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1. 发明申请

WO2011123030A1 NANOPARTICLES COMPRISING A CORE OF AMORPHOUS RARE EARTH ELEMENT HYDROXIDE AND AN ORGANIC COATING 审中-公开
标题翻译：包含非晶体稀土元素氢氧化物和有机涂层的纳米颗粒
公开(公告)号：WO2011123030A1
公开(公告)日：2011-10-06
申请号：PCT/SE2011/050345
申请日：2011-03-29
申请人： SPAGO IMAGING AB , AXELSSON, Oskar , EK, Fredrik , PETORAL JR, Rodrigo M.
发明人： AXELSSON, Oskar , EK, Fredrik , PETORAL JR, Rodrigo M.
IPC分类号： A61K49/18 , A61K51/12 , A61K103/30 , A61K103/34
CPC分类号： A61K49/1848 , A61K49/0002 , A61K49/0021 , A61K49/0039 , A61K49/0093 , A61K49/0428 , A61K49/1839 , A61K49/186 , B82Y5/00
摘要： The present invention relates to paramagnetic nanoparticles which may be used as contrast agents for visualizing or imaging biological material. Said nanoparicles comprise a core of amorphous rare earth element hydroxide, and an organic coating comprising silicon atoms and phosphorus atoms. Preferably, the coating comprises an oriented monolayer of one or more organo-oxysilane residue(s). A second silane, binding in between the larger organo-oxysilane, may be added in order to stabilize the coating. Methods for preparing said nanoparticles are also disclosed.
摘要翻译：本发明涉及可用作造影剂或成像生物材料的造影剂的顺磁性纳米粒子。所述纳米颗粒包含无定形稀土元素氢氧化物的核心和包含硅原子和磷原子的有机涂层。优选地，涂层包含一个或多个有机 - 氧代硅烷残基的取向单层。可以加入结合在较大的有机氧基硅烷之间的第二硅烷，以稳定涂层。还公开了制备所述纳米颗粒的方法。

2. 发明申请

WO2008096280A1 VISUALIZATION OF BIOLOGICAL MATERIAL BY THE USE OF COATED CONTRAST AGENTS 审中-公开
标题翻译：通过使用涂层对比剂代替生物材料的可视化
公开(公告)号：WO2008096280A1
公开(公告)日：2008-08-14
申请号：PCT/IB2008/050084
申请日：2008-01-10
申请人： SPAGO IMAGING AB , AXELSSON, Oskar , UVDAL, Kajsa
发明人： AXELSSON, Oskar , UVDAL, Kajsa
IPC分类号： A61K49/18
CPC分类号： A61K49/1824 , A61K49/1848 , A61K49/186 , B82Y5/00
摘要： A method for visualizing biological material, preferably by MRI, comprising the steps of: (i) bringing a population of coated nanoparticles into contact with said biological material, each of which nanoparticles comprises a) a metal oxide of a transition metal, said metal oxide preferably being paramagnetic and preferably comprising a lanthanide (+III) such as gadolinium (+III), and b) a coating covering the surface of the core particle, and (ii) recording the image; wherein the coating is hydrophilic and comprises a silane layer which is located next to the surface of the core particle and comprises one or more different silane groups which each comprises an organic group R and a silane- siloxane linkage where a) R comprises a hydrophilic organic group R' and a hydrophobic spacer B, b) O is oxygen directly binding to a surface metal ion of the metal oxide, and c) C is carbon and is also part of B. A composition for visualization and methods for the manufacture of the nanoparticles and core particles are also disclosed. Visualization includes imaging by MR, CT, X-ray, near IR fluorescence, PET, microscopying etc with the largest advantages accomplished for in-vivo imaging.
摘要翻译：一种用于使生物材料可视化的方法，优选通过MRI显示，其包括以下步骤：（i）使被覆纳米颗粒群与所述生物材料接触，其中每一种纳米颗粒包含a）过渡金属的金属氧化物，所述金属氧化物优选是顺磁性的，优选包含镧系元素（+ III）如钆（+ III），和b）覆盖核心颗粒表面的涂层，和（ii）记录图像; 其中所述涂层是亲水性的并且包含位于所述核心颗粒表面旁边的硅烷层，并且包含一个或多个不同的硅烷基团，每个硅烷基团包含有机基团R和硅烷 - 硅氧烷键合，其中a）R包含亲水性有机物基团R'和疏水性间隔物B，b）O是与金属氧化物的表面金属离子直接结合的氧，c）C是碳，也是B的一部分。用于可视化的组合物和用于制备还公开了纳米颗粒和芯颗粒。可视化包括MR，CT，X射线，近红外荧光，PET，显微镜等成像，具有体内成像最大的优点。

