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1. 发明申请

WO2008076847A3 REGIONAL DELIVERY OF THERAPEUTIC AGENTS FOR THE TREATMENT OF VASCULAR DISEASES 审中-公开
公开(公告)号：WO2008076847A3
公开(公告)日：2008-06-26
申请号：PCT/US2007/087487
申请日：2007-12-13
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC. , PACETTI, Stephen, D. , CONSIGNY, Paul , HEIL, Ronald, W. , LUDWIG, Florian, N. , DAVALIAN, Dariush , ZHAO, Li , ASTAFIEVA, Irina , WAN, Jinping , EL-NOUNOU, Fozan , MURASE, Katsuyuki , HOSSAINY, Syed, Faiyaz Ahmed , BRIGHT, Rachel , ELLIS, Jeffrey
发明人： PACETTI, Stephen, D. , CONSIGNY, Paul , HEIL, Ronald, W. , LUDWIG, Florian, N. , DAVALIAN, Dariush , ZHAO, Li , ASTAFIEVA, Irina , WAN, Jinping , EL-NOUNOU, Fozan , MURASE, Katsuyuki , HOSSAINY, Syed, Faiyaz Ahmed , BRIGHT, Rachel , ELLIS, Jeffrey
IPC分类号： A61M29/02 , A61F2/84 , A61F2/82
摘要： The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.

2. 发明申请

WO2006068944A3 VULNERABLE PLAQUE MODIFICATION METHODS AND APPARATUSES 审中-公开
标题翻译：易破碎的改性方法和装置
公开(公告)号：WO2006068944A3
公开(公告)日：2006-10-12
申请号：PCT/US2005045628
申请日：2005-12-16
申请人： ADVANCED CARDIOVASCULAR SYSTEM , COX DANIEL L , ELLIS JEFFREY T , LEE JEONG S , KLEINE KLAUS , TANNIER ALAN
发明人： COX DANIEL L , ELLIS JEFFREY T , LEE JEONG S , KLEINE KLAUS , TANNIER ALAN
IPC分类号： A61F2/82 , A61M29/02
CPC分类号： A61F2/91 , A61B2017/22081 , A61F2/07 , A61F2/915 , A61F2/958 , A61F2002/075 , A61F2002/825 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2220/005 , A61F2230/0013 , A61F2230/0078 , A61F2250/0018 , A61F2250/0039 , A61F2250/0048 , A61M25/1002 , A61M2025/1052 , A61M2025/1059 , A61M2025/1072
摘要： A method including introducing an expandable body (2840) into a blood vessel at a point coextensive with a vulnerable plaque lesion, and expanding the expandable body from a first diameter to a different second diameter sufficient to modify the shape of an inner diameter of the blood vessel at th point coextensive with the lesion without rupturing the lesion. An apparatus including a cannula having a dimension suitable for insertion into a blood vessel and including an expandable body coupled thereto, the expandable body including a first outer diameter suitable for insertion through the blood vessel and a second outer diameter greater than the first diameter and having a maximum dimension to modify the shape of an inner diameter of the blood vessel and retain a same perimeter. A kit including a cannula including an expandable body and a stent. An expandable framework comprising a polymer material. An apparatus including an expandable body.
摘要翻译：一种方法，包括将可膨胀体（2840）引入到与易损斑块病变共同延伸的点处的血管中，以及将可膨胀体从第一直径扩大到不同的第二直径，以足以改变血液的内径的形状血管与病变共同延伸，不破坏病变。一种包括插管的装置，其具有适于插入血管并且包括与其连接的可扩张体的尺寸，所述可扩张体包括适于插入通过血管的第一外径和大于第一直径的第二外径，并且具有最大尺寸以改变血管内径的形状并保持相同的周边。一种套件，其包括包括可扩张体和支架的套管。包含聚合物材料的可膨胀骨架。一种包括可膨胀体的装置。

