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1. 发明申请

WO2017129796A1 ORGANIC REACTIONS CARRIED OUT IN AQUEOUS SOLUTION IN THE PRESENCE OF A HYDROXYALKYL(ALKYL)CELLULOSE OR AN ALKYLCELLULOSE 审中-公开
标题翻译：在羟烷基（烷基）纤维素或烷基醇的存在下，在水溶液中进行有机反应
公开(公告)号：WO2017129796A1
公开(公告)日：2017-08-03
申请号：PCT/EP2017/051858
申请日：2017-01-27
申请人： ABBVIE DEUTSCHLAND GMBH & CO. KG , ABBVIE INC.
发明人： BRAJE, Wilfried , BRITZE, Katarina , DIETRICH, Justin, D. , JOLIT, Anais , KASCHEL, Johannes , KLEE, Johanna , LINDNER, Tanja
IPC分类号： C07D215/227 , C07B37/04 , C07B43/04 , C07B43/06 , C07D405/04 , C07D239/26 , C07D409/04 , C07F5/02 , C07D307/36
CPC分类号： C07B63/04 , C07B37/04 , C07B43/04 , C07B43/06 , C07C41/46 , C07C67/62 , C07C209/90 , C07C213/10 , C07C231/22 , C07C253/32 , C07C269/08 , C07C273/189 , C07C303/42 , C07C319/26 , C07D205/04 , C07D207/34 , C07D209/08 , C07D209/48 , C07D211/06 , C07D213/74 , C07D215/227 , C07D239/26 , C07D239/42 , C07D307/36 , C07D307/81 , C07D311/58 , C07D405/04 , C07D409/04 , C07D471/04 , C07D495/04 , C07F5/02 , C07F5/025
摘要： The present invention relates to a method of carrying out an organic reaction in aqueous solution in the presence of a hydroxyalkyl(alkyl)cellulose or an alkylcellulose.
摘要翻译：本发明涉及在羟烷基（烷基）纤维素或烷基纤维素存在下在水溶液中进行有机反应的方法。

2. 发明申请

WO2015095346A1 LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS 审中-公开
标题翻译：用于交付活性剂的脂肪和脂质组合物
公开(公告)号：WO2015095346A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/070891
申请日：2014-12-17
申请人： NOVARTIS AG , BRITO, Luis , CHEN, Delai , GAMBER, Gabriel Grant , GEALL, Andrew , LOVE, Kevin , ZABAWA, Thomas , ZECRI, Frederic
发明人： BRITO, Luis , CHEN, Delai , GAMBER, Gabriel Grant , GEALL, Andrew , LOVE, Kevin , ZABAWA, Thomas , ZECRI, Frederic
IPC分类号： C07D319/06 , C07D233/60 , C07C219/06 , C07C229/12 , C07D207/12 , C07D207/16 , C07D211/22 , C07D295/088 , C07D211/62 , A61K31/7088
CPC分类号： A61K9/5123 , A61K9/1272 , A61K31/7105 , A61K31/713 , A61K38/1816 , A61K38/2264 , A61K39/12 , A61K47/18 , A61K2039/53 , C07C219/06 , C07C219/16 , C07C229/12 , C07C235/08 , C07C323/52 , C07D207/12 , C07D207/16 , C07D211/06 , C07D211/22 , C07D211/46 , C07D211/62 , C07D233/60 , C07D233/64 , C07D295/088 , C07D295/13 , C07D319/06 , C12N7/00 , C12N15/1137 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2760/00034 , C12N2760/00071
摘要： This invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 -R 3 , n, p, L 1 and L 2 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中R1-R3，n，p，L1和L2在本文中定义。式（I）化合物及其药学上可接受的盐是可用于将生物活性剂递送至细胞和组织的阳离子脂质。

3. 发明申请

WO2015088905A1 SYNTHESIS OF ZEOLITES USING AN ORGANOAMMONIUM COMPOUND 审中-公开
标题翻译：使用有机金属化合物合成ZOOLITE
公开(公告)号：WO2015088905A1
公开(公告)日：2015-06-18
申请号：PCT/US2014/068785
申请日：2014-12-05
申请人： UOP LLC
发明人： NICHOLAS, Christopher P. , MILLER, Mark A.
IPC分类号： C01B39/06
CPC分类号： C07D211/06 , B01J29/70 , B01J35/002 , C01B39/48 , C07D207/04 , C07D295/037 , C07D471/10
摘要： A method for synthesizing a zeolite includes the steps of: (a) preparing an aqueous mixture comprising water, a substituted hydrocarbon and an amine; (b) reacting the aqueous mixture; (c) obtaining a solution comprising an organoammonium product; (d) forming a reaction mixture including reactive sources of M, Al, Si, optionally seeds of a layered material L, and the solution, wherein M is a metal; and (e) heating the reaction mixture to form the zeolite. The substituted hydrocarbon can be an α,ω-dihalogen substituted alkane, and the amine is preferably essentially incapable of undergoing pyramidal inversion.
摘要翻译：合成沸石的方法包括以下步骤：（a）制备含水，取代的烃和胺的含水混合物; （b）使含水混合物反应; （c）获得包含有机铵产物的溶液; （d）形成包含M，Al，Si的反应性源的反应混合物，任选的层状材料L的种子和溶液，其中M是金属; 和（e）加热反应混合物以形成沸石。取代的烃可以是α，ω-二卤素取代的烷烃，并且胺优选基本上不能经历锥体反转。

