专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO2005116002A2 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 审中-公开
标题翻译： 11-羟基甾体脱氢酶1型抑制剂
公开(公告)号：WO2005116002A2
公开(公告)日：2005-12-08
申请号：PCT/US2005018081
申请日：2005-05-24
申请人： AMGEN INC , BIOVITRUM AB , HENRIKSSON MARTIN , HOMAN EVERT , JOHANSSON LARS , VALLGARDA JERK , WILLIAMS MEREDITH , BERCOT ERIC , FOTSCH CHRISTOPHER H , LI AIWEN , CAI GUOLIN , HUNGATE RANDALL W , YUAN CHESTER CHENGUANG , TEGLEY CHIRSTOPHER , ST JEAN DAVID , HAN NIANHE , HUANG QI , LIU QINGYIAN , BARTBERGER MICHAEL D , MONIZ GEORGE A , FRIZZLE MATTHEW J
发明人： HENRIKSSON MARTIN , HOMAN EVERT , JOHANSSON LARS , VALLGARDA JERK , WILLIAMS MEREDITH , BERCOT ERIC , FOTSCH CHRISTOPHER H , LI AIWEN , CAI GUOLIN , HUNGATE RANDALL W , YUAN CHESTER CHENGUANG , TEGLEY CHIRSTOPHER , ST JEAN DAVID , HAN NIANHE , HUANG QI , LIU QINGYIAN , BARTBERGER MICHAEL D , MONIZ GEORGE A , FRIZZLE MATTHEW J
IPC分类号： A61K31/42 , A61K31/426 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P19/10 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/12 , C07D20060101 , C07D263/48 , C07D277/42 , C07D277/54 , C07D277/60 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D513/10 , C07F7/18
CPC分类号： C07D417/06 , C07D263/34 , C07D263/48 , C07D275/03 , C07D277/42 , C07D277/54 , C07D277/60 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D513/10 , C07F7/1856
摘要： The present invention relates to compounds with the formula (I), (II), (III) or (IV): (I) (II), (III), or (IV), wherein R , R , R , R , R , R , R , X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-beta-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-beta-hydroxysteroid dehydrogenase type 1 enzyme.
摘要翻译：本发明涉及具有式（I），（II），（III）或（IV）：（I）（II），（III）或（IV））的化合物，其中R 1，R 2 R 3，R 4，R 5，R 6，R 7，X 7和Z如本文所定义，并且还涉及包含该化合物的药物组合物，以及使用方法的用于治疗与人类11-β-羟基类固醇脱氢酶1型酶相关的疾病的化合物和用于制备作用于人类11-β-羟基类固醇脱氢酶1型酶的药物。

22. 发明申请

WO2005087751A2 SUBSTITUTED HYDROXYETHYLAMINE ASPARTYL PROTEASE INHIBITORS 审中-公开
标题翻译：取代的羟乙基胺ASPARTYL蛋白酶抑制剂
公开(公告)号：WO2005087751A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/007771
申请日：2005-03-09
申请人： ELAN PHARMACEUTICALS, INC. , JOHN, Varghese , MAILLARD, Michel , TUCKER, John , AQUINO, Jose , JAGODZINSKA, Barbara , BROGLEY, Louis , TUNG, Jay , BOWERS, Simeon , DRESSEN, Darren , PROBST, Gary , SHAH, Neerav
发明人： JOHN, Varghese , MAILLARD, Michel , TUCKER, John , AQUINO, Jose , JAGODZINSKA, Barbara , BROGLEY, Louis , TUNG, Jay , BOWERS, Simeon , DRESSEN, Darren , PROBST, Gary , SHAH, Neerav
IPC分类号： C07D257/04
CPC分类号： C07D419/12 , C07C215/28 , C07C215/50 , C07C217/30 , C07C217/34 , C07C217/48 , C07C217/52 , C07C217/58 , C07C225/06 , C07C225/20 , C07C229/16 , C07C229/42 , C07C229/60 , C07C233/43 , C07C237/20 , C07C237/30 , C07C271/12 , C07C311/24 , C07C317/28 , C07C323/25 , C07C323/30 , C07C323/32 , C07C2601/02 , C07C2601/14 , C07C2602/04 , C07C2602/10 , C07C2602/42 , C07C2603/18 , C07C2603/74 , C07D207/323 , C07D207/325 , C07D213/38 , C07D215/42 , C07D231/12 , C07D231/38 , C07D233/54 , C07D233/64 , C07D233/88 , C07D239/42 , C07D239/48 , C07D249/04 , C07D249/06 , C07D249/14 , C07D257/04 , C07D263/34 , C07D271/113 , C07D275/02 , C07D277/42 , C07D285/08 , C07D285/10 , C07D285/135 , C07D307/52 , C07D309/14 , C07D311/74 , C07D333/36 , C07D335/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D495/04
摘要： The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
摘要翻译：本发明涉及新化合物，还涉及使用这些化合物治疗至少一种与淀粉样变性相关的疾病，病症或病症的方法。淀粉样变性是指与A-β蛋白异常沉积有关的疾病，病症和病症的集合。

