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1. 发明申请

WO2016085513A1 REGENERATIVE RESPIRATORY TRACT PROSTHESES 审中-公开
标题翻译：再生呼吸道诱导
公开(公告)号：WO2016085513A1
公开(公告)日：2016-06-02
申请号：PCT/US2014/067809
申请日：2014-11-28
申请人： CORMATRIX CARDIOVASCULAR, INC.
发明人： MATHENY, Robert, G.
IPC分类号： A61F2/04 , A61F2/20 , A61L27/36
CPC分类号： A61F2/203 , A61F2/04 , A61F2002/046 , A61F2210/0004 , A61F2220/0016 , A61F2230/0065 , A61L27/3633 , A61L27/3804 , A61L27/50 , A61L27/54 , A61L27/58 , A61L2300/402 , A61L2300/406 , A61L2300/408 , A61L2300/41 , A61L2300/414 , A61L2300/422 , A61L2430/22
摘要： A regenerative respiratory tract prosthesis comprising a tubular extracellular matrix (ECM) member having a lumen therethrough, at least first and second biodegradable polymeric anchors disposed on the tubular member exterior surface. The first and second anchors can include a microneedle tissue engagement member.
摘要翻译：一种再生呼吸道假体，其包括具有通过其中的腔的管状细胞外基质（ECM）构件，至少第一和第二可生物降解的聚合物锚固件，设置在管状构件外表面上。第一和第二锚固件可以包括微针组织接合构件。

2. 发明申请

WO2014044704A9 HYDROGEL COATED SCAFFOLD 审中-公开
公开(公告)号：WO2014044704A9
公开(公告)日：2014-09-12
申请号：PCT/EP2013069355
申请日：2013-09-18
申请人： CORTICALIS AS
发明人： LYNGSTADAAS PETTER S , HAUGEN HÅVARD J , TIAINEN HANNA
IPC分类号： A61L27/06 , A61L27/10 , A61L27/34 , A61L27/54 , A61L27/56
CPC分类号： A61L27/34 , A61L27/06 , A61L27/10 , A61L27/3821 , A61L27/3834 , A61L27/425 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/25 , A61L2300/412 , A61L2300/422 , A61L2300/64 , A61L2400/18 , A61L2420/02 , A61L2420/04 , A61L2420/06 , A61L2430/02 , A61L2430/12
摘要： The present document is directed to a titanium dioxide scaffold comprising a hydrogel coating comprising a biologically active substance. Also disclosed is a method for producing a thin hydrogel coating on a titanium dioxide scaffold and uses of the hydrogel coated scaffolds as medical implants.
摘要翻译：本文件涉及包含包含生物活性物质的水凝胶涂层的二氧化钛支架。还公开了一种在二氧化钛支架上制备薄水凝胶涂层的方法以及将水凝胶涂层的支架用作医疗植入物的用途。

3. 发明申请

WO2010138062A1 MULTILAYER PROTEIN FILMS, METHODS OF MAKING, AND DRUG DELIVERY DEVICES AND BIOMEDICAL IMPLANTS EMPLOYING THE FILMS 审中-公开
标题翻译：多层蛋白膜，制造方法和药物递送装置和使用膜的生物医用植入物
公开(公告)号：WO2010138062A1
公开(公告)日：2010-12-02
申请号：PCT/SE2010/050560
申请日：2010-05-24
申请人： ADDBIO AB , VIKINGE, Ella Cathrine , ENGSTRÖM, Elin , ARONSSON, Henrik , AXELSSON, Oskar
发明人： VIKINGE, Ella Cathrine , ENGSTRÖM, Elin , ARONSSON, Henrik , AXELSSON, Oskar
IPC分类号： A61L27/22 , A61C8/00 , A61L31/10 , A61C13/00 , A61K6/08 , A61L27/54 , A61L31/16
CPC分类号： A61L27/54 , A61C8/0013 , A61L27/34 , A61L2300/112 , A61L2300/252 , A61L2300/406 , A61L2300/422 , A61L2300/608 , Y10T428/273 , C08L89/00
摘要： A multilayer protein film has a mass of greater than 0.5 μg/cm 2 and consists essentially of protein. A drug delivery device comprises the multilayer protein film onto which a pharmaceutically active agent can be loaded. A biomedical implant comprises an implant substrate and the multilayer protein film on at least a portion of the implant substrate surface. A method of making a multilayer protein film having a mass of greater than 0.5 μg/cm 2 comprises contacting a substrate with a protein solution at a temperature of from about 30 0 C to about 95 0 C, wherein a multilayer protein film having a mass of greater than 0.5 μg/cm 2 is formed on the substrate.
摘要翻译：多层蛋白质膜具有大于0.5μg/ cm 2的质量，并且基本上由蛋白质组成。药物递送装置包括其上可以加载药物活性剂的多层蛋白质膜。生物医学植入物包括在植入物衬底表面的至少一部分上的植入物基底和多层蛋白质膜。制备质量大于0.5μg/ cm 2的多层蛋白质膜的方法包括在约30℃至约95℃的温度下使底物与蛋白质溶液接触，其中质量大于在基板上形成0.5μg/ cm 2。

