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1. 发明申请

WO2016009317A4 SYSTEM AND APPARATUS COMPRISING A MULTISENSOR GUIDEWIRE FOR USE IN INTERVENTIONAL CARDIOLOGY 审中-公开
标题翻译：包括用于介入心脏病学的多传感器指导的系统和设备
公开(公告)号：WO2016009317A4
公开(公告)日：2016-03-10
申请号：PCT/IB2015055240
申请日：2015-07-10
申请人： THREE RIVERS CARDIOVASCULAR SYSTEMS INC
发明人： CARON ERIC , BILODEAU LUC
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/0215 , A61B5/026 , A61B5/042 , A61F2/24
CPC分类号： A61B5/6851 , A61B5/02154 , A61B5/02158 , A61B5/042 , A61B2560/0462 , A61B2560/066 , A61B2562/228 , A61F2/24 , A61F2/2418 , A61F2/2427
摘要： A system (1) and apparatus comprising a multisensor guidewire (100/200/300) for use in interventional cardiology, e.g., Transcatheter Valve Therapies (TVT), comprises a plurality of optical sensors (10/20) for direct measurement of cardiovascular parameters, e.g. transvalvular blood pressure gradients and flow. A conventional outer coil wire (35) contains a shaped core wire (31) having a cross-section defining a channel surface (132), e.g. grooves (32), extending along its length, to position optical fibers (11) and optical sensors (10/20) in a channel (33). Advantageously, the core wire has a diameter that provides sufficient stiffness to the guidewire for use as a support guidewire for TVT, e.g. Transcatheter Aortic Valve Implantation (TAVI), while accommodating multiple sensors and fibers within a guidewire of outside diameter ≤0.89mm. An optical connector (112) couples the guidewire to a control system (150). Optionally, the guidewire includes a contact force sensor (60), a pre-formed tip (400-1/400-2) and a separable micro- connector (140).
摘要翻译：包括用于例如经导管瓣膜治疗（TVT）的介入心脏病学的多传感器导丝（100/200/300）的系统（1）和装置包括用于直接测量心血管参数的多个光学传感器（10/20），例如跨瓣血压梯度和流量。传统的外部线圈线（35）包含具有限定通道表面（132）的横截面的成形芯线（31），例如，沿着其长度延伸的槽（32），以将光纤（11）和光学传感器（10/20）定位在通道（33）中。有利的是，芯线的直径为导丝提供足够的硬度，以用作TVT的支撑导丝，例如，经导管主动脉瓣植入（TAVI），同时在外径≤0.89mm的导丝内容纳多个传感器和纤维。光学连接器（112）将导丝连接到控制系统（150）。可选地，导丝包括接触力传感器（60），预成型尖端（400-1 / 400-2）和可分离微型连接器（140）。

2. 发明申请

WO2015054161A3 REGIONAL OXIMETRY SENSOR 审中-公开
标题翻译：区域氧化传感器
公开(公告)号：WO2015054161A3
公开(公告)日：2015-06-18
申请号：PCT/US2014059366
申请日：2014-10-06
申请人： MASIMO CORP
发明人： AL-ALI AMMAR , FORREST KEVIN , ABDUL-HAFIZ YASSIR , WEBER WALTER M , MANGOSING PETE , HWANG SUJIN
IPC分类号： A61B5/1455
CPC分类号： A61B5/14542 , A61B5/1455 , A61B5/14551 , A61B5/14552 , A61B5/14553 , A61B5/14557 , A61B5/6833 , A61B5/7275 , A61B5/742 , A61B5/746 , A61B2562/22 , A61B2562/222 , A61B2562/225 , A61B2562/227 , A61B2562/228 , H01R13/5224 , H01R2201/12
摘要： A regional oximetry sensor has a sensor head attachable to a patient skin surface so as to transmit optical radiation into the skin and receive that optical radiation after attenuation by blood flow within the skin. The sensor includes windows that press into the skin to maximize optical transmission. A stem extending from the sensor head transmits electrical signals between the sensor head and an attached cable. In a peel resistant configuration, the stem is terminated interior to the sensor head and away from a sensor head edge so as to define feet along either side of the stem distal the stem termination. The stem interior termination transforms a peel load on a sensor head adhesive to less challenging tension and shear loads on the sensor head adhesive.
摘要翻译：局部血氧测定传感器具有可附接到患者皮肤表面的传感器头，以便将光辐射传输到皮肤中并在被皮肤内的血流衰减之后接收该光辐射。传感器包括压入皮肤的窗口，以最大限度地提高光传输。从传感器头部伸出的杆在传感器头部和连接的电缆之间传输电信号。在抗剥离构型中，杆在传感器头的内部终止并且远离传感器头部边缘，以便沿杆的远离杆端部的任一侧限定脚。杆内部终端将传感器头粘合剂上的剥离负载转化为传感器头粘合剂上更难以承受的张力和剪切负载。

