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41. 发明申请

WO2014172359A1 CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) BASED MRI USING REPORTER GENES AND SUBSTRATES AND METHODS THEREOF 审中-公开
标题翻译：使用报告基因和基质的化学交换饱和转移（CEST）基础的MRI及其方法
公开(公告)号：WO2014172359A1
公开(公告)日：2014-10-23
申请号：PCT/US2014/034181
申请日：2014-04-15
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： GILAD, Assaf, A. , BAR-SHIR, Amnon , BULTE, JEFF, W.M , LIU, Guanshu , AIRAN, Raag, D. , MCMAHON, Michael , VAN ZIJL, PETER, C.M.
IPC分类号： A61B5/055 , A61K49/14 , A61K48/00
CPC分类号： A61K49/12 , A61B5/055 , A61K49/14
摘要： The present invention features polypeptide or protein based reporters, wherein the MRI contrast is generated by the protein itself, and methods, MRI systems and MRI imaging kits related thereto. The present invention also features enzyme based reporters, wherein the contrast is generated by the substrate/ product of an enzyme, and methods, MRI systems and MRI imaging kits related thereto.
摘要翻译：本发明的特征在于基于多肽或蛋白质的记者，其中MRI对比度由蛋白质本身产生，以及与其相关的方法，MRI系统和MRI成像试剂盒。本发明还特征为基于酶的报告者，其中由酶的底物/产物产生对比度，以及与其相关的方法，MRI系统和MRI成像试剂盒。

42. 发明申请

WO2013190165A1 COMPUESTOS CON FUNCIONALIDAD MAGNÉTICA, IMPLANTES O GELES DERIVADOS DE ELLOS, Y EL USO DE AMBOS PARA DETERMINAR LA ACTIVIDAD ENZIMÁTICA DE UNA ENZIMA 审中-公开
标题翻译：具有从其衍生的磁性功能，植入物或凝胶的化合物，以及两种使用方法来确定酶的酶活性
公开(公告)号：WO2013190165A1
公开(公告)日：2013-12-27
申请号：PCT/ES2013/070407
申请日：2013-06-21
申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)
发明人： VELEZ TIRADO, Marisela , DAICH, Julián
IPC分类号： A61K49/14 , A61K49/18 , G01N33/53
CPC分类号： A61K49/1821 , A61K49/085 , A61K49/12 , A61K49/14 , A61K49/1863 , A61K49/1866 , C12Q1/26 , C12Q1/34 , C12Q1/37 , G01N33/54326 , G01N2800/10
摘要： Implante o gel que comprende al menos un compuesto con funcionalidad magnética que comprende a su vez un sustrato de al menos una enzima implicada en la regeneración de la matriz extracelular y una pluralidad de partículas magnéticas. Así como, compuesto con funcionalidad magnética que comprende un sustrato de al menos una enzima implicada en la regeneración de la matriz extracelular y una pluralidad de partículas magnéticas, preferiblemente sin recubrimiento o modificación de superficie o funcionalizadas con grupos carboxílicos, para fabricar un implante o gel para monitorizar una actividad enzimática implicada en la regeneración de la matriz extracelular. Preferiblemente el sustrato se selecciona del grupo que consiste en colágeno, condroitin sulfato y ácido hialurónico y las partículas magnéticas son partículas superparamagnéticas.
摘要翻译：本发明涉及包含至少一种具有磁性功能的化合物的植入物或凝胶，该化合物又包含参与再生细胞外基质的至少一种酶的底物和多个磁性颗粒。本发明还涉及具有磁性官能团的化合物，其包括参与再生细胞外基质的至少一种酶的底物和多个磁性颗粒，优选无涂层或表面改性或用羧基官能化的磁性颗粒，用于生产用于监测涉及再生细胞外基质的酶活性的植入物或凝胶。底物优选选自包括胶原蛋白，硫酸软骨素和透明质酸的组，磁性颗粒是超顺磁性颗粒。