4. 发明申请

WO2009061787A1 COATED DEVICES AND METHOD OF MAKING COATED DEVICES THAT REDUCE SMOOTH MUSCLE CELL PROLIFERATION AND PLATELET ACTIVITY 审中-公开
标题翻译：涂覆的装置和制造减少平滑肌细胞增殖和平板活性的涂层装置的方法
公开(公告)号：WO2009061787A1
公开(公告)日：2009-05-14
申请号：PCT/US2008/082440
申请日：2008-11-05
申请人： NANOCOPOEIA, INC. , LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER OFFICE OF RESEARCH , DUGAS, Tammy, R. , KHANDELWAL, Alok , KLEINEDLER, III, James, John , FOLEY, John, Devlin
发明人： DUGAS, Tammy, R. , KHANDELWAL, Alok , KLEINEDLER, III, James, John , FOLEY, John, Devlin
IPC分类号： A61F2/00
CPC分类号： A61F2/82 , A61F2/915 , A61F2002/91508 , A61F2002/91558 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/422 , A61L2300/608
摘要： The present invention relates generally to the maintenance of blow flood using drug eluting stents and/or other coated medical devices to increased length of time of blood flow. Further, the present invention relates to drug-releasing coated devices for reducing smooth muscle cell proliferation and platelet activity to further limit restenosis utilizing resveratrol and quercetin, polyphenols that are linked to the cardioprotection of red wine consumption. The present invention also provides products and methods for treating or preventing atherosclerosis, stenosis, restenosis, smooth muscle cell proliferation, platelet cell activation and other clotting mechanisms, occlusive disease, or other abnormal lumenal cellular proliferation condition in a location within the body of a patient.
摘要翻译：本发明一般涉及使用药物洗脱支架和/或其它涂覆的医疗装置来维持使用增加血液流动时间的吹气。此外，本发明涉及用于减少平滑肌细胞增殖和血小板活性的药物释放包被装置，以进一步限制利用白藜芦醇和槲皮素的再狭窄，与红酒消费的心脏保护相关的多酚。本发明还提供了在患者体内的位置处理或预防动脉粥样硬化，狭窄，再狭窄，平滑肌细胞增殖，血小板细胞活化和其它凝血机制，闭塞性疾病或其它异常的腔内细胞增殖状况的产物和方法。

5. 发明申请

WO03074101A8 METHOD OF TREATING ATHEROSCLEROSIS AND HYPERCHOLESTEROLEMIA 审中-公开
标题翻译：治疗甲状腺功能亢进症和高胆固醇血症的方法
公开(公告)号：WO03074101A8
公开(公告)日：2005-04-07
申请号：PCT/US0302685
申请日：2003-02-14
申请人： LILLY CO ELI , BURRIS THOMAS PATRICK
发明人： BURRIS THOMAS PATRICK
IPC分类号： A61K31/16 , A61K31/17 , A61K31/18 , A61K31/203 , A61K31/397 , A61L31/10 , A61L31/16
CPC分类号： A61K31/203 , A61K31/16 , A61K31/17 , A61K31/18 , A61K31/397 , A61L31/16 , A61L2300/40 , A61L2300/422
摘要： A method of treatment of cardiovascular diseases comprising the use of an LXR agonist impregnated on a stent is disclosed.
摘要翻译：公开了一种治疗心血管疾病的方法，包括使用浸渍在支架上的LXR激动剂。

