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1. 发明申请

WO2017078819A3 CUFF ELECTRODE WITH LYSING AGENT 审中-公开
标题翻译： CUFF电极与溶剂
公开(公告)号：WO2017078819A3
公开(公告)日：2017-07-13
申请号：PCT/US2016046802
申请日：2016-08-12
申请人： UNIV SOUTHERN CALIFORNIA , HUNTINGTON MEDICAL RES INST
发明人： MENG ELLIS , PIKOV VICTOR
IPC分类号： A61N1/05 , A61M5/14
CPC分类号： A61N1/0556 , A61B5/04001 , A61B5/6877 , A61B2562/125
摘要： A new class of peripheral nerve interfaces that combines microfluidics with microelectronics. A peripheral nerve interface that allows intraneural targeting through the combined use and sequential application of lysing agents and neurotrophic factors.
摘要翻译：一类将微流体与微电子相结合的外周神经接口。外周神经界面，通过裂解剂和神经营养因子的联合使用和顺序应用，允许神经内靶向。

2. 发明申请

WO2015157469A3 POLYPEPTIDE COMPOSITIONS WITH TYPE VII COLLAGEN FIBRONECTIN TYPE III- LIKE REPEATS AND TREATMENT METHODS FOR WOUND CLOSURE AND HEALING 审中-公开
标题翻译：具有VII型胶原纤维结合素III型样多肽的多肽组合物和用于伤口愈合和愈合的治疗方法
公开(公告)号：WO2015157469A3
公开(公告)日：2015-12-30
申请号：PCT/US2015025005
申请日：2015-04-08
申请人： UNIV SOUTHERN CALIFORNIA
发明人： CHEN MEI , WOODLEY DAVID T
IPC分类号： A61K38/39 , C12N5/00
CPC分类号： C07K14/78 , A61K38/00
摘要： Disclosed are compositions arid methods for accelerating wound closure and preventing inhibiting or reducing scarring or fibrosis. The methods of the present invention include administering to a person in need thereof an effective amount of a pharmaceutical composition comprising collagen 7 and/or one: or snore functional fragments or variants thereof. The functional fragments generally comprise at last one of the nine Fibronectin Type Ill-like Region of the NC1 region of collagen 7.
摘要翻译：公开了用于加速伤口闭合并防止抑制或减少瘢痕形成或纤维化的组合物和方法。本发明的方法包括向有需要的人施用有效量的包含胶原蛋白7和/或其一种或其打鼾功能片段或变体的药物组合物。功能片段通常包含胶原蛋白7的NC1区域的9个纤连蛋白III型样区域中的最后一个。

3. 发明申请

WO2015120206A9 MAO INHIBITORS AND THEIR CONJUGATES AS THERAPEUTICS FOR THE TREATMENT OF BRAIN CANCER 审中-公开
标题翻译： MAO抑制剂及其共轭物作为治疗脑癌的治疗药物
公开(公告)号：WO2015120206A9
公开(公告)日：2015-12-17
申请号：PCT/US2015014695
申请日：2015-02-05
申请人： UNIV SOUTHERN CALIFORNIA
发明人： SHIH JEAN C , HOFMAN FLORENCE M , CHEN THOMAS C
IPC分类号： A61K31/135 , A61K31/138 , A61K31/352 , A61K31/353 , A61K31/381 , A61K31/404 , A61K31/5375 , A61P35/00
CPC分类号： A61K31/5375 , A61K31/135 , A61K31/138 , A61K31/352 , A61K31/353 , A61K31/381 , A61K31/404
摘要： A pharmaceutical composition and method for treating brain cancer are provided. The method includes administering to a patient in need thereof an effective amount of one or more compounds that include moclobemide, clorgyline, clorgyline's Near-infra-red dye Monoamine Oxidase Inhibitor (NMI), and MHI 148- clorgyline, and their salt thereof. The composition and method are particularly effective in reducing the size of glioblastomas that are temozolomide (TMZ) resistant.
摘要翻译：提供了用于治疗脑癌的药物组合物和方法。该方法包括给有此需要的患者施用有效量的一种或多种化合物，所述化合物包括吗氯贝胺，clorgyline，clorgyline的近红外染料单胺氧化酶抑制剂（NMI）和MHI 148-克分子，及其盐。该组合物和方法在降低耐替莫唑胺（TMZ）的胶质母细胞瘤的大小方面特别有效。