3. 发明申请

WO2015010064A1 BLOOD PRESSURE ANALYSIS SYSTEM AND METHOD 审中-公开
标题翻译：血压分析系统及方法
公开(公告)号：WO2015010064A1
公开(公告)日：2015-01-22
申请号：PCT/US2014/047260
申请日：2014-07-18
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人： PURDY, Phillip, Douglas , JENNINGS, Ronald, Bruce
IPC分类号： A61B5/0215
CPC分类号： A61B5/02108 , A61B5/002 , A61B5/0215 , A61B5/02156 , A61B5/02158 , A61B5/022 , A61B5/036 , A61B5/7235 , A61B2560/0223 , A61B2560/0257 , A61B2562/0247 , A61B2562/0266 , A61B2562/22 , A61B2562/223 , A61B2562/228
摘要： A blood pressure analysis system/method allowing conversion from an analog sensor input to a standardized analog output interface is disclosed. In some preferred embodiments the system/method permits a fiber optic pressure sensor to be interfaced to a standard patient care monitor (PCM) system using standardized Wheatstone Bridge analog interface inputs. Within this context the Wheatstone Bridge sensed output is defined by stimulus from the PCM and modulation of bridge element values by the conditioned output of an analog pressure sensor. The use of analog-to-digital-to-analog conversion in this blood pressure analysis permits retrofitting of PCM devices having analog Wheatstone Bridge inputs with advanced patient monitoring sensors without the need for specialized modifications to the baseline PCM data collection framework. Methods disclosed herein include techniques to connect arbitrary types/numbers of analog sensors to traditional PCM systems without the need for PCM system hardware/software modifications.
摘要翻译：公开了一种允许从模拟传感器输入到标准化模拟输出接口的转换的血压分析系统/方法。在一些优选实施例中，系统/方法允许使用标准化的惠斯通电桥模拟接口输入将光纤压力传感器接口到标准的病人护理监视器（PCM）系统。在这种情况下，惠斯通电桥感测输出由PCM的激励定义，并通过模拟压力传感器的调节输出调制桥元件值。在该血压分析中使用模数转换器可以对具有模拟惠斯通电桥输入的PCM器件进行改进，并具有先进的患者监控传感器，无需对基线PCM数据采集框架进行专门的修改。本文公开的方法包括将任意类型/数量的模拟传感器连接到传统PCM系统而不需要PCM系统硬件/软件修改的技术。