6. 发明申请

WO2014158261A1 DRUG DELIVERY DEVICE FOR PERIPHERAL ARTERY DISEASE 审中-公开
标题翻译：用于外周动脉疾病的药物递送装置
公开(公告)号：WO2014158261A1
公开(公告)日：2014-10-02
申请号：PCT/US2013/076302
申请日：2013-12-18
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC.
发明人： WANG, Yunbing , OBERHAUSER, James , GADA, Manish
IPC分类号： A61L31/14 , A61L31/16 , A61L31/04
CPC分类号： A61F2/06 , A61L31/041 , A61L31/129 , A61L31/148 , A61L31/16 , A61L2300/422 , C08L67/04
摘要： A medical device implantable within a peripheral vessel of the body composed of a bioresorbable polymer is disclosed. The device has a high resistance to fracture, is very flexible, and has a high crush recovery when subjected to crushing, axial, or torsional forces.
摘要翻译：公开了一种可植入在由生物可再吸收的聚合物组成的身体的外周血管内的医疗装置。该装置具有高抗断裂性，非常柔软，并且当受到破碎，轴向或扭转力时具有高的压碎恢复性。

7. 发明申请

WO2014154804A1 PHARMACEUTICAL FORMULATION FOR USE IN THE TREATMENT AND/OR PREVENTION OF RESTENOSIS 审中-公开
标题翻译：用于治疗和/或预防保留的药物制剂
公开(公告)号：WO2014154804A1
公开(公告)日：2014-10-02
申请号：PCT/EP2014/056157
申请日：2014-03-27
申请人： CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS (C.H.U.V)
发明人： DELIE, Florence , JORDAN, Olivier , LUCA, Ludmila , SAUCY, François , HAEFLIGER, Jacques-Antoine , MYLONAKI, Ioanna
IPC分类号： A61K9/06 , A61K9/16 , A61K47/36 , A61L31/16 , A61L31/14 , A61P9/10 , A61K45/06
CPC分类号： A61K9/5084 , A61K9/0024 , A61K9/06 , A61K9/1647 , A61K31/132 , A61K31/22 , A61K31/337 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/47 , A61K31/60 , A61K31/616 , A61K31/65 , A61K47/36 , A61L31/042 , A61L31/145 , A61L31/16 , A61L2300/416 , A61L2300/422 , C08L5/08 , A61K2300/00
摘要： The present invention relates generally to a pharmaceutical formulation for use in the treatment and/or prevention of restenosis in a subject in need thereof. Methods of treatment and /or prevention are also provided.
摘要翻译：本发明一般涉及用于治疗和/或预防有需要的受试者的再狭窄的药物制剂。还提供了治疗和/或预防的方法。

8. 发明申请

WO2014044704A1 HYDROGEL COATED SCAFFOLD 审中-公开
标题翻译：水胶涂层脚手架
公开(公告)号：WO2014044704A1
公开(公告)日：2014-03-27
申请号：PCT/EP2013/069355
申请日：2013-09-18
申请人： CORTICALIS AS
发明人： LYNGSTADAAS, Petter, S. , HAUGEN, Håvard, J. , TIAINEN, Hanna
IPC分类号： A61L27/06 , A61L27/10 , A61L27/34 , A61L27/54 , A61L27/56
CPC分类号： A61L27/34 , A61L27/06 , A61L27/10 , A61L27/3821 , A61L27/3834 , A61L27/425 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/25 , A61L2300/412 , A61L2300/422 , A61L2300/64 , A61L2400/18 , A61L2420/02 , A61L2420/04 , A61L2420/06 , A61L2430/02 , A61L2430/12
摘要： The present document is directed to a titanium dioxide scaffold comprising a hydrogel coating comprising a biologically active substance. Also disclosed is a method for producing a thin hydrogel coating on a titanium dioxide scaffold and uses of the hydrogel coated scaffolds as medical implants.
摘要翻译：本文件涉及包含含有生物活性物质的水凝胶涂层的二氧化钛支架。还公开了一种在二氧化钛支架上制备薄水凝胶涂层的方法以及将该水凝胶涂层的支架用作医用植入物的方法。

