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1. 发明申请

WO2017221030A1 GAS CAPTURE USING POLYMERIC PARTICLES 审中-公开
标题翻译：用聚合物颗粒捕集气体
公开(公告)号：WO2017221030A1
公开(公告)日：2017-12-28
申请号：PCT/GB2017/051850
申请日：2017-06-23
申请人： CHARMSTAR CAMBRIDGE LIMITED
发明人： NABAVI, Seyed Ali , VLADISAVLJEVIC, Goran , MANOVIC, Vasilije
IPC分类号： B01J20/26 , B01J20/30 , B01J20/28 , B01D53/02
CPC分类号： B01J20/267 , B01D53/02 , B01D2253/202 , B01D2257/108 , B01D2257/302 , B01D2257/404 , B01D2257/502 , B01D2257/504 , B01J20/262 , B01J20/268 , B01J20/28016 , B01J20/28019 , B01J20/3057 , B01J20/3071 , B01J20/3085 , Y02C10/08
摘要： Disclosed herein is a method of making a polymeric material for selective adsorption of a gas. The method comprises dissolving a monomer comprising a functional group having an affinity for the gas in a solvent with a cross-linker and an initiator; emulsifying the solution in a liquid which is immiscible with the first solvent; and agitating and heating the emulsion to cause polymerization of the monomer into a cross-linked polymer having nanocavities with functional groups covalently- incorporated on walls thereof. Also disclosed are polymeric particles, an apparatus for forming the particles and a method of adsorbing a selected gas.
摘要翻译：本文公开了一种制造用于选择性吸附气体的聚合物材料的方法。该方法包括用交联剂和引发剂将包含对气体具有亲和性的官能团的单体溶解在溶剂中; 将该溶液在与第一溶剂不混溶的液体中乳化; 搅拌和加热乳液以引起单体聚合成具有共价结合在其壁上的官能团的纳米腔的交联聚合物。还公开了聚合物颗粒，用于形成颗粒的装置和吸附选定气体的方法。

2. 发明申请

WO2017185120A1 SPEICHERUNG VON KODES IN MOLEKULAR GEPRÄGTEN POLYMEREN 审中-公开
标题翻译：代码在分子引发聚合物中的存储
公开(公告)号：WO2017185120A1
公开(公告)日：2017-11-02
申请号：PCT/AT2017/060111
申请日：2017-04-27
申请人： JOHANNES KEPLER UNIVERSITÄT LINZ , MOSBACH, Klaus
发明人： MOSBACH, Klaus , BRÜGGEMANN, Oliver , WOLFSCHLUCKER, Jacqueline
IPC分类号： G11C13/00 , B01J20/26
CPC分类号： G11C13/0016 , B01J20/268 , C08L101/00 , G01N24/08 , G06K19/06187
摘要： Es wird ein molekular geprägtes Polymer (9) zur Speicherung eines definierten Werts eines Zahlenkodes insbesondere Binärkodes in dessen molekularen Abdrücken und ein Verfahren zu dessen Herstellung beschrieben. Für das molekulare Prägen werden geeignete Template (1) mit einer definierten Sequenz von mindestens zwei verschiedenen Bausteinen, die jeweils eine unterschiedliche chemische Funktionalität aufweisen, verwendet.
摘要翻译：描述了分子聚合的聚合物（9）用于在其分子印迹及其制备方法中存储确定的数值代码值，特别是二进制代码。对于分子测定，使用具有确定的至少两种不同结构单元的序列的合适的模板（1），每个具有不同的化学官能度。

