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1. 发明申请

WO2002085522A1 MICROFLUIDIC DEVICE WITH PARTIALLY RESTRAINED ELEMENT 审中-公开
标题翻译：具有局部限制元素的微流体装置
公开(公告)号：WO2002085522A1
公开(公告)日：2002-10-31
申请号：PCT/US2002/015034
申请日：2002-04-18
申请人： NANOSTREAM, INC. , KARP, Christoph, D. , PEZZUTO, Marci , MARESCH, Laird , O'CONNOR, Stephen, D.
发明人： KARP, Christoph, D. , PEZZUTO, Marci , MARESCH, Laird , O'CONNOR, Stephen, D.
IPC分类号： B01L3/00
CPC分类号： F04B43/043 , B01L3/502738 , B01L2300/0681 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2400/0481 , B01L2400/0622 , B01L2400/0638 , B01L2400/084 , F16K99/0001 , F16K99/0007 , F16K99/003 , F16K99/0057 , F16K2099/008 , F16K2099/0084 , F16K2099/0094
摘要： A microfluidic flow control device (32) includes a moveable flap (30) capable of intermittently engaging a sealing surface(21A). One-way or check valve utility may be provided. Multiple valves may be coupled to various fluid displacement means to provide pumping utility. Devices may be constructed with stencil layers from various materials, including polymeric materials, adhesive tapes, and/or filter materials. Flow control devices may be passively activated by fluidic contents or by external actuation means.
摘要翻译：微流体流量控制装置（32）包括能够间歇地接合密封表面（21A）的可移动翼片（30）。可以提供单向或单向阀实用程序。多个阀可以联接到各种流体移动装置以提供泵送效用。装置可以用来自各种材料的模板层构造，包括聚合材料，胶带和/或过滤材料。流量控制装置可以被流体内容物或外部致动装置被动地激活。

2. 发明申请

WO2004004906A1 MICROFLUIDIC CLOSED-END METERING SYSTEMS AND METHODS 审中-公开
标题翻译：微流封闭式测量系统及方法
公开(公告)号：WO2004004906A1
公开(公告)日：2004-01-15
申请号：PCT/US2003/021039
申请日：2003-07-03
申请人： NANOSTREAM, INC. , KARP, Christoph, D.
发明人： KARP, Christoph, D.
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L2200/0605 , B01L2300/0816 , B01L2300/0887 , B01L2400/0481 , Y10T436/2575
摘要： Microfluidic devices and methods for segregating aliquots of fluid from large fluid volumes are provided. Preferably, a device includes an actuating channel, a metering channel and a deformable membrane disposed therebetween. The metering channel is in fluid communication with a fluid source, but is otherwise closed. The pressure in the actuating channel may be varied to deform the deformable membrane. The volume of the metering channel varies in proportion with the deformation of the deformable membrane, creating a pressure differential between the metering channel and the fluid source that causes fluid to be drawn into or expelled from the metering channel. Magnetic or mechanical actuating means may be substituted for the actuating channel. Multiple aliquots of different liquids may be drawn into metering channels and mixed thereafter in one or many different mixing proportions.
摘要翻译：提供了用于从大流体体积分离液体等分液体的微流体装置和方法。优选地，装置包括致动通道，计量通道和设置在其间的可变形膜。计量通道与流体源流体连通，但是否则关闭。可以改变致动通道中的压力以使可变形膜变形。计量通道的体积与可变形膜的变形成比例地变化，从而在计量通道和流体源之间产生压力差，导致流体被吸入或从计量通道排出。磁性或机械致动装置可以代替致动通道。不同液体的多个等分试样可以被吸入计量通道中，然后以一种或多种不同的混合比例混合。

