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21. 发明申请

WO2004073491A8 BATTERY-POWERED PATIENT IMPLANTABLE DEVICE 审中-公开
标题翻译：电池供电的患者植入装置
公开(公告)号：WO2004073491A8
公开(公告)日：2006-11-16
申请号：PCT/US2004004088
申请日：2004-02-11
申请人： MANN ALFRED E FOUND SCIENT RES
发明人： SCHULMAN JOSEPH H , DELL ROBERT DAN , GORD JOHN C
IPC分类号： A61B19/00 , A61B20060101 , A61B5/00 , A61B5/053 , A61B5/07 , A61F2/50 , A61F2/70 , A61F2/72 , A61N1/372 , A61N1/378
CPC分类号： A61N1/3787 , A61B5/0031 , A61B5/053 , A61B5/07 , A61B5/145 , A61B5/14532 , A61B5/4519 , A61B2560/0219 , A61B2562/08 , A61F2/72 , A61F2002/5058 , A61F2002/704 , A61F2002/705 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37288
摘要： A device configured for implanting beneath a patient's skin for the purpose of tissue, e.g., nerve or muscle, stimulation and/or parameter monitoring and/or data communication. Devices in accordance with the invention are comprised of a sealed housing (100), typically having an axial dimension of less than 60 mm and a lateral dimension of less than 6 mmm, having a non-circular cross-section containing a power source for powering electronic circuitry within including a controller, an address storage means, a data signal receiver and an input/output transducer.
摘要翻译：为了组织（例如神经或肌肉），刺激和/或参数监测和/或数据通信的目的而配置用于植入患者皮肤下方的装置。根据本发明的设备包括密封外壳（100），其通常具有小于60mm的轴向尺寸和小于6mm的横向尺寸，具有非圆形横截面，其包含用于供电的电源包括控制器内的电子电路，地址存储装置，数据信号接收器和输入/输出换能器。

22. 发明申请

WO2004044163A3 METHODS FOR IDENTIFYING RISK OF MELANOMA AND TREATMENTS THEREOF 审中-公开
标题翻译：用于鉴定MELANOMA及其治疗的风险的方法
公开(公告)号：WO2004044163A3
公开(公告)日：2006-10-05
申请号：PCT/US0335876
申请日：2003-11-06
申请人： SEQUENOM INC
发明人： ROTH RICHARD B , NELSON MATTHEW ROBERTS , BRAUN ANDREAS , KAMMERER STEFAN M
IPC分类号： A61K35/12 , A61B20060101 , A61K31/4745 , A61K33/24 , A61K38/16 , A61K38/17 , A61K38/45 , A61K39/395 , A61K48/00 , A61P35/00 , C07H21/00 , C07K14/47 , C12N20060101 , C12N1/00 , C12N5/06 , C12N9/10 , C12N15/12 , C12N15/54 , C12Q1/68
CPC分类号： C07K14/4748 , C12Q1/6827
摘要： Provided herein are methods for identifying risk of melanoma in a subject and/or subjects at risk of melanoma, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating melanoma, therapeutic methods for treating melanoma in a subject and compositions comprising one or more melanoma cells and one or more NRPl, NID2 or END0180 directed agents. These embodiments are based upon an analysis of polymorphic variations in a NRPl, NID2 or END0180 nucleic acid, exemplified by nucleotide sequences of SEQ ID NO: 1, 2 or 3.
摘要翻译：本文提供用于鉴定受试者和/或患有黑素瘤风险的受试者的黑色素瘤的风险的方法，用于实施该方法的试剂和试剂盒的方法，用于鉴定治疗黑素瘤的候选治疗剂的方法，用于治疗受试者的黑色素瘤的治疗方法和包含一种或多种黑素瘤细胞和一种或多种NRP1，NID2或END0180定向药剂。这些实施方案基于NRP1，NID2或END0180核酸中的多态性变异的分析，例如SEQ ID NO：1,2或3的核苷酸序列。

