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1. 发明申请

WO2010147653A1 OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译： OPSIN-BINDING LIGANDS，COMPOSITIONS AND METHODS OF USE
公开(公告)号：WO2010147653A1
公开(公告)日：2010-12-23
申请号：PCT/US2010/001739
申请日：2010-06-16
申请人： BIKAM PHARMACEUTICALS, INC. , GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, Robert , BREWER, Mark, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
发明人： GARVEY, David, S. , LAROSA, Gregory, J. , GREENWOOD, Jeremy, Robert , BREWER, Mark, L. , QUACH, Tan , COTE, Jamie, B. , BERMAN, Judd
IPC分类号： A01N35/00 , A61K31/11
CPC分类号： C07D295/215 , C07B59/002 , C07B2200/05 , C07C233/10 , C07C275/14 , C07C2601/16 , C07D205/04 , C07D207/12 , C07D207/14 , C07D211/38 , C07D241/04 , C07D241/08 , C07D243/08 , C07D295/182 , C07D295/185 , C07D295/194 , C07D295/205 , C07D295/26 , C07D491/10 , C07D493/08
摘要： Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.
摘要翻译：公开了所述化合物的化合物和组合物以及化合物的使用方法，用于治疗与视蛋白蛋白质错位定位相关的眼科疾病，突变视蛋白蛋白质的错误折叠以及积聚在眼睛中的毒性视觉循环产物的产生。还描述了可用于这些方法中的单独或与其它治疗剂组合的化合物和组合物。

2. 发明申请

WO2009091350A1 POLYCARBAMIDES, POLYCARBAMATES, AND POLYCARBAMIDE-FORMALDEHYDE AND POLYCARBAMATE-FORMALDEHYDE CONDENSATION RESINS 审中-公开
标题翻译：聚碳酸酯，聚碳酸酯和聚碳酸酯 - 甲醛和聚碳酸酯 - 甲醛缩合树脂
公开(公告)号：WO2009091350A1
公开(公告)日：2009-07-23
申请号：PCT/US2007/025200
申请日：2007-12-10
申请人： MISSISSIPPI STATE UNIVERSITY , KIM, Moon
发明人： KIM, Moon
IPC分类号： B32B27/00
CPC分类号： C07C271/12 , C07C275/14 , C08G12/04 , C08G12/06 , C08L61/22
摘要： The present invention provides manufacturing of and the use of novel polycarbamates and polycarbamides and their condensation reaction products formed by reacting with formaldehyde as wood composite binder resins and in other applications. These resins have thermosetting capabilities and usefulness as binders for wood and other materials with superior resin properties of low cost, colorlessness, exceptionally good binding, and fast curing characteristics, as well as very low formaldehyde emissions. The newly-designed and synthesized novel starting materials for the thermosetting resins of the present invention are diethylene tricarbamide and various polycarbamates derived from corresponding polyols.
摘要翻译：本发明提供新型聚氨酯和聚氨酯及其与甲醛作为木材复合粘合剂树脂反应形成的缩合反应产物的制备和应用，以及其它应用。这些树脂具有热固性和作为木材和其它材料的粘合剂的有用性，具有优异的低成本，无色性，特别好的结合性和快速固化特性以及非常低的甲醛释放性的树脂性质。新设计合成的本发明热固性树脂的新型起始材料是二亚乙基三胺和衍生自相应多元醇的各种聚氨酯。

3. 发明申请

WO2006135694A2 UII-MODULATING COMPOUNDS AND THEIR USE 审中-公开
标题翻译： UII调节化合物及其用途
公开(公告)号：WO2006135694A2
公开(公告)日：2006-12-21
申请号：PCT/US2006/022337
申请日：2006-06-08
申请人： ACADIA PHARMACEUTICALS INC. , LUTHMAN, Ingrid, Kristina , LEHMANN, Fredrik
发明人： LUTHMAN, Ingrid, Kristina , LEHMANN, Fredrik
IPC分类号： C07C217/48 , C07C219/22 , C07C233/78 , C07C271/28 , C07C275/28 , C07C311/18 , C07D209/24 , C07D333/38 , A61K31/137 , A61K31/166 , A61K31/17 , A61K31/24 , A61K31/18 , A61K31/27 , A61K31/381
CPC分类号： C07C311/18 , C07C217/48 , C07C219/14 , C07C219/22 , C07C233/40 , C07C233/78 , C07C235/34 , C07C271/28 , C07C271/30 , C07C275/14 , C07C275/28 , C07C275/34 , C07D209/24 , C07D295/13 , C07D317/68 , C07D333/38
摘要： Disclosed herein are novel aromatic-containing compounds and methods for using various aromatic-containing compounds for treatment and prevention of diseases and disorders related to the Urotensin II receptor.
摘要翻译：本文公开了含有芳族化合物的新化合物和使用各种含芳族化合物来治疗和预防与促肾上腺素II受体有关的疾病和病症的方法。