43. 发明申请

WO2013130761A1 INDOLE DERIVATIVES AS LABELING DYE FOR BIOMOLECULE 审中-公开
标题翻译：作为生物分子标签的染色体衍生物
公开(公告)号：WO2013130761A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/028252
申请日：2013-02-28
申请人： PIERCE BIOTECHNOLOGY, INC. , DYOMICS, Gmbh , HERMANSON, Greg , CZERNEY, Peter, T. , DESAI, Surbhi , WENZEL, Matthias, S. , DWORECKI, Boguslawa, R , LEHMANN, Frank, G. , NLEND, Marie, Christine
发明人： HERMANSON, Greg , CZERNEY, Peter, T. , DESAI, Surbhi , WENZEL, Matthias, S. , DWORECKI, Boguslawa, R , LEHMANN, Frank, G. , NLEND, Marie, Christine
IPC分类号： C07D403/06 , C07D403/08 , C09B23/00 , G01N33/58
CPC分类号： C07D401/14 , A61K47/6871 , A61K49/04 , A61K49/12 , A61K49/143 , A61K49/16 , A61K49/221 , C07D209/18 , C07D403/06 , C07D403/08 , C07K16/40 , C07K2317/76 , C09B23/06 , G01N33/582
摘要： Indole derivatives used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific nonlimiting examples of each are provided.
摘要翻译：用作具有与已知荧光化合物相当的性质的标记的吲哚衍生物。这些化合物可以与蛋白质和核酸结合，用于生物成像和分析。提供了化合物的合成，共轭化合物的形成和使用以及各自的具体非限制性实例。

44. 发明申请

WO2012094620A8 HYDROPHOBIC MOLECULE-INDUCED BRANCHED POLYMER AGGREGATES AND THEIR USE 审中-公开
标题翻译：疏水分子分解聚合物聚合物及其用途
公开(公告)号：WO2012094620A8
公开(公告)日：2013-08-08
申请号：PCT/US2012020524
申请日：2012-01-06
申请人： ANP TECHNOLOGIES INC , QIN DUJIE , YIN RAY , PAN JING , ZHANG YUBEI
发明人： QIN DUJIE , YIN RAY , PAN JING , ZHANG YUBEI
IPC分类号： A61K47/30 , A61K47/48 , A61K49/04 , A61K49/06
CPC分类号： A61K9/14 , A61K9/19 , A61K9/513 , A61K9/5146 , A61K31/337 , A61K31/4375 , A61K33/24 , A61K45/06 , A61K47/34 , A61K47/48384 , A61K47/6803 , A61K49/0004 , A61K49/12 , A61K51/06
摘要： Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with water insoluble or poorly water soluble pharmaceutically active agents (PAA). The aggregates formed are specifically induced by interaction of PAA and homopolymer and are different from aggregates that are formed by the polymer alone in the absence of the PAA or by the PAA alone in the absence of the polymer. Such aggregates can be used to improve drug solubility, stability, delivery and efficacy.
摘要翻译：对称和不对称支化的均聚物在表面水平上用能够与水不溶性或水溶性差的药物活性剂（PAA）形成聚集体的官能团进行改性。形成的聚集体由PAA和均聚物的相互作用特异性诱导，并且不同于在不存在PAA的情况下单独由聚合物形成的聚集体，或者不存在聚合物时单独由PAA形成的聚集体。这样的聚集体可用于改善药物溶解度，稳定性，递送和功效。