3. 发明申请

WO2017001451A1 PREPARATION OF MOLECULARLY IMPRINTED POLYMERS BY TWO-PHOTON STEREOLITHOGRAPHY 审中-公开
标题翻译：分子印迹聚合物的制备通过双光子立体成像
公开(公告)号：WO2017001451A1
公开(公告)日：2017-01-05
申请号：PCT/EP2016/065096
申请日：2016-06-29
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE HAUTE ALSACE , UTC (UNIVERSITÉ DE TECHNOLOGIE DE COMPIÈGNE)
发明人： SPANGENBERG, Arnaud , CHIA GOMEZ, Laura , MALVAL, Jean-Pierre , SOPPERA, Olivier , FUCHS, Yannick , TON, Xuan-Anh , BOKELOH, Frank , HAUPT, Karsten
IPC分类号： B01J20/26 , C08F2/48
CPC分类号： B01J20/268 , C08F2/48 , C09D4/00 , G01N2600/00 , C08F220/06 , C08F2222/1026
摘要： The present invention relates to a method using two-photon stereolithography for preparing molecularly imprinted polymers, notably 3D-structured molecularly imprinted polymers.
摘要翻译：本发明涉及一种使用双光子立体光刻技术制备分子印迹聚合物，特别是3D结构分子印迹聚合物的方法。

4. 发明申请

WO2015118294A1 MOLECULAR SENSOR PREPARATIONS AND USES THEREOF 审中-公开
标题翻译：分子传感器的制备及其用途
公开(公告)号：WO2015118294A1
公开(公告)日：2015-08-13
申请号：PCT/GB2015/050086
申请日：2015-01-16
申请人： THE UNIVERSITY OF BIRMINGHAM
发明人： MENDES, Paula , FOSSEY, John S. , STEPHENSON-BROWN, Alexander
IPC分类号： B01D15/38 , B01J20/26 , B01J20/30
CPC分类号： G01N33/54386 , B01D15/3852 , B01J20/268 , G01N33/5308 , G01N33/573 , G01N2333/922 , G01N2333/96411 , G01N2600/00 , G01N2610/00
摘要： The present invention relates to a method of preparing a molecular sensor that is specific for a target molecule having a saccharide or peptide region. The method comprises using the target molecule as a template and incubating the template with a receptor to form a template-receptor complex. A molecular scaffold is formed on a surface around the template-receptor complex such that the receptor and at least a portion of the template are embedded in the scaffold, and the template is removed to produce a cavity defined by the scaffold, such that the cavity is complementary to at least a portion of the saccharide or peptide region of the target molecule.
摘要翻译：本发明涉及一种制备对具有糖或肽区的靶分子具有特异性的分子传感器的方法。该方法包括使用靶分子作为模板，并用受体孵育模板以形成模板 - 受体复合物。在模板 - 受体复合物周围的表面上形成分子支架，使得受体和模板的至少一部分嵌入在支架中，并且去除模板以产生由支架限定的空腔，使得腔与目标分子的糖或肽区域的至少一部分互补。

5. 发明申请

WO2013179196A1 PROCESS FOR THE TREATMENT OF FERMENTED VEGETABLE-BASED BEVERAGES 审中-公开
标题翻译：处理基于蔬菜的饮料的方法
公开(公告)号：WO2013179196A1
公开(公告)日：2013-12-05
申请号：PCT/IB2013/054311
申请日：2013-05-24
申请人： ESSECO S.R.L.
发明人： TROTTA, Francesco , BIASIZZO, Miriam , FERRUTI, Paolo , RANUCCI, Elisabetta
IPC分类号： C12H1/04 , A23F3/20 , A23L2/70 , A23D9/02 , C12C7/28 , C08B37/00 , C08F283/00 , B01J20/26 , B01J20/30 , C08F220/06 , C08F226/06 , C12G3/08 , C12J1/00
CPC分类号： A23L2/80 , B01J20/268 , B01J20/3057 , C08B37/0012 , C08B37/0015 , C12H1/0424 , C12J1/00
摘要： A process of treatment of fermented beverages of vegetable origin, in particular wine, is disclosed, which provides the contact between the beverage and a polymer obtained by radical or sol-gel synthesis, selected from the group based on a-, p -, y-cyclodextrins and their derivatives and mixtures. This treatment removes from the fermented beverage molecules that harm its organoleptic propertes. According to a variant of the process, said polymers are synthetised according to the technique of the molecular imprinting. Advantageously, the process is implemented by packing a column, for example a chromatographic column, with polymer, for example in pellets, powder or bead, and by passing the beverage to be treated with a calculated flow rate in order to allow the beverage to stay sufficient time in the column to allow the said absorption. The process according to this invention can be utilised for stabilising the protein fractions in wines.
摘要翻译：公开了一种处理植物来源的发酵饮料，特别是葡萄酒的方法，其提供饮料与通过自由基或溶胶 - 凝胶合成获得的聚合物之间的接触，所述聚合物选自基于a-，p - y 环糊精及其衍生物和混合物。这种处理从发生的损害其感官特性的饮料分子中除去。根据该方法的变体，根据分子印迹的技术合成所述聚合物。有利地，该方法通过用聚合物（例如，丸粒，粉末或珠粒）填充柱，例如色谱柱，并且通过以计算的流速通过待处理的饮料以允许饮料停留在柱中足够的时间允许所述吸收。根据本发明的方法可用于稳定葡萄酒中的蛋白质级分。