4. 发明申请

WO2013188707A1 SYSTEM AND METHOD FOR PRODUCING PARAMETRIC MAPS OF OPTOACOUSTIC DATA 审中-公开
标题翻译：用于生产光学数据参数的系统和方法
公开(公告)号：WO2013188707A1
公开(公告)日：2013-12-19
申请号：PCT/US2013/045736
申请日：2013-06-13
申请人： SENO MEDICAL INSTRUMENTS, INC.
发明人： ZALEV, Jason , CLINGMAN, Bryan
IPC分类号： A61B8/00
CPC分类号： A61B5/0095 , A61B5/0035 , A61B5/14542 , A61B5/4312 , A61B5/7425 , A61B8/4281 , A61B2560/0233 , A61B2560/0437 , A61B2562/0204 , A61B2562/228 , A61B2576/02
摘要： A method is disclosed for creating and outputting a masked parametric map (e.g., hemoglobin oxygenation) that reflects parameters in a first parametric map (e.g., relative oxygenation) and second parametric map (e.g., relative hemoglobin). In an illustrative embodiment, the method comprises a steps of generating a first parametric map, generating a second parametric map, and then generating a masked parametric map that reflects parameters in the first and second parametric maps. The masked map may present information not readily apparent from the first parametric map and the second parametric map, and not obtainable from the first and second parametric maps independently. The first parametric map may be based upon portions of two optoacoustic images created using differing wavelengths of light. The first parametric map is reflective of areas within the volume of tissue that have a differing response to the longer wavelength light event compared to the shorter one. The second parametric map is reflective of areas within the volume of tissue that have a stronger response to the longer and shorter wavelength light events than the surrounding areas. A masked parametric map is output which is reflective of a combination of information in the first and second parametric maps. In an embodiment, the masked parametric map is generated by generating a mask reflective of a combination of information in the first and second parametric maps, and applying the mask to one of the first or second parametric maps to form the masked parametric map. In an embodiment, one or more of the parametric maps is coregistered with, and overlayed on an ultrasound image of the same volume of tissue before being output.
摘要翻译：公开了一种用于创建和输出反映第一参数图（例如，相对氧合）和第二参数图（例如，相对血红蛋白）中的参数的掩蔽参数图（例如，血红蛋白氧合）的方法。在说明性实施例中，该方法包括以下步骤：产生第一参数图，生成第二参数图，然后生成反映第一参数图和第二参数图中参数的蒙版参数图。掩蔽地图可以呈现从第一参数图和第二参数图不容易看出的信息，并且不能独立地从第一和第二参数图获得。第一参数图可以基于使用不同波长的光产生的两个光声图像的部分。第一参数图反映了组织体积内与较短波长光事件相比具有不同响应的区域。第二参数图反映了组织体积内对周围区域的更长和较短波长的光事件具有较强反应的区域。输出掩蔽的参数图，其反映第一和第二参数图中的信息的组合。在一个实施例中，通过生成反映第一参数图和第二参数图中的信息的组合的掩模，并将该掩模应用于第一或第二参数图之一来生成掩蔽参数图，以形成掩蔽参数图。在一个实施例中，在输出之前，一个或多个参数图与核相同体积的组织的核心配合并叠加在超声图像上。

5. 发明申请

WO2012158387A2 HIGH-THROUGHPUT ALIGNMENT-INSENSITIVE OPTICAL CONNECTOR FOR LASER-BASED PHOTOPLETHYSMOGRAPHY 审中-公开
标题翻译：用于基于激光的光电子能谱的高通孔对准 - 抗敏光学连接器
公开(公告)号：WO2012158387A2
公开(公告)日：2012-11-22
申请号：PCT/US2012/036829
申请日：2012-05-07
申请人： KESTREL LABS, INC. , DELIANIDES, Theodore , POLOGE, Jonas
发明人： DELIANIDES, Theodore , POLOGE, Jonas
CPC分类号： A61B5/02416 , A61B5/14551 , A61B2562/228 , G02B6/262 , G02B6/3807
摘要： One embodiment of an optical coupling for use in a photoplethysmographic device having a first light guide (160) with core (150) that mates to a second light guide (210) that has a core (220) with a diameter and numerical aperture that are larger than those of the first light guide. This results in a high-throughput optical coupling that is insensitive to lateral offset and angular misalignments of the light guide axes. It allows the use of lower-cost, lower-precision molded parts in the manufacture of optical connectors, yet maximizes the light that is available for delivery to the tissue-under-test. Other embodiments are described and shown.
摘要翻译：用于光电体积描记术装置的光耦合器的一个实施例，其具有第一光导件（160），其具有与具有直径和数值孔径的芯（220）的第二光导（210）配合的芯（150）大于第一导光体的尺寸。这导致对光导轴的横向偏移和角度对准不敏感的高通量光耦合。它允许在制造光学连接器时使用低成本，低精度的模制零件，同时最大限度地提供可用于输送到被测组织的光。描述和示出了其他实施例。

