael , CORBETT, John, Michael, Jr.
IPC分类号： C12Q1/68
CPC分类号： B04B15/02 , B01L7/52 , B01L2200/147 , B01L2300/0803 , B01L2300/1844 , B01L2300/1872 , C12Q1/686 , C12Q2563/173
摘要： The invention relates to a method for the amplification of DNA and apparatus for such amplification. The method comprises steps typically found in amplification methods but utilises an optical procedure to detect denaturation of DNA or attainment of the desired denaturation temperature. The apparatus (1) comprises a temperature controllable chamber (2) including a rotor (3) for holding a plurality of reaction vessels (see 7 for example) for reaction mixtures including DNA, a drive means for the rotor, a heater (8) within the chamber for transiently supplying infrared energy to the reaction vessels, and an optical system (12-16) for determining denaturation of at least a reference DNA or for detecting attainment of a desired denaturation temperature in at least a reference reaction vessel.
摘要翻译：本发明涉及扩增DNA的方法和用于扩增的装置。该方法包括通常在扩增方法中发现的步骤，但利用光学方法检测DNA的变性或达到所需的变性温度。装置（1）包括温度可控的室（2），其包括用于保持用于包括DNA的反应混合物的多个反应容器（例如7）的转子（3），用于转子的驱动装置，加热器（8）在室内瞬时向反应容器提供红外能量;以及光学系统（12-16），用于确定至少参考DNA的变性或用于在至少参考反应容器中检测达到所需的变性温度。

7. 发明申请

WO2003093835A1 分析用具の温調方法、および温調機能を備えた分析装置审中-公开
标题翻译：用于调节分析工具温度的方法和具有调节温度功能的分析装置
公开(公告)号：WO2003093835A1
公开(公告)日：2003-11-13
申请号：PCT/JP2003/005480
申请日：2003-04-28
申请人：アークレイ株式会社 , 田口尊之 , 北村茂
发明人：田口尊之 , 北村茂
IPC分类号： G01N35/08
CPC分类号： G01N35/00029 , B01L3/5027 , B01L7/00 , B01L2300/0816 , B01L2300/1861 , B01L2300/1872 , B01L2400/0421 , G01N27/44734 , G01N2035/00237 , G01N2035/00415 , Y10T436/25
摘要：本発明は、試料の分析を行うために使用される分析用具(１)において、この分析用具(１)に保持された液成分(１０)を目的温度に調整する技術に関する。本発明では、液成分(１０)を昇温する場合に、光源(２３)からの光エネルギを利用して液成分の加熱を行う。液成分の昇温は、たとえば液成分に光エネルギを直接供給することにより行う。液成分の昇温は、液成分に近接して設けられた昇温領域に対して光エネルギを照射し、この昇温領域から移動する熱エネルギにより行うようにしてもよい。昇温用の光源(２３)としては、レーザダイオードまたは発光ダイオードを用いるのが好ましい。
摘要翻译：一种用于调节保持在分析工具（1）中的液体组分（10）的方法，用于对样品进行分析以具有客观温度，其包括利用来自光源（23），用于提高液体组分的温度; 其中将光直接供应到液体组分以实现升温的方法，或者其中将光提供给设置在用于升温的液体组分附近的区域，并且部件的温度升高由热量从该地区转移的能源; 以及其中光源（23）是激光二极管或发光二极管的方法。

8. 发明申请

WO99039120A1 THERMAL EXPANSION-INDUCED FLUID CONTROL FOR MICROFLUIDIC DEVICES 审中-公开
标题翻译：微流控装置的热膨胀流体控制
公开(公告)号：WO99039120A1
公开(公告)日：1999-08-05
申请号：PCT/US1999/001831
申请日：1999-01-28
IPC分类号： B01L3/00 , F16K13/10 , C12Q1/68
CPC分类号： F16K13/10 , B01L3/50273 , B01L2300/1872
摘要： A new method is proposed for the precise manipulation of picoliter-nanoliter volumes in microfluidic chips. The technique relies on the thermal expansion of fluids whereby fluid pressure and flow is easily manipulated through control of the fluid temperature. Heat can be efficiently applied in a sample manner using a light/infrared source (30) (e.g., a halogen lamp) which selectively heats the fluid (36) in the chip device through absorption of the optical energy in the visible-infrared (VIS/IR) portion of the electromagnetic spectrum. Several applications for fluid control and manipulation on microfluidic chips are proposed using the VIS/IR-induced fluid pumping mechanism, including valving.
摘要翻译：本发明涉及用于精确操纵微流控芯片中的皮升 - 纳升量的新方法。该技术涉及流体的热膨胀，压力和流体流动通过调节流体的温度而容易地被操纵。简单地借助于光/红外光源（30）（例如卤素灯）可以有效地施加热量，该光源/光源通过吸收芯片中的光能来选择性地加热芯片中的流体（36）电磁波谱的可见 - 红外部分（VIS / IR）。使用VIS / IR激活流体泵机构（包括阀门）可以在微流控芯片上实现多种流体控制和流体处理应用。

