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1. 发明申请

WO2015104664A1 MAGNETIC NANOPARTICLES FUNCTIONALIZED WITH CATHECOL, PRODUCTION AND USE THEREOF 审中-公开
标题翻译：功能齐全的磁性纳米粒子，其生产和使用
公开(公告)号：WO2015104664A1
公开(公告)日：2015-07-16
申请号：PCT/IB2015/050122
申请日：2015-01-07
申请人： COLOROBBIA ITALIA S.P.A.
发明人： BALDI, Giovanni , RAVAGLI, Costanza , COMES FRANCHINI, Mauro , D'ELIOS, Mario Milco , BENAGIANO, Marisa , BITOSSI, Marco
IPC分类号： A61K49/18 , H01F1/00
CPC分类号： A61K49/186 , A61K9/1075 , A61K9/20 , A61K9/5031 , A61K9/5089 , A61K41/0052 , A61K49/1857 , H01F1/0054 , H01F1/0063
摘要： There are described magnetic nanoparticles the surface of which is functionalized with catechol and constructs comprising a plurality of said nanoparticles encapsulated in a biocompatible polymer matrix, wherein a molecule with therapeutic action is optionally dispersed, said polymer matrix optionally being in turn further functionalized; there are further described cells of the immune system incorporating said polymeric constructs giving rise to their engineering.
摘要翻译：描述了磁性纳米颗粒，其表面用邻苯二酚和包含多个包封在生物相容性聚合物基质中的所述纳米颗粒的构建体功能化，其中具有治疗作用的分子任选地分散，所述聚合物基质任选进一步官能化; 进一步描述包含所述聚合物构建体的免疫系统的细胞产生其工程化。

2. 发明申请

WO2012050810A3 SHAPE-CONTROLLED MAGNETIC NANOPARTICLES AS T1 CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：形状控制磁性纳米粒子作为T1对比剂用于磁共振成像
公开(公告)号：WO2012050810A3
公开(公告)日：2012-07-19
申请号：PCT/US2011053268
申请日：2011-09-26
申请人： UNIV ALABAMA , BAO YUPING Y
发明人： BAO YUPING Y
IPC分类号： A61K49/18 , A61K9/16 , A61K47/48 , A61K49/06
CPC分类号： A61K49/1839 , A61K49/1833 , A61K49/1854 , A61K49/1857 , Y10T428/2982
摘要： Methods are provided for the generation of nanostructures suitable for use in magnetic resonance imaging where the nanostructures have at least one dimension of about 2 nm or less. In particular, the methods comprise the selective use of incubation temperatures that result in the controlled removal of ligands from metallic cores to which they are attached, allowing the metallic cores or the precursor moieties to unite to form nanostructures of defined and predictable shapes, but having at least one dimension significantly less that at least one other dimension. Accordingly, the nanostructures of the disclosure may be ultrathin sheets, rods, whiskers and the like, or even structures that are thin and porous resembling rice grains. The temperatures useful in the methods of the disclosure are less than 300 °C and allow for progressive elevation of the incubation temperature. The methods are especially advantageous for synthesizing nanoparticles that may be administered to an animal or human subject for imaging with magnetic resonance. Accordingly, the nanostructures of the disclosure comprise a metallic core, most typically, but not necessarily limited to, a ferrite moiety that can be a ferrous or ferric ion alone or in combination with other metallic elements. However, the methods of the disclosure are also suitable for generating nanostructures with non-ferrous cores such as magnesium or manganese cores.
摘要翻译：提供了用于产生适用于磁共振成像的纳米结构的方法，其中纳米结构具有约2nm或更小的至少一个维度。特别地，所述方法包括选择性地使用孵育温度，其导致从其连接的金属核心控制去除配体，允许金属核心或前体部分团聚以形成具有限定和可预测形状的纳米结构，但具有至少一个维度显着小于至少一个其他维度。因此，本公开的纳米结构可以是超薄片，棒，晶须等，或者甚至是类似于米粒的薄且多孔的结构。在本公开的方法中有用的温度低于300℃，并允许温育温度逐渐升高。该方法对于合成可以施用于动物或人受试者用于用磁共振成像的纳米颗粒是特别有利的。因此，本公开的纳米结构包括金属芯，最典型地但不一定限于铁氧体部分，其可以是单独的或与其它金属元素组合的亚铁或三价铁离子。然而，本公开的方法也适用于产生具有有色金属芯（例如镁或锰核）的纳米结构。

