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    • 10. 发明申请
    • MEDICAL DEVICES, COMPOSITIONS AND METHODS FOR TREATING VULNERABLE PLAQUE
    • 医疗器械,组合物和治疗易损液体的方法
    • WO2002072014A2
    • 2002-09-19
    • PCT/US2002/007244
    • 2002-03-08
    • VOLCANO THERAPEUTICS, INC.BROWN, David, L.
    • BROWN, David, L.
    • A61K
    • A61L31/16A61K31/16A61K31/18A61L27/54A61L29/16A61L2300/422A61L2300/434A61L2300/602A61L2300/606A61K2300/00
    • Medical devices, compositions and methods for treating or preventing atherosclerotic plaque rupture are disclosed. Specifically, medical devices that deliver to a treatment site metalloproteinase inhibitors (MMPI) are disclosed. The medical devices include catheters, guide wires, vascular stents, micro-particles, electronic leads, probes, sensors, drug depots, transdermal patches, and vascular patches. Representative MMPIs included zinc chelators, urea derivatives, caprolactone-based inhibitors, phoshoinamides, piperazines, sulfonamides, tertiary amines, carbamate derivatives, mercaptoalcohols, mecaptoketones, antimicrobial tertracyclines, non-antimicrobial tetracyclines, and derivatives and combinations thereof. In one embodiment a self-expanding vascular stent is coated with at least one MMPI and deployed at a site within an artery where vulnerable plaque has been identified.
    • 公开了用于治疗或预防动脉粥样硬化斑块破裂的医疗装置,组合物和方法。 具体地,公开了递送到治疗部位金属蛋白酶抑制剂(MMPI)的医疗装置。 医疗装置包括导管,引导线,血管支架,微粒子,电子引线,探针,传感器,药物库,透皮贴片和血管贴片。 代表性的MMPI包括锌螯合剂,脲衍生物,基于己内酯的抑制剂,磷酰胺,哌嗪,磺酰胺,叔胺,氨基甲酸酯衍生物,巯基醇,麦芽糖酮,抗微生物四环素,非抗微生物四环素及其衍生物和组合。 在一个实施方案中,自扩张血管支架涂覆有至少一种MMPI并且部署在已经鉴定易感斑块的动脉内的部位。