6. 发明申请

WO2012034946A1 PREPARATION OF A MOLECULAR RECOGNITION ELEMENT 审中-公开
标题翻译：分子识别元素的制备
公开(公告)号：WO2012034946A1
公开(公告)日：2012-03-22
申请号：PCT/EP2011/065671
申请日：2011-09-09
申请人： FACHHOCHSCHULE NORDWESTSCHWEIZ, HOCHSCHULE FÜR LIFESCIENCE , SHAHGALDIAN, Patrick , CUMBO, Alessandro , CORVINI, Philippe
发明人： SHAHGALDIAN, Patrick , CUMBO, Alessandro , CORVINI, Philippe
IPC分类号： G01N33/543
CPC分类号： C08G77/18 , B01J20/268 , G01N33/54313 , G01N33/54353 , G01N2600/00
摘要： The present invention relates to a method for preparation of a molecular recognition element (1, 11, 111) comprising the steps of binding a template (4) to a surface of a carrier material (3, 30), providing a recognition material to the surface of the carrier material (3, 30), initiating polymerization of the recognition material on the surface of the carrier material (3, 30), stopping the polymerization of the recognition material on the surface of the carrier material (3, 30), and releasing the template (4) from the surface of the carrier material (3, 30) and the polymerized recognition material (6, 60). The method is characterized in that an aim size of individual imprints (10, 100, 120) is predefined, and the polymerization of the recognition material on the surface of the carrier material (3, 30) is stopped when a size of individual imprints (10, 100, 120) of the polymerized recognition material (6, 60) essentially equals the predefined aim size. This method is readily applicable for preparation of a molecular recognition element al (1, 11, 111) useful as a drug, catalyst, competitive affinity ligand inhibitor, competitor, agonist, antagonist or diagnostic agent.
摘要翻译：本发明涉及一种用于制备分子识别元件（1,11,111）的方法，包括以下步骤：将模板（4）结合到载体材料（3,30）的表面，从而提供识别材料在载体材料（3,30）的表面上引发识别材料在载体材料（3,30）的表面上的聚合，停止识别材料在载体材料（3,30）的表面上的聚合，以及从载体材料（3,30）的表面和聚合的识别材料（6,60）释放模板（4）。该方法的特征在于，预定了单个印记（10,100,120）的目标尺寸，并且当个体印记的尺寸（...）时，停止载体材料（3,30）表面上识别材料的聚合聚合识别材料（6,60）10,100,120）基本上等于预定义的目标尺寸。该方法可用于制备可用作药物，催化剂，竞争性亲和配体抑制剂，竞争剂，激动剂，拮抗剂或诊断剂的分子识别元件al（1,11,111）。