23. 发明申请

WO2005016120A3 GRAFTED NETWORK INCORPORATING A MULTIPLE CHANNEL FLUID FLOW CONNECTOR 审中-公开
标题翻译：集成多个通道流体连接器的网络
公开(公告)号：WO2005016120A3
公开(公告)日：2006-09-14
申请号：PCT/US2004024743
申请日：2004-08-03
申请人： CABG MEDICAL INC , VILLAFANA MANUEL A , PALMQUIST WILLIAM E , FLETCHER BRUCE
发明人： VILLAFANA MANUEL A , PALMQUIST WILLIAM E , FLETCHER BRUCE
IPC分类号： A61B20060101 , A61B17/00 , A61F2/00 , A61F2/06 , A61M5/00 , A61M37/00 , A61B17/08
CPC分类号： A61F2/06 , A61B2017/00243 , A61F2002/065 , A61F2250/0039
摘要： A grafted network (10) including one or more graft segments (11, 16, 18) for use in coronary bypass procedures and which are configured to operably transport bypass blood flow from a singular supply location to one or more delivery locations, and which is provided in combination with one or more flow multiple channel blood flow connectors(13, 112, 144, 176,213) for directing such bypass blood flow in the grafted network to one or more vascular members requiring restorative blood flow thereto. The grafted network also preferably includes one or more devices for operably maintaining the grafted network under relatively high internal fluid pressure so as to continuously supply selective vascular members with adequate bypass blood flow.
摘要翻译：一种移植网络（10），包括一个或多个用于冠状动脉旁路手术的移植物段（11,16,18），并且被构造成将旁路血流从单个供应位置运输到一个或多个递送位置，提供与一个或多个流动多通道血流连接器（13,112,144,176,213）组合，用于将所述移植网络中的旁路血流引导到需要恢复性血液流动的一个或多个血管构件。接枝网络还优选地包括一个或多个装置，用于在相对较高的内部流体压力下可操作地保持接枝网络，以便以适当的旁路血流连续供应选择性血管构件。

24. 发明申请

WO2004069037A3 MULTIDIAMETER SYRINGE FAMILIES 审中-公开
标题翻译：多种类的SYRINGE家族
公开(公告)号：WO2004069037A3
公开(公告)日：2006-09-14
申请号：PCT/US2004003007
申请日：2004-02-03
申请人： SCIENCE AND TECHNOLOGY CORP UN
发明人： SIBBITT WILMER L
IPC分类号： A61M5/00 , A61B20060101 , A61M5/315 , A61M5/32
CPC分类号： A61M5/31511 , A61M5/3213 , A61M5/3243 , A61M2005/31516 , A61M2005/3215
摘要： Danger from pricks by contaminated hypodermic needles is reduced by the configuring of a family of single diameter and multiple diameter syringes that accommodate conventional hypodermic needles but also a variety of universal needle-based guards, shields, and safety needles. The family of syringes has as a common property among all the members of the family, a standardized diameter (d) of that portion of the syringe barrel (240) adjacent the needle (210). The portion of the syringe barrels in the family having the standardized diameter can accommodate universal safety needles regardless of the volume of the syringe.
摘要翻译：通过配置容纳常规皮下注射针的单直径和多重直径注射器系列，还可以通过各种通用的针头护罩，护罩和安全针来减少被污染的皮下注射针刺伤的刺痛。所述注射器系列在家庭的所有成员中具有共同的属性，即与针（210）相邻的注射器筒（240）的该部分的标准化直径（d）。具有标准化直径的家庭中的注射器筒的部分可以容纳通用安全针，而与注射器的体积无关。

25. 发明申请

WO2005006947A3 CELLS FOR USE IN LOCATING AND TARGETING TUMOR CELLS 审中-公开
标题翻译：用于定位和靶向肿瘤细胞的细胞
公开(公告)号：WO2005006947A3
公开(公告)日：2006-09-08
申请号：PCT/US2004021490
申请日：2004-07-02
申请人： FORD HENRY HEALTH SYSTEM , CHOPP MICHAEL , ZHANG ZHENGGANG
发明人： CHOPP MICHAEL , ZHANG ZHENGGANG
IPC分类号： A61B5/1477 , A61B20060101 , A61B5/055 , A61B5/1468 , A61K48/00 , C12N5/00 , C12N5/0775 , C12N5/0789 , C12N5/0797 , C12N5/16 , C12N5/22
CPC分类号： A61K35/30 , A61K35/28 , A61K38/208 , C12N5/0623 , C12N5/0647 , C12N5/0663 , C12N2501/23 , C12N2510/00 , A61K2300/00
摘要： A composition for locating tumors, the composition includes adult cells capable of locating tumor cells. Scout cells for use in locating and treating tumors. A method of locating and treating a tumor by administering to a patient an effective amount of scout cells, wherein the scout cells locate and subsequently treat a tumor.
摘要翻译：用于定位肿瘤的组合物，该组合物包括能够定位肿瘤细胞的成体细胞。 Scout细胞用于定位和治疗肿瘤。通过向患者施用有效量的侦察细胞来定位和治疗肿瘤的方法，其中侦察细胞定位并随后治疗肿瘤。

