专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2022271113A1 THE PHYTOCHEMICAL AGENT CONTAINING BETALAIN USED IN MAGNETIC RESONANCE IMAGING (MRI) AND THAT ENHANCES THE T1 AND T2 CONTRAST QUALITY AND ITS' CHARACTERISTIC 审中-公开
公开(公告)号：WO2022271113A1
公开(公告)日：2022-12-29
申请号：PCT/TR2021/050696
申请日：2021-07-08
申请人： EVRENSEL SENFONİ SAĞLIK BAHÇESİ TİCARET LİMİTED ŞİRKETİ
发明人： ÖZSUNAR, Yelda
IPC分类号： A61K49/06 , A61K36/21
摘要： This invention is a phytochemical agent developed from natural and food based nutrients and plants which will help to enhance the imaging contrast of all tissues and organs and make radiological diagnoses, particularly in imaging stomach and intestines (gastrointestinal system), used in a fast improving field such as radiology, of which's invitro and invivo experiments are made and MR signal qualities are analyzed, enables t1 and t2 contrast enhancement and contains betalain which's used in magnetic resonance imaging (MRI) and tested by the inventor on himself/herself and rats, and its' characteristic is being obtained by the following steps of processes; washing 500 gr of Beta Vulgaris (BV) plant with water (10), peeling and slicing it (20), pulping it (30), boiling it (40), cooling it (50), draining it (60), separating the liquid part of the material (70), adding garlic, 4-5 branches of saffron and cilantro on 150 ml liquid to enhance the flavor (80), obtaining Betanin and Vulgaxanthin extract from the particles of Beta Vulgaris (BV) through ethanoic extraction method (90) and adding betanin (3/4) and vulgaxanthin (1/4) onto the 150 ml liquid (80) in a 30 ml extract form (100). In case the purpose is to view the upper or lower gastrointestinal system, the consistency and the paramagnetic effect can be enhanced through adding oil ozonizing method to the process.

2. 发明申请

WO2022092192A1 軟骨の損傷を検出するための造影剤、並びに当該造影剤を利用した軟骨の損傷を検査する方法及びプログラム审中-公开
公开(公告)号：WO2022092192A1
公开(公告)日：2022-05-05
申请号：PCT/JP2021/039798
申请日：2021-10-28
申请人：国立大学法人北海道大学 , 大陽日酸株式会社
发明人：小野寺　智洋 , 工藤　與亮 , 細川　吉暁 , 岩崎　倫政 , 亀田　浩之
IPC分类号： A61K49/06 , A61B5/055
摘要：本発明は、17O標識水を含有する軟骨の損傷を検出するためのMRI造影剤、並びに当該造影剤を利用した軟骨の損傷を検査する方法及びプログラムを提供する。本発明によると、17O標識水を造影剤として使用することで、軟骨損傷、特に従来は検出が困難であった軟骨表層の軽微な損傷を検出することができる。

3. 发明申请

WO2020263761A1 IRON(III) AND GALLIUM(III) METAL ORGANIC POLYHEDRA, METHODS OF MAKING SAME, AND USES THEREOF 审中-公开
公开(公告)号：WO2020263761A1
公开(公告)日：2020-12-30
申请号：PCT/US2020/039025
申请日：2020-06-22
申请人： THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
发明人： MORROW, Janet, R. , COOK, Timothy, R. , SOKOLOW, Gregory, E. , RIVERA, Amber
IPC分类号： A61K49/06 , A61K49/00 , C07C63/33 , C07C63/331 , C07F15/02
摘要： Compounds may have at least two structural units, which may be referred to as ligands. Each structural unit includes at least one spacer group and two or more donor groups. Compounds may have two or more iron(III) cations, one or more of which may be a high- spin iron(III) cation or high-spin iron(III) cations, two or more gallium(III) cations, or at least one iron(III) cation, one or more of which may be a high-spin iron(III) cation or high-spin iron(III) cations, and at least one gallium(III) cation, where the iron(III) cation(s) and/or the gallium(III) cation(s) coordinate to the donor groups. The compounds may be self-assembled cages. A composition may include one or more of the compound(s) and a pharmaceutically accepted carrier. Methods of imaging use one or more of the compound(s) and/or one or more of the composition(s).

4. 发明申请

WO2020257690A1 TEMPORAL TRAUMATIC BRAIN INJURY BIOMARKERS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2020257690A1
公开(公告)日：2020-12-24
申请号：PCT/US2020/038795
申请日：2020-06-19
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
发明人： MARTINEZ, Briana , STABENFELDT, Sarah , DIEHNELT, Chris , STEPHANOPOULOS, Nicholas , WILLINGHAM, Crystal , WITTEN, Amanda , LUNDGREEN, Kendall
IPC分类号： A61K51/08 , A61K49/06 , A61K49/00
摘要： A unique pipeline is employed for biomarker discovery that entailed domain antibody phage display, next generation sequencing analysis, and nanotechnology strategies to generate antibody mimetics are disclosed. Also disclosed are the temporal biomarkers of traumatic brain injury and their methods of use. In some embodiments, the temporal biomarkers are synthetic peptides comprising the HCDR3 sequences identified using the disclosed pipeline. In some aspects, the synthetic peptides have less than 30 amino acid residues and comprise a biotin scaffold that is linked to the HCDR3 sequences.