4. 发明申请

WO2014194261A3 COATING PARTICLES 审中-公开
标题翻译：涂层颗粒
公开(公告)号：WO2014194261A3
公开(公告)日：2015-01-22
申请号：PCT/US2014040345
申请日：2014-05-30
申请人： UNIV SOUTHERN CALIFORNIA
发明人： ZHOU CHONGWU , RONG JIEPENG , GE MINGYUAN , FANG XIN
IPC分类号： H01M4/13
CPC分类号： H01M4/625 , H01M4/136 , H01M4/366 , H01M4/5815 , H01M10/0525 , H01M2004/028
摘要： A method includes combining a coating material and an uncoated particulate core material in a solution having a selected ionic strength. The selected ionic strength promotes coating of the uncoated particulate core material with the coating material to form coated particles; and the coated particles can be collected after formation. The coating material has a higher electrical conductivity than the core material.
摘要翻译：一种方法包括将涂层材料和未涂覆的颗粒芯材料组合在具有选定离子强度的溶液中。选择的离子强度促进未涂覆的颗粒芯材料与涂层材料的涂层以形成涂覆的颗粒; 并且可以在形成后收集涂覆的颗粒。涂层材料具有比芯材更高的导电性。

5. 发明申请

WO2014182948A3 EPICARDIAL LEAD DESIGN 审中-公开
公开(公告)号：WO2014182948A3
公开(公告)日：2015-01-15
申请号：PCT/US2014037366
申请日：2014-05-08
申请人： LOS ANGELES CHILDRENS HOSPITAL , UNIV SOUTHERN CALIFORNIA
发明人： BAR-COHEN YANIV , LOEB GERALD , ZHOU LI , PECK RAYMOND , NUTT STEPHEN
IPC分类号： A61N1/362
CPC分类号： A61N1/375 , A61N1/0587 , A61N1/059 , A61N1/362 , A61N1/37205 , A61N1/37288 , A61N1/3756 , A61N1/3787
摘要： The present invention provides advancements in the art of cardiac pacemakers. The invention provides a pacemaker system that comprises at least one pacemaker and that is, to a large extent, self-controlled, allows for long-term implantation in a patient, and minimizes current inconveniences and problems associated with battery life. The invention further includes a mechanism in which at least two pacemakers are implanted in a patient, and in which the pacemakers communicate with each other at the time of a given pacing or respiratory event, without any required external input, and adjust pacing parameters to respond to the patient's need for blood flow. The invention further provides a design for a pacemaker in which the pacemaker electrode is connected to the pacemaker body by a lead that is configured to allow the pacemaker to lie parallel to the epicardial surface and to reduce stress on the pacemaker and heart tissue.
摘要翻译：本发明提供心脏起搏器领域的进步。本发明提供了一种起搏器系统，其包括至少一个起搏器，并且在很大程度上是自我控制的，允许长期植入患者体内，并且最小化与电池寿命相关的当前不便和问题。本发明还包括一种机构，其中至少两个起搏器被植入患者体内，并且其中起搏器在给定的起搏或呼吸事件时彼此通信，而没有任何需要的外部输入，并且调整起搏参数以响应对患者的血液流动需求。本发明还提供了一种起搏器的设计，其中起搏器电极通过引线连接到起搏器主体，所述引线被构造成允许起搏器平行于心外膜表面平行并且减小起搏器和心脏组织上的压力。

6. 发明申请

WO2014025435A3 DIPYRRIN BASED MATERIALS FOR PHOTOVOLTAICS, COMPOUNDS CAPABLE OF UNDERGOING SYMMETRY BREAKING INTRAMOLECULAR CHARGE TRANSFER IN A POLARIZING MEDIUM AND ORGANIC PHOTOVOLTAIC DEVICES COMPRISING THE SAME 审中-公开
标题翻译：用于光伏电池的基于双吡喃的材料，可用于对称介质中的分子内电荷转移的化合物以及包含该电致发光器件的有机光伏器件
公开(公告)号：WO2014025435A3
公开(公告)日：2014-06-12
申请号：PCT/US2013041079
申请日：2013-05-15
申请人： UNIV MICHIGAN , UNIV SOUTHERN CALIFORNIA , FORREST STEPHEN R , THOMPSON MARK E , CHEN JOHN J , SOMMER JONATHAN R , DJUROVICH PETER I , ALLEN KATHRYN R
发明人： FORREST STEPHEN R , THOMPSON MARK E , CHEN JOHN J , SOMMER JONATHAN R , DJUROVICH PETER I , ALLEN KATHRYN R
IPC分类号： H01L51/46
CPC分类号： H01L51/008 , B82Y10/00 , H01L51/0046 , H01L51/009 , H01L51/4253 , Y02E10/549 , Y02P70/521
摘要： The present disclosure generally relates to organic photosensitive optoelectronic devices comprising at least one boron dipyrrin compound. In addition, the present disclosure relates to methods of making organic photosensitive optoelectronic devices comprising at least one boron dipyrrin compound. The present disclosure also generally relates to chromophoric compounds that combine strong absorption of light at visible wavelengths with the ability to undergo symmetry-breaking intramolecular charge transfer (ICT), and their use for the generation of free carriers in organic photovoltaic cells (OPVs) and electric-field-stabilized geminate polaron pairs. The present disclosure also relates to the synthesis of such compounds, methods of manufacture, and applications in photovoltaic systems and organic lasers.
摘要翻译：本公开总体涉及包含至少一种硼二吡咯化合物的有机光敏光电子器件。另外，本公开涉及制造包含至少一种硼二吡咯化合物的有机光敏光电子器件的方法。本公开还总体上涉及将可见光波长的光的强吸收与经历对称破坏的分子内电荷转移（ICT）的能力结合的发色团化合物，以及它们用于在有机光伏电池（OPV）中产生自由载流子的用途，和电场稳定的成对极化子对。本公开还涉及这些化合物的合成，制造方法以及在光伏系统和有机激光器中的应用。