4. 发明申请

WO2004062601A3 ANTIBACTERIAL AGENTS 审中-公开
标题翻译：抗菌剂
公开(公告)号：WO2004062601A3
公开(公告)日：2005-04-21
申请号：PCT/US2004000433
申请日：2004-01-08
申请人： CHIRON CORP , ANDERSON NEILS H , BOWMAN JASON , ERWIN ALICE , HARWOOD ERIC , KLINE TONI , MDLULI KHISIMUZI , NG SIMON , PFISTER KEITH B , SHAWAR RIBHI , WAGMAN ALLAN , YABANNAVAR ASHA
发明人： ANDERSON NEILS H , BOWMAN JASON , ERWIN ALICE , HARWOOD ERIC , KLINE TONI , MDLULI KHISIMUZI , NG SIMON , PFISTER KEITH B , SHAWAR RIBHI , WAGMAN ALLAN , YABANNAVAR ASHA
IPC分类号： C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/26 , C07D207/27 , C07D207/32 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/54 , C07D235/10 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/00 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58 , C07D453/00 , C07C233/00 , A61K31/16 , A61K31/165
CPC分类号： C07D453/00 , C07C233/83 , C07C239/16 , C07C251/40 , C07C255/24 , C07C255/25 , C07C255/44 , C07C255/57 , C07C259/06 , C07C275/14 , C07C275/16 , C07C275/26 , C07C279/14 , C07C311/06 , C07C311/08 , C07C311/19 , C07C311/21 , C07C317/32 , C07C323/25 , C07C323/41 , C07C323/60 , C07C323/62 , C07C335/08 , C07C337/08 , C07C381/00 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07C2603/74 , C07D207/08 , C07D207/09 , C07D207/14 , C07D207/16 , C07D207/27 , C07D207/327 , C07D211/26 , C07D211/42 , C07D211/56 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/40 , C07D213/54 , C07D213/56 , C07D213/61 , C07D213/74 , C07D213/80 , C07D213/81 , C07D213/82 , C07D215/48 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/64 , C07D235/14 , C07D239/26 , C07D239/42 , C07D241/04 , C07D241/12 , C07D241/18 , C07D263/34 , C07D285/01 , C07D295/13 , C07D295/135 , C07D295/155 , C07D295/192 , C07D295/215 , C07D307/68 , C07D311/24 , C07D317/60 , C07D317/68 , C07D333/20 , C07D333/24 , C07D333/32 , C07D333/36 , C07D333/58
摘要： Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.
摘要翻译：提供了式（I）的抗菌化合物：以及立体异构体，其药学上可接受的盐，酯和前药; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 和化合物的制备方法。