5. 发明申请

WO2020093642A1 含金属原子簇的磁性氧化铁纳米颗粒及其制备和应用审中-公开
公开(公告)号：WO2020093642A1
公开(公告)日：2020-05-14
申请号：PCT/CN2019/078427
申请日：2019-03-18
申请人：西安超磁纳米生物科技有限公司
发明人：樊海明 , 刘晓丽 , 彭明丽
IPC分类号： C01G49/06 , B82Y40/00 , A61K49/06 , H01F1/11
摘要：提供一种含金属原子簇的磁性氧化铁纳米颗粒，其中金属原子簇嵌合在氧化铁晶体基质中，且金属原子簇的含量占比为0.1-15％。还提供该纳米颗粒的制备方法，包括将氧化铁的金属前驱体、有机酸、有机胺溶于有机溶剂中形成均匀的反应体系，然后将反应体系在惰性气体氛围内加热到150-350℃后，加入金属原子簇前驱体，升温回流反应至金属原子簇前驱体全部分解即可。该纳米颗粒由于金属原子簇的嵌合使得磁性氧化铁颗粒的磁学性质得到提高，而氧化铁又充分保证了纳米颗粒性质的稳定性，因而能够更好的应用于生物医学检测与治疗等领域。

6. 发明申请

WO2019165464A1 3-DIMENSIONAL REPRESENTATIONS OF POST-CONTRAST ENHANCED BRAIN LESIONS 审中-公开
公开(公告)号：WO2019165464A1
公开(公告)日：2019-08-29
申请号：PCT/US2019/019652
申请日：2019-02-26
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人： OKUDA, Darin
IPC分类号： G01R35/02 , G01R33/44 , G01R33/563 , A61K49/06 , A61K35/30 , G06T7/10 , G06T7/11 , G06T13/20
摘要： Methods, apparatuses, systems, and implementations for creating 3 -dimensional (3D) representations exhibiting geometric and surface characteristics of post-contrast brain lesions are disclosed. 3D MRI images of the brain may be created and acquired. After administration of a contrast substance, brain lesions and other abnormalities may be identified and isolated from the 3D MRI images, with each lesion serving as a region of interest (ROI). 3D region of contrast enhancement images may be created from segmented 3D MRI images and different regions of contrast enhancement of the brain lesion may be depicted. Saved regions of contrast enhancement may be converted into stereolithography format, maximum intensity projection (MIP) images, and/or orthographic projection images. Data corresponding to these resulting 3D region of contrast enhancement images may be used to create 3D printed models of the isolated region of contrast enhancement using 3D printing technology. Analysis of the 3D brain region of contrast enhancement images and the 3D printed region of contrast enhancement models may enable a more efficient and accurate way of determining brain lesion risk factors and effective treatment regimens.

7. 发明申请

WO2019143073A1 가도테리돌 중간체 및 이를 이용한 가도테리돌 제조방법 审中-公开
公开(公告)号：WO2019143073A1
公开(公告)日：2019-07-25
申请号：PCT/KR2019/000483
申请日：2019-01-11
申请人： 주식회사 엔지켐생명과학
发明人： 이재용 , 이종수 , 강병규 , 이병우 , 이상오 , 윤대명 , 방제훈 , 손기영
IPC分类号： C07D257/02 , A61K49/06 , A61K49/10
摘要： MRI조영제로 사용되는 가도테리돌의 중간체 및 이를 이용한 가도테리돌의 제조방법이 개시된다. 가도테리돌 중간체로서 명세서 내에 화학식 1로 표시되는 10-(2-하이드록시프로필)-1,4,7,10-테트라아자싸이클로도데칸 또는 명세서 내에 화학식 3으로 표시되는 그의 염산염을 제공한다.

8. 发明申请

WO2018048884A1 METHODS AND MATERIALS FOR IDENTIFYING AND TREATING AUTOIMMUNE GFAP ASTROCYTOPATHY 审中-公开
标题翻译：鉴定和治疗自身免疫性GFAP星形细胞肿瘤的方法和材料
公开(公告)号：WO2018048884A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050252
申请日：2017-09-06
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： LENNON, Vanda A. , MCKEON, Andrew , FANG, Boyan , HINSON, Shannon , KRYZER, Thomas J.
IPC分类号： A61K49/06 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/564
摘要： This document provides methods and materials involved in identifying and treating autoimmune GFAP (glial fibrillary acidic protein) astrocytopathy, a novel meningoencephalomyelitis, in humans as well as methods and materials for identifying and offering early treatment for patients having autoimmune GFAP astrocytopathy whose autoantibody profile predicts a high likelihood of having underlying cancer (e.g., adenocarcinoma or teratoma).
摘要翻译：本文件提供了识别和治疗人类自身免疫性GFAP（胶质纤维酸性蛋白质）星形细胞病（一种新型脑膜脑炎）的方法和材料，以及用于鉴别和为患有早期治疗的患者提供的方法和材料自身免疫性GFAP星形细胞病，其自身抗体谱预测具有潜在癌症（例如腺癌或畸胎瘤）的高可能性。