4. 发明申请

WO2014154682A1 NOVEL VIRAL REPLICATION INHIBITORS 审中-公开
标题翻译：新型病毒复制抑制剂
公开(公告)号：WO2014154682A1
公开(公告)日：2014-10-02
申请号：PCT/EP2014/055946
申请日：2014-03-25
申请人： KATHOLIEKE UNIVERSITEIT LEUVEN
发明人： BARDIOT, Dorothée , CARLENS, Gunter , DALLMEIER, Kai , KAPTEIN, Suzanne , KOUKNI, Mohamed , MARCHAND, Arnaud , NEYTS, Johan , SMETS, Wim
IPC分类号： C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D223/04 , C07D231/12 , C07D333/22 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/06
CPC分类号： C07D471/04 , A61K31/34 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/437 , A61K31/4439 , A61K45/06 , C07D207/06 , C07D207/323 , C07D207/335 , C07D211/06 , C07D211/16 , C07D223/04 , C07D231/12 , C07D241/04 , C07D243/06 , C07D243/08 , C07D261/08 , C07D263/32 , C07D265/30 , C07D267/10 , C07D271/04 , C07D271/08 , C07D275/02 , C07D277/28 , C07D279/12 , C07D285/06 , C07D285/10 , C07D307/46 , C07D307/52 , C07D333/22 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/12 , C07D417/14 , C07D487/04 , C07D498/04 , C07D513/04 , Y02A50/385 , Y02A50/387 , A61K2300/00
摘要： The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.
摘要翻译：本发明涉及一系列新化合物，通过使用新化合物预防或治疗动物中的病毒感染的方法和用作药物的所述新化合物，更优选用作治疗或预防病毒感染的药物，特别是RNA病毒感染，更特别是属于黄病毒科病毒的病毒感染，更特别是登革病毒感染。本发明还涉及新化合物的药物组合物或组合制剂，用作药物的组合物或制剂，更优选用于预防或治疗病毒感染。本发明还涉及制备化合物的方法。

5. 发明申请

WO2014146111A2 ANALGESIC COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：化学化合物及其使用方法
公开(公告)号：WO2014146111A2
公开(公告)日：2014-09-18
申请号：PCT/US2014031089
申请日：2014-03-18
申请人： UNIV CALIFORNIA
发明人： LEVINE JON D , GALLARDO-GODOY ALEJANDRA
CPC分类号： C07D491/107 , C07D207/06 , C07D207/09 , C07D207/263 , C07D211/06 , C07D211/12 , C07D401/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D489/00 , C07D489/02
摘要： Provided herein, inter alia, are methods and compositions for achieving an analgesic effect in subjects in need thereof.
摘要翻译：本文提供的是用于在有需要的受试者中实现镇痛作用的方法和组合物。

6. 发明申请

WO2014108629A1 NOUVEAUX DÉRIVÉS DE L'ACIDE SINAPINIQUE 审中-公开
标题翻译：新药的新型衍生物
公开(公告)号：WO2014108629A1
公开(公告)日：2014-07-17
申请号：PCT/FR2014/050017
申请日：2014-01-07
申请人： PHARMASYNTHESE , INABATA FRANCE
发明人： LE ROY, Pierre-Yves , LE GUEN, Yves
IPC分类号： C07D309/40 , C07C69/618 , C07C323/20 , C07C235/34 , C07C235/38 , C07D209/16 , C07D211/06 , C07D295/192 , A61Q19/08 , A61K31/216 , A61P17/00
CPC分类号： A61Q19/06 , A61K8/36 , A61K8/37 , A61K8/375 , A61K8/42 , A61K8/46 , A61K8/49 , A61K8/492 , A61K8/4926 , A61K8/498 , A61K2800/78 , A61Q19/02 , A61Q19/08 , C07C69/734 , C07C235/34 , C07C235/36 , C07C235/38 , C07C323/19 , C07C2601/02 , C07C2601/14 , C07D209/16 , C07D211/06 , C07D265/30 , C07D295/192 , C07D309/40
摘要： La présente invention a pour objet un composé de formule générale (I) ainsi que son sel pharmaceutiquement acceptable, et l'utilisation de ce composé pour des applications cosmétiques ou pharmaceutiques.
摘要翻译：本发明涉及具有通式（I）的化合物及其药学上可接受的盐，以及所述化合物在化妆品或药物用途中的用途。

