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1. 发明申请

WO2019121068A1 FLUOROPHORE MULTIPLEXING VIA PH MODULATION 审中-公开
公开(公告)号：WO2019121068A1
公开(公告)日：2019-06-27
申请号：PCT/EP2018/083987
申请日：2018-12-07
申请人： ROBERT BOSCH GMBH
发明人： AHMAD, Habibullah , LAERMER, Franz , STEIGERT, Juergen , JOHNSON, Christopher , STALEY, Patrick , FOMINA, Nadezda , LANG, Christoph
IPC分类号： C12Q1/68 , C12Q1/6825 , G01N33/537 , G01N33/543 , G01N33/58
CPC分类号： G01N21/6428 , C12M23/16 , C12Q1/68 , C12Q1/6825 , G01N21/6486 , G01N33/533 , G01N33/5438 , G01N33/582 , G01N2021/6441 , C12Q2527/119 , C12Q2537/143 , C12Q2563/107 , C12Q2563/113 , C12Q2523/115 , C12Q2565/102 , C12Q2565/607
摘要： An apparatus to detect more than one analyte in a solution comprising at least one electrode in contact with the solution, at least two dyes including a first dye and a second dye, and an electrochemically active agent, where the solution has a pH, the electrode is configured to modulate the pH of the solution by oxidizing or reducing the electrochemically active agent, the first dye and the second dye fluoresce at different pH levels, fluorescence of the first dye is used to indicate the presence of a first analyte, and fluorescence of the second dye is used to indicate the presence of a second analyte. Methods of detecting multiple analytes in a solution are also provided.

2. 发明申请

WO2019075292A1 PROSTATE CANCER PROTEASE NANOSENSORS AND USES THEREOF 审中-公开
公开(公告)号：WO2019075292A1
公开(公告)日：2019-04-18
申请号：PCT/US2018/055557
申请日：2018-10-12
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： DUDANI, Jaideep, S. , BHATIA, Sangeeta, N.
IPC分类号： G01N33/543 , G01N33/58
CPC分类号： G01N27/3278 , C12Q1/005 , G01N33/54353 , G01N33/5438 , G01N33/57434 , G01N33/582
摘要： In some aspects, the disclosure relates to compositions and method for detection, classification, and treatment of prostate cancer. In some embodiments, the disclosure relates to prostate protease nanosensors comprising a scaffold linked to a prostate-specific substrate that include a detectable marker capable of being released from the prostate protease nanosensor when exposed to an enzyme present in a prostate. In some embodiments, the disclosure relates to methods of classifying prostate cancer in a subject based upon detection of detectable markers in a sample obtained from a subject who has been administered prostate protease nanosensors.

3. 发明申请

WO2018229663A1 BIS-ACETAL-BASED SUBSTRATES FOR IMAGING EXO-GLYCOSIDASE ACTIVITY 审中-公开
公开(公告)号：WO2018229663A1
公开(公告)日：2018-12-20
申请号：PCT/IB2018/054273
申请日：2018-06-12
申请人： ALECTOS THERAPEUTICS INC.
发明人： VOCADLO, David J. , CECIONI, Samy
IPC分类号： C07H15/26 , A61K49/00 , C12Q1/34 , G01N33/52
CPC分类号： C12Q1/34 , C07H15/26 , G01N33/582
摘要： The invention provides fluorescence-quenched substrates of exo -glycosidase enzymes. The invention also provides methods for imaging exo -glycosidase enzymes activity within cells.

4. 发明申请

WO2018167502A1 LABELLED KINASES FOR DRUG DISCOVERY 审中-公开
公开(公告)号：WO2018167502A1
公开(公告)日：2018-09-20
申请号：PCT/GB2018/050677
申请日：2018-03-15
申请人： IMPERIAL INNOVATIONS LIMITED
发明人： DODSON, Charlotte A. , GILBURT, James A. H. , YING, Liming
IPC分类号： A61K31/00 , C12Q1/48 , G01N21/64 , G01N33/58
CPC分类号： C12Q1/485 , A61K45/06 , C12Q1/48 , G01N33/573 , G01N33/58 , G01N33/582
摘要： A kinase or kinase fragment comprising a first label and a second label, wherein: the kinase or kinase fragment has a first conformation and second conformation; one or both of the first and second label are fluorophores; the first label and second label comprise an interacting pair capable of interacting with each other by static quenching or Dexter quenching or PET (photoinduced electron transfer) or exciplex formation to produce a quenched pair; and wherein the first and second labels are positioned on the kinase or kinase fragment such that when the kinase or kinase fragment is in the first conformation the labels are distal to each other such that static quenching or PET or Dexter quenching or exciplex formation does not occur and when the kinase or kinase fragment is in the second conformation the labels are brought into close proximity such that static quenching or PET or Dexter quenching or exciplex formation of one or both labels occurs.

