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1. 发明申请

WO2019094868A1 BIODEGRADABLE POLYMER AND USE THEREOF 审中-公开
公开(公告)号：WO2019094868A1
公开(公告)日：2019-05-16
申请号：PCT/US2018/060575
申请日：2018-11-12
申请人： ANP TECHNOLOGIES, INC.
发明人： YIN, Ray , PAN, Jing , ZHOU, Zhiying , WANG, Xiaoyu , QI, Kai
IPC分类号： A61K47/34 , A61K47/36 , A61K47/42 , A61K47/56 , A61K47/64 , A61K9/51 , A61K48/00 , C08G83/00 , C08G69/02 , C08G73/04 , C12N15/87 , A01N25/10
摘要： This invention is directed to a biodegradable polymer that can be degraded in vivo. The biodegradable polymer comprises a biodegradable polymer segment having at least a biodegradable bond and two or more cationic components, wherein each of said cationic components is covalently attached to the biodegradable polymer segment and the two cationic components/molecules are separated by at least one biodegradable bond in the backbone. The biodegradable polymer can be used for targeting desired ceils in vivo including T cells, NK (natural killer) ceils, cancer cells, or a combination thereof, delivering genes, DNA, oligodeoxynucleotide, oligonucleotide, RNA, mRNA, RNAi, siRNA, microRNA, protein, peptide, antibody, fragment of an antibody, small molecule drug including chemotherapy drugs, or other bioactive agents into cells, or being used as a vaccine or drug for treating a disease such as a cancer in a subject.

2. 发明申请

WO2013020005A3 OXAZOLINE POLYMER COMPOSITIONS AND USE THEREOF 审中-公开
标题翻译： OXAZOLINE聚合物组合物及其用途
公开(公告)号：WO2013020005A3
公开(公告)日：2013-04-11
申请号：PCT/US2012049410
申请日：2012-08-03
申请人： ANP TECHNOLOGIES INC , YIN RAY , PAN JING , QIN DUJIE , ZHANG YUBEI
发明人： YIN RAY , PAN JING , QIN DUJIE , ZHANG YUBEI
IPC分类号： C08G73/06 , A61K47/48 , C08G81/00 , C08L79/04
CPC分类号： A61K47/48192 , A61K31/4745 , A61K31/7068 , A61K47/48207 , A61K47/484 , A61K47/59 , A61K47/595 , A61K47/6807 , C08G69/48 , C08G73/0233 , C08G81/00 , C08G83/004 , G01N33/545
摘要： Compositions comprising an oxazoline polymer and optional linkers to carry a variety of molecules.
摘要翻译：包含恶唑啉聚合物和任选的接头以携带各种分子的组合物。

3. 发明申请

WO2012094620A2 HYDROPHOBIC MOLECULE-INDUCED BRANCHED POLYMER AGGREGATES AND THEIR USE 审中-公开
标题翻译：疏水性分子引发的支化聚合物聚集体及其应用
公开(公告)号：WO2012094620A2
公开(公告)日：2012-07-12
申请号：PCT/US2012020524
申请日：2012-01-06
申请人： ANP TECHNOLOGIES INC , DUJIE QIN , YIN RAY , PAN JING , ZHANG YUBEI
发明人： DUJIE QIN , YIN RAY , PAN JING , ZHANG YUBEI
IPC分类号： A61K47/30 , A61K47/48 , A61K49/04 , A61K49/06
CPC分类号： A61K9/14 , A61K9/19 , A61K9/513 , A61K9/5146 , A61K31/337 , A61K31/4375 , A61K33/24 , A61K45/06 , A61K47/34 , A61K47/48384 , A61K47/6803 , A61K49/0004 , A61K49/12 , A61K51/06
摘要： Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with water insoluble or poorly water soluble pharmaceutically active agents (PAA). The aggregates formed are specifically induced by interaction of PAA and homopolymer and are different from aggregates that are formed by the polymer alone in the absence of the PAA or by the PAA alone in the absence of the polymer. Such aggregates can be used to improve drug solubility, stability, delivery and efficacy.
摘要翻译：对称和不对称支化均聚物在表面水平被官能团改性，所述官能团能够与水不溶性或水溶性差的药物活性剂（PAA）形成聚集体。形成的聚集体由PAA和均聚物的相互作用特异性诱导，并且不同于不存在PAA时单独由聚合物形成的聚集体或不存在聚合物时由单独PAA形成的聚集体。这种聚集体可用于改善药物的溶解性，稳定性，递送和功效。