7. 发明申请

WO2013072705A1 MUSCARINIC M1 RECEPTOR AGONISTS 审中-公开
标题翻译： MUSCARINIC M1受体激素
公开(公告)号：WO2013072705A1
公开(公告)日：2013-05-23
申请号：PCT/GB2012/052857
申请日：2012-11-16
申请人： HEPTARES THERAPEUTICS LIMITED
发明人： CONGREVE, Miles , BROWN, Giles , CANSFIELD, Julie , TEHAN, Benjamin
IPC分类号： A61K31/4545 , A61K31/55 , A61P25/00 , C07D401/04
CPC分类号： A61K31/55 , A61K31/4545 , C07D211/06 , C07D401/04 , C07D401/14
摘要： This invention relates to compounds that are agonists of the muscarinic M1 receptor and which are useful in the treatment of muscarinic M1 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds provided are of formula I, where n is 1 or 2; p is 0, 1 or 2; q is 0, 1 or 2; and R 1 -R 6 are as defined herein.
摘要翻译：本发明涉及作为毒蕈碱M1受体的激动剂并可用于治疗毒蕈碱M1受体介导的疾病的化合物。还提供含有化合物的药物组合物和化合物的治疗用途。所提供的化合物为式I，其中n为1或2; p为0,1或2; q是0,1或2; 和R 1 -R 6如本文所定义。

8. 发明申请

WO2010123894A2 CHEMICAL AND BIOLOGICAL AGENTS FOR THE CONTROL OF MOLLUSCS 审中-公开
标题翻译：化学和生物学的控制莫尔斯
公开(公告)号：WO2010123894A2
公开(公告)日：2010-10-28
申请号：PCT/US2010/031746
申请日：2010-04-20
申请人： MARRONE BIO INNOVATIONS, INC. , ASOLKAR, Ratnakar , DOW, Sarahann , HUANG, Huazhang , KOIVUNEN, Marja , MARRONE, Pamela , SHU, Stephanie
发明人： ASOLKAR, Ratnakar , DOW, Sarahann , HUANG, Huazhang , KOIVUNEN, Marja , MARRONE, Pamela , SHU, Stephanie
IPC分类号： A01N63/02 , A01N43/08 , A01N43/72 , A01N35/06 , A01P9/00
CPC分类号： A61K35/618 , A01N37/02 , A01N37/18 , A01N37/36 , A01N37/46 , A01N43/08 , A01N43/16 , A01N43/36 , A01N43/76 , A01N49/00 , A01N63/02 , A61K35/74 , C07C59/42 , C07C233/06 , C07C233/09 , C07D207/04 , C07D207/06 , C07D211/06 , C07D211/16 , C07D223/04 , C07D295/18 , C07D307/33 , C07D309/30 , C09D5/1625
摘要： Compositions and methods for controlling molluscs, members of the Gastropoda and Bivalvia classes which includes but is not limited to lactones, lactams, carbamates, amides, and/or carboxylic acid containing compounds as active ingredients and/ or compounds derived from Pseudomonas and/or Erwinia. Also provided are methods and compositions for increasing the efficacy of chemical and biological control for invasive molluscs in open waters, power plants, and drinking water treatment facilities under coldwater conditions.
摘要翻译：包括但不限于内含物，内酰胺，氨基甲酸酯，酰胺和/或含羧酸的化合物作为活性成分和/或衍生自假单胞菌属和/或欧文氏菌的化合物的组合物和方法，用于控制软体动物，胃食管和百合属成分的成分。还提供了用于在冷水条件下提高开放水域，发电厂和饮用水处理设施中侵入性软体动物的化学和生物控制功效的方法和组合物。