26. 发明申请

WO2004071279A3 SURGICAL DRAIN WITH SENSORS FOR TISSUE MONITORING 审中-公开
标题翻译：具有组织监测传感器的外科漏斗
公开(公告)号：WO2004071279A3
公开(公告)日：2006-07-27
申请号：PCT/US2004003807
申请日：2004-02-09
申请人： ALFRED E MANN INST BIOMED ENG , SHEHADA RAMEZ EMILE NECOLA , JABBOUR NICOLAS
发明人： SHEHADA RAMEZ EMILE NECOLA , JABBOUR NICOLAS
IPC分类号： A61M1/00 , A61B20060101 , A61B1/00 , A61B1/07 , A61B5/00 , A61B5/03 , A61B6/00 , A61B8/00 , A61B10/00 , A61M27/00
CPC分类号： A61B5/6882 , A61B5/0031 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/01 , A61B5/036 , A61B5/145 , A61B5/14503 , A61B5/14539 , A61B5/1459 , A61B5/412 , A61B5/413 , A61B5/42 , A61B5/6885 , A61B2562/228 , A61M27/002
摘要： The present invention is directed to devices and methods of using a surgical drain, and more particularly to a surgical drain having at least one sensor for monitoring and/or recording the condition of the anatomical site or fluid emitted from the site where the surgical drain is placed. The invention may also include modifications of the surgical drain to improve stabilization or immobilization in the proximity of the anatomical site to be monitored.
摘要翻译：本发明涉及使用手术排水管的装置和方法，更具体地涉及一种具有至少一个传感器的手术排泄物，所述传感器用于监测和/或记录解剖部位的状况或从手术排泄物的位置发射的液体放置。本发明还可以包括手术排水管的改进，以改善在要被监测的解剖部位附近的稳定性或固定。

27. 发明申请

WO2004091382A3 MONITORING CIRCADIAN ACTIVITY 审中-公开
标题翻译：监测CIRCADIAN活动
公开(公告)号：WO2004091382A3
公开(公告)日：2006-07-20
申请号：PCT/US2004009699
申请日：2004-03-31
申请人： CARNEGIE INST OF WASHINGTON , BORJIGIN JIMO
发明人： BORJIGIN JIMO
IPC分类号： C07D209/16 , A61B20060101 , A61B5/00 , A61B17/16 , A61K49/00
CPC分类号： G01N33/9406 , A61B5/415 , A61B5/4857 , G01N33/5058 , G01N33/5088 , G01N33/942 , G01N2800/2864
摘要： The invention is directed to a new method for long-term measurement of daily serotonin (5-HT) and melatonin contents in the pineal gland. The disclosed method allows visualization of the pineal gland for accurate targeting of the guide cannula which minimizes bleeding, incurs no direct injury to the surrounding brain tissue and cause no interference with the sympathetic innervation from the superior cervical ganglion. The improved method allows effects of pharmacological agents on in vivo pineal gland circulation to be studied reproducibly over time and gene expression profiles correlated with physiological consequences in the same or different individuals. More importantly, the method allows accurate assessment of the endogenous circadian clock function. The method can be used for high throughput screening to identify candidate agents which may accelerate adaptation to new time zones, to alleviate symptoms resulting from jet lag, frequent shift work sleep abnormalities and seasonal affective illnesses.
摘要翻译：本发明涉及一种用于长期测量松果体中日常5-羟色胺（5-HT）和褪黑激素含量的新方法。所公开的方法允许松果体的可视化以精确地定向引导套管，从而使出血最小化，不会对周围脑组织造成直接的伤害，并且不会妨碍来自上颈椎神经节的交感神经支配。改进的方法允许药物剂对体内松果体循环的影响随着时间的推移可重复研究，基因表达谱与相同或不同个体的生理后果相关。更重要的是，该方法可以准确评估内源昼夜节律钟功能。该方法可用于高通量筛选以鉴定可加速适应新时区的候选药物，以减轻由于时差，频繁换班工作睡眠异常和季节性情感疾病引起的症状。