3. 发明申请

WO2012030134A3 IRON OXIDE NANOCAPSULES, METHOD OF MANUFACTURING THE SAME, AND MRI CONTRAST AGENT USING THE SAME 审中-公开
标题翻译：氧化铁纳米粒子，其制造方法和使用其的MRI对比剂
公开(公告)号：WO2012030134A3
公开(公告)日：2012-06-28
申请号：PCT/KR2011006396
申请日：2011-08-30
申请人： HANWHA CHEMICAL CORP , JEON BONG-SIK , KIM EUNG GYU , KWON EUN BYUL , PARK JU YOUNG , MYEONG WAN JAE
发明人： JEON BONG-SIK , KIM EUNG GYU , KWON EUN BYUL , PARK JU YOUNG , MYEONG WAN JAE
IPC分类号： B82B3/00 , A61K49/06
CPC分类号： A61K49/1893 , A61K49/1824 , A61K49/1827 , A61K49/1839 , A61K49/1857 , A61K49/1887
摘要： Provided are iron oxide nanocapsules for an MRI contrast agent having high contrast, in which a plurality of iron oxide nanopart icles having a hydrophobic ligand attached thereto are encapsulated in an encapsulation material including a biodegradable polymer and a surfactant, and which satisfy Relations 1, 2, 3, 4 and 5 below. Also a method of manufacturing the iron oxide nanocapsules is provided. [Relation 1] 5 = 100* Dm(I0)/ Cv(I0) [Relation 2] 2.5 = 100* Dm(Cap)/ Cv(Cap) [Relation 3] 0.5 wt% m(I0) m(Cap) = 200 nm.
摘要翻译：本发明提供了一种具有高对比度的MRI造影剂的氧化铁纳米胶囊，其中具有附着于其上的疏水配体的多个氧化铁纳米颗粒被包封在包括可生物降解的聚合物和表面活性剂的包封材料中，并且满足关系1,2 ，3，4和5。还提供了一种制造氧化铁纳米胶囊的方法。 [关系1] 5 = 100 * Dm（I0）/ Cv（I0）[关系2] 2.5 = 100 * Dm（Cap）/ Cv（Cap）[关系3] 0.5wt％m（I0）m（Cap）= 200nm。

4. 发明申请

WO2012080290A1 NANOPARTICLE COMPOSITION AND ASSOCIATED METHODS THEREOF 审中-公开
标题翻译：纳米材料组合物及其相关方法
公开(公告)号：WO2012080290A1
公开(公告)日：2012-06-21
申请号：PCT/EP2011/072676
申请日：2011-12-14
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE AS , BALES, Brian, C. , HAY, Bruce, Allan , LUTTREL, Michael, Todd , KANDAPALLIL, Binil, Itty, Ipe
发明人： BALES, Brian, C. , HAY, Bruce, Allan , LUTTREL, Michael, Todd , KANDAPALLIL, Binil, Itty, Ipe
IPC分类号： A61K49/18 , B82Y5/00 , B82Y15/00
CPC分类号： A61K49/186 , A61K49/1857 , B82Y15/00 , B82Y30/00 , B82Y40/00 , H01F1/0054
摘要： A nanoparticle composition is provided, wherein the composition comprises a nanoparticulate metal oxide; and a phosphorylated polyol comprising at least two phosphate groups. The polyol comprises one or more hydrophilic groups selected from the group consisting of polyethylene ether moieties, polypropylene ether moieties, polybutylene ether moieties, and combinations of two or more of the foregoing hydrophilic moieties. A method of making the nanoparticle composition is also provided. The nanoparticle compositions provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.
摘要翻译：提供纳米颗粒组合物，其中所述组合物包含纳米颗粒金属氧化物; 和包含至少两个磷酸酯基团的磷酸化多元醇。多元醇包含一个或多个选自聚乙烯醚部分，聚丙烯醚部分，聚丁烯醚部分以及前述亲水部分中两个或更多个的组合的亲水基团。还提供了制备纳米颗粒组合物的方法。本发明提供的纳米颗粒组合物可用作医学成像技术如X射线和磁共振成像中的造影剂。