5. 发明申请

WO2002070493A1 BISARYL DERIVATIVES HAVING FSH RECEPTOR MODULATORY ACTIVITY 审中-公开
标题翻译：具有FSH受体调节剂活性的双联衍生物
公开(公告)号：WO2002070493A1
公开(公告)日：2002-09-12
申请号：PCT/US2002/003777
申请日：2002-01-18
申请人： PHARMACOPEIA, INC. , GUO, Tao , HO, Koc-Kan , MCDONALD, Edward , DOLLE, Roland, Ellwood , SAIONZ, Kurt, W. , KULTGEN, Steven, G. , LIU, Ruiyan , DONG, Guizhen , GENG, Peng , ADANG, Anton, Egbert, Peter , VAN STRATEN, Nicole, Corine, Renee
发明人： GUO, Tao , HO, Koc-Kan , MCDONALD, Edward , DOLLE, Roland, Ellwood , SAIONZ, Kurt, W. , KULTGEN, Steven, G. , LIU, Ruiyan , DONG, Guizhen , GENG, Peng , ADANG, Anton, Egbert, Peter , VAN STRATEN, Nicole, Corine, Renee
IPC分类号： C07D241/08
CPC分类号： C07D207/273 , A61K38/00 , C07C237/22 , C07C271/22 , C07C275/14 , C07C2601/02 , C07D223/10 , C07D233/76 , C07D241/08 , C07D243/08 , C07K5/06078 , C07K5/06191
摘要： The invention relates to a bisaryl derivative of the formula I, wherein (R, R) is selected from (H, H), O, (H, CH 3 ), (H, OH) and (H, CN); Ar is substituted phenyl; and A is a group of following formula II, III, IV or V: The compounds of the invention have FSH receptor modulatory activity and can be used for the control of fertility, for contraception or for treatment of hormone-dependent disorders.
摘要翻译：本发明涉及式I的二芳基衍生物，其中（R，R）选自（H，H），O，（H，CH 3），（H，OH）和（H，CN）; Ar是取代的苯基; 并且A是以下式II，III，IV或V的组：本发明的化合物具有FSH受体调节活性，并且可用于控制生育力，避孕或用于治疗激素依赖性疾病。

6. 发明申请

WO02012168A1 NOVEL N-(2-PHENYL-3-AMINOPROPYL)NAPHTAMIDES 审中-公开
标题翻译：新型N-（2-苯基-3-氨基丙基）NAPHTAMIDES
公开(公告)号：WO02012168A1
公开(公告)日：2002-02-14
申请号：PCT/SE2001/001687
申请日：2001-07-31
IPC分类号： A61P1/08 , A61K31/277 , A61P3/04 , A61P7/10 , A61P9/12 , A61P13/10 , A61P17/00 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/14 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P27/16 , A61P29/00 , A61P29/02 , A61P35/00 , A61P37/08 , A61P43/00 , C07C233/78 , C07C255/57 , C07C275/14 , C07C279/28 , C07C311/05 , A61K31/166 , C07C235/66 , C07C255/52
CPC分类号： C07C311/05 , C07B2200/07 , C07C255/57 , C07C275/14 , C07C279/28
摘要： A compound having general formula (I) and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.
摘要翻译：具有通式（I）的化合物和使用这些化合物治疗疾病的方法和包含这些化合物的药物组合物。