23. 发明申请

WO2005044804A1 VERFAHREN ZUM HERSTELLEN VON FLUORMETHYL-SUBSTITUIERTEN HETEROCYCLEN 审中-公开
标题翻译：用于生产氟取代的甲基杂环
公开(公告)号：WO2005044804A1
公开(公告)日：2005-05-19
申请号：PCT/EP2004/011809
申请日：2004-10-19
申请人： BAYER CROPSCIENCE GMBH , LANTZSCH, Reinhard , PAZENOK, Sergiy , MEMMEL, Frank
发明人： LANTZSCH, Reinhard , PAZENOK, Sergiy , MEMMEL, Frank
IPC分类号： C07D231/14
CPC分类号： C07D263/34 , C07D231/14 , C07D277/30
摘要： Die vorliegende Erfindung betrifft ein Verfahren zum Derstellen von fluormethyl-substituierten Heterocyclen der Formel (I) in welcher R 1 , R 2 , R 3 und A die in der Beschreibung angegebenen Bedeutungen haben, durch Fluorierung der entsprechenden chlormethyl-substituierte Vorstufen.
摘要翻译：本发明涉及的式（I）中R <1>，R <2>，R <3>和A具有在说明书中给出的含义的氟甲基取代的杂环化合物在S Tellen的方法，由相应的氯甲基的氟化取代的前体。

24. 发明申请

WO2005020897A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION 审中-公开
标题翻译：治疗与TRP-P8表达相关疾病的组合物和方法
公开(公告)号：WO2005020897A2
公开(公告)日：2005-03-10
申请号：PCT/US2004/026931
申请日：2004-08-20
申请人： DENDREON CORPORATION , NATARAJAN, Sateesh K. , MORENO, Ofir , GRADDIS, Thomas J. , DUNCAN, David , LAUS, Reiner , CHEN, Feng
发明人： NATARAJAN, Sateesh K. , MORENO, Ofir , GRADDIS, Thomas J. , DUNCAN, David , LAUS, Reiner , CHEN, Feng
IPC分类号： A61K
CPC分类号： C07C233/60 , A61K31/498 , A61K31/517 , A61K45/06 , C07C233/58 , C07C243/36 , C07C243/38 , C07C311/20 , C07C311/37 , C07C323/40 , C07C323/44 , C07C333/06 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D207/06 , C07D207/09 , C07D207/325 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/20 , C07D209/48 , C07D211/06 , C07D213/40 , C07D215/04 , C07D215/08 , C07D215/46 , C07D217/06 , C07D223/04 , C07D231/12 , C07D231/14 , C07D231/56 , C07D235/18 , C07D235/26 , C07D239/42 , C07D241/18 , C07D241/44 , C07D241/54 , C07D251/54 , C07D263/34 , C07D263/57 , C07D279/12 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/26 , C07D307/52 , C07D311/16 , C07D317/66 , C07D333/34 , C07D401/04 , C07D403/14 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04 , C07D493/08 , C07D495/04 , C07D513/04 , G01N33/5011 , G01N33/6872 , G01N2500/10 , A61K2300/00
摘要： Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.
摘要翻译：提供的是小分子Trp-p8调节剂，包括Trp-p8激动剂和Trp-p8拮抗剂，以及包含小分子Trp-p8激动剂的组合物以及用于鉴定和表征新型小分子Trp-p8调节剂的方法和方法降低Trp-p8表达细胞的生存力和/或抑制Trp-p8表达细胞的生长，用于激活Trp-p8介导的阳离子流入的方法，用于刺激凋亡和/或坏死的方法，以及用于治疗疾病的相关方法，包括癌症如肺，乳腺，结肠癌和/或前列腺癌以及与Trp-p8表达相关的其它疾病，例如良性前列腺增生。

