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1. 发明申请

WO2007149546A2 IMPLANTABLE MEDICAL DEVICES COMPRISING CATHODIC ARC PRODUCED STRUCTURES 审中-公开
标题翻译：包含阴极弧生产结构的可植入医疗器械
公开(公告)号：WO2007149546A2
公开(公告)日：2007-12-27
申请号：PCT/US2007014509
申请日：2007-06-21
申请人： PROTEUS BIOMEDICAL INC , COSTELLO BENEDICT JAMES , JENSEN MARC , ZDEBLICK MARK , FRANK JEREMY , GELFANDBEIN VLADIMIER , ARNE LAWRENCE
发明人： COSTELLO BENEDICT JAMES , JENSEN MARC , ZDEBLICK MARK , FRANK JEREMY , GELFANDBEIN VLADIMIER , ARNE LAWRENCE
IPC分类号： A61N1/04
CPC分类号： C23C14/0641 , C04B35/56 , C04B35/5611 , C04B35/5626 , C04B35/58 , C04B38/0022 , C04B2111/00793 , C04B2111/0081 , C04B2111/00836 , C04B2111/00844 , C23C14/0635 , C23C14/0664 , C23C14/325 , H01J37/32055
摘要： Implantable medical devices that include cathodic arc produced structures are provided. Cathodic arc produced structures of the invention may be thick, stress-free metallic structures that have configurations heretofore not available in implantable medical devices. In yet other embodiments, the structures may be crenulated or porous layers. Also provided are methods of producing implantable medical devices as well as systems for practicing the subject methods.
摘要翻译：提供了包括阴极电弧产生结构的植入式医疗设备。本发明的阴极电弧产生的结构可以是厚的，无应力的金属结构，其具有以前在植入式医疗装置中不可用的构造。在其他实施例中，结构可以是经过弯曲的或多孔的层。还提供了生产可植入医疗装置的方法以及用于实施本发明方法的系统。

2. 发明申请

WO2005058133A3 IMPLANTABLE PRESSURE SENSORS 审中-公开
标题翻译：可压式传感器
公开(公告)号：WO2005058133A3
公开(公告)日：2006-06-22
申请号：PCT/US2004041430
申请日：2004-12-10
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK , COSTELLO BENEDICT JAMES
发明人： ZDEBLICK MARK , COSTELLO BENEDICT JAMES
IPC分类号： A61B20060101 , A61B5/0215 , A61N1/362 , A61N1/365 , G01L9/00 , G01L9/04 , G01L9/06 , H01L21/44 , H01L21/48 , G01B7/16 , G01L1/04 , G01L1/26
CPC分类号： A61B5/0215 , A61B5/412 , A61B2562/02 , A61N1/3627 , A61N1/36564 , G01L9/0042 , G01L9/0055 , G01L9/045 , G01L9/065
摘要： Implantable pressure sensor (20) and method for making and using the same are provided. A feature of the embodiments of the subject pressure sensors is that they are low-drift sensors. The subject sensors find use in a variety of applications.
摘要翻译：提供了可植入压力传感器（20）及其制造和使用方法。本发明的压力传感器的实施例的特征在于它们是低漂移传感器。主题传感器可用于各种应用。

3. 发明申请

WO2013009786A3 POLYPHARMACY CO-PACKAGED MEDICATION DOSING UNIT INCLUDING COMMUNICATION SYSTEM THEREFOR 审中-公开
标题翻译：多功能包装药物剂量单位包括通讯系统
公开(公告)号：WO2013009786A3
公开(公告)日：2013-04-11
申请号：PCT/US2012046124
申请日：2012-07-10
申请人： PROTEUS BIOMEDICAL INC , ROBERTSON TIMOTHY , MOON GREGORY , COSTELLO BENEDICT , ZDEBLICK MARK , HAFEZI HOOMAN
发明人： ROBERTSON TIMOTHY , MOON GREGORY , COSTELLO BENEDICT , ZDEBLICK MARK , HAFEZI HOOMAN
IPC分类号： A61J7/04 , A61J1/00 , B65D51/24 , G06Q50/22 , G08B21/02
CPC分类号： A61J3/007 , A61B5/0002 , A61B5/073 , A61B5/4839 , A61B2560/0412 , A61J7/0084 , A61J7/04 , A61J7/0418 , A61J7/0436 , A61J7/0481 , A61J2200/30 , A61J2205/60 , G06F19/3462 , H01Q1/273 , Y10T29/49826
摘要： A custom medication dosing unit is disclosed. The custom medication dosing unit includes a housing having a shell element provided with a bottom surface and a circumferential edge extending from the bottom surface and a portion defining an opening for accommodating a medication. A first closure element provided with a circumferential edge is placed on the circumferential edge of the shell element in an adhering and closing manner. A medication is disposed within the opening defined between the shell element and the first closure element. A circuit module is associated within the first closure element. A system includes the custom medication dosing unit operative to communicate with a local node. Also disclosed is a method of manufacturing the custom medication dosing unit.
摘要翻译：公开了一种定制的药物给药单元。定制药物给药单元包括壳体，壳体具有底部表面和从底部表面延伸的周向边缘以及限定用于容纳药物的开口的部分。具有圆周边缘的第一封闭元件以粘合和封闭方式放置在外壳元件的圆周边缘上。药物设置在限定在壳元件和第一闭合元件之间的开口内。电路模块连接在第一封闭元件内。系统包括用于与本地节点通信的定制药物给药单元。还公开了制造定制药物给药单元的方法。

