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    • 8. 发明申请
    • METHODS AND COMPOSITIONS FOR THE TREATMENT OF HYPERLIPIDEMIA
    • 治疗高脂血症的方法和组合物
    • WO2006029577A1
    • 2006-03-23
    • PCT/CN2005/001489
    • 2005-09-19
    • INSTITUTE OF MEDICINAL BIOTECHNOLOGY, CHINESE ACADEMY OF MEDICAL SCIENCESJIANG, Jian-DongKONG, Wei-JiaZHAO, Li-XunSONG, Dan-QingWEI, Jing
    • JIANG, Jian-DongKONG, Wei-JiaZHAO, Li-XunSONG, Dan-QingWEI, Jing
    • A61K31/4375A61P3/06A61P9/00A61P9/10
    • A61K31/4375
    • Methods and compositions containing a berberine compound or berberine related or derivative compound are provided for the prevention and treatment of hyperlipidemia, elevated cholesterol, and/or cardiovascular disease in mammalian subjects. The methods and compositions of the invention are effective for prevention and treatment of atherosclerosis, coronary artery disease, angina pectoris, carotid artery disease, stroke, cerebral arteriosclerosis, high blood pressure, myocardial infarction, cerebral infarction, restenosis following balloon angioplasty, intermittent claudication, dyslipidemia post-prandial lipidemia or xanthoma. Additional compositions and methods are provided which employ a berberine compound or berberine related or derivative compound in combination with a second anti-hyperlipidemia agent, or a different therapeutic agent to yield more effective treatment tools against hyperlipidemia and/or cardiovascular disease, and/or dual activity therapeutic methods and formulations useful to prevent or reduce hyperlipidemia and one or more causal or related symptoms or conditions associated with hyperlipidemia in mammalian subjects.
    • 提供含有小檗碱化合物或小檗碱相关或衍生化合物的方法和组合物用于预防和治疗哺乳动物受试者中的高脂血症,升高的胆固醇和/或心血管疾病。 本发明的方法和组合物可有效预防和治疗动脉粥样硬化,冠状动脉疾病,心绞痛,颈动脉疾病,中风,脑动脉硬化,高血压,心肌梗塞,脑梗塞,球囊血管成形术后的再狭窄,间歇性跛行, 餐后血脂异常或血清白血病。 提供了额外的组合物和方法,其使用小檗碱化合物或小檗碱相关或衍生化合物与第二抗高脂血症药物或不同治疗剂组合以产生更有效的治疗工具来抵抗高脂血症和/或心血管疾病和/或双重 用于预防或减少高脂血症的活性治疗方法和制剂以及与哺乳动物受试者中的高脂血症相关的一个或多个因果或相关症状或病症。