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1. 发明申请

WO2008076847A2 REGIONAL DELIVERY OF THERAPEUTIC AGENTS FOR THE TREATMENT OF VASCULAR DISEASES 审中-公开
标题翻译：用于治疗血管疾病的治疗药物的区域性递送
公开(公告)号：WO2008076847A2
公开(公告)日：2008-06-26
申请号：PCT/US2007087487
申请日：2007-12-13
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , PACETTI STEPHEN D , CONSIGNY PAUL , HEIL RONALD W , LUDWIG FLORIAN N , DAVALIAN DARIUSH , ZHAO LI , ASTAFIEVA IRINA , WAN JINPING , EL-NOUNOU FOZAN , MURASE KATSUYUKI , HOSSAINY SYED FAIYAZ AHMED , BRIGHT RACHEL , ELLIS JEFFREY
发明人： PACETTI STEPHEN D , CONSIGNY PAUL , HEIL RONALD W , LUDWIG FLORIAN N , DAVALIAN DARIUSH , ZHAO LI , ASTAFIEVA IRINA , WAN JINPING , EL-NOUNOU FOZAN , MURASE KATSUYUKI , HOSSAINY SYED FAIYAZ AHMED , BRIGHT RACHEL , ELLIS JEFFREY
CPC分类号： A61M25/1002 , A61F2/82 , A61F2250/0067 , A61K31/27 , A61K31/44 , A61K31/56 , A61K31/66 , A61K38/1709 , A61L29/08 , A61L29/16 , A61L31/08 , A61L31/16 , A61L2300/112 , A61L2300/216 , A61L2300/252 , A61L2300/40 , A61L2300/41 , A61L2300/416 , A61L2300/606 , A61L2300/62 , A61M25/10 , A61M37/0015 , A61M2025/105 , A61M2025/1086 , A61M2037/0023 , A61M2037/0061 , A61M2210/12
摘要： The present invention relates to the regional delivery of therapeutic agents for the treatment of vascular diseases wherein regional delivery refers to delivery of a therapeutically effective amount of the therapeutic agent to an area of the vessel that includes not only afflicted tissue but non-afflicted tissue at the periphery of the afflicted tissue as well.
摘要翻译：本发明涉及用于治疗血管疾病的治疗剂的区域递送，其中区域递送是指将治疗有效量的治疗剂递送至血管的区域，该区域不仅包括受到损伤的组织而且包括非折磨组织受影响组织的外围也是如此。

2. 发明申请

WO2011100209A3 MAGNETICALLY SENSITIVE DRUG CARRIERS FOR TREATMENT OR TARGETED DELIVERY 审中-公开
标题翻译：用于治疗或有针对性的交付的磁性敏感药物载体
公开(公告)号：WO2011100209A3
公开(公告)日：2012-08-02
申请号：PCT/US2011023967
申请日：2011-02-08
申请人： ABBOTT CARDIOVASCULAR SYSTEMS , DAVALIAN DARIUSH , HOSSAINY SYED FAIYAZ AHMED , BRIGHT RACHEL , WAN JINPING , LUDWIG FLORIAN NIKLAS
发明人： DAVALIAN DARIUSH , HOSSAINY SYED FAIYAZ AHMED , BRIGHT RACHEL , WAN JINPING , LUDWIG FLORIAN NIKLAS
IPC分类号： A61K9/00 , A61K9/16 , A61K9/50 , A61K31/436 , A61K31/4745
CPC分类号： A61K31/436 , A61K9/0009 , A61K9/0019 , A61K9/19 , A61K9/5094
摘要： Compositions of matter comprising a magnetically sensitive drug carrier and a related drug as well as methods for administering these compositions and causing them to localize within the patient using an internal or external magnetic field are described.
摘要翻译：描述了包含磁敏感药物载体和相关药物的物质组合物以及用于施用这些组合物并使其使用内部或外部磁场定位在患者体内的方法。