6. 发明申请

WO2010103440A1 IRRADIATING AN ABSORPTION CONTRAST AGENT CONTAINED IN A TURBID MEDIUM 审中-公开
标题翻译：吸收涡轮介质中含有的吸收剂对照剂
公开(公告)号：WO2010103440A1
公开(公告)日：2010-09-16
申请号：PCT/IB2010/050952
申请日：2010-03-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , BRENDEL, Bernhard, J. , NIELSEN, Tim , KOEHLER, Thomas , ZIEGLER, Ronny
发明人： BRENDEL, Bernhard, J. , NIELSEN, Tim , KOEHLER, Thomas , ZIEGLER, Ronny
IPC分类号： A61B5/00
CPC分类号： A61B5/0073 , A61B5/0091 , A61B5/4312 , A61B2562/146 , A61B2562/228
摘要： The invention relates to a device and a method of irradiating an absorption contrast agent contained in a turbid medium (10). The absorption contrast agent has different absorption coefficients for light of a first wavelength (λ1) and light of a second wavelength (λ2), and the turbid medium (10) has similar optical properties for light of the first and second wavelengths (λ1, λ2). The turbid medium (10) is irradiated with light of the first wavelength (λ1) and light of the second wavelength (λ2) at the same source position, and an intensity of light having the first wavelength (λ1) emanating from the turbid medium (10) at at least one detection position, and an intensity of light having the second wavelength (λ2) emanating substantially simultaneously from the turbid medium (10) at the same detection position are measured. An image may be reconstructed from the measured intensities.
摘要翻译：本发明涉及一种照射包含在浑浊介质（10）中的吸收造影剂的装置和方法。吸收造影剂对于第一波长（λ1）的光和第二波长（λ2）的光具有不同的吸收系数，并且浑浊介质（10）对于第一和第二波长（λ2）的光具有相似的光学性质。 1，θ2）。在相同的源位置处照射第一波长（λ1）的光和第二波长的光（λ2）的混浊介质（10），并且从第一波长（λ1）发出的光的强度从测量至少一个检测位置处的混浊介质（10），并且测量在相同检测位置从混浊介质（10）基本同时发出的具有第二波长（λ2）的光强度。可以从测量的强度重建图像。

7. 发明申请

WO2008036149A3 METHODS AND DEVICES FOR FACILITATING VISUALIZATION IN A SURGICAL ENVIRONMENT 审中-公开
标题翻译：在手术环境中促进可视化的方法和装置
公开(公告)号：WO2008036149A3
公开(公告)日：2008-08-28
申请号：PCT/US2007016213
申请日：2007-07-17
申请人： ACCLARENT INC , GOLDFARB ERIC , MORRISS JOHN , CHANG JOHN Y , FACTEAU WILLIAM M
发明人： GOLDFARB ERIC , MORRISS JOHN , CHANG JOHN Y , FACTEAU WILLIAM M
IPC分类号： A61B5/00
CPC分类号： A61B34/20 , A61B1/00126 , A61B1/063 , A61B1/0684 , A61B1/07 , A61B1/233 , A61B5/0084 , A61B5/061 , A61B5/062 , A61B5/064 , A61B5/6851 , A61B17/24 , A61B2017/246 , A61B2018/2255 , A61B2034/2055 , A61B2090/306 , A61B2217/005 , A61B2562/228 , A61M25/0105 , A61M25/09 , A61M29/02 , A61M2025/0166 , A61M2025/09008 , A61M2025/09083 , A61M2025/09125 , A61M2025/09166 , A61M2025/09175 , A61M2029/025 , G02B6/0006 , G02B6/0008 , G02B6/04 , G02B6/1228 , G02B6/125 , G02B6/241 , G02B6/262 , G02B6/4292 , G02B23/2469
摘要： Devices for visually confirming the positioning of a distal end portion of an illuminating device placed within a patient, include inserting a distal end portion of an illuminating device internally into a patient, emitting light from the distal end portion of the illuminating device, observing transillumination resulting from the light emitted from the distal end portion of the illuminating device that occurs on an external surface of the patient, and correlating the location of the observed transillumination on the external surface of the patient with an internal location of the patient that underlies the location of observed transillumination, to confirm positioning of the distal end portion of the illuminating device.
摘要翻译：用于在视觉上确认放置在患者体内的照明装置的远端部分的定位的装置包括将照明装置的远端部分内部插入患者体内，从照明装置的远端部分发出光，观察透照产生的从照射装置的远端部分发射的发生在患者外表面上的光，并且将在患者外表面上观察到的透照的位置与患者外部表面上的位置相关联观察透照，以确认照明装置的远端部分的定位。