5. 发明申请

WO2018128974A1 CHARACTERIZATION OF TYPE 1 COLLAGEN SYNTHESIS BY FLUORESCENCE IMAGING AND RELATED DRUG SCREENING TECHNIQUE 审中-公开
公开(公告)号：WO2018128974A1
公开(公告)日：2018-07-12
申请号：PCT/US2018/012045
申请日：2018-01-02
申请人： FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
发明人： STEFANOVIC, Branko
IPC分类号： A61K31/7088 , A61K38/39 , A61K39/395 , C07K7/64 , C12Q1/02 , C12Q1/37
CPC分类号： G01N33/6887 , G01N33/5008 , G01N33/5038 , G01N33/582 , G01N2333/78
摘要： A method includes fluorescence imaging a cell that synthesizes Type 1 collagen. The cell includes a first gene encoding collagen a1(I) tagged with a first fluorescent tag and a second gene encoding collagen a2(I) tagged with a second fluorescent tag.

6. 发明申请

WO2018098142A1 METHODS FOR COMPLETE BLOOD COUNT MEASUREMENT 审中-公开
公开(公告)号：WO2018098142A1
公开(公告)日：2018-05-31
申请号：PCT/US2017/062765
申请日：2017-11-21
申请人： CYTOCHIP INC.
发明人： SHI, Wendian , DING, Yuzhe
IPC分类号： G01N15/02 , G01N15/14 , G01N21/05 , G01N21/64 , G01N33/52
CPC分类号： G01N15/1459 , G01N15/0205 , G01N15/0227 , G01N15/1404 , G01N15/1429 , G01N15/1434 , G01N33/56972 , G01N33/582 , G01N33/80 , G01N2015/0065 , G01N2015/1486
摘要： The disclosure relates to devices and methods for analyzing blood cells in a sample. In various embodiments, the present disclosure provides devices and methods of performing complete blood count (CBC) testing. In various embodiments, the present disclosure provides a cartridge device and a reader instrument device, wherein the reader instrument device receives, operates, and/or actuates the cartridge device. In various embodiments, the present disclosure provides a method of using a device as disclosed herein for analyzing blood cells in a sample.

7. 发明申请

WO2018073267A1 USES, METHODS, KITS, COMPOSITIONS AND ANTIBODIES FOR IDENTIFYING HEMATOPOIETIC CELL SUBTYPES 审中-公开
标题翻译：用于鉴别造血细胞亚型的用途，方法，试剂盒，组合物和抗体
公开(公告)号：WO2018073267A1
公开(公告)日：2018-04-26
申请号：PCT/EP2017/076517
申请日：2017-10-17
申请人： OSPEDALE SAN RAFFAELE S.R.L. , FONDAZIONE TELETHON
发明人： BASSO-RICCI, Luca , BIASCO, Luca , AIUTI, Alessandro
IPC分类号： G01N15/14 , G01N33/50 , G01N33/532 , G01N33/533
CPC分类号： G01N15/1459 , G01N33/5094 , G01N33/582 , G01N2015/1006 , G01N2015/1402
摘要： Use of (i) an anti-CD3 antibody, (ii) an anti-CD56 antibody, (iii) an anti-CD14 antibody, (iv) an anti-CD38 antibody, (v) an anti-CD45 antibody, (vi) an anti-CD90 antibody, (vii) an anti- CD135 antibody, (viii) an anti-CD10 antibody, (ix) an anti-CD11c antibody, (x) an anti-CD19 antibody, (xi) an anti-CD34 antibody, (xii) an anti-CD45RA antibody, (xiii) an anti-CD7 antibody, (xiv) an anti-CD71 antibody, (xv) an anti-CD41/CD61 complex antibody or an anti- CD41 antibody and/or an anti-CD61 antibody (xvi) an anti-CD33 antibody and/or an anti- CD66b antibody, for identifying hematopoietic cell subtypes in an isolated sample, determining the relative frequency of hematopoietic cell subtypes in an isolated sample and/or quantifying the number of cells within hematopoietic cell subtypes in an isolated sample, wherein each of (i) to (xvi) is labelled with a different fluorochrome, wherein when (xvi) is an anti-CD33 antibody and an anti-CD66b antibody, the anti-CD33 antibody and anti-CD66b are labelled with the same fluorochrome, and wherein when (xv) is an anti-CD41 antibody and an anti-CD61 antibody, the anti-CD4 antibody and the anti-CD61 antibody are labelled with the same fluorochrome.
摘要翻译：（i）抗CD3抗体，（ii）抗CD56抗体，（iii）抗CD14抗体，（iv）抗CD38抗体，（v）（vi）抗CD90抗体，（vii）抗CD135抗体，（viii）抗CD10抗体，（ix）抗CD11c抗体，（x）抗CD19抗体，（xi）抗CD34抗体，（xii）抗CD45RA抗体，（xiii）抗CD7抗体，（xiv）抗CD71抗体，（xv）抗CD41 / CD61复合体抗体或抗CD41抗体 -CD41抗体和/或抗CD61抗体（xvi）抗CD33抗体和/或抗CD66b抗体，用于鉴定分离的样品中的造血细胞亚型，确定分离的样品中造血细胞亚型的相对频率和/或量化分离的样品中造血细胞亚型内细胞的数量，其中（i）至（xvi）中的每一个用不同的荧光染料标记，其中当（xvi）是抗CD33抗体和抗CD66b 抗体，抗CD33抗体和a nti-CD66b用相同的荧光染料标记，并且其中当（xv）是抗CD41抗体和抗CD61抗体时，用相同的荧光染料标记抗CD4抗体和抗CD61抗体。