7. 发明申请

WO01046124A1 AROMATIC DIAMIDE DERIVATIVES, CHEMICALS FOR AGRICULTURAL OR HORTICULTURAL USE AND USAGE THEREOF 审中-公开
标题翻译：芳香族DIAMIDE衍生物，农业或农业用途化学品及其用途
公开(公告)号：WO01046124A1
公开(公告)日：2001-06-28
申请号：PCT/JP2000/009146
申请日：2000-12-22
IPC分类号： A01N37/30 , A01N41/06 , A01N43/16 , A01N43/28 , A01N43/40 , A01N47/12 , A01N47/28 , A01N57/14 , C07C233/66 , C07C233/69 , C07C233/75 , C07C233/78 , C07C239/16 , C07C271/12 , C07C271/20 , C07C271/28 , C07C275/14 , C07C307/06 , C07C311/05 , C07C311/18 , C07C323/12 , C07C323/43 , C07C335/08 , C07D295/205 , C07F9/24 , A01N47/16 , A01N47/24 , C07C317/28 , C07C323/42 , C07D211/58 , C07D213/30 , C07D213/61 , C07D239/28 , C07D241/24 , C07D285/12 , C07D307/82 , C07D309/04 , C07D317/28 , C07D317/46 , C07D319/20 , C07F9/165 , C07F9/58
CPC分类号： C07D295/205 , A01N37/30 , A01N41/06 , A01N43/16 , A01N43/28 , A01N43/40 , A01N47/12 , A01N47/28 , A01N57/14 , C07C233/66 , C07C233/69 , C07C233/75 , C07C233/78 , C07C239/16 , C07C271/12 , C07C271/20 , C07C271/28 , C07C275/14 , C07C307/06 , C07C311/05 , C07C311/18 , C07C323/12 , C07C323/43 , C07C335/08 , C07C2601/02 , C07F9/2458
摘要： Aromatic diamide derivatives of general formula (I) or salts thereof; chemicals for agricultural or horticultural use; and usage thereof [wherein A is optionally substituted C1-8 alkylene, C3-8 alkenylene, or the like; B is O- or -N(R )- (wherein R is H, C1-6 alkyl, halo C1-6 alkyl, or the like); R is H, C1-6 alkyl, optionally substituted phenyl, an optionally substituted heterocyclic group, or the like; R and R are each H, C3-6 cycloalkyl, or -A -R (wherein A is C(=O)-, -C(=S)-, or -C(=NR )-; and R and R are each H, C1-6 alkyl, or the like); Q to Q are each carbon or nitrogen; X and Y are each halogeno, cyano, nitro, C3-6 cycloalkyl, optionally substituted phenyl, an optionally substituted heterocyclic group, or the like; n is 0 to 4; m is 1 to 5; and Z and Z are each O or S]. The above chemicals exhibit remarkable controlling effects against various agricultural, forest and horticultural insect pests and stored grain insect pests which injure paddy rice, fruit trees, vegetables, other crop plants, flowers, ornamental plants, or the like.
摘要翻译：通式（I）的芳族二酰胺衍生物或其盐; 用于农业或园艺用途的化学品; 及其用途[其中A 1为任选取代的C 1-8亚烷基，C 3-8亚烯基等; B是O-或-N（R 4） - （其中R 4是H，C 1-6烷基，卤代C 1-6烷基等）; R 1是H，C 1-6烷基，任选取代的苯基，任选取代的杂环基等; R 2和R 3各自为H，C 3-6环烷基或-A 2 -R 8（其中A 2为C（= O） - ， - C（= S） - ，或-C（= NR 9） - ; R 8和R 9各自为H，C 1-6烷基等）; Q 1至Q 5各自为碳或氮; X和Y各自为卤素，氰基，硝基，C 3-6环烷基，任选取代的苯基，任选取代的杂环基等; n为0〜4; m为1〜5; Z 1和Z 2各自为O或S]。上述化学品对各种农，林，园艺害虫和储存的水稻，果树，蔬菜，其他作物，花卉，观赏植物等的害虫都具有显着的防治效果。

8. 发明申请

WO1994006756A1 N-(ACYLAMINOMETHYL)GLUTARYL AMINO ACIDS AND THEIR USE AS DUAL INHIBITORS OF NEUTRAL ENDOPEPTIDASE AND ANGIOTENSIN CONVERTING ENZYME 审中-公开
标题翻译： N-（ACYLAMINOMETHYL）GLUTARYL氨基酸及其作为中性内切酶和血管紧张素转换酶的双重抑制剂的用途
公开(公告)号：WO1994006756A1
公开(公告)日：1994-03-31
申请号：PCT/US1993008706
申请日：1993-09-21
申请人： SCHERING CORPORATION
发明人： SCHERING CORPORATION , NEUSTADT, Bernard, R.
IPC分类号： C07C271/22
CPC分类号： C07D295/215 , C07C237/24 , C07C271/22 , C07C275/14 , C07C307/06 , C07C311/05 , C07C2601/08
摘要： Novel glutarylamino acid derivative dual inhibitors of neutral endopeptidase and angiotensin converting enzyme of formula (I) wherein: R1 and R3 are independently hydroxy, lower alkoxy, aryllower alkoxy, amino, lower alkylamino and di-(lower alkyl)amino; R2 is H or hydroxy; R4 is aryl, substituted aryl, heteroaryl or substituted heteroaryl; R6 is H or R7-(CH2)3-, wherein R7 is amino or (aryllower alkoxy)carbonylamino; Q is -C(O)- or -SO2; Y is lower alkyl, lower alkoxy, aryllower alkoxy, amino, lower alkylamino, di-(lower alkyl)amino, or a group of formula (a), wherein A is a bond, -N(R5)-, or -O-; and R5 is H or lower alkyl; B is H or Z-(CH2)m-; Z is amino, lower alkylamino, di-(lower alkyl)amino, (aryllower alkoxy)carbonylamino, 1-pyrrolidino or 1-piperidino; m = 1, 2, 3, 4 or 5; and n = 1, 2 or 3; or a pharmaceutically acceptable addition salt thereof; useful in the treatment of cardiovascular disorders, are disclosed.
摘要翻译：式（I）的中性内肽酶和血管紧张素转换酶的新型戊二酰氨基酸衍生物双重抑制剂，其中：R1和R3独立地是羟基，低级烷氧基，芳基低级烷氧基，氨基，低级烷基氨基和二 - （低级烷基）氨基; R2是H或羟基; R4是芳基，取代的芳基，杂芳基或取代的杂芳基; R6是H或R7-（CH2）3-，其中R7是氨基或（芳基低级烷氧基）羰基氨基; Q是-C（O） - 或-SO 2; Y是低级烷基，低级烷氧基，芳基低级烷氧基，氨基，低级烷基氨基，二（低级烷基）氨基或式（a）的基团，其中A是键，-N（R5） - 或-O- ; R5为H或低级烷基; B是H或Z-（CH 2）m - ; Z是氨基，低级烷基氨基，二（低级烷基）氨基，（芳基低级烷氧基）羰基氨基，1-吡咯烷子基或1-哌啶子基; m = 1,2,3,4或5; 和n = 1,2或3; 或其药学上可接受的加成盐; 可用于治疗心血管疾病。