3. 发明申请

WO2006068944A2 VULNERABLE PLAQUE MODIFICATION METHODS AND APPARATUSES 审中-公开
标题翻译：易破碎的改性方法和装置
公开(公告)号：WO2006068944A2
公开(公告)日：2006-06-29
申请号：PCT/US2005/045628
申请日：2005-12-16
申请人： ADVANCED CARDIOVASCULAR SYSTEMS, INC. , COX, Daniel, L. , ELLIS, Jeffrey, T. , LEE, Jeong, S. , KLEINE, Klaus , TANNIER, Alan
发明人： COX, Daniel, L. , ELLIS, Jeffrey, T. , LEE, Jeong, S. , KLEINE, Klaus , TANNIER, Alan
IPC分类号： A61F2/06 , A61F2/84 , A61M25/10 , A61M29/02
CPC分类号： A61F2/91 , A61B2017/22081 , A61F2/07 , A61F2/915 , A61F2/958 , A61F2002/075 , A61F2002/825 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2220/005 , A61F2230/0013 , A61F2230/0078 , A61F2250/0018 , A61F2250/0039 , A61F2250/0048 , A61M25/1002 , A61M2025/1052 , A61M2025/1059 , A61M2025/1072
摘要： A method including introducing an expandable body into a blood vessel at a point coextensive with a vulnerable plaque lesion, and expanding the expandable body from a first diameter to a different second diameter sufficient to modify the shape of an inner diameter of the blood vessel at the point coextensive with the lesion without rupturing the lesion. An apparatus including a cannula having a dimension suitable for insertion into a blood vessel and including an expandable body coupled thereto, the expandable body including a first outer diameter suitable for insertion through the blood vessel and a second outer diameter greater than the first diameter and having a maximum dimension to modify the shape of an inner diameter of the blood vessel and retain a same perimeter. A kit including a cannula including an expandable body and a stent. An expandable framework comprising a polymer material. An apparatus including an expandable body.
摘要翻译：一种方法，包括将可膨胀体引入到与易损斑块病变共同延伸的点处的血管中，以及将可膨胀体从第一直径扩大到不同的第二直径，以足以改变血管内径的形状点与病变共同延伸而不破坏病变。一种包括插管的装置，其具有适于插入血管并且包括与其连接的可扩张体的尺寸，所述可扩张体包括适于插入通过血管的第一外径和大于第一直径的第二外径，并且具有最大尺寸以改变血管内径的形状并保持相同的周边。一种套件，其包括包括可扩张体和支架的套管。包含聚合物材料的可膨胀骨架。一种包括可膨胀体的装置。

4. 发明申请

WO2006004792A1 DRUG-DELIVERY STENT FORMULATIONS FOR RESTENOSIS AND VULNERABLE PLAQUE 审中-公开
标题翻译：用于保留和易受伤害的药物的药物递送制剂
公开(公告)号：WO2006004792A1
公开(公告)日：2006-01-12
申请号：PCT/US2005/023006
申请日：2005-06-27
申请人： ADVANCED CARDIOVASCULAR SYSTEMS, INC. , HOSSAINY, Syed, F.A. , STEWART, Gordon , KILPATRICK, Deborah , ELLIS, Jeffrey , PARK, Gene , ZHANG, Gina , CONSIGNY, Paul , TANG, Yiwen
发明人： HOSSAINY, Syed, F.A. , STEWART, Gordon , KILPATRICK, Deborah , ELLIS, Jeffrey , PARK, Gene , ZHANG, Gina , CONSIGNY, Paul , TANG, Yiwen
IPC分类号： A61L31/16
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译：提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。支架可用于治疗诸如再狭窄和易损斑块的疾病。