4. 发明申请

WO2014116727A1 ONE-STEP RAPID ASSAY FOR THE DETECTION OF INHIBITORS OF ENZYMES 审中-公开
标题翻译：用于检测酶的抑制剂的一步快速测定
公开(公告)号：WO2014116727A1
公开(公告)日：2014-07-31
申请号：PCT/US2014/012582
申请日：2014-01-22
申请人： ANP TECHNOLOGIES, INC.
发明人： VALLEJO, Yli, Remo , MILUNIC, David , YIN, Ray , STREET, Renee , CHEN, De
IPC分类号： G01N33/53 , C12M1/34 , G01N33/573
CPC分类号： C12Q1/46 , C12Q1/26 , C12Q1/42 , C12Q1/44 , C12Y301/01001 , C12Y301/01007 , G01N33/558 , G01N2333/916
摘要： A device and method for the rapid on-site detection of inhibitors of enzymes, such as acetylcholinesterase, is described wherein the device contains all reagents added to a sample pad containing dried releasable enzyme creating a reaction mixture wherein inhibitor deactivates the enzyme, while said reaction mixture travels via a longitudinal membrane to a distal porous pad containing a substrate for the enzyme. The reaction of the enzyme and the substrate results in a product that can generate a measurable signal such as color, fluorescence or luminescence to serve as a reporter. Signal that is generated at this reaction zone is inversely proportional to inhibitor concentration in the test sample. A device containing two such strips, one for a test sample, the other for a negative control fluid as an onboard comparator is described. A purpose-built reader or an illuminating device, such as, containing an incandescent light source, a diode, a UV light source or any other illumination source that is suitable for the reporter or mere visualization is used to determine the level of reporter.
摘要翻译：描述了用于快速现场检测酶抑制剂如乙酰胆碱酯酶的装置和方法，其中装置包含添加到含有干燥的可释放酶的样品垫中的所有试剂，产生其中抑制剂使酶失活的反应混合物，而所述反应混合物通过纵向膜移动到包含酶的底物的远端多孔垫。酶和底物的反应产生可产生诸如颜色，荧光或发光之类的可测信号作为报道者的产物。在该反应区产生的信号与测试样品中的抑制剂浓度成反比。描述了包含两个这样的条的装置，一个用于测试样品，另一个用于作为板载比较器的负控制流体。使用专门的读取器或照明装置，例如包含白炽灯光源，二极管，UV光源或适用于报告人或仅仅可视化的任何其他照明源，以确定报告者的水平。

5. 发明申请

WO2012129444A3 RAPID TESTS FOR THE DETECTION OF INHIBITORS OF ENZYMES AND HUMAN EXPOSURE TO THE SAME 审中-公开
标题翻译：用于检测酶的抑制剂和人体接触的快速检测
公开(公告)号：WO2012129444A3
公开(公告)日：2013-01-03
申请号：PCT/US2012030196
申请日：2012-03-22
申请人： ANP TECHNOLOGIES INC , VALLEJO YLI REMO , MILUNIC DAVID
发明人： VALLEJO YLI REMO , MILUNIC DAVID
IPC分类号： G01N33/68 , C12Q1/44 , G01N33/52
CPC分类号： G01N21/6486 , C12Q1/44 , C12Q1/46
摘要： A device and method for the rapid on-site detection of inhibitors of enzymes, such as, acetylcholinesterase is described where the device contains 2 reaction zones containing a reporter enzyme substrate. One reaction zone is for the test sample while the other is for an onboard negative control. Sample and control fluids are preincubated with the enzyme in separate reaction containers, then an aliquot of each reaction mixture is added to designated reaction zones on the test device. A purpose- built reader or an illuminating device, such as, containing an incandescent light source, a diode, a UV light source or any other illumination source that is suitable for the reporter or mere visualization is used to determine the level of reporter.
摘要翻译：描述了用于快速现场检测酶抑制剂如乙酰胆碱酯酶的装置和方法，其中装置包含含有报告酶底物的2个反应区。一个反应区用于测试样品，另一个用于板载阴性对照。将样品和对照流体与酶在不同的反应容器中预温育，然后将各反应混合物的等分试样加入到测试装置上的指定反应区。使用专门的读取器或照明装置，例如包含白炽灯光源，二极管，UV光源或适用于报告人或仅仅可视化的任何其他照明源，以确定报告人的水平。

6. 发明申请

WO2012094620A9 HYDROPHOBIC MOLECULE-INDUCED BRANCHED POLYMER AGGREGATES AND THEIR USE 审中-公开
公开(公告)号：WO2012094620A9
公开(公告)日：2012-07-12
申请号：PCT/US2012/020524
申请日：2012-01-06
申请人： ANP TECHNOLOGIES, INC. , DUJIE, Qin , YIN, Ray , PAN, Jing , ZHANG, Yubei
发明人： DUJIE, Qin , YIN, Ray , PAN, Jing , ZHANG, Yubei
IPC分类号： A61K47/30 , A61K49/06 , A61K49/04 , A61K47/48
摘要： Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with water insoluble or poorly water soluble pharmaceutically active agents (PAA). The aggregates formed are specifically induced by interaction of PAA and homopolymer and are different from aggregates that are formed by the polymer alone in the absence of the PAA or by the PAA alone in the absence of the polymer. Such aggregates can be used to improve drug solubility, stability, delivery and efficacy.