3. 发明申请

WO2003068402A1 MICROFLUIDIC SEPARATION COLUMN DEVICES AND FABRICATION METHODS 审中-公开
标题翻译：微流化分离柱装置和制造方法
公开(公告)号：WO2003068402A1
公开(公告)日：2003-08-21
申请号：PCT/US2003/004540
申请日：2003-02-13
申请人： NANOSTREAM, INC.
发明人： KOEHLER, Jeffrey, A. , PATEL, Paren, P. , GREGORI, Matthew, M. , HOBBS, Steven, E. , COVINGTON, Joseph, F. , KARP, Christoph, D.
IPC分类号： B01L3/00
CPC分类号： B01F13/0059 , B01F15/0264 , B01J19/0093 , B01L3/502707 , B01L3/50273 , B01L3/502753 , B01L3/502761 , B01L2300/0681 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B01L2400/0406 , B01L2400/0688 , B29C65/02 , B29C66/02 , B29C66/026 , B29C66/71 , B29C66/727 , B29K2023/00 , B29K2023/12 , B29L2031/756 , B81B2201/058 , B81C3/008 , G01N30/6095 , G01N2030/565 , B29C2035/0827
摘要： Pressure-driven microfluidic separation devices, such as may be used for performing high performance liquid chromatography, are provided. Multiple separation columns may be defined in a single device and packed with stationary phase material retained by porous frits. One or more splitters may be provided to distribute slurry and/or mobile phase among multiple separation columns. In one embodiment, separation devices are substantially planar and fabricated with multiple device layers. Systems and methods employing slurry for packing separation devices are also provided.
摘要翻译：提供压力驱动的微流体分离装置，例如可用于执行高效液相色谱。多个分离柱可以在单个装置中定义并且填充有被多孔玻璃料保留的固定相材料。可以提供一个或多个分离器以在多个分离柱之间分配淤浆和/或流动相。在一个实施例中，分离装置基本上是平面的并且用多个装置层制造。还提供了使用用于包装分离装置的浆料的系统和方法。

4. 发明申请

WO2003059498A1 MICROFLUIDIC APERTURE MIXERS 审中-公开
标题翻译：微流控孔混合器
公开(公告)号：WO2003059498A1
公开(公告)日：2003-07-24
申请号：PCT/US2003/000903
申请日：2003-01-11
申请人： NANOSTREAM, INC.
发明人： KARP, Christoph, D.
IPC分类号： B01F13/00
CPC分类号： B01F5/0471 , B01F5/0604 , B01F5/0646 , B01F13/0059 , Y10S366/04
摘要： Robust microfluidic mixing devices mix multiple fluid streams passively, without the use of moving parts. In one embodiment, these devices contain microfluidic channels that are formed in various layers of a three-dimensional structure. Mixing may be accomplished with various manipulations of fluid flow paths and/or contacts between fluid streams. In various embodiments, structures such as channel overlaps, slits, converging/diverging regions, turns, and/or apertures may be designed into a mixing device. Mixing devices may be rapidly constructed and prototyped using a stencil construction method in which channels are cut through the entire thickness of a material layer, although other construction methods including surface micromachining techniques may be used.
摘要翻译：强大的微流体混合装置将被动地混合多个流体流，而不使用运动部件。在一个实施例中，这些装置包含在三维结构的各个层中形成的微流体通道。混合可以通过流体流动路径和/或流体流之间的接触的各种操作来实现。在各种实施例中，可以将诸如通道重叠，狭缝，会聚/发散区域，匝和/或孔的结构设计成混合装置。混合装置可以使用模板施工方法进行快速构造和原型制备，其中通道切割材料层的整个厚度，尽管可以使用包括表面微加工技术的其他构造方法。

5. 发明申请

WO2003072255A1 MICROFLUIDIC MULTI-SPLITTER 审中-公开
标题翻译：微流控多分离器
公开(公告)号：WO2003072255A1
公开(公告)日：2003-09-04
申请号：PCT/US2003/005192
申请日：2003-02-21
申请人： NANOSTREAM, INC.
发明人： KARP, Christoph, D. , HIGHTOWER, Adrian
IPC分类号： B01L3/00
CPC分类号： B01F5/0471 , B01F13/0059 , B01F15/0264 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/025 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , G01N30/10 , G01N30/6095 , Y10T137/2224
摘要： A splitter for multi-layer microfluidic devices is provided. The splitter includes multiple forked channels defined in two or more device layers. The forked channels communicate fluidically at overlap regions. The overlap regions, in combination with symmetrical channel geometries balance the fluidic impedance in the system and promote even splitting.
摘要翻译：提供了用于多层微流体装置的分离器。分离器包括在两个或更多个设备层中限定的多个分叉通道。叉形通道在重叠区域流动地通信。重叠区域与对称沟道几何结合平衡系统中的流体阻抗并促进均匀分裂。