7. 发明申请

WO2012013617A2 POLYMERIC COMPLEMENTS TO B-AMYLOID PEPTIDES 审中-公开
标题翻译：聚合物补充到B-淀粉样肽
公开(公告)号：WO2012013617A2
公开(公告)日：2012-02-02
申请号：PCT/EP2011/062712
申请日：2011-07-25
申请人： TECHNISCHE UNIVERSITÄT DORTMUND , SELLERGREN, Börje , ANTUNES AURELIANO, Carla Sofia , URRACA RUIZ, Javier , SCHILLINGER, Eric
发明人： SELLERGREN, Börje , ANTUNES AURELIANO, Carla Sofia , URRACA RUIZ, Javier , SCHILLINGER, Eric
IPC分类号： B01J20/26 , C07K14/47 , G01N33/68
CPC分类号： A61K51/065 , A61K49/12 , B01J20/268 , C07K14/4711 , C07K17/14 , G01N33/6896 , G01N2800/2821
摘要： The present invention relates to the preparation and use of polymer complements to β-amyloid peptides (Αβ) for detecting soluble or aggregated Αβ in fluid samples or for treating a subject having a neurodegenerative disease.
摘要翻译：本发明涉及用于检测流体样品中的可溶性或聚集的Aβ或用于治疗患有神经变性疾病的受试者的β-淀粉样肽（Aβ）的聚合物补体的制备和用途。 >

8. 发明申请

WO2011071447A1 MOLECULAR IMPRINTS 审中-公开
标题翻译：分子印迹
公开(公告)号：WO2011071447A1
公开(公告)日：2011-06-16
申请号：PCT/SE2010/051352
申请日：2010-12-08
申请人： NICHOLLS, Ian A. , NILSSON-EKDAHL, Kristina
发明人： NICHOLLS, Ian A. , NILSSON-EKDAHL, Kristina
IPC分类号： G01N33/545 , B01J20/26
CPC分类号： G01N33/5308 , A61M1/3673 , B01J20/268 , G01N2400/40 , G01N2600/00
摘要： The invention relates to a polymer network surface having a plurality of molecular imprints from components in blood and the ability to bind said components present in blood. Examples of components include exogenous components as well as endogenous such as endogenous coagulation cascade inhibitors or glycosaminoglycan. The invention also relates to implants or extracorporeal devices comprising said polymer network surfaces or a method producing them.
摘要翻译：本发明涉及一种聚合物网络表面，其具有来自血液中的成分的多种分子印记和结合存在于血液中的所述成分的能力。组分的实例包括外源成分以及内源性如内源性凝血级联抑制剂或糖胺聚糖。本发明还涉及包括所述聚合物网络表面的植入物或体外装置或其制备方法。