45. 发明申请

WO2013041623A1 NOVEL MANGANESE COMPRISING NANOSTRUCTURES 审中-公开
标题翻译：包含纳米结构的新型锰
公开(公告)号：WO2013041623A1
公开(公告)日：2013-03-28
申请号：PCT/EP2012/068541
申请日：2012-09-20
申请人： SPAGO IMAGING AB
发明人： AXELSSON, Oskar , PETORAL JR., Rodrigo M. , EK, Fredrik , LAURITZSON, Petter
IPC分类号： A61K49/12 , A61K49/18 , B82Y5/00 , B82Y15/00
CPC分类号： A61K51/065 , A61K49/12 , A61K49/124 , A61K49/128 , A61K49/1818 , A61K49/1857 , B82Y5/00 , B82Y15/00 , C08G73/0206 , C08G73/0213
摘要： Disclosed herein are nanostructures comprising a polymeric framework comprising at least five geminal bisphosphonate groups, wherein the geminal bisphosphonate groups independently of each other are incorporated as - R 3 R 4 C(P=O(OR 1 )(OR 2 )) 2 , wherein R 1 and R 2 are independently selected from the group consisting of a negative charge, H, alkyl and aryl, and wherein at least one of R 3 and R 4 is a group connected to the polymeric framework with the proviso that when only one of R 3 and R 4 is such a connected group, the other of R 3 and R 4 is either a group being able to connect to the polymeric framework, or the residue of such a group, or selected from the group consisting of H, OH, OR 5 and R 5 , wherein R 5 is a lower alkyl. The polymeric framework may comprise manganese ions. Disclosed are also methods for producing such manganese containing nanostructures, compositions comprising such manganese containing nanostructures and use of such manganese con¬ taining nanostructures, i.a. as MRI contrasting agents.
摘要翻译：本文公开了包含包含至少五个偕二膦酸酯基团的聚合物骨架的纳米结构，其中偕双膦酸酯基团彼此独立地并入作为-R 3 R 4 C（P = O（OR 1）（OR 2））2），其中R 1和R 2独立地选自由负电荷，H，烷基和芳基组成的组，并且其中R 3和R 4中的至少一个是与聚合物骨架连接的基团，条件是当只有R3和R4之一是这样的连接基团时， R3和R4中的另一个是能够连接到聚合物骨架的基团，或这种基团的残基，或选自H，OH，OR 5和R 5，其中R 5是低级烷基。聚合物骨架可以包含锰离子。还公开了生产这种含锰纳米结构的方法，包含这种含锰纳米结构的组合物和使用这种含有纳米结构的锰，例如，作为MRI造影剂。

46. 发明申请

WO2012142670A1 NUCLEAR MAGNETIC RESONANCE AGENT 审中-公开
标题翻译：核磁共振剂
公开(公告)号：WO2012142670A1
公开(公告)日：2012-10-26
申请号：PCT/AU2012/000415
申请日：2012-04-20
申请人： THE UNIVERSITY OF QUEENSLAND , WHITTAKER, Andrew Keith , PENG, Hui , THURECHT, Kristofer James , BLAKEY, Idriss
发明人： WHITTAKER, Andrew Keith , PENG, Hui , THURECHT, Kristofer James , BLAKEY, Idriss
IPC分类号： A61K49/06 , A61K49/18 , A61B5/055
CPC分类号： A61K49/12 , A61B5/055 , G01R33/5601
摘要： The invention provides a switchable nuclear magnetic resonance (NMR) agent comprising a plurality of covalently coupled NMR nuclides selected from one or more of D, B, F, Br, P and Si, one or more of said nuclides being covalently coupled to a polymer chain, said agent having a first form in which the NMR signal of said nuclides is diminished, wherein the agent is capable of undergoing a chemical reaction that causes the first form of the agent to switch into a second form in which the NMR signal of said nuclides is amplified.
摘要翻译：本发明提供了可切换的核磁共振（NMR）试剂，其包含选自D，B，F，Br，P和Si中的一种或多种的多个共价键合的NMR核素，一种或多种所述核素共价偶联于聚合物所述试剂具有其中所述核素的NMR信号减小的第一形式，其中所述试剂能够经历化学反应，所述化学反应使所述试剂的第一形式转变为第二形式，其中所述核酸信号核素被扩增。