6. 发明申请

WO2002101383A1 MICROFLUIDIC SEPARATION DEVICES WITH ON-COLUMN SAMPLE INJECTION 审中-公开
标题翻译：具有柱内样品注射的微流体分离装置
公开(公告)号：WO2002101383A1
公开(公告)日：2002-12-19
申请号：PCT/US2002/017958
申请日：2002-06-06
申请人： NANOSTREAM, INC.
发明人： HOBBS, Steven, E. , KARP, Christoph, D.
IPC分类号： G01N30/60
CPC分类号： G01N30/6095 , B01L3/5027 , G01N30/16 , G01N30/466 , G01N2030/167 , Y10T436/25125 , Y10T436/255 , Y10T436/2575
摘要： A pressure-driven microfluidic device (100, 120, 200, 300, 400, 550, 601) for separating chemical or biological species from a sample includes on-column injection, namely, a separation channel (114, 142, 281, 310, 320, 330, 340, 350, 360, 370, 380, 420, 440, 460, 480, 561) containing stationary phase material (115, 138, 291, 319, 329, 339, 349, 359, 369, 379, 389, 429, 449, 469, 489, 571) and a sample input (110, 135A, 236A-236H, 314, 324, 334, 344, 354, 360A, 374, 384, 427A, 427B, 447, 467A, 467B, 487) disposed between a first end (114A, 142A, 281A, 310A, 320A, 330A, 340A, 350A, 360A, 370A, 380A, 420A, 440A, 460A, 480A, 561A) and a second end (114B, 142B, 281B, 310B, 320B, 330B, 340B, 350B, 360B, 370B, 380B, 420B, 440B, 460B, 480B, 561B) of the separation channel or column. One or many separation channels may be provided in a single microfluidic device, which may be fabricated with sandwiched stencil layers (102, 103, 122, 125, 202-208, 302, 305, 402, 405, 408) using various materials including polymers. Sealing means associated with a sample input, such as a mechanical seal (520, 530, 606) adapted to selectively seal the sample input, are provide. Various sample injector configurations are provided. A separation system including a microfluidic device having on-column injection further includes a pressure source (603) and a detector (607).
摘要翻译：用于从样品中分离化学或生物物质的压力驱动的微流体装置（100,120,200,300,400,550,601）包括柱上注射，即分离通道（114,142,281,301,610，包含固定相材料（115,138,391,319,329,339,349,399,369,379,389，...，320,330,340,350,360,370,380,420,440,460,480,561），429,449,469,489,571）和样本输入（110,135A，236A-236H，314,324,334,344,354,360A，374,384,427A，427B，447,467A，467B，（114A，320A，330A，340A，350A，360A，370A，380A，420A，440A，460A，480A，561A）和第二端（114B，142B，281B ，310B，320B，330B，340B，350B，360B，370B，380B，420B，440B，460B，480B，561B）。可以在单个微流体装置中提供一个或多个分离通道，其可以使用包括聚合物的各种材料制成夹层的蜡纸层（102,103,122,125,202-208,302,305,402,405,408）。提供与样品输入相关联的密封装置，例如适于选择性地密封样品输入的机械密封件（520,530,606）。提供了各种样品注射器配置。包括具有柱内注射的微流体装置的分离系统还包括压力源（603）和检测器（607）。

7. 发明申请

WO2002083310A3 MICROFLUIDIC METERING SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2002083310A3
公开(公告)日：2002-10-24
申请号：PCT/US2001/031790
申请日：2001-10-12
申请人： NANOSTREAM, INC. , O'CONNOR, Stephen, D. , KARP, Christoph, D. , PEZZUTO, Marci , DANTSKER, Eugene
发明人： O'CONNOR, Stephen, D. , KARP, Christoph, D. , PEZZUTO, Marci , DANTSKER, Eugene
IPC分类号： B01L3/00
摘要： Microfluidic devices capable of metering fluid flow are provided. Devices and methods for trunk-branch metering of fluid plugs in which one or more branch channels of defined volume are metered from a bulk fluid are described. Also described are the metering of at least one discrete plug by selecting the supply conditions of a first and a second fluid to a microfluidic channel. The first fluid may be a liquid and the second fluid a gas. Reduced-area channel segments are provided to assist with metering one or more discrete fluid plugs. In another aspect, a microfluidic volume is metered by filling a microfluidic chamber with fluid, sealing an inlet channel, and then extracting the fluid.

8. 发明申请

WO2004101151A1 SAMPLE PREPARATION FOR PARALLEL CHROMATOGRAPHY 审中-公开
标题翻译：用于平行色谱的样品制备
公开(公告)号：WO2004101151A1
公开(公告)日：2004-11-25
申请号：PCT/US2004/014148
申请日：2004-05-07
申请人： NANOSTREAM, INC. , O'CONNOR, Stephen, D. , DANTSKER, Eugene , KARP, Christoph, D. , LEE, Mike, S. , VAJJHALA, Surekha
发明人： O'CONNOR, Stephen, D. , DANTSKER, Eugene , KARP, Christoph, D. , LEE, Mike, S. , VAJJHALA, Surekha
IPC分类号： B01L3/00
CPC分类号： B01L3/5025 , B01L3/502715 , B01L3/502753 , B01L3/565 , B01L2200/027 , B01L2200/0689 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , G01N30/10 , G01N30/461 , G01N30/466 , G01N