4. 发明申请

WO2012033923A2 MAINTAINING HIGH PACE RATE CHARGE BALANCE 审中-公开
标题翻译：维持高价格收费平衡
公开(公告)号：WO2012033923A2
公开(公告)日：2012-03-15
申请号：PCT/US2011050842
申请日：2011-09-08
申请人： PROTEUS BIOMEDICAL INC , LEICHNER ROBERT , BERKMAN JEFFREY , ZDEBLICK MARK
发明人： LEICHNER ROBERT , BERKMAN JEFFREY , ZDEBLICK MARK
IPC分类号： A61N1/36 , A61N1/08 , A61N1/362
CPC分类号： A61N1/36125 , A61N1/37
摘要： Disclosed are a charge balance apparatus and a method for balancing at least one pacing electrode electrically coupled to the charge balance circuit. The charge balance apparatus receives a pace waveform from a pulse generator and provides a balanced flow of charge to the at least one pacing electrode. A charge monitor circuit is electrically coupled to the at least one pacing electrode and measures a flow of charge through the at least one pacing electrode in a first direction. A logic circuit interrupts a flow of charge in a second direction when a measured flow of charge in the second direction is substantially equal to a measured flow of charge in the first direction.
摘要翻译：公开了一种电荷平衡装置和用于平衡电耦合到电荷平衡电路的至少一个起搏电极的方法。电荷平衡装置从脉冲发生器接收步速波形，并向至少一个起搏电极提供平衡的电荷流。电荷监测电路电耦合到所述至少一个起搏电极并且测量沿着第一方向通过所述至少一个起搏电极的电荷流。当测量的第二方向的电荷基本上等于测量的第一方向的电荷时，逻辑电路在第二方向上中断电荷流。

5. 发明申请

WO2010105250A3 VOLUME SENSING 审中-公开
标题翻译：体积感知
公开(公告)号：WO2010105250A3
公开(公告)日：2011-01-13
申请号：PCT/US2010027261
申请日：2010-03-13
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK
发明人： ZDEBLICK MARK
IPC分类号： A61B5/0295
CPC分类号： A61B5/029 , A61B5/0535 , A61B5/0538 , A61B5/6846
摘要： Each sensor in one or more pairs of sensors is associated with a particular tissue, for example a first tissue location and a second tissue location respectively. Tissue at a particular tissue location may be solid, for example, muscle tissue, fat tissue, etc., or fluid, for example, blood, fluids associated with edema, etc. The area between the two tissue locations associated with a pair of sensors may comprise solid tissue, fluid tissue, an empty chamber, or combinations thereof. For each pair of sensors in the at least one pair of sensors, a first impedance measurement between the pair of sensors and associated with a first frequency is determined. For each pair of sensors in the at least one pair of sensors, a second impedance measurement between the pair of sensors and associated with a second frequency is determined. A comparison of a ratio of the first impedance measurement at a point in time to the second impedance measurement at a corresponding point in time may be made to determine a volume- related value associated with an area located between the first tissue location and the second tissue location.
摘要翻译：一对或多对传感器中的每个传感器分别与特定组织，例如第一组织位置和第二组织位置相关联。在特定组织位置处的组织可以是实心的，例如肌肉组织，脂肪组织等，或流体，例如血液，与水肿相关的流体等。与一对传感器相关联的两个组织位置之间的区域可以包括固体组织，流体组织，空腔或其组合。对于至少一对传感器中的每对传感器，确定该对传感器之间并与第一频率相关联的第一阻抗测量。对于至少一对传感器中的每对传感器，确定一对传感器之间并与第二频率相关联的第二阻抗测量。可以对在相应时间点的时间点上的第一阻抗测量值与第二阻抗测量值的比率进行比较，以确定与位于第一组织位置和第二组织之间的区域相关联的体积相关值位置。