5. 发明申请

WO2012078745A1 MAGNETIC NANOPARTICLE FORMULATIONS, METHODS FOR MAKING SUCH FORMULATIONS, AND METHODS FOR THEIR USE 审中-公开
标题翻译：磁性纳米材料制剂，制备这种制剂的方法及其使用方法
公开(公告)号：WO2012078745A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/063723
申请日：2011-12-07
申请人： SANFORD RESEARCH/USD , CHAUHAN, Subhash , JAGGI, Meena , YALLAPU, Murali, Mohan
发明人： CHAUHAN, Subhash , JAGGI, Meena , YALLAPU, Murali, Mohan
IPC分类号： H01F1/00
CPC分类号： A61K49/1824 , A61K9/5161 , A61K9/5192 , A61K31/12 , A61K41/0052 , A61K41/0057 , A61K49/1845 , A61K49/1857 , A61N2/002 , B82Y25/00 , H01F1/0054
摘要： The present invention provides derivatized magnetic nanoparticles, methods for making such nanoparticles, and methods for their use.
摘要翻译：本发明提供衍生化的磁性纳米颗粒，制备这种纳米颗粒的方法及其使用方法。

6. 发明申请

WO2011122770A3 MAGNETIC RESONANCE IMAGING CONTRAST AGENT COATED WITH POLYMER HAVING MANNOSE-MODIFIED TERMINAL, AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：用具有MANNOSE改性终端的聚合物涂覆的磁共振成像对比剂及其制备方法
公开(公告)号：WO2011122770A3
公开(公告)日：2012-01-26
申请号：PCT/KR2011001544
申请日：2011-03-07
申请人： INTRON BIOTECHNOLOGY INC , YOON SEONG JUN , JUN SOO YOUN , KANG SANG HYEON , JEONG YONG YEON , PARK IN KYU , CHO CHONG SU , YOO MI KYONG
发明人： YOON SEONG JUN , JUN SOO YOUN , KANG SANG HYEON , JEONG YONG YEON , PARK IN KYU , CHO CHONG SU , YOO MI KYONG
IPC分类号： A61K49/10 , A61K49/06 , A61K49/12
CPC分类号： A61K49/1857 , A61K49/1848 , A61K49/1863
摘要： The present invention relates to a magnetic resonance imaging contrast agent surface-coated with a polymer which has high stability in the body and biocompatibility, and more specifically, to a superparamagnetic magnetic resonance imaging contrast agent coated with a polymer having a mannose-modified terminal which can be used for enhancing the contrast of images in lymphography, and a preparation method thereof. The superparamagnetic magnetic resonance imaging contrast agent coated with a polymer having a mannose-modified terminal according to the present invention can provide high stability in the body and biocompatibility and can be used for easy diagnosis of the metastasis of cancer to lymph nodes.
摘要翻译：本发明涉及一种表面涂覆聚合物的磁共振成像造影剂，该聚合物在体内具有高稳定性和生物相容性，更具体地说，涉及涂覆有具有甘露糖修饰末端的聚合物的超顺磁磁共振成像造影剂，可用于增强淋巴图像中的图像的对比度及其制备方法。涂有根据本发明的具有甘露糖修饰末端的聚合物的超顺磁性磁共振成像造影剂可以在体内提供高稳定性和生物相容性，并且可用于容易地诊断癌症转移至淋巴结。