5. 发明申请

WO2004038597A8 METHODS AND SYSTEMS FOR EXCHANGING REACHABILITY INFORMATION AND SWITCHING BETWEEN REDUNDANT INTERFACES IN A NETWORK CLUSTER 审中-公开
标题翻译：用于交换网络集群中冗余接口之间的可达性信息和切换的方法和系统
公开(公告)号：WO2004038597A8
公开(公告)日：2004-07-29
申请号：PCT/US0333347
申请日：2003-10-21
申请人： TEKELEC US , RUDD JOSEPH MICHAEL , ROBINSON BENJAMIN CRAWFORD , ELLIS JEFFREY LYNN , KNIERIM DAVID F
发明人： RUDD JOSEPH MICHAEL , ROBINSON BENJAMIN CRAWFORD , ELLIS JEFFREY LYNN , KNIERIM DAVID F
IPC分类号： H04L12/56 , H04L29/06 , H04L29/08 , H04L29/12 , G06F15/173
CPC分类号： H04L29/12349 , H04L45/02 , H04L45/28 , H04L61/2507 , H04L67/1002 , H04L67/101 , H04L69/169 , H04L2029/06054
摘要： Methods and systems for exchanging reachability information and for switching between redundant interfaces in a network cluster are disclosed. Nodes in the network cluster are connected via redundant links and exchange reachability messages at periodic intervals. Each node includes a kernel routing table used to route messages and a reachability application routing table for storing reachability information used to update entries in the kernel routing table. Each node executes a predetermined algorithm for selecting entries in the reachability application routing table to be written to the kernel routing table.
摘要翻译：公开了用于交换可达性信息和用于在网络集群中的冗余接口之间切换的方法和系统。网络集群中的节点通过冗余链路连接，并以周期性间隔交换可达性消息。每个节点包括用于路由消息的内核路由表和用于存储用于更新内核路由表中的条目的可达性信息的可达性应用程序路由表。每个节点执行预定算法，用于选择要写入内核路由表的可达性应用程序路由表中的条目。

6. 发明申请

WO2008076847A2 REGIONAL DELIVERY OF THERAPEUTIC AGENTS FOR THE TREATMENT OF VASCULAR DISEASES 审中-公开
标题翻译：用于治疗血管疾病的治疗药物的区域性递送
公开(公告)号：WO2008076847A2
公开(公告)日：2008-06-26
申请号：PCT/US2007087487
申请日：2007-12-13
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , PACETTI STEPHEN D , CONSIGNY PAUL , HEIL RONALD W , LUDWIG FLORIAN N , DAVALIAN DARIUSH , ZHAO LI , ASTAFIEVA IRINA , WAN JINPING , EL-NOUNOU FOZAN , MURASE KATSUYUKI , HOSSAINY SYED FAIYAZ AHMED , BRIGHT RACHEL , ELLIS JEFFREY
发明人： PACETTI STEPHEN D , CONSIGNY PAUL , HEIL RONALD W , LUDWIG FLORIAN N , DAVALIAN DARIUSH , ZHAO LI , ASTAFIEVA IRINA , WAN JINPING , EL-NOUNOU FOZAN , MURASE KATSUYUKI , HOSSAINY SYED FAIYAZ AHMED , BRIGHT RACHEL , ELLIS JEFFREY
CPC分类号： A61M25/1002 , A61F2/82 , A61F2250/0067 , A61K31/27 , A61K31/44 , A61K31/56 , A61K31/66 , A61K38/1709 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/112 , A61L2300/216 , A61L2300/252 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2300/62 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2025/1086 , A61M2037/0023 , A61M2037/0061 , A61M2210/12
摘要： The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.
摘要翻译：本发明涉及用于治疗血管疾病的治疗剂的区域递送，其中区域递送是指将治疗有效量的治疗剂递送至血管的区域，该区域不仅包括受到损伤的组织而且包括非折磨组织受影响组织的外围也是如此。