28. 发明申请

WO2005034719A3 CANDIDATE GENES, PATHWAYS AND MECHANISMS FOR BIPOLAR AND RELATED DISORDERS 审中-公开
标题翻译：候鸟基因，途径和机制用于双极和相关疾病
公开(公告)号：WO2005034719A3
公开(公告)日：2006-07-13
申请号：PCT/US2004015261
申请日：2004-05-17
申请人： UNIV CALIFORNIA , NICULESCU ALEXANDER B , KUCZENSKI RONALD T , LOHR JAMES B
发明人： NICULESCU ALEXANDER B , KUCZENSKI RONALD T , LOHR JAMES B
IPC分类号： C12Q1/68 , A61B20060101 , C07H21/04
CPC分类号： C12Q1/6883 , B82Y15/00 , B82Y30/00 , C12Q2600/158
摘要： Identification of nucleic acids and gene expression profiles involved in neuropsychiatric disorders (e.g., bipolar and related disorders), and the use of such expression profiles and nucleic acids in methods for identifying candidate agents which modulate neuropsychiatric disorders or neuropsychiatric disorder susceptibility. Methods and reagents for the diagnosis and treatment of neuropsychiatric disorders. Methods for the diagnosis of neuropsychiatric disorders and susceptibility to neuropsychiatric disorders by detecting polymorphisms, mutations, variations, alterations in expression, and the like, in neuropsychiatric disorder-related genes, or polymorphisms linked to these genes. Compositions and methods for treating neuropsychiatric disorders or neuropsychiatric disorder susceptibility. Pharmaceutical compositions for treating a neuropsychiatric disorder or neuropsychiatric disorder susceptibility are provided.
摘要翻译：鉴定参与神经精神障碍（例如双相和相关病症）的核酸和基因表达谱，以及这些表达谱和核酸在鉴定调节神经精神障碍或神经精神障碍易感性的候选药物的方法中的用途。用于诊断和治疗神经精神障碍的方法和试剂。通过检测神经精神障碍相关基因中的多态性，突变，变异，表达变化等，或与这些基因相关的多态性来诊断神经精神障碍和对神经精神障碍的敏感性的方法。用于治疗神经精神障碍或神经精神障碍易感性的组合物和方法。提供了用于治疗神经精神障碍或神经精神障碍易感性的药物组合物。

29. 发明申请

WO2005058133A3 IMPLANTABLE PRESSURE SENSORS 审中-公开
标题翻译：可压式传感器
公开(公告)号：WO2005058133A3
公开(公告)日：2006-06-22
申请号：PCT/US2004041430
申请日：2004-12-10
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK , COSTELLO BENEDICT JAMES
发明人： ZDEBLICK MARK , COSTELLO BENEDICT JAMES
IPC分类号： A61B20060101 , A61B5/0215 , A61N1/362 , A61N1/365 , G01L9/00 , G01L9/04 , G01L9/06 , H01L21/44 , H01L21/48 , G01B7/16 , G01L1/04 , G01L1/26
CPC分类号： A61B5/0215 , A61B5/412 , A61B2562/02 , A61N1/3627 , A61N1/36564 , G01L9/0042 , G01L9/0055 , G01L9/045 , G01L9/065
摘要： Implantable pressure sensor (20) and method for making and using the same are provided. A feature of the embodiments of the subject pressure sensors is that they are low-drift sensors. The subject sensors find use in a variety of applications.
摘要翻译：提供了可植入压力传感器（20）及其制造和使用方法。本发明的压力传感器的实施例的特征在于它们是低漂移传感器。主题传感器可用于各种应用。

30. 发明申请

WO2005042858A3 CURED-IN-PLACE CONSTRUCTION SYSTEM AND METHOD 审中-公开
标题翻译：固定式施工系统和方法
公开(公告)号：WO2005042858A3
公开(公告)日：2006-06-22
申请号：PCT/US2004036458
申请日：2004-11-01
申请人： UNIV SOUTHERN CALIFORNIA , TEITELBAUM GEORGE P , LARSEN DONALD W
发明人： TEITELBAUM GEORGE P , LARSEN DONALD W
IPC分类号： B32B1/00 , A61B20060101 , A61B17/58 , A61B17/88 , B32B1/08 , E04B20060101
CPC分类号： E04B1/30 , E04B1/1903 , E04B1/35 , E04B1/58 , E04B2001/1939 , E04C5/01 , E04C5/07 , E04H2015/201 , F16L13/11 , Y10T428/1393
摘要： A construction system of a plurality of interlocking construction elements is disclosed. At least one of the interlocking elements is a cured-in-place element (10) having a pliable exterior shell defining a cavity and a strength-imparting core placed inside the cavity. The system also includes a hardenable media for filling the cavity. The exterior shell of the cured-in-place element is adapted to expand as its cavity is filled with the hardenable media or as the hardenable media cures, whereby the interlocking elements bond into an integral structure (30) by an interference fit or a friction fit. Methods of construction of new structures and reinforcement of preexisting ones are also disclosed.
摘要翻译：公开了一种多个互锁构造元件的构造系统。互锁元件中的至少一个是固化元件（10），其具有限定空腔的柔性外壳和放置在腔内的强度赋予芯。该系统还包括用于填充空腔的可硬化介质。固化固化元件的外壳适于当其空腔填充有可硬化介质或随着可硬化介质固化时膨胀，由此互锁元件通过过盈配合或摩擦力结合成整体结构（30）适合。还公开了新结构的施工方法和预先加固的方法。

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