9. 发明申请

WO2017171283A1 항원 반응형 항체-형광염료 결합체 및 이를 이용한 표적 세포의 형광영상 검출방법 审中-公开
标题翻译：使用其的抗原反应性抗体 - 荧光染料缀合物和靶细胞的荧光图像检测方法
公开(公告)号：WO2017171283A1
公开(公告)日：2017-10-05
申请号：PCT/KR2017/002924
申请日：2017-03-20
申请人： 국립암센터
发明人： 최용두 , 김현진
IPC分类号： G01N33/58 , G01N33/574 , A61K49/00 , A61K49/06
摘要： 본 발명은 암세포 특이적 형광영상 진단이 가능한 항체-형광염료 결합체에 관한 것으로, 형광염료가 공유결합에 의하여 표지된 항체를 포함하되, 상기 형광염료는 항체 내 트립토판, 타이로신, 히스티딘 및 메티오닌으로 이루어진 군 중에서 선택되는 잔기와의 상호 작용에 의하여 소광되고, 세포 표면에 존재하는 항원과 항체가 결합할 때에는 소광작용이 해소되어 형광을 발생하여, 표적 항원을 표면에 갖는 세포를 영상 진단할 수 있다. 본 발명에 따른 항체-형광염료 결합체를 사용할 경우, 비트로(in vitro) 세포시험, 대용량 세포 스크리닝 및 미세유체를 이용한 세포진단 방법에 있어서 세척과정 없이도 특정 항원을 세포 표면에 발현하고 있는 암세포의 존재를 높은 특이도 및 감도로서 확인 할 수 있는 효과가 있고, 짧은 시간 내에 원발성 및 전이 암세포의 위치를 높은 대조도로 확인할 수 있기 때문에 형광영상-유도 수술에 의한 수술의 정확도 및 치료 효과를 향상시킬 수 있는 효과가 있다.
摘要翻译：
本发明是癌症特异性荧光成像是可能的抗体针对一种荧光染料偶联物，但荧光染料包括通过共价键，其中，所述荧光染料是在色氨酸的抗体的标记抗体，和由残基的相互作用淬火和选自酪氨酸，组氨酸和蛋氨酸的组中选择，所述淬灭效应被消除时，抗原和抗体存在于细胞表面上结合产生的荧光，其具有在表面上的靶抗原的细胞可以成像。抗体根据本发明，使用荧光染料偶联物的情况下，比特（体外）细胞试验，表达，而不需要使用所述筛选和细流体到细胞表面的细胞的诊断方法的清洗步骤的特定抗原大细胞癌细胞的存在实现能够改善感应手术操作的准确性和功效的 - 的效果，它可以使高特异性为道路和灵敏度，并且因为它可确定在短时间内荧光图像的初级和转移性癌细胞道路高对比度的位置。

10. 发明申请

WO2017066070A2 ACETATE COMPLEXES AND METHODS FOR ACETATE QUANTIFICATION 审中-公开
标题翻译：醋酸酯配合物和醋酸酯定量方法
公开(公告)号：WO2017066070A2
公开(公告)日：2017-04-20
申请号：PCT/US2016/055673
申请日：2016-10-06
申请人： GENERAL ELECTRIC COMPANY
发明人： LEACH, Andrew , CHEN, Rui , PALACIOS, Manuel
IPC分类号： C07F15/02 , A61K49/06
CPC分类号： G01N33/15 , C07F15/025 , G01N21/31
摘要： The present invention is directed to methods of acetate quantification and acetate complexes useful in the methods of acetate quantification. Such methods and complexes are useful for any application where acetate quantification is desired, including measuring of concentration of 13 C hyperpolarized acetate for imaging agent quality control in MRI and NMR spectroscopy. The disclosed acetate complexes may be prepared from acetate, Fe 3+ , and sulfosalicylic acid and from acetate, Fe 3+ , and salicylic acid.
摘要翻译：本发明涉及用于乙酸盐定量方法的乙酸盐定量方法和乙酸盐复合物。此类方法和复合物可用于需要进行醋酸盐定量的任何应用，包括测量13 C超极化醋酸盐的浓度以用于MRI和NMR光谱学中的成像剂质量控制。所公开的乙酸盐配合物可以由乙酸盐，Fe 3+和磺基水杨酸以及乙酸盐，Fe 3+和水杨酸来制备。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式