7. 发明申请

WO2011122770A2 MAGNETIC RESONANCE IMAGING CONTRAST AGENT COATED WITH POLYMER HAVING MANNOSE-MODIFIED TERMINAL, AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：用具有MANNOSE改性终端的聚合物涂覆的磁共振成像对比剂及其制备方法
公开(公告)号：WO2011122770A2
公开(公告)日：2011-10-06
申请号：PCT/KR2011001544
申请日：2011-03-07
申请人： INTRON BIOTECHNOLOGY INC , YOON SEONG JUN , JUN SOO YOUN , KANG SANG HYEON , JEONG YONG YEON , PARK IN KYU , CHO CHONG SU , YOO MI KYONG
发明人： YOON SEONG JUN , JUN SOO YOUN , KANG SANG HYEON , JEONG YONG YEON , PARK IN KYU , CHO CHONG SU , YOO MI KYONG
IPC分类号： A61K49/10 , A61K49/06 , A61K49/12
CPC分类号： A61K49/1857 , A61K49/1848 , A61K49/1863
摘要： The present invention relates to a magnetic resonance imaging contrast agent surface-coated with a polymer which has high stability in the body and biocompatibility, and more specifically, to a superparamagnetic magnetic resonance imaging contrast agent coated with a polymer having a mannose-modified terminal which can be used for enhancing the contrast of images in lymphography, and a preparation method thereof. The superparamagnetic magnetic resonance imaging contrast agent coated with a polymer having a mannose-modified terminal according to the present invention can provide high stability in the body and biocompatibility and can be used for easy diagnosis of the metastasis of cancer to lymph nodes.
摘要翻译：本发明涉及一种表面涂覆聚合物的磁共振成像造影剂，该聚合物在体内具有高稳定性和生物相容性，更具体地说，涉及涂覆有具有甘露糖修饰末端的聚合物的超顺磁磁共振成像造影剂，可用于增强淋巴图像中的图像的对比度及其制备方法。涂有根据本发明的具有甘露糖修饰末端的聚合物的超顺磁性磁共振成像造影剂可以在体内提供高稳定性和生物相容性，并且可用于容易地诊断癌症转移至淋巴结。

8. 发明申请

WO2009135937A3 NOVEL PEI-PEG GRAFT COPOLYMER COATING OF IRON OXIDE NANOPARTICLES FOR INFLAMMATION IMAGING 审中-公开
标题翻译：用于荧光成像的氧化乙烯纳米粒子的新型PEI-PEG共聚物涂层
公开(公告)号：WO2009135937A3
公开(公告)日：2010-12-23
申请号：PCT/EP2009055598
申请日：2009-05-08
申请人： GEN ELECTRIC , GE HEALTHCARE AS , KULKARNI AMIT , GRIMMOND BRIAN , BALES BRIAN C , TREYNOR CHIAKI , MEYER DAN
发明人： KULKARNI AMIT , GRIMMOND BRIAN , BALES BRIAN C , TREYNOR CHIAKI , MEYER DAN
IPC分类号： A61K49/18
CPC分类号： A61K49/186 , A61K49/1839 , A61K49/1857
摘要： A nanostructure includes a nanoparticle core (110) and a ligand (120) bonded to the nanoparticle core (110). The ligand includesa linking group (130) having a first end bonded to a polyethylene imine (PEI) polymer (140) and a second end bonded to the nanoparticle core (110) and a polyethylene glycol (PEG) polymer (150) grafted to the PEI polymer (140). Methods for making these nanostructures and their use in magnetic resonance imaging and management of inflammatory conditions are provided.
摘要翻译：纳米结构包括纳米颗粒核心（110）和与纳米颗粒核心（110）结合的配体（120）。配体包括具有与聚乙烯亚胺（PEI）聚合物（140）结合的第一末端的结合基团（130）和与纳米颗粒核心（110）结合的第二末端和接枝到所述聚乙二醇（PEG）聚合物上的聚乙二醇（PEG）聚合物（150） PEI聚合物（140）。提供了制备这些纳米结构的方法及其在磁共振成像和炎症状态管理中的应用。