7. 发明申请

WO2006007028A3 AUTOMATED PURCHASING METHOD WITH FEATURES FOR HIGH VOLUME PURCHASING 审中-公开
标题翻译：自动采购方法，适用于大批量采购
公开(公告)号：WO2006007028A3
公开(公告)日：2006-03-09
申请号：PCT/US2005014943
申请日：2005-04-29
申请人： KIMBERLY CLARK CO , GRAF STEPHEN , HANLEY JR ROBERT F , LANKEY TODD T , ELLIS JEFFREY R , HOLCOMBE CAROL E
发明人： GRAF STEPHEN , HANLEY JR ROBERT F , LANKEY TODD T , ELLIS JEFFREY R , HOLCOMBE CAROL E
IPC分类号： G06Q30/00
CPC分类号： G06Q10/087 , G06Q30/06
摘要： An automated purchasing method for buyers using a high volume database (22) and a high volume software program that is compatible with business management software (23) having a material master database includes creating a new record upon having received a request for purchase of a new item (10), determining whether the new item is a high volume item (20), determining whether the new item has a matching entry in a high volume database (12), and either automatically or manually updating a purchasing info record (26) and source list entry (32) for the item. A requisition and purchase order for the new item may then be sent to a vendor (38). Optimized prices may be negotiated from the vendor based on documented records of the total items purchased from various respective manufacturers and vendors (42).
摘要翻译：对于使用大容量数据库（22）的买家和与具有物料主数据库的业务管理软件（23）兼容的大量软件程序的买方的自动购买方法包括：在收到新购买的请求后创建新记录项目（10），确定所述新项目是否是大量项目（20），确定所述新项目是否具有在高体积数据库（12）中的匹配条目，以及自动或手动更新购买信息记录（26）和项目的源列表条目（32）。然后可以将新项目的申请和采购订单发送给供应商（38）。根据从各个制造商和供应商购买的总物品的记录记录，可以从供应商谈判优化价格（42）。

8. 发明申请

WO2004099417A1 GENETIC SEQUENCES OF PLANT PATHOGEN AVIRULENCE GENES AND USES THEREFOR 审中-公开
标题翻译：植物病原性基因的遗传序列及其用途
公开(公告)号：WO2004099417A1
公开(公告)日：2004-11-18
申请号：PCT/AU2004/000602
申请日：2004-05-07
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , GRAINS RESEARCH AND DEVELOPMENT CORPORATION , DODDS, Peter, Norman , LAWRENCE, Gregory, James , AYLIFFE, Michael, Anthony , ELLIS, Jeffrey, Graham
发明人： DODDS, Peter, Norman , LAWRENCE, Gregory, James , AYLIFFE, Michael, Anthony , ELLIS, Jeffrey, Graham
IPC分类号： C12N15/31
CPC分类号： C07K14/375 , C12N15/8261 , C12N15/8279 , C12N15/8282 , C12Q1/6895 , C12Q2600/156 , C12Q2600/158 , Y02A40/146
摘要： The invention provides an isolated nucleic acid molecule comprising a sequence of nucleotides encoding or complementary to a sequence of nucleotides encoding an avirulence product of a plant rust fungus, and its use in transformation of a plant to induce a disease resistance response in the plant, optionally by co-expression with a corresponding disease resistance gene in the plant. The invention also provides a method of identifying a ucleic acid sequence which encodes an avirulence product of a plant rust fungus.
摘要翻译：本发明提供了一种分离的核酸分子，其包含编码或编码植物生锈真菌无效产物的核苷酸序列的核苷酸序列，以及其在植物转化中诱导植物抗病性反应的用途，任选地通过与植物中相应的抗病基因共表达。本发明还提供了鉴定编码植物锈菌的无毒产物的核酸序列的方法。