7. 发明申请

WO2012125652A3 ANTIBODY AND ANTIBODY MIMETIC FOR VISUALIZATION AND ABLATION OF ENDOGENOUS PROTEINS 审中-公开
标题翻译：抗体和抗体蛋白质可视化和内源性蛋白质的消除
公开(公告)号：WO2012125652A3
公开(公告)日：2013-02-07
申请号：PCT/US2012028947
申请日：2012-03-13
申请人： UNIV SOUTHERN CALIFORNIA , ARNOLD DON B , ROBERTS RICHARD W , GROSS GARRETT G , MORA RUDY , JUNGE JASON
发明人： ARNOLD DON B , ROBERTS RICHARD W , GROSS GARRETT G , MORA RUDY , JUNGE JASON
IPC分类号： C12N15/62 , C07K16/00 , C07K19/00 , C12N15/63 , G01N33/532
CPC分类号： G01N33/581 , C07K14/78 , C07K16/18 , C07K16/40 , C07K2317/80 , C07K2317/81 , C07K2317/92 , C07K2318/20 , C07K2319/60 , C07K2319/70 , C07K2319/81 , C12N15/62 , G01N33/582
摘要： Provided are compositions and methods for labeling an endogenous protein, in particular, in a live cell, or for ablating an endogenous or target protein. The compositions relate to a fusion protein having a binding moiety such as an antibody, an antigen binding fragment of an antibody or an antibody mimetic that recognizes the endogenous or target protein.
摘要翻译：提供用于标记内源性蛋白质，特别是在活细胞中或用于烧蚀内源或靶蛋白质的组合物和方法。组合物涉及具有结合部分的融合蛋白，例如抗体，抗体的抗原结合片段或识别内源或靶蛋白的抗体模拟物。

8. 发明申请

WO2012149468A3 INSTRUMENTS AND METHODS FOR THE IMPLANTATION OF CELL-SEEDED SUBSTRATES 审中-公开
标题翻译：用于植入细胞种子基质的仪器和方法
公开(公告)号：WO2012149468A3
公开(公告)日：2012-12-27
申请号：PCT/US2012035654
申请日：2012-04-27
申请人： UNIV SOUTHERN CALIFORNIA , CALIFORNIA INST OF TECHN , UNIV CALIFORNIA AT SANTA BARBARA , HUMAYUN MARK , AHUJA ASHISH , TAI YU-CHONG , HINTON DAVID , GRUBBS ROBERT , BRANT RODRIGO , WELLS TRENT
发明人： HUMAYUN MARK , AHUJA ASHISH , TAI YU-CHONG , HINTON DAVID , GRUBBS ROBERT , BRANT RODRIGO , WELLS TRENT
IPC分类号： A61B17/00 , A61B17/28 , A61F2/00 , A61K35/12 , A61L27/56
CPC分类号： A61B17/2909 , A61B2017/2937 , A61B2017/2945 , A61B2017/305 , A61F2/14 , A61F2/4601 , A61F9/0017 , A61F9/00736 , A61K35/50 , A61L27/16 , A61L27/34 , A61L27/3813 , A61L27/50 , A61L2430/16 , A61M1/12 , A61M5/14 , A61M2202/09 , C12N5/0621 , C12N2506/02 , C12N2533/30 , C12N2533/40 , C12N2533/50 , C08L65/04 , C08L89/00
摘要： Disclosed herein are instruments and methods for delivery of substrates, including cell- seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
摘要翻译：本文公开了用于将包括细胞接种的底物在内的底物递送到需要治疗诱导细胞死亡，损伤或功能丧失的各种疾病的靶组织的器械和方法。衬底被配置为向包括干细胞的细胞提供允许细胞与目标组织之间的生物信号相互连接和传输的结构支撑。