9. 发明申请

WO2012031164A2 DRUG DELIVERY BY CARBON NANOTUBE ARRAYS 审中-公开
标题翻译：通过碳纳米管阵列递送药物
公开(公告)号：WO2012031164A2
公开(公告)日：2012-03-08
申请号：PCT/US2011/050270
申请日：2011-09-01
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY , GHARIB, Morteza , ARIA, Adrianus, Indrat , BEIZAI, Masoud
发明人： GHARIB, Morteza , ARIA, Adrianus, Indrat , BEIZAI, Masoud
IPC分类号： A61K47/24 , A61K47/26 , A61K47/32 , A61K47/48 , A61K9/00
CPC分类号： A61K47/02 , A61K9/5192 , A61K31/337 , A61K31/352 , A61K47/6929 , A61K49/0004 , A61K49/0095 , A61L29/103 , A61L29/16 , A61L2300/422 , B82Y5/00 , B82Y40/00
摘要： The invention generally relates to carbon nanotube based drug delivery methods, devices, and compositions. More particularly, the invention relates to controlled drug delivery using anchored carbon nanotube arrays.
摘要翻译：本发明一般涉及基于碳纳米管的药物递送方法，装置和组合物。更具体地，本发明涉及使用锚定碳纳米管阵列的受控药物递送。

10. 发明申请

WO2002072014A2 MEDICAL DEVICES, COMPOSITIONS AND METHODS FOR TREATING VULNERABLE PLAQUE 审中-公开
标题翻译：医疗器械，组合物和治疗易损液体的方法
公开(公告)号：WO2002072014A2
公开(公告)日：2002-09-19
申请号：PCT/US2002/007244
申请日：2002-03-08
申请人： VOLCANO THERAPEUTICS, INC. , BROWN, David, L.
发明人： BROWN, David, L.
IPC分类号： A61K
CPC分类号： A61L31/16 , A61K31/16 , A61K31/18 , A61L27/54 , A61L29/16 , A61L2300/422 , A61L2300/434 , A61L2300/602 , A61L2300/606 , A61K2300/00
摘要： Medical devices, compositions and methods for treating or preventing atherosclerotic plaque rupture are disclosed. Specifically, medical devices that deliver to a treatment site metalloproteinase inhibitors (MMPI) are disclosed. The medical devices include catheters, guide wires, vascular stents, micro-particles, electronic leads, probes, sensors, drug depots, transdermal patches, and vascular patches. Representative MMPIs included zinc chelators, urea derivatives, caprolactone-based inhibitors, phoshoinamides, piperazines, sulfonamides, tertiary amines, carbamate derivatives, mercaptoalcohols, mecaptoketones, antimicrobial tertracyclines, non-antimicrobial tetracyclines, and derivatives and combinations thereof. In one embodiment a self-expanding vascular stent is coated with at least one MMPI and deployed at a site within an artery where vulnerable plaque has been identified.
摘要翻译：公开了用于治疗或预防动脉粥样硬化斑块破裂的医疗装置，组合物和方法。具体地，公开了递送到治疗部位金属蛋白酶抑制剂（MMPI）的医疗装置。医疗装置包括导管，引导线，血管支架，微粒子，电子引线，探针，传感器，药物库，透皮贴片和血管贴片。代表性的MMPI包括锌螯合剂，脲衍生物，基于己内酯的抑制剂，磷酰胺，哌嗪，磺酰胺，叔胺，氨基甲酸酯衍生物，巯基醇，麦芽糖酮，抗微生物四环素，非抗微生物四环素及其衍生物和组合。在一个实施方案中，自扩张血管支架涂覆有至少一种MMPI并且部署在已经鉴定易感斑块的动脉内的部位。

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