8. 发明申请

WO2007131231A3 INTRAMEDULLARY TRANSILLUMINATION APPARATUS, SURGICAL KIT AND METHOD FOR ACCURATE PLACEMENT OF LOCKING SCREWS IN LONG BONE INTRAMEDULLARY RODDING 审中-公开
标题翻译：外科手术器械，外科手术套件及长时间锁定螺钉锁紧螺钉的精确放置方法
公开(公告)号：WO2007131231A3
公开(公告)日：2008-07-24
申请号：PCT/US2007068387
申请日：2007-05-07
申请人： JG MEDICAL PRODUCTS LLC , GURTOWSKI JAMES P
发明人： GURTOWSKI JAMES P
IPC分类号： A61B17/56 , A61B17/58 , A61B17/60 , A61F2/00 , A61F2/30
CPC分类号： A61B17/1703 , A61B5/0084 , A61B5/4504 , A61B17/1725 , A61B90/361 , A61B2562/228
摘要： Apparatus, including a surgical kit, for use with a surgical drill, in the repair of bones using an intramedullary nail (30) insertable into a patient's bone (20), comprising a rod like device (70, 72) for insertion into the intramedullary nail (30), the device having a light source (73, 74, 75, 86, 88) emitting electromagnetic non-ionizing radiation, and the device being positionable so that the light source (74) emits the radiation through a distal transverse hole of the intramedullary nail; and a surgical instrument (95, 99, 102, 104) for exposing an exterior surface of a portion of the bone (20) illuminated by the radiation for view by the surgeon or a surgical robot. The radiation can be detected on the exterior surface of the bone (20) toalign the surgical drill (110) to the radiation passing through a transverse hole (42, 44) of the intramedullary nail (30), permitting accurate drilling of a hole through the bone and passage of the drill through the transverse hole (42, 44) of the intramedullary nail (30).
摘要翻译：包括用于外科手术钻头的外科手术套件的装置在使用可插入到患者骨骼（20）中的髓内钉（30）修复骨骼时，包括用于插入髓内的棒状装置（70,72）钉（30），该装置具有发射电磁非电离辐射的光源（73,74,85,88,88），并且该装置可定位成使得光源（74）通过远端横向孔的髓内钉; 以及用于暴露由辐射照射的骨骼的一部分的外表面的外科器械（95,99,102,104），以便由外科医生或手术机器人观察。可以在骨骼（20）的外表面上检测放射线，以将外科手术钻头（110）对准通过髓内钉（30）的横向孔（42,44）的辐射，允许精确钻孔通孔所述钻头的骨骼和通道穿过髓内钉（30）的横向孔（42,44）。