9. 发明申请

WO2007118051A3 LIPID THERAPY 审中-公开
标题翻译：脂肪疗法
公开(公告)号：WO2007118051A3
公开(公告)日：2008-07-24
申请号：PCT/US2007065791
申请日：2007-04-02
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , KILPATRICK DEBORAH , HOSSAINY SYED FAIYAZ AHMED , ASTAFIEVA IRINA , LUDWIG FLORIAN N , CONSIGNY PAUL M , ELLIS JEFFREY T , LIM FLORENCIA
发明人： KILPATRICK DEBORAH , HOSSAINY SYED FAIYAZ AHMED , ASTAFIEVA IRINA , LUDWIG FLORIAN N , CONSIGNY PAUL M , ELLIS JEFFREY T , LIM FLORENCIA
IPC分类号： A61K38/00 , A61P9/10 , C07K14/755
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/1275 , A61K9/1617 , A61K9/1658 , A61M1/3472 , A61M1/3486 , A61M2202/0456 , A61K2300/00
摘要： A method including introducing into a blood stream a delipidated high density lipoprotein (HDL) and a bioactive agent. A composition including a delipidated high density lipoprotein (HDL) and an auxiliary agent in a form suitable for delivery into a blood vessel. A composition including Apo Al comprising a hydrophobic ligand suitable to interact with cell surface binding sites. A composition including Apo Al and an agent selected to one of increase the ATP-binding cassette protein 1 (ABCAl) transporter expression in macrophages and protect ABCAl from thiol-mediated degradation.
摘要翻译：一种方法，包括向血液中引入脱脂高密度脂蛋白（HDL）和生物活性剂。包含脱脂高密度脂蛋白（HDL）和适合于输送到血管中的辅助剂的组合物。包含Apo A1的组合物，其包含适于与细胞表面结合位点相互作用的疏水性配体。一种组合物，其包含Apo A1和选自用于增加巨噬细胞中ATP结合盒蛋白1（ABCA1）转运蛋白表达的一种试剂，并保护ABCA1免受硫醇介导的降解。

10. 发明申请

WO2006007028A2 AUTOMATED PURCHASING METHOD WITH FEATURES FOR HIGH VOLUME PURCHASING 审中-公开
标题翻译：自动采购方法，适用于大批量采购
公开(公告)号：WO2006007028A2
公开(公告)日：2006-01-19
申请号：PCT/US2005/014943
申请日：2005-04-29
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , GRAF, Stephen , HANLEY JR., Robert, F. , LANKEY, Todd, T. , ELLIS, Jeffrey, R. , HOLCOMBE, Carol, E.
发明人： GRAF, Stephen , HANLEY JR., Robert, F. , LANKEY, Todd, T. , ELLIS, Jeffrey, R. , HOLCOMBE, Carol, E.
IPC分类号： G06F17/60
CPC分类号： G06Q10/087 , G06Q30/06
摘要： An automated purchasing method for buyers using a high volume database and a high volume software program that is compatible with SAP® business management software having an SAP material master database includes creating a new record upon having received a request for purchase of a new item, determining whether the new item is a high volume item, determining whether the new item has a matching entry in a high volume database, and either automatically or manually updating a purchasing info record and source list entry for the item. A requisition and purchase order for the new item may then be sent to a vendor. Optimized prices may be negotiated from the vendor based on documented records of the total items purchased from various respective manufacturers and vendors. Updates or discounts then applicable to the given purchase order are returned and updated in the high volume system such that those discounts and pricing updates are available for subsequent requests and purchases via the high volume program.
摘要翻译：对于使用大容量数据库的买家和与具有SAP材料主数据库的SAP®业务管理软件兼容的大量软件程序的买方的自动采购方法包括：在接收到购买新项目的请求之后创建新记录，确定新项目是否是大量项目，确定新项目是否具有大容量数据库中的匹配条目，以及自动或手动更新该项目的采购信息记录和源列表条目。然后可以将新项目的请购单和订单发送给供应商。可以根据从各个制造商和供应商购买的总项目的记录记录，从供应商谈判优化的价格。然后适用于给定采购订单的更新或折扣将在大量系统中返回和更新，以便这些折扣和定价更新可用于通过大量程序的后续请求和购买。

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