47. 发明申请

WO2012094620A3 HYDROPHOBIC MOLECULE-INDUCED BRANCHED POLYMER AGGREGATES AND THEIR USE 审中-公开
标题翻译：疏水分子分解聚合物聚合物及其用途
公开(公告)号：WO2012094620A3
公开(公告)日：2012-10-26
申请号：PCT/US2012020524
申请日：2012-01-06
申请人： ANP TECHNOLOGIES INC , DUJIE QIN , YIN RAY , PAN JING , ZHANG YUBEI
发明人： DUJIE QIN , YIN RAY , PAN JING , ZHANG YUBEI
IPC分类号： A61K47/30 , A61K47/48 , A61K49/04 , A61K49/06
CPC分类号： A61K9/14 , A61K9/19 , A61K9/513 , A61K9/5146 , A61K31/337 , A61K31/4375 , A61K33/24 , A61K45/06 , A61K47/34 , A61K47/48384 , A61K47/6803 , A61K49/0004 , A61K49/12 , A61K51/06
摘要： Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with water insoluble or poorly water soluble pharmaceutically active agents (PAA). The aggregates formed are specifically induced by interaction of PAA and homopolymer and are different from aggregates that are formed by the polymer alone in the absence of the PAA or by the PAA alone in the absence of the polymer. Such aggregates can be used to improve drug solubility, stability, delivery and efficacy.
摘要翻译：对称和不对称支化的均聚物在表面水平上用能够与水不溶性或水溶性差的药物活性剂（PAA）形成聚集体的官能团进行改性。形成的聚集体由PAA和均聚物的相互作用特异性诱导，并且不同于在不存在PAA的情况下单独由聚合物形成的聚集体，或者不存在聚合物时单独由PAA形成的聚集体。这样的聚集体可用于改善药物溶解度，稳定性，递送和功效。

48. 发明申请

WO2012076191A1 APTAMER LABELED WITH F-19 NUCLEUS FOR TARGETED MOLECULAR IMAGING BY MRI 审中-公开
标题翻译：标有F-19核子的APTAMER通过MRI进行靶向分子成像
公开(公告)号：WO2012076191A1
公开(公告)日：2012-06-14
申请号：PCT/EP2011/006255
申请日：2011-12-12
申请人： MERCK PATENT GMBH , GUENTHER, Ralf , HOCK, Bjoern , GOODMAN, Simon , PIATER, Birgit
发明人： GUENTHER, Ralf , HOCK, Bjoern , GOODMAN, Simon , PIATER, Birgit
IPC分类号： A61K49/12
CPC分类号： C12N15/115 , A61K49/12 , A61K49/126
摘要： Magnetic Resonance Imaging, usually based on 1 H as the magnetic nucleus, is an important diagnostic technique that is commonly used in hospitals for the diagnosis of disease. MRI allows for the non- invasive imaging of soft tissue with a superb spatial resolution. Magnetic Resonance Imaging based on 19 F instead of 1 H opens up new diagnostic possibilities. The 19 F nucleus has a high gyromagnetic ratio (40 MHz/T) and a natural isotopic abundance ratio of 100%. In the human body, 19 F containing structures are exclusively present in the form of solid salts in e.g. teeth and bones. As a consequence, the J2 relaxation times of the endogenous 19 F atoms are extremely short and the MR signal is hardly detectable, in other words, the lack of endogenous, 19 F-based structures with relatively high transverse relaxation times assures a very low background MR signal. Therefore, exogenous 19 F-based MRI contrast agents allow for "hot spot" imaging in a way similar to other techniques such as PET (positron emission tomography). As a useful extension of its diagnostic use, MRI is also proposed for the monitoring of the delivery of bio-active agents such as therapeutic or diagnostic agents. I.e., MRI can not only be used for treatment planning, but also to control local drug delivery under image guidance.
摘要翻译：磁共振成像通常以1H为磁核，是医院常用于诊断疾病的重要诊断技术。 MRI允许具有极好的空间分辨率的软组织的非侵入性成像。基于19F而不是1H的磁共振成像开辟了新的诊断可能性。 19F核具有高回旋比（40MHz / T）和100％的天然同位素丰度比。在人体中，含有19F的结构仅以例如固体盐的形式存在。牙齿和骨头。因此，内源性19F原子的J2松弛时间非常短，并且MR信号几乎不可检测，换句话说，缺乏具有相对较高的横向弛豫时间的内源性19F基结构，确保非常低的背景MR信号。因此，外源性基于19F的MRI造影剂允许以与PET（正电子发射断层摄影）等其他技术相似的方式进行“热点”成像。作为其诊断用途的有用扩展，还提出了用于监测生物活性剂如治疗剂或诊断剂的递送的MRI。即，MRI不仅可以用于治疗计划，还可以在图像引导下控制局部药物传播。