6. 发明申请

WO2010127164A2 IMPLANTABLE DEVICE, SYSTEM, AND METHOD FOR MEASURING PHYSIOLOGIC PARAMETERS 审中-公开
标题翻译：可植入装置，系统和测量生理参数的方法
公开(公告)号：WO2010127164A2
公开(公告)日：2010-11-04
申请号：PCT/US2010033040
申请日：2010-04-29
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK
发明人： ZDEBLICK MARK
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/08 , A61B5/0538 , A61B5/085 , A61B5/6855 , A61B5/6871 , A61B5/6874 , A61N1/36135 , A61N1/36521 , A61N1/368
摘要： An apparatus having at least one implantable lead, e.g., two leads, three leads, etc., is provided. In one example, the apparatus includes at least two satellites electrically coupled to a common implantable pulse generator by at least two conductors extending from the common implantable pulse generator to each of the at least two satellites. Each satellite, for example, is associated with a respective tissue site such as a cardiac wall.
摘要翻译：提供了具有至少一个可植入引线的装置，例如两个引线，三个引线等。在一个示例中，该装置包括至少两个卫星，该至少两个卫星通过从公共可植入脉冲发生器延伸到至少两个卫星中的每个卫星的至少两个导体电耦合到公共可植入脉冲发生器。每个卫星例如与相应的组织部位如心脏壁相关联。

7. 发明申请

WO2008095183A3 INGESTIBLE EVENT MARKER SYSTEMS 审中-公开
标题翻译：令人难以置信的事件标记系统
公开(公告)号：WO2008095183A3
公开(公告)日：2008-12-18
申请号：PCT/US2008052845
申请日：2008-02-01
申请人： PROTEUS BIOMEDICAL INC , ROBERTSON TIMOTHY , SAVAGE GEORGE , ZDEBLICK MARK , BEHZADI YASHAR , COSTELLO BENEDICT , FRANK JEREMY , HAFEZI HOOMAN , HANIFF TARIQ , O'REILLY DAVID
发明人： ROBERTSON TIMOTHY , SAVAGE GEORGE , ZDEBLICK MARK , BEHZADI YASHAR , COSTELLO BENEDICT , FRANK JEREMY , HAFEZI HOOMAN , HANIFF TARIQ , O'REILLY DAVID
IPC分类号： A61B1/05
CPC分类号： A61B5/073 , A61B5/0028 , A61B5/0031 , A61B5/0073 , A61B5/0205 , A61B5/14507 , A61B5/6846 , A61B5/6861 , A61B5/6873 , A61B2560/0214 , A61J3/007 , G01N27/3277 , H01M6/005 , H01Q1/273 , H04B5/0068 , Y10S128/903
摘要： Ingestible event marker systems that include an ingestible event marker (i.e., an IEM) and a personal signal receiver are provided. Embodiments of the IEM include an identifier, which may or may not be present in a physiologically acceptable carrier. The identifier is characterized by being activated upon contact with a target internal physiological site of a body, such as digestive tract internal target site. The personal signal receiver is configured to be associated with a physiological location, e.g., inside of or on the body, and to receive a signal the IEM. During use, the IEM broadcasts a signal which is received by the personal signal receiver.
摘要翻译：提供了包括可摄取事件标记（即，IEM）和个人信号接收器的可摄入事件标记系统。 IEM的实施例包括可能存在或可能不存在于生理上可接受的载体中的标识符。该标识符的特征在于在与身体的目标内部生理部位（例如消化道内部目标部位）接触时被激活。个人信号接收器被配置为与例如身体内部或身体上的生理位置相关联，并且接收IEM的信号。在使用期间，IEM广播由个人信号接收器接收的信号。