9. 发明申请

WO2013126714A3 MICROFLUIDIC CARTRIDGE 审中-公开
标题翻译：微型墨盒
公开(公告)号：WO2013126714A3
公开(公告)日：2013-11-14
申请号：PCT/US2013027341
申请日：2013-02-22
申请人： EGAN MICHAEL , ROOT BRIAN , SCOTT ORION N , SOUTH DOUGLAS J , BIENVENUE JOAN , KINNON PAUL , LANDERS JAMES , SAUL DAVID , TSUEI AN-CHI , HAYES JASON , SPRINGER MATTHEW , SOLOMON MATTHEW , VAN RUIJVEN PETER
发明人： EGAN MICHAEL , ROOT BRIAN , SCOTT ORION N , SOUTH DOUGLAS J , BIENVENUE JOAN , KINNON PAUL , LANDERS JAMES , SAUL DAVID , TSUEI AN-CHI , HAYES JASON , SPRINGER MATTHEW , SOLOMON MATTHEW , VAN RUIJVEN PETER
IPC分类号： B01L3/00
CPC分类号： C12Q1/686 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502753 , B01L3/502784 , B01L3/5029 , B01L7/52 , B01L2200/027 , B01L2200/04 , B01L2200/0684 , B01L2200/0689 , B01L2200/10 , B01L2200/148 , B01L2200/16 , B01L2300/044 , B01L2300/0654 , B01L2300/0663 , B01L2300/0672 , B01L2300/0816 , B01L2300/0832 , B01L2300/0864 , B01L2300/0867 , B01L2300/0877 , B01L2300/14 , B01L2300/161 , B01L2300/18 , B01L2300/1872 , B01L2400/0487 , B01L2400/049 , B01L2400/0683 , B01L2400/088 , C12P19/34 , C12Q1/6844 , C12Q1/6853 , G01N21/75
摘要： A microfluidic cartridge can include at least one nucleic acid analysis portion. Each nucleic acid analysis portion can include a fluidic network being configured for micro-liter volumes or less, a sample input at the beginning of the fluidic network, a plurality of vent ports and fluidic channels in the fluidic network configured to effectuate hydrodynamic movement within the fluidic network, an extraction mixture reservoir in the fluidic network, a mixing chamber in the fluidic network, an amplification chamber in the fluidic network, and a separation channel in the fluidic network. A nucleic acid analyzer can be capable of performing nucleic acid analysis using the microfluidic cartridge. A nucleic acid analysis method can be performed using the microfluidic cartridge.
摘要翻译：微流控盒可以包括至少一个核酸分析部分。每个核酸分析部分可以包括被配置用于微升体积或更小体积的流体网络，流体网络开始处的样品输入，流体网络中的多个通气端口和流体通道，其被配置为实现流体网络内的流体动力学运动流体网络中的提取混合物储存器，流体网络中的混合室，流体网络中的扩散室和流体网络中的分离通道。核酸分析仪能够使用微流控盒进行核酸分析。可以使用微流控盒进行核酸分析方法。

10. 发明申请

WO2008125927A3 MICROFLUIDIC SYSTEM WITH ACTUATORS 审中-公开
标题翻译：具有执行器的微流控系统
公开(公告)号：WO2008125927A3
公开(公告)日：2009-01-29
申请号：PCT/IB2007055104
申请日：2007-12-14
申请人： KONINKL PHILIPS ELECTRONICS NV , GILLIES MURRAY F , DEN TOONDER JACOB M J , PONJEE MARC W G , JOHNSON MARK T
发明人： GILLIES MURRAY F , DEN TOONDER JACOB M J , PONJEE MARC W G , JOHNSON MARK T
IPC分类号： F04B19/00 , B01L3/00
CPC分类号： B01F13/0059 , B01F13/0091 , B01L3/50273 , B01L3/502792 , B01L7/52 , B01L7/54 , B01L2300/0819 , B01L2300/089 , B01L2300/1822 , B01L2300/1827 , B01L2300/1872 , B01L2400/0484 , B01L2400/0633 , B01L2400/0688 , F04B19/006 , F04B19/24 , F04D33/00
摘要： The invention relates to microfluidic system (100), particularly a biosensor, for manipulating a sample in a sample chamber (1). The device comprises at least one actuator (10) that reversibly changes its spatial configuration if it is heated and/or cooled. The actuator (10) may particularly be arranged adjacent to an associated heating element (20) of a 5 heating array that is used to establish a predetermined spatial and/or temporal temperature profile in the sample chamber (1). The configuration change of the actuator (10) can be used to move the sample fluid or to control its passage through fluid channels. A plurality of actuators (10) may optionally be provided that undergo their configuration changes at different temperatures, particularly temperatures within a range that is passed during a 10 reaction like PCR.
摘要翻译：本发明涉及用于操纵样品室（1）中的样品的微流体系统（100），特别是生物传感器。该装置包括至少一个致动器（10），其如果被加热和/或冷却则可逆地改变其空间构造。致动器（10）可以特别地布置成与用于在样品室（1）中建立预定空间和/或时间温度分布的5个加热阵列的相关联的加热元件（20）相邻。致动器（10）的配置变化可用于移动样品流体或控制其通过流体通道。可以任选地提供多个致动器（10），其在不同温度，特别是在10反应期间通过的范围内的温度（如PCR）中进行其配置变化。

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