49. 发明申请

WO2012013617A2 POLYMERIC COMPLEMENTS TO B-AMYLOID PEPTIDES 审中-公开
标题翻译：聚合物补充到B-淀粉样肽
公开(公告)号：WO2012013617A2
公开(公告)日：2012-02-02
申请号：PCT/EP2011/062712
申请日：2011-07-25
申请人： TECHNISCHE UNIVERSITÄT DORTMUND , SELLERGREN, Börje , ANTUNES AURELIANO, Carla Sofia , URRACA RUIZ, Javier , SCHILLINGER, Eric
发明人： SELLERGREN, Börje , ANTUNES AURELIANO, Carla Sofia , URRACA RUIZ, Javier , SCHILLINGER, Eric
IPC分类号： B01J20/26 , C07K14/47 , G01N33/68
CPC分类号： A61K51/065 , A61K49/12 , B01J20/268 , C07K14/4711 , C07K17/14 , G01N33/6896 , G01N2800/2821
摘要： The present invention relates to the preparation and use of polymer complements to β-amyloid peptides (Αβ) for detecting soluble or aggregated Αβ in fluid samples or for treating a subject having a neurodegenerative disease.
摘要翻译：本发明涉及用于检测流体样品中的可溶性或聚集的Aβ或用于治疗患有神经变性疾病的受试者的β-淀粉样肽（Aβ）的聚合物补体的制备和用途。 >

50. 发明申请

WO2011075476A1 METHODS AND COMPOSITIONS RELATING TO REPORTER GELS FOR USE IN MRI TECHNIQUES 审中-公开
标题翻译：与MRI技术中使用的记录凝胶相关的方法和组合物
公开(公告)号：WO2011075476A1
公开(公告)日：2011-06-23
申请号：PCT/US2010/060282
申请日：2010-12-14
申请人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , BENNETT, Kevin, M.
发明人： BENNETT, Kevin, M.
IPC分类号： A61B5/055
CPC分类号： G01R33/5601 , A61K49/12 , A61K49/14 , A61K49/1803 , A61K49/1887 , A61L15/54 , A61L15/60 , A61L27/50 , A61L27/52 , A61L29/145 , A61L29/18 , A61L31/145 , A61L31/18 , G01N24/08
摘要： The present invention describes methods and compositions for non-invasively assessing the molecular structure of biocompatible hydrogels using MRI analysis. It is shown that biocompatible hydrogels prepared from polymerizing macromolecules that are attached to a paramagnetic, superparamagnetic or ferromagnetic contrast agents form reporter gels wherein monitoring of the changes in the structure of the hydrogels by MRI is facilitated by the presence of such paramagnetic, superparamagnetic or ferromagnetic agents in the biocompatible hydrogel.
摘要翻译：本发明描述了使用MRI分析非侵入性评估生物相容性水凝胶的分子结构的方法和组合物。显示由连接到顺磁性，超顺磁性或铁磁性造影剂的聚合大分子制备的生物相容性水凝胶形成报道凝胶，其中通过存在这种顺磁性，超顺磁性或铁磁性的MRI来监测水凝胶的结构变化生物相容性水凝胶中的药剂。

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