9. 发明申请

WO2011033021A2 IMPROVED PURIFICATION OF MULTI-SPECIFIC RECEPTORS 审中-公开
标题翻译：改善多特异性受体的纯化
公开(公告)号：WO2011033021A2
公开(公告)日：2011-03-24
申请号：PCT/EP2010/063614
申请日：2010-09-16
申请人： MIPSALUS APS , KROGH, Nicolas, Otto , GREGORIUS, Klaus
发明人： KROGH, Nicolas, Otto , GREGORIUS, Klaus
IPC分类号： B01D15/38
CPC分类号： A61K31/74 , B01D15/1807 , B01D15/3804 , B01J20/26 , B01J20/268
摘要： Disclosed is a method for preparing a composition enriched for receptors (typically molecular impringet polymers, MIPs) that bind an agent, where said receptors each specifically bind at least two discrete sites on said agent, by subjecting a sample of receptors to a first step of affinity purification with the agent where one binding site on the agent is non-accessible for binding to the receptors and subsequently subjecting the purified receptors to at least one further step of affinity purification with the agent where a second binding site on the agent is non-accessible. Also disclosed is a method for treatment, amelioration or prophylaxis of a disease selected from the group consisting of phenylketonuria (PKU, Følling's disease), hyperphenylalaninemia (HPA), alcaptonuria (black urine disease), tyrosinemia, hypertyrosinemia, myasthenia gravis, histidinemia, urocanic aciduria, maple syrup urine disease (MSUD), isovaleric acidemia (isovaleryl-CoA dehydrogenase deficiency), homocystinuria, propionic acidemia, methylmalonic acidemia, and glutaric aciduria Type 1 (GA-I), galactosemia, comprising administering to the gastrointestinal tract of a patient in need thereof an effective amount of a composition of molecular imprinted polymers (MIPs), said composition being capable of binding a symptom provoking agent of said disease.
摘要翻译：公开了一种制备富集结合试剂的受体（通常是分子侵入物聚合物，MIP）的组合物的方法，其中所述受体通过使受体样品经受第一步的第一步，每个特异性结合所述试剂上的至少两个离散位点与试剂亲和纯化，其中试剂上的一个结合位点不能与受体结合，随后使纯化的受体与试剂上的第二结合位点不相容的至少一个亲和纯化的另外步骤进行，无障碍。还公开了治疗，改善或预防选自苯丙酮尿症（PKU，Følling氏病），高苯丙氨酸血症（HPA），尿磷酸尿症（黑尿病），酪氨酸血症，高铁血症，重症肌无力，组氨酸血症，尿路感染尿酸，枫糖尿病（MSUD），异戊酸 - 乙酰脱氢酶缺乏症，同型半胱氨酸尿，丙酸血症，甲基丙二酸血症和戊二酸1型糖尿病（GA-I），半乳糖血症，包括给予患者胃肠道在需要时，有效量的分子印迹聚合物（MIP）的组合物，所述组合物能够结合所述疾病的症状发作剂。

10. 发明申请

WO2010092071A1 CUSTOMIZED MOLECULARLY IMPRINTED POLYMER (MIP) UNITS 审中-公开
标题翻译：定制的分子量聚合物（MIP）单位
公开(公告)号：WO2010092071A1
公开(公告)日：2010-08-19
申请号：PCT/EP2010/051629
申请日：2010-02-10
申请人： IMEGO AKTIEBOLAG , KROZER, Anatol , REIMHULT, Kristina , LÖFVING, Björn , MALM, Björn , YE, Lei , YOSHIMATSU, Keiichi
发明人： KROZER, Anatol , REIMHULT, Kristina , LÖFVING, Björn , MALM, Björn , YE, Lei , YOSHIMATSU, Keiichi
IPC分类号： C08F2/44 , C08F2/06 , B01J20/26 , C08F8/00 , B01D15/38 , G01N33/58 , C08F8/14 , C08F8/10 , C08F220/06
CPC分类号： C08F8/14 , B01D15/3852 , B01J20/26 , B01J20/268 , B01J2220/54 , C08F2/14 , C08F2/44 , C08F8/10 , C08F220/06 , C08F2222/1026 , G01N2600/00 , Y10T428/2982
摘要： A method of manufacturing at least one customized MIP unit comprising: (a) providing at least one MIP unit having a surface comprising at least one target binding site configured to resemble a target molecule and surface-bound chargeable groups; (b) contacting the MIP unit(s) from the step (a) with at least one template molecule in a first solvent allowing the template molecule (s) to bind to the MIP unit(s); (c) passivating the surface-bound chargeable groups on the MIP unit(s) by adding a passivating agent; and (d) removing the template molecule (s) by washing in a second solvent, wherein the passivating agent binds to the surface of the unit(s) through bonds which remain stable upon washing in the second solvent.
摘要翻译：一种制造至少一个定制的MIP单元的方法，包括：（a）提供至少一个MIP单元，其具有包括至少一个目标结合位点的表面，所述靶结合位点被配置为类似于目标分子和表面结合的可带电基团; （b）使来自步骤（a）的MIP单元与第一溶剂中的至少一个模板分子接触，允许模板分子与MIP单元结合; （c）通过添加钝化剂钝化MIP单元上的表面结合的可充电基团; 和（d）通过在第二溶剂中洗涤去除模板分子，其中钝化剂通过在第二溶剂中洗涤时保持稳定的键而与单元的表面结合。

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