9. 发明申请

WO1992008699A1 RETROVIRAL PROTEASE INHIBITORS 审中-公开
标题翻译：替代蛋白酶抑制剂
公开(公告)号：WO1992008699A1
公开(公告)日：1992-05-29
申请号：PCT/US1991008593
申请日：1991-11-18
申请人： MONSANTO COMPANY
发明人： MONSANTO COMPANY , REED, Kathryn, Lea , TALLEY, John, Jeffrey
IPC分类号： C07D215/48
CPC分类号： C07D213/40 , A61K31/17 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C07C213/02 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/24 , C07C275/28 , C07C311/06 , C07C311/13 , C07C311/19 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C335/12 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/81 , C07D215/48 , C07D215/50 , C07D215/54 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D307/85 , C07D401/12 , C07K5/0207 , C07K5/06026 , C07K5/06139 , C07K5/06191
摘要： Compounds represented by formula (I) wherein B represents R and radicals represented by formula (II) (values for the variables given herein), are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
摘要翻译：由式（I）表示的其中B表示R 5的化合物和由式（II）表示的基团（本文给出的变量的值）作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。

10. 发明申请

WO1992008698A1 RETROVIRAL PROTEASE INHIBITORS 审中-公开
标题翻译：替代蛋白酶抑制剂
公开(公告)号：WO1992008698A1
公开(公告)日：1992-05-29
申请号：PCT/US1991008582
申请日：1991-11-18
申请人： MONSANTO COMPANY
发明人： MONSANTO COMPANY , DECRESCENZO, Gary, Anthony , FRESKOS, John, Nicholas , GETMAN, Daniel, Paul , LIN, Ko-Chung , ROGIER, Donald, Joseph, Jr. , TALLEY, John, Jeffrey
IPC分类号： C07D215/48
CPC分类号： C07K5/06191 , A61K31/17 , A61K31/195 , A61K31/197 , A61K31/27 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K38/00 , C07C213/02 , C07C271/20 , C07C271/22 , C07C275/14 , C07C275/18 , C07C275/24 , C07C275/28 , C07C311/47 , C07C317/44 , C07C317/50 , C07C323/60 , C07C335/12 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/81 , C07D215/48 , C07D215/54 , C07D215/56 , C07D217/26 , C07D235/06 , C07D235/24 , C07D239/38 , C07D241/44 , C07D295/13 , C07D295/15 , C07D307/85 , C07D401/12 , C07K5/0207 , C07K5/06026 , C07K5/06139
摘要： Compounds represented by formula (I) wherein A represents R, R and radicals represented by formula (II), B represents R and radicals represented by formula (III) (values for the variables given herein) are effective as retroviral protease inhibitors and in particular as inhibitors of HIV protease.
摘要翻译：由式（I）表示的化合物，其中A表示R，R 13和由式（II）表示的基团，B表示R 5，由式（III）表示的基团（本文给出的变量的值）作为逆转录病毒蛋白酶抑制剂，特别是作为HIV蛋白酶的抑制剂。

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