3. 发明申请

WO2013041623A1 NOVEL MANGANESE COMPRISING NANOSTRUCTURES 审中-公开
标题翻译：包含纳米结构的新型锰
公开(公告)号：WO2013041623A1
公开(公告)日：2013-03-28
申请号：PCT/EP2012/068541
申请日：2012-09-20
申请人： SPAGO IMAGING AB
发明人： AXELSSON, Oskar , PETORAL JR., Rodrigo M. , EK, Fredrik , LAURITZSON, Petter
IPC分类号： A61K49/12 , A61K49/18 , B82Y5/00 , B82Y15/00
CPC分类号： A61K51/065 , A61K49/12 , A61K49/124 , A61K49/128 , A61K49/1818 , A61K49/1857 , B82Y5/00 , B82Y15/00 , C08G73/0206 , C08G73/0213
摘要： Disclosed herein are nanostructures comprising a polymeric framework comprising at least five geminal bisphosphonate groups, wherein the geminal bisphosphonate groups independently of each other are incorporated as - R 3 R 4 C(P=O(OR 1 )(OR 2 )) 2 , wherein R 1 and R 2 are independently selected from the group consisting of a negative charge, H, alkyl and aryl, and wherein at least one of R 3 and R 4 is a group connected to the polymeric framework with the proviso that when only one of R 3 and R 4 is such a connected group, the other of R 3 and R 4 is either a group being able to connect to the polymeric framework, or the residue of such a group, or selected from the group consisting of H, OH, OR 5 and R 5 , wherein R 5 is a lower alkyl. The polymeric framework may comprise manganese ions. Disclosed are also methods for producing such manganese containing nanostructures, compositions comprising such manganese containing nanostructures and use of such manganese con¬ taining nanostructures, i.a. as MRI contrasting agents.
摘要翻译：本文公开了包含包含至少五个偕二膦酸酯基团的聚合物骨架的纳米结构，其中偕双膦酸酯基团彼此独立地并入作为-R 3 R 4 C（P = O（OR 1）（OR 2））2），其中R 1和R 2独立地选自由负电荷，H，烷基和芳基组成的组，并且其中R 3和R 4中的至少一个是与聚合物骨架连接的基团，条件是当只有R3和R4之一是这样的连接基团时， R3和R4中的另一个是能够连接到聚合物骨架的基团，或这种基团的残基，或选自H，OH，OR 5和R 5，其中R 5是低级烷基。聚合物骨架可以包含锰离子。还公开了生产这种含锰纳米结构的方法，包含这种含锰纳米结构的组合物和使用这种含有纳米结构的锰，例如，作为MRI造影剂。

4. 发明申请

WO2011123031A1 BRANCHED, COMPACT POLYETHYLENEGLYCOL DERIVATIVES 审中-公开
标题翻译：分支，紧密聚乙烯醇衍生物
公开(公告)号：WO2011123031A1
公开(公告)日：2011-10-06
申请号：PCT/SE2011/050346
申请日：2011-03-29
申请人： SPAGO IMAGING AB , AXELSSON, Oskar , EK, Fredrik
发明人： AXELSSON, Oskar , EK, Fredrik
IPC分类号： C08G81/02 , C08G65/32
CPC分类号： C08G65/329 , C08G65/336 , C08G65/337 , C08L2203/02
摘要： The present invention relates to branched polyethyleneglycol (PEG) derivatives consisting of a molecule with a quaternary carbon connected to three PEG chains, wherein all three PEG chains are of equal length and each comprises 1 -30 -OCH 2 CH 2 - units, and one group with at least one carbon atom, wherein said at least one carbon atom is attached to the quaternary carbon. Also compositions containing such derivatives and use of such derivatives are disclosed.
摘要翻译：本发明涉及由具有与三个PEG链连接的季碳的分子组成的支链聚乙二醇（PEG）衍生物，其中所有三个PEG链均具有相同的长度，并且每个包含1至30个-OCH 2 CH 2 - 单元，至少一个碳原子，其中所述至少一个碳原子连接到季碳上。还公开了含有这些衍生物的组合物和这些衍生物的用途。

5. 发明申请

WO2008096279A1 COMPOSITIONS CONTAINING METAL OXIDE PARTICLES AND THEIR USES 审中-公开
标题翻译：含有金属氧化物颗粒的组合物及其用途
公开(公告)号：WO2008096279A1
公开(公告)日：2008-08-14
申请号：PCT/IB2008/050083
申请日：2008-01-10
申请人： SPAGO IMAGING AB , UVDAL, Kajsa
发明人： UVDAL, Kajsa
IPC分类号： A61K49/18
CPC分类号： A61K49/1824 , A61K49/1848 , A61K49/186 , B82Y5/00
摘要： A composition of metal oxide nanoparticles in which individual nanoparticles comprises a core that optionally is coated and the metal oxide comprises a metal oxide lattice in which 5 there are two, three, four or more different kinds of metal ions: A) one of these metal ions is selected among lanthanide ions (typically ions of elements 57- B 71), and ) at least one, two, three or more of the other different kinds of metal ions is selected aamong 10 )i transition metal ions of elements of Groups 3b-7b, 8, 1b, 2b other than the lanthanide b ons of elements 57-71, and/or A ) lanthanide ions other than the kind of lanthanide ion selected in A. typical metal ion of (A) is Gd3+, of (B.a) is Fe3+ and of (B.b) is Tb3+. 1 5A v method for coating core forms of the particles, and the use of the particles for visualizing arious kinds of biological material, e.g. by magnetic resonance, are also provided.
摘要翻译：金属氧化物纳米颗粒的组合物，其中单个纳米颗粒包含任选地被包覆的芯，并且金属氧化物包括金属氧化物晶格，其中5有两种，三种，四种或更多种不同种类的金属离子：A）这些金属之一离子选自镧系元素离子（通常是元素57-B 71的离子），并且在其中选择至少一种，两种，三种或更多种其他不同种类的金属离子。10）i过渡金属离子组3b （A）的典型金属离子中选择的镧系元素离子以外的镧系元素离子是（Gd 3+），（A）的（ⅰ） Ba）为Fe3 +，（Bb）为Tb3 +。用于涂覆颗粒形式的颗粒的方法，以及用于使各种生物材料可视化的颗粒的使用，例如，也提供了磁共振。

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