7. 发明申请

WO2006102484A3 SYMMETRICALLY BRANCHED POLYMER CONJUGATES AND MICROARRAY ASSAYS 审中-公开
标题翻译：对称聚合物共聚物和微量测定
公开(公告)号：WO2006102484A3
公开(公告)日：2006-12-07
申请号：PCT/US2006010519
申请日：2006-03-21
申请人： ANP TECHNOLOGIES INC , YIN RAY , QIN DUJIE , PAN JING
发明人： YIN RAY , QIN DUJIE , PAN JING
IPC分类号： C07K1/13 , A61K31/74 , A61K31/785 , A61K31/80 , C12M1/00 , G01N33/24 , G01N33/53 , G01N33/532 , G01N33/547
CPC分类号： G01N33/545 , G01N33/544
摘要： Modified symmetrically branched polymers are combined with bioactive agents for a variety of purposes including drug delivery and conjugation to one member of a binding pair for use in an assay.
摘要翻译：改进的对称支化聚合物与生物活性剂结合用于各种目的，包括药物递送和与用于测定中的结合对的一个成员结合。

8. 发明申请

WO2012129444A2 RAPID TESTS FOR THE DETECTION OF INHIBITORS OF ENZYMES AND HUMAN EXPOSURE TO THE SAME 审中-公开
标题翻译：用于检测酶的抑制剂和人体接触的快速检测
公开(公告)号：WO2012129444A2
公开(公告)日：2012-09-27
申请号：PCT/US2012/030196
申请日：2012-03-22
申请人： ANP TECHNOLOGIES, INC. , VALLEJO, Yli, Remo , MILUNIC, David
发明人： VALLEJO, Yli, Remo , MILUNIC, David
IPC分类号： G01N33/68 , C12Q1/44 , G01N33/52
CPC分类号： G01N21/6486 , C12Q1/44 , C12Q1/46
摘要： A device and method for the rapid on-site detection of inhibitors of enzymes, such as, acetylcholinesterase is described where the device contains 2 reaction zones containing a reporter enzyme substrate. One reaction zone is for the test sample while the other is for an onboard negative control. Sample and control fluids are preincubated with the enzyme in separate reaction containers, then an aliquot of each reaction mixture is added to designated reaction zones on the test device. A purpose- built reader or an illuminating device, such as, containing an incandescent light source, a diode, a UV light source or any other illumination source that is suitable for the reporter or mere visualization is used to determine the level of reporter.
摘要翻译：描述了用于快速现场检测酶抑制剂如乙酰胆碱酯酶的装置和方法，其中装置包含含有报告酶底物的2个反应区。一个反应区用于测试样品，另一个用于板载阴性对照。将样品和对照流体与酶在不同的反应容器中预温育，然后将各反应混合物的等分试样加入到测试装置上的指定的反应区。使用专门的读取器或照明装置，例如包含白炽光源，二极管，UV光源或适用于报告人或仅仅可视化的任何其他照明源，以确定报告者的水平。

9. 发明申请

WO2008024778A1 AUTOMATED SELF-CONTAINED LIQUID HANDLING AND DETECTION SYSTEM DEVICE 审中-公开
标题翻译：自动自含液体处理和检测系统装置
公开(公告)号：WO2008024778A1
公开(公告)日：2008-02-28
申请号：PCT/US2007/076426
申请日：2007-08-21
申请人： ANP TECHNOLOGIES, INC. , COGENT SYSTEMS, INC. , YIN, Ray , WANG, Ankuo , LI, Songtao
发明人： YIN, Ray , WANG, Ankuo , LI, Songtao
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N35/00029
摘要： The present invention combines automated liquid handling, rapid planar binding assay format, reservoir of assay devices, automated package opening device, and automated reader for obtaining assay results, with an optional means for data analysis, data storage and data management in an integrated system device.
摘要翻译：本发明结合自动化液体处理，快速平面结合测定形式，测定装置储存器，自动包装开启装置和用于获得测定结果的自动读取器，具有用于集成系统装置中的数据分析，数据存储和数据管理的可选装置。

10. 发明申请

WO2006119160A2 POLYMER CONJUGATE ENHANCED BIOASSAYS 审中-公开
标题翻译：聚合物增强生物多样性
公开(公告)号：WO2006119160A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/016580
申请日：2006-05-02
申请人： ANP TECHNOLOGIES, INC. , YIN, Ray , QIN, Dujie , PAN, Jing
发明人： YIN, Ray , QIN, Dujie , PAN, Jing
IPC分类号： G01N33/53
CPC分类号： G01N33/545 , B82Y5/00 , B82Y10/00 , G01N33/532 , G01N33/54353 , G01N33/6854
摘要： Modified branched polymers are combined with bioactive agents which are one member of a binding pair for use in an assay.
摘要翻译：改性支链聚合物与作为测定中使用的结合对的一个成员的生物活性剂组合。

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