9. 发明申请

WO1997003603A1 METHOD AND APPARATUS FOR DIODE LASER PULSE OXIMETRY USING MULTIFIBER OPTICAL CABLES AND DISPOSABLE FIBER OPTIC PROBES 审中-公开
标题翻译：使用多纤维光纤和可剥离光纤探头的二极管激光脉冲测量的方法和装置
公开(公告)号：WO1997003603A1
公开(公告)日：1997-02-06
申请号：PCT/US1996011871
申请日：1996-07-18
申请人： RESPIRONICS, INC.
发明人： RESPIRONICS, INC. , SHEMWELL, David, M. , RYAN, George, R.
IPC分类号： A61B05/00
CPC分类号： A61B5/6826 , A61B5/14552 , A61B5/6838 , A61B2562/228
摘要： This invention is a method and apparatus for transferring two frequencies of electromagnetic energy to and from a portion of a living body (25) for the purpose of blood oxygen saturation measurements. The two frequencies of electromagnetic energy are transferred to the portion of the living body (25) through a single optical fiber cable (26) to a coupler (20), and then through a short section of optical cable (22) to an optical element (24) adjacent to the portion of the living body (25). After the two frequencies of electromagnetic energy are transmitted through the portion of the living body (25) they are received by another optical element (30), and transported away from the portion of the living body (25) to a coupler (36) through a short section of optical cable (32) where they may be converted to electrical signals. Alternatively, the two frequencies of electromagnetic energy are carried away from the coupler (30). The signals for the coupler are directed to a measurement instrument (18), which through an adapter may be a conventional measurement instrument known in the prior art or a measurement instrument (18) specifically designed for use with the signals produced at the coupler. The two short sections of optical cable (22, 32) and the two optical elements (24, 30) adjacent to the portion of the living body (25) and the coupler (20, 36) are combined to form a disposable probe. Alternatively, the disposable probe can include a transducer to convert the transmitted optical energy to electrical signals.
摘要翻译：本发明是一种为了血氧饱和度测量的目的而将两个频率的电磁能量传送到生物体（25）的一部分和从活体（25）的一部分转移的方法和装置。电磁能的两个频率通过单个光纤电缆（26）传送到生物体（25）的一部分到耦合器（20），然后通过短的光缆（22）传递到光学元件（24）邻近生物体（25）的部分。在电磁能量的两个频率通过活体（25）的部分传播之后，它们被另一个光学元件（30）接收，并且通过生物体（25）的部分从生物体（25）的一部分传送到耦合器（36）光缆（32）的短部分，其中它们可以被转换成电信号。或者，电磁能量的两个频率被从耦合器（30）移出。耦合器的信号被引导到测量仪器（18），其通过适配器可以是现有技术中已知的常规测量仪器或专门设计用于与耦合器处产生的信号一起使用的测量仪器（18）。光缆（22,32）的两个短部分和邻近生物体（25）的部分和耦合器（20,36）的两个光学元件（24,30）组合以形成一次性探针。或者，一次性探头可以包括用于将传输的光能转换成电信号的换能器。

10. 发明申请

WO2016140835A1 STABILIZED SENSOR MODULES AND MONITORING DEVICES INCORPORATING SAME 审中-公开
标题翻译：稳定传感器模块和监控器件
公开(公告)号：WO2016140835A1
公开(公告)日：2016-09-09
申请号：PCT/US2016/019114
申请日：2016-02-23
申请人： VALENCELL, INC.
发明人： WAGNER, Wolfgang , JUST, Steven Matthew , WALTER, Jonathan T. , TUCKER, Jesse Berkley , LEBOEUF, Steven Francis
IPC分类号： A61B5/00 , A61B5/024 , A61B5/02 , A61B5/021 , A61B5/1455
CPC分类号： A61B5/6844 , A61B5/0013 , A61B5/02427 , A61B5/0261 , A61B5/14552 , A61B5/6803 , A61B5/6804 , A61B5/6817 , A61B5/721 , A61B2562/0238 , A61B2562/046 , A61B2562/146 , A61B2562/228
摘要： A sensor module includes a housing and a sensor assembly disposed within the housing. The sensor assembly includes a base having at least one energy emitter and at least one energy detector, and a guide layer overlying the base in face-to-face relationship. The guide layer has at least one protrusion extending outwardly to accommodate the at least one energy emitter, and a plurality of outwardly extending stabilizing members. The housing has at least one first opening through which the at least one protrusion extends, and a plurality of second openings through which the stabilizing members extend. Some of the stabilizing members have an outwardly extending length that is greater than an outwardly extending length of the at least one protrusion. Some of the stabilizing members are substantially cylindrical and have a circular cross-sectional profile, and some of the stabilizing members are partially cylindrical and have a partially circular cross-sectional profile.
摘要翻译：传感器模块包括壳体和设置在壳体内的传感器组件。传感器组件包括具有至少一个能量发射器和至少一个能量检测器的基座，以及以面对面关系覆盖基座的引导层。导向层具有向外延伸以容纳至少一个能量发射器的至少一个突起，以及多个向外延伸的稳定构件。壳体具有至少一个第一开口，至少一个突起延伸穿过该第一开口，以及多个第二开口，稳定构件穿过该第二开口延伸。一些稳定构件具有大于至少一个突起的向外延伸的长度的向外延伸的长度。一些稳定构件基本上是圆柱形的并且具有圆形横截面轮廓，并且一些稳定构件是部分圆柱形的并且具有部分圆形的横截面轮廓。

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