3. 发明申请

WO2008018932A3 METHOD AND USE OF NANO-SCALE DEVICES FOR REDUCTION OF TISSUE INJURY IN ISCHEMIC AND REPERFUSION INJURY 审中-公开
标题翻译：用于减少组织损伤和再灌注损伤的纳米尺度装置的方法和用途
公开(公告)号：WO2008018932A3
公开(公告)日：2008-09-25
申请号：PCT/US2007010600
申请日：2007-05-01
申请人： UNIV LELAND STANFORD JUNIOR , UNIV JOHNS HOPKINS , BRIGHT CORINNE , BRIGHT RACHEL , CHURCHILL ERIC , LEONG KAM W , MOCHLY-ROSEN DARIA
发明人： BRIGHT CORINNE , BRIGHT RACHEL , CHURCHILL ERIC , LEONG KAM W , MOCHLY-ROSEN DARIA
IPC分类号： A61K31/765 , A61K9/107 , A61K9/127 , A61K9/51 , A61P9/10
CPC分类号： A61K9/14 , A61K9/5138 , A61K31/765 , A61K31/78 , A61K45/06
摘要： A method for protection of tissues subject to ischemic and/or reperfusion damage is provided. The method includes administering to the tissue a composition comprising nanodevices. The nanodevices can take the form of, for example, polymeric nanoparticles or lipidic nanoparticles. The nanodevices also find use in methods for reducing ischemic injury in tissue at risk of such injury, such as heart and brain tissue.
摘要翻译：提供了一种保护缺血和/或再灌注损伤的组织的方法。该方法包括向组织施用包含纳米装置的组合物。纳米装置可以采用例如聚合物纳米颗粒或脂质纳米颗粒的形式。纳米装置还可用于减少患有这种损伤风险的组织中的缺血性损伤的方法，例如心脏和脑组织。

4. 发明申请

WO2006078421A3 METHODS OF INCREASING CEREBRAL BLOOD FLOW 审中-公开
标题翻译：增加脑血流量的方法
公开(公告)号：WO2006078421A3
公开(公告)日：2007-03-22
申请号：PCT/US2005046951
申请日：2005-12-23
申请人： UNIV LELAND STANFORD JUNIOR , MOCHLY-ROSEN DARIA , BRIGHT RACHEL
发明人： MOCHLY-ROSEN DARIA , BRIGHT RACHEL
IPC分类号： A61K38/08 , A61P9/10 , C07K7/06
CPC分类号： A61K38/45 , A61K38/08
摘要： Methods of increasing blood flow in a mammalian brain blood vessel characterized by, or otherwise experiencing, decreased blood flow due to an ischemic or other hypoxic event, vasoconstriction or vasospasm following hemorrhagic stroke; due to chronic high blood pressure; and/or due to idiopathic causes are provided. The method for increasing blood flow in such a mammalian brain blood vessel includes administering to a patient in need thereof a therapeutically effective amount of an inhibitor of protein kinase C. In certain embodiments, the inhibitor can be chronically administered without causing desensitization of the patient to the inhibitor. Kits for increasing blood flow in a mammalian brain blood vessel characterized by, or otherwise experiencing, decreased blood flow due to an ischemic or other hypoxic event, vasoconstriction or vasospasm following hemorrhagic stroke; due to chronic high blood pressure; and/or due to idiopathic causes are provided.
摘要翻译：增加哺乳动物脑血管中血液流动的方法，其特征在于或以其他方式经历由于缺血性或其它缺氧事件导致的血流减少，出血性中风后的血管收缩或血管痉挛; 由于慢性高血压; 和/或由于特发性原因。用于增加这种哺乳动物脑血管中的血流量的方法包括向有需要的患者施用治疗有效量的蛋白激酶C抑制剂。在某些实施方案中，抑制剂可以长期施用而不引起患者的脱敏抑制剂。用于增加哺乳动物脑血管中的血液流动的特征，其特征在于或以其它方式经历由于缺血性或其它缺氧事件引起的血流减少，出血性中风后的血管收缩或血管痉挛; 由于慢性高血压; 和/或由于特发性原因。

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