9. 发明申请

WO2009135937A2 NOVEL PEI-PEG GRAFT COPOLYMER COATING OF IRON OXIDE NANOPARTICLES FOR INFLAMMATION IMAGING 审中-公开
标题翻译：用于荧光成像的氧化乙烯纳米粒子的新型PEI-PEG共聚物涂层
公开(公告)号：WO2009135937A2
公开(公告)日：2009-11-12
申请号：PCT/EP2009/055598
申请日：2009-05-08
申请人： GENERAL ELECTRIC COMPANY , GE HEALTHCARE AS , KULKARNI, Amit , GRIMMOND, Brian , BALES, Brian, C. , TREYNOR, Chiaki , MEYER, Dan
发明人： KULKARNI, Amit , GRIMMOND, Brian , BALES, Brian, C. , TREYNOR, Chiaki , MEYER, Dan
IPC分类号： A61K49/18
CPC分类号： A61K49/186 , A61K49/1839 , A61K49/1857
摘要： A nanostructure includes a nanoparticle core (110) and a ligand (120) bonded to the nanoparticle core (110). The ligand includesa linking group (130) having a first end bonded to a polyethylene imine (PEI) polymer (140) and a second end bonded to the nanoparticle core (110) and a polyethylene glycol (PEG) polymer (150) grafted to the PEI polymer (140). Methods for making these nanostructures and their use in magnetic resonance imaging and management of inflammatory conditions are provided.
摘要翻译：纳米结构包括纳米颗粒核心（110）和与纳米颗粒核心（110）结合的配体（120）。配体包括具有与聚乙烯亚胺（PEI）聚合物（140）结合的第一末端的结合基团（130）和与纳米颗粒核心（110）结合的第二末端和接枝到聚乙烯亚胺聚合物（110）上的聚乙二醇（PEG）聚合物（150） PEI聚合物（140）。提供了制备这些纳米结构的方法及其在磁共振成像和炎症状态管理中的应用。

10. 发明申请

WO2009116755A2 MAGNETIC RESONANCE IMAGING T1 CONTRAST MEDIA CONTAINING MANGANESE TETROXIDE NANOPARTICLES AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：磁共振成像T1对比介质含锰锰酸盐纳米微粒及其制备方法
公开(公告)号：WO2009116755A2
公开(公告)日：2009-09-24
申请号：PCT/KR2009001277
申请日：2009-03-14
申请人： SNU R&DB FOUNDATION , HYEON TAEGHWAN , YU TAEKYUNG
发明人： HYEON TAEGHWAN , YU TAEKYUNG
IPC分类号： B82B3/00
CPC分类号： B82Y5/00 , A61K49/1854 , A61K49/1857 , A61K49/186 , A61K49/1863 , B82Y30/00 , C01G45/02 , C01P2002/72 , C01P2004/03 , C01P2004/20 , C01P2004/32 , C01P2004/64
摘要： The present invention relates to a method for manufacturing manganese tetroxide (Mn304) nanoparticles. More particularly, the present invention relates to a method for manufacturing manganese tetroxide nanoparticles, the method including a step of adding one element selected from the group consisting of water, hydrogen peroxide, an aqueous solution of hydrogen peroxide, C1 to C4 alcohols, and an aqueous solution of C1 to C4 alcohols, to a mixture of an organic solvent, a manganese precursor, and a surfactant, and heating the resultant matter, and also relates to magnetic resonance imaging T1 contrast media containing manganese tetroxide nanoparticles and a manufacturing method thereof.
摘要翻译：本发明涉及一种用于制造四氧化锰（Mn304）纳米颗粒的方法。更具体地说，本发明涉及一种四氧化锰纳米粒子的制造方法，该方法包括：添加选自水，过氧化氢，过氧化氢水溶液，C1〜C4醇中的一种元素和 C1至C4醇的水溶液，有机溶剂，锰前体和表面活性剂的混合物，并加热所得物质，并且涉及含有四氧化锰纳米颗粒的磁共振成像T1造影剂及其制造方法。

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