25. 发明申请

WO2005019174A1 ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE 审中-公开
标题翻译：作为乙酰脱乙酰基酶抑制剂的乙烯衍生物
公开(公告)号：WO2005019174A1
公开(公告)日：2005-03-03
申请号：PCT/US2004/027053
申请日：2004-08-19
申请人： AXYS PHARMACEUTICALS, INC. , SENDZIK, Martin
发明人： SENDZIK, Martin
IPC分类号： C07D209/42
CPC分类号： C04B35/632 , C07C259/10 , C07C271/02 , C07C275/30 , C07C275/32 , C07C311/19 , C07D209/42 , C07D215/48 , C07D231/12 , C07D235/24 , C07D239/70 , C07D261/08 , C07D263/34 , C07D277/56 , C07D277/68 , C07D307/85 , C07D333/70 , C07D401/12 , C07D405/12
摘要： The present invention is directed to certain hydroxamate derivatives that are inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.
摘要翻译：本发明涉及作为组蛋白脱乙酰酶抑制剂的某些异羟肟酸衍生物，因此可用于治疗与组蛋白脱乙酰酶活性相关的疾病。还公开了制备这些化合物的药物组合物和方法。

26. 发明申请

WO2004089937A1 ７員複素環誘導体审中-公开
标题翻译： 7成员的杂环衍生物
公开(公告)号：WO2004089937A1
公开(公告)日：2004-10-21
申请号：PCT/JP2004/004999
申请日：2004-04-07
申请人：第一製薬株式会社 , 落合雄一 , 石山崇 , 金谷直明
发明人：落合雄一 , 石山崇 , 金谷直明
IPC分类号： C07D401/14
CPC分类号： C07D263/34 , C07D233/88 , C07D263/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D419/14
摘要： A compound of the general formula: (I) or its salt or a solvate thereof; and a drug comprising the same, e.g., a preventive and/or therapeutic agent for ischemic diseases or platelet aggregation inhibitor comprising the compound, salt or solvate.
摘要翻译：通式为：（I）的化合物或其盐或其溶剂合物; 和包含其的药物，例如包含该化合物，盐或溶剂化物的缺血性疾病或血小板聚集抑制剂的预防和/或治疗剂。

27. 发明申请

WO2004072068A1 VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS 审中-公开
标题翻译： VANILLOID受体配体及其在治疗中的应用
公开(公告)号：WO2004072068A1
公开(公告)日：2004-08-26
申请号：PCT/US2004/003908
申请日：2004-02-09
申请人： AMGEN INC.
发明人： DOHERTY, Elizabeth, M. , HAN, Nianhe , HUNGATE, Randall, W. , LIU, Qingyian , NORMAN, Mark, H. , XI, Ning , XU, Shimin , FOTSCH, Christopher, H.
IPC分类号： C07D417/04
CPC分类号： C07D233/90 , C07D263/34 , C07D277/56 , C07D403/04 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译：具有一般结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙痛，一般头痛，偏头痛，丛集性头痛，混合血管和非血管综合征，紧张性头痛，一般炎症，关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎症性或不稳定性膀胱病，银屑病，皮肤炎症成分炎症，慢性炎性病症，炎性疼痛及相关的痛觉过敏和异常性疼痛，神经性疼痛及相关的痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，咳嗽痛，交感神经痛，交感综合症，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸系统内脏运动紊乱，泌尿生殖道，胃肠道或血管区，伤口，烧伤，过敏性皮肤反应，瘙痒，白癜风， G 腹部溃疡，十二指肠溃疡，腹泻，坏死因子诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