8. 发明申请

WO2018048477A1 ENGINEERING AND UTILITY OF FLUORESCENT NANODIAMOND PARTICLES (NDP-F) FOR DIAGNOSTICS AND TREATMENT OF BLOOD CLOTS IN HUMAN AND VETERINARY MEDICINE 审中-公开
标题翻译：荧光纳米颗粒（NDP-F）用于人体和兽医血液学诊断和治疗的工程及应用
公开(公告)号：WO2018048477A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/025742
申请日：2017-04-03
申请人： DEBINA DIAGNOSTICS, INC.
发明人： FEUERSTEIN, Giora, Z. , STERNBERG, Mark, E.
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , A61P7/00 , A61P9/00 , A61P9/10 , A61P35/00
CPC分类号： A61P7/00 , A61P9/00 , A61P9/10 , A61P35/00 , G01N33/582 , G01N33/68 , G01N33/6893 , G01N2800/32
摘要： The present invention provides an imaging agent for identifying sites of platelet activation. As such, it provides methods for identifying thrombus formation in a human or non-human animal, methods for making the imaging agent, and kits for use of the imaging.
摘要翻译：本发明提供了用于鉴定血小板活化部位的显像剂。因此，它提供了用于识别人类或非人类动物中血栓形成的方法，制备显像剂的方法以及用于成像的试剂盒。

9. 发明申请

WO2018017738A1 METHODS FOR FLUORESCENCE IMAGING MICROSCOPY 审中-公开
标题翻译：荧光成像显微镜的方法
公开(公告)号：WO2018017738A1
公开(公告)日：2018-01-25
申请号：PCT/US2017/042896
申请日：2017-07-19
申请人： ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES , UNIVERSITY OF WASHINGTON
发明人： STAMATOYANNOPOULOS, John, A. , AKILESH, Shreeram
IPC分类号： C12P19/34 , C12Q1/68 , C40B30/04 , C40B40/06 , G01N21/64 , G01N21/78
CPC分类号： G01N21/64 , A01N1/0221 , C12N5/0634 , C12N5/0694 , C12P19/34 , C12Q1/6837 , C12Q1/6841 , C40B30/04 , C40B40/06 , G01N1/30 , G01N21/6458 , G01N21/78 , G01N33/56966 , G01N33/574 , G01N33/582 , G01N2015/0038 , C12Q2521/301 , C12Q2563/107
摘要： Disclosed herein are methods of detecting a regulatory element, determining the localization of a regulatory element, and/or measuring the activity of a regulatory element.
摘要翻译：本文公开了检测调节元件，确定调节元件的定位和/或测量调节元件的活性的方法。

10. 发明申请

WO2017100347A1 MICROFLUIDIC DEVICES AND KITS AND METHODS FOR USE THEREOF 审中-公开
标题翻译：微流体装置和套件及其使用方法
公开(公告)号：WO2017100347A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/065426
申请日：2016-12-07
申请人： BERKELEY LIGHTS, INC.
发明人： BEAUMONT, Kristin, G. , BEEMILLER, Peter, J. , KURZ, Volker, L., S. , LAVIEU, Gregory, G. , WANG, Xiaohua
IPC分类号： G01N33/543 , B01L3/00
CPC分类号： G01N33/54386 , B01L3/502707 , B01L3/502761 , B01L3/502792 , B01L2200/0668 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2400/0424 , B01L2400/0427 , G01N33/54366 , G01N33/545 , G01N33/582
摘要： In situ-generated microfluidic capture structures incorporating a solidified polymer network, methods of preparation and use, compositions and kits therefor are described. Microfluidic capture structures may be advantageously used for assays performed within the microfluidic environment, providing flexibility in assaying micro-objects such as biological cells. Assay reagents and analytes may be incorporated within the microfluidic capture structures.
摘要翻译：描述了包含固化聚合物网络的原位产生的微流体捕获结构，制备和使用的方法，组合物和试剂盒。微流体捕获结构可以有利地用于在微流体环境内执行的分析，为分析诸如生物细胞的微物体提供灵活性。分析试剂和分析物可以结合到微流体捕获结构中。

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