9. 发明申请

WO2005020897A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION 审中-公开
标题翻译：治疗与TRP-P8表达相关疾病的组合物和方法
公开(公告)号：WO2005020897A2
公开(公告)日：2005-03-10
申请号：PCT/US2004/026931
申请日：2004-08-20
申请人： DENDREON CORPORATION , NATARAJAN, Sateesh K. , MORENO, Ofir , GRADDIS, Thomas J. , DUNCAN, David , LAUS, Reiner , CHEN, Feng
发明人： NATARAJAN, Sateesh K. , MORENO, Ofir , GRADDIS, Thomas J. , DUNCAN, David , LAUS, Reiner , CHEN, Feng
IPC分类号： A61K
CPC分类号： C07C233/60 , A61K31/498 , A61K31/517 , A61K45/06 , C07C233/58 , C07C243/36 , C07C243/38 , C07C311/20 , C07C311/37 , C07C323/40 , C07C323/44 , C07C333/06 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D207/06 , C07D207/09 , C07D207/325 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/20 , C07D209/48 , C07D211/06 , C07D213/40 , C07D215/04 , C07D215/08 , C07D215/46 , C07D217/06 , C07D223/04 , C07D231/12 , C07D231/14 , C07D231/56 , C07D235/18 , C07D235/26 , C07D239/42 , C07D241/18 , C07D241/44 , C07D241/54 , C07D251/54 , C07D263/34 , C07D263/57 , C07D279/12 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/26 , C07D307/52 , C07D311/16 , C07D317/66 , C07D333/34 , C07D401/04 , C07D403/14 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04 , C07D493/08 , C07D495/04 , C07D513/04 , G01N33/5011 , G01N33/6872 , G01N2500/10 , A61K2300/00
摘要： Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.
摘要翻译：提供的是小分子Trp-p8调节剂，包括Trp-p8激动剂和Trp-p8拮抗剂，以及包含小分子Trp-p8激动剂的组合物以及用于鉴定和表征新型小分子Trp-p8调节剂的方法和方法降低Trp-p8表达细胞的生存力和/或抑制Trp-p8表达细胞的生长，用于激活Trp-p8介导的阳离子流入的方法，用于刺激凋亡和/或坏死的方法，以及用于治疗疾病的相关方法，包括癌症如肺，乳腺，结肠癌和/或前列腺癌以及与Trp-p8表达相关的其它疾病，例如良性前列腺增生。

10. 发明申请

WO2004033422A3 MODULATION OF ANXIETY THROUGH BLOCKADE OF ANANDAMIDE HYDROLYSIS 审中-公开
标题翻译：通过水杨苷水解的片段调节
公开(公告)号：WO2004033422A3
公开(公告)日：2004-07-29
申请号：PCT/US0331844
申请日：2003-10-07
申请人： UNIV CALIFORNIA , PIOMELLI DANIELE , DURANTI ANDREA , TONTINI ANDREA , MOR MARCO , TARZIA GEORGIO
发明人： PIOMELLI DANIELE , DURANTI ANDREA , TONTINI ANDREA , MOR MARCO , TARZIA GEORGIO
IPC分类号： C07C271/00 , C07C271/56 , C07C275/54 , C07C311/29 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D409/04 , C07D409/06 , C07D409/12 , A61K31/21
CPC分类号： C07C311/29 , C07C271/56 , C07C275/54 , C07C2601/14 , C07D209/08 , C07D211/06 , C07D215/06 , C07D307/79 , C07D487/04
摘要： Fatty acid amide hydrolase inhibitors of the Formula (I) are provided, wherein X is NH, CH2, O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of substituted or unsubstituted aryl; substituted or unsubstituted biphenylyl, substituted or unsubstituted naphthyl, and substituted or unsubstituted phenyl; substituted or unsubstituted terphenylyl; substituted or unsubstituted cycloalkyl, heteroaryl, or alkyl; and R1 and R2 are independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, and substituted or unsubstituted phenyl, substituted or unsubstituted biphenylyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl; with the proviso that if Z is O, one of R1 and R2 is absent, and that, if Z is N, optionally R1 and R2 may optionally be taken together to form a substituted or unsubstituted N-heterocycle or substituted or unsubstituted heteroaryl with the N atom to which they are each attached. Pharmaceutical compositions comprising the compounds of Formula (I) and methods of using them to inhibit FAAH and/or treat appetite disorders, glaucoma, pain, insomnia, and neurological and psychological disorders including anxiety disorders, epilepsy, and depression are provided.
摘要翻译：提供式（I）的脂肪酸酰胺水解酶抑制剂，其中X是NH，CH 2，O或S; Q是O或S; Z是O或N; R是选自取代或未取代的芳基的芳族部分; 取代或未取代的联苯基，取代或未取代的萘基和取代或未取代的苯基; 取代或未取代的三联苯基; 取代或未取代的环烷基，杂芳基或烷基; 并且R 1和R 2独立地选自H，取代或未取代的烷基，取代或未取代的杂烷基和取代或未取代的苯基，取代或未取代的联苯基，取代或未取代的芳基和取代或未取代的杂芳基; 条件是如果Z是O，则不存在R 1和R 2中的一个，并且如果Z是N，则任选地R 1和R 2可以任选地一起形成取代或未取代的N-杂环或取代或未取代的杂芳基，其中它们各自连接的N原子。提供了包含式（I）化合物的药物组合物及其用于抑制FAAH和/或治疗食欲障碍，青光眼，疼痛，失眠以及包括焦虑障碍，癫痫和抑郁症在内的神经和心理障碍的方法。

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