28. 发明申请

WO2004065374A1 OXAZOLE DERIVATIVES AS INHIBITORS OF CYCLOOXYGENASE 审中-公开
标题翻译：作为CYCLOOXYGENASE的抑制剂的唑酮衍生物
公开(公告)号：WO2004065374A1
公开(公告)日：2004-08-05
申请号：PCT/JP2004/000339
申请日：2004-01-16
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , YAMAMOTO, Hirofumi , ISHIDA, Junya , TANABE, Daisuke , SATOH, Shigeki, , SAWADA, Yuki, , OHKAWA, Takehiko, , IMAMURA, Kenichiro, , NAKAMURA, Katsuya,
发明人： YAMAMOTO, Hirofumi , ISHIDA, Junya , TANABE, Daisuke , SATOH, Shigeki, , SAWADA, Yuki, , OHKAWA, Takehiko, , IMAMURA, Kenichiro, , NAKAMURA, Katsuya,
IPC分类号： C07D263/32
CPC分类号： C07D413/04 , C07D263/32 , C07D263/34 , C07D263/38 , C07D263/46 , C07D263/48 , C07D413/06 , C07D413/12 , C07D413/14 , C07D487/04
摘要： A compound of the formula (I): wherein R 1 is cycloalkyl, etc; R 2 is (lower)alkoxy, etc; R 3 is (lower)alkylene, etc; R 4 is (lower)alkylene, etc; R 5 is hydroxy, etc; X is "0", "S", "SO", or "S0 2 "; Y is "CH" or "N"; n is 0 or 1; or pharmaceutically acceptable salts thereof, which are useful as a medicament.
摘要翻译：式（I）的化合物：其中R 1是环烷基等; R 2为（低级）烷氧基等; R 3为（低级）亚烷基等; R 4为（低级）亚烷基等; R 5是羟基等; X为“0”，“S”，“SO”或“S02”; Y为“CH”或“N”; n为0或1; 或其药学上可接受的盐，其可用作药物。

29. 发明申请

WO2004062601A2 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO2004062601A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000433
申请日：2004-01-08
申请人： CHIRON CORPORATION , ANDERSON, Neils, H. , BOWMAN, Jason , ERWIN, Alice , HARWOOD, Eric , KLINE, Toni , MDLULI, Khisimuzi , NG, Simon , PFISTER, Keith, B. , SHAWAR, Ribhi , WAGMAN, Allan , YABANNAVAR, Asha
发明人： ANDERSON, Neils, H. , BOWMAN, Jason , ERWIN, Alice , HARWOOD, Eric , KLINE, Toni , MDLULI, Khisimuzi , NG, Simon , PFISTER, Keith, B. , SHAWAR, Ribhi , WAGMAN, Allan , YABANNAVAR, Asha
IPC分类号： A61K
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译：提供了式（I）的抗菌化合物：以及立体异构体，其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。