8. 发明申请

WO2006116718A3 PHARMA-INFORMATICS SYSTEM 审中-公开
标题翻译：药物信息系统
公开(公告)号：WO2006116718A3
公开(公告)日：2008-01-17
申请号：PCT/US2006016370
申请日：2006-04-28
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK , THOMPSON ANDREW , PIKELNY ALEKSANDR , ROBERTSON TIMOTHY
发明人： ZDEBLICK MARK , THOMPSON ANDREW , PIKELNY ALEKSANDR , ROBERTSON TIMOTHY
IPC分类号： A61B5/07 , A61K9/48
CPC分类号： A61B5/6861 , A61B5/0028 , A61B5/0031 , A61B5/07 , A61B5/073 , A61B5/1473 , A61B5/4833 , A61B5/4839 , A61B5/681 , A61B5/7282 , A61B2560/0214 , A61B2560/0462 , A61B2562/08 , A61B2562/162 , A61J3/007 , G06K7/10168 , H01Q1/273 , Y10T29/49117
摘要： Compositions, systems and methods that allow for the detection of the actual physical delivery of a pharmaceutical agent to a body are provided. Embodiments of the compositions include an identifier and an active agent. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.
摘要翻译：提供了允许检测药物到身体的实际物理输送的组合物，系统和方法。组合物的实施方案包括标识符和活性剂。本发明可用于各种不同的应用，包括但不限于监测治疗方案依从性，跟踪药剂的历史等。

9. 发明申请

WO2006105474A2 AUTOMATED OPTIMIZATION OF MULTI-ELECTRODE PACING FOR CARDIAC RESYNCHRONIZATION 审中-公开
标题翻译：用于心脏再生的多电极电泳自动优化
公开(公告)号：WO2006105474A2
公开(公告)日：2006-10-05
申请号：PCT/US2006012246
申请日：2006-03-31
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK , SAVAGE GEORGE , OMIDVAR FATANEH , COLLIOU OLIVIER , ARNE LAWRENCE , COSTELLO BEN , THOMPSON TODD
发明人： ZDEBLICK MARK , SAVAGE GEORGE , OMIDVAR FATANEH , COLLIOU OLIVIER , ARNE LAWRENCE , COSTELLO BEN , THOMPSON TODD
IPC分类号： A61N1/06
CPC分类号： A61N1/3627 , A61N1/08 , A61N1/36185 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/3686 , A61N1/37247
摘要： One embodiment of the present invention provides a system for automatically optimizing CRT procedures using a multi-electrode pacing lead. During operation, the system performs a first set of iterations to select one or more satellites on one or more pacing leads inserted in a patient. A pacing lead includes a plurality of pacing satellites, and a pacing satellite includes a plurality of electrodes that can be individually addressed and used for transmitting or detecting electric signals. The system then performs a second set of iterations to select one or more electrodes on the selected satellites. The system further performs a third set of iterations to select one or more timing configurations for pacing signals transmitted through one or more of the selected electrodes.
摘要翻译：本发明的一个实施例提供一种用于使用多电极起搏引线自动优化CRT程序的系统。在操作期间，系统执行第一组迭代以在插入患者体内的一个或多个起搏引线上选择一个或多个卫星。起搏引线包括多个起搏卫星，并且起搏卫星包括多个电极，其可单独寻址并用于发送或检测电信号。然后，系统执行第二组迭代以选择所选卫星上的一个或多个电极。系统进一步执行第三组迭代以选择一个或多个定时配置，用于通过一个或多个所选择的电极发射的起搏信号。

10. 发明申请

WO2010135463A2 METHOD AND APPARATUS FOR NEURAL SIGNAL DETERMINATION AND THERAPY ENHANCEMENT 审中-公开
标题翻译：用于神经信号测定和治疗增强的方法和装置
公开(公告)号：WO2010135463A2
公开(公告)日：2010-11-25
申请号：PCT/US2010035466
申请日：2010-05-19
申请人： PROTEUS BIOMEDICAL INC , ZDEBLICK MARK , WHITE ROBERT
发明人： ZDEBLICK MARK , WHITE ROBERT
IPC分类号： A61B5/16 , A61B5/04
CPC分类号： A61B5/04001 , A61B5/4839
摘要： A method and device are provided that detect and identify a neural signal by type and optionally or automatically provide a signal that affects a nerve carrying the neural signal. A plurality of electrodes is positioned along a nerve and monitors the electrical activity of the nerve. The invented system analyzes the monitored data to determine when the monitored activity can be identified as a known type of bioelectric signal, e.g., a pain nerve signal. The system may optionally attempt to affect, disrupt, diminish, nullify or block transmission of bioelectric signals along the nerve, e.g., by directing electrical energy through an electrode to nullify a bioelectric signal along a pain nerve.
摘要翻译：提供了通过类型检测和识别神经信号的方法和装置，并且可选地或自动地提供影响携带神经信号的神经的信号。沿着神经定位多个电极并监测神经的电活动。本发明的系统分析所监测的数据，以确定监测的活动何时可以被识别为已知类型的生物电信号，例如疼痛神经信号。系统可以可选地尝试影响，破坏，减少，消除或阻止沿着神经的生物电信号的传播，例如通过将电能引导通过电极来消除沿着疼痛神经的生物电信号。

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