9. 发明申请

WO2012054736A3 CHARGE-BASED PHASE LOCKED LOOP CHARGE PUMP 审中-公开
标题翻译：基于充电的锁相环电荷泵
公开(公告)号：WO2012054736A3
公开(公告)日：2012-06-14
申请号：PCT/US2011057116
申请日：2011-10-20
申请人： UNIV SOUTHERN CALIFORNIA , SCHOBER SUSAN M , SCHOBER ROBERT C
发明人： SCHOBER SUSAN M , SCHOBER ROBERT C
IPC分类号： H03L7/093 , H02M3/07
CPC分类号： H03L7/0896 , H03L7/0895
摘要： Charge-based charge pumps are described which include a switchable capacitor configured for connection to a voltage source, a ground, and a charge pump output. A first pair of switches include a first switch configured to connect the switchable capacitor to ground and a second switch configured to connect the switchable capacitor to the voltage source. A second pair of switches include a third switch configured to connect a first node, between the switchable capacitor and ground, to the charge pump output, and a fourth switch configured to connect a second node, between the switchable capacitor and the voltage source, to the charge pump output. Locked loop designs, such as phase locked loops or delay locked loops, are described that include charge-based charge pumps.
摘要翻译：描述了基于电荷的电荷泵，其包括配置用于连接到电压源，地和电荷泵输出的可切换电容器。第一对开关包括被配置为将可开关电容器连接到地的第一开关以及被配置为将可开关电容器连接到电压源的第二开关。第二对开关包括第三开关，该第三开关被配置为将可开关电容器和地之间的第一节点连接到电荷泵输出，以及第四开关，其被配置为将可开关电容器和电压源之间的第二节点连接到电荷泵输出。描述了锁定环路设计，例如锁相环路或延迟锁定环路，其包括基于电荷的电荷泵。

10. 发明申请

WO2012068299A2 CBP/CATENIN ANTAGONISTS FOR ENHANCING ASYMMETRIC DIVISION OF SOMATIC STEM CELLS 审中-公开
标题翻译： CBP / CATENIN ANTAGONISTS用于增强异位干细胞的不对称性
公开(公告)号：WO2012068299A2
公开(公告)日：2012-05-24
申请号：PCT/US2011061062
申请日：2011-11-16
申请人： UNIV SOUTHERN CALIFORNIA , KAHN MICHAEL , TEO JIA-LING , MCMILLAN MICHAEL , ZHAO YI , WU YONGFENG
发明人： KAHN MICHAEL , TEO JIA-LING , MCMILLAN MICHAEL , ZHAO YI , WU YONGFENG
IPC分类号： A61K31/519 , A61K31/53 , A61K31/5517 , A61P17/00
CPC分类号： A61K31/519 , A61K31/167 , A61K31/4375 , A61K31/4985 , A61K31/506 , A61K31/5575 , A61K31/573 , A61K31/58 , A61K38/50 , A61K45/06 , C07D487/04 , A61K2300/00
摘要： Provided are: methods for treating aging or an age-related condition, symptom or disease; methods for stimulating hair growth, regrowth or pigmentation (or preventing hair loss); methods for increasing the expression of an adenosine receptor in dermal cells (in combination with hair growth); methods for treating a condition or disease of the skin or at least one symptom thereof, including cosmetic treatment (e.g., wrinkles, hyperpigmentation, redness, rosacea, dryness, cracking, loss of firmness, loss of elasticity, thinning, and loss of vibrance). The methods comprise administering a sufficient amount of a CBP/catenin (e.g., CBP/ß-catenin) antagonist as disclosed, and particularly wherein administration is in an amount and manner sufficient to provide for increasing the number of asymmetric renewing divisions relative to, or at the expense of symmetric divisions in relevant somatic stem cell population. In particular aspects, the CBP/catenin (e.g., CBP/ß-catenin) antagonist comprises an alkyl and/or fatty acid ester derivative thereof as disclosed herein.
摘要翻译：提供：治疗老化或年龄相关疾病，症状或疾病的方法; 刺激毛发生长，再生长或色素沉着（或预防脱发）的方法; 用于增加真皮细胞中腺苷受体表达的方法（与毛发生长相结合）; 治疗皮肤状况或疾病或其至少一种症状的方法，包括美容治疗（例如皱纹，色素沉着过度，发红，红斑痤疮，干燥，开裂，硬度丧失，弹性丧失，变薄和活动丧失）。所述方法包括施用足量的CBP /连环蛋白（例如，CBP /β-连环蛋白）拮抗剂，如所公开的，特别是其中施用量和方式足以提供相对于或不增加不对称更新分隔数量以相关体细胞干细胞群体的对称分裂为代价。在具体方面，CBP /连环蛋白（例如，CBP /β-连环蛋白）拮抗剂包含本文公开的烷基和/或脂肪酸酯衍生物。

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