30. 发明申请

WO2004058723A1 BIPHENYL DERIVATIVES AND THEIR USE AS FUNGICIDES 审中-公开
标题翻译：苯乙烯衍生物及其作为杀真菌剂使用
公开(公告)号：WO2004058723A1
公开(公告)日：2004-07-15
申请号：PCT/EP2003/014248
申请日：2003-12-15
申请人： SYNGENTA PARTICIPATIONS AG , EHRENFREUND, Josef , LAMBERTH, Clemens , TOBLER, Hans , WALTER, Harald
发明人： EHRENFREUND, Josef , LAMBERTH, Clemens , TOBLER, Hans , WALTER, Harald
IPC分类号： C07D231/14
CPC分类号： C07D213/82 , A01N43/06 , A01N43/14 , A01N43/32 , A01N43/36 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/58 , A01N43/60 , A01N43/74 , A01N43/80 , C07C25/24 , C07C211/45 , C07C211/52 , C07C217/76 , C07C219/32 , C07C233/03 , C07C2601/02 , C07C2601/08 , C07D207/34 , C07D231/14 , C07D231/16 , C07D237/24 , C07D239/28 , C07D239/30 , C07D263/34 , C07D277/56 , C07D307/68 , C07D309/28 , C07D327/06 , C07D333/38 , C07F7/0812
摘要： A fungicidally active compound of formula (I): where Het is a substituted 5- or 6-membered heterocyclic ring; R 1 is hydrogen, formyl, CO-C 1-4 alkyl, COO-C 1-4 alkyl, C 1-4 alkoxy(C 1-4 )alkylene, CO-C 1-4 alkylenoxy(C 1-4 )alkyl, propargyl or allenyl; R 2 , R 3 , R 4 and R 5 are each, independently, hydrogen, halogen, methyl or CF 3 ; each R 6 is, independently, halogen, methyl or CF 3 ; R 7 is (Z) m C=C(Y 1 ), (Z) m C(Y 1 )=C(Y 2 )(Y 3 ) or tri(C 1-4 )alkylsilyl; X is O or S; Y 1 , Y 2 and Y 3 are each, independently, hydrogen, halogen, C 1-6 alkyl [optionally substituted by one or more substituents each independently selected from halogen, hydroxy, C 1-4 alkoxy, C 1-4 haloalkoxy, C 1-4 alkylthio, C 1-4 haloalkylthio, C 1-4 alkylamino, di(C 1-4 )alkylamino, C 1-4 alkoxycarbonyl, C 1-4 alkylcarbonyloxy and tri(C 1-4 )alkylsilyl], C 2-4 alkenyl [optionally substituted by one or more substituents each independently selected from halogen], C 2-4 alkynyl [optionally substituted by one or more substituents each independently selected from halogen], C 3-7 cycloalkyl [optionally substituted by one or more substituents each independently selected from halogen, C 1-4 alkyl and C 1-4 haloalkyl] or tri(C 14 )alkylsilyl; Z is C 1-4 alkylene [optionally substituted by one or more substituents each independently selected from hydroxy, cyano, C 1-4 alkoxy, halogen, C 1-4 haloalkyl, C 1-4 haloalkoxy, C 1-4 alkylthio, COOH and COO-C 1-4 alkyl]; m is 0 or 1; and n is 0, 1 or 2; the invention also relates to novel intermediates used in the preparation of these compounds, to agrochemical compositions which comprise at least one of the novel compounds as active ingredient and to the use of the active ingredients or compositions in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.
摘要翻译：杀真菌活性的式（I）化合物：其中Het是取代的5或6元杂环; R 1是氢，甲酰基，CO-C 1-4烷基，COO-C 1-4烷基，C 1-4烷氧基（C 1-4）亚烷基，CO-C 1-4亚烷基氧基（C 1-4）烷基，炔丙基或烯丙基 ; R 2，R 3，R 4和R 5各自独立地为氢，卤素，甲基或CF 3; 每个R 6独立地是卤素，甲基或CF 3; R 7是（Z）m C = C（Y 1），（Z）m C（Y 1）= C（Y 2）（Y 3）或三（C 1-4）烷基甲硅烷基 ; X为O或S; Y 1，Y 2和Y 3各自独立地为氢，卤素，C 1-6烷基（任选被一个或多个取代基取代，各自独立地选自卤素，羟基，C 1-4烷氧基， 4卤代烷氧基，C 1-4烷硫基，C 1-4卤代烷硫基，C 1-4烷基氨基，二（C 1-4）烷基氨基，C 1-4烷氧基羰基，C 1-4烷基羰基氧基和三（C 1-4）烷基甲硅烷基]，C 2-4链烯基[ 任选被一个或多个各自独立地选自卤素的取代基取代的C 2-4炔基[任选被一个或多个各自独立地选自卤素的取代基取代]，C 3-7环烷基[任选地被一个或多个各自独立地选自卤素，C 1-4烷基和C 1-4卤代烷基]或三（C 14）烷基甲硅烷基; Z是C1-4亚烷基[任选地被一个或多个取代基取代，各自独立地选自羟基，氰基，C 1-4烷氧基，卤素，C 1-4卤代烷基，C 1-4卤代烷氧基，C 1-4烷硫基，COOH和COO- 4烷基]; m为0或1; 并且n为0,1或2; 本发明还涉及用于制备这些化合物的新型中间体，包含至少一种新化合物作为活性成分的农用化学组合物以及农业或园艺中的活性成分或组合物用于控制或预防植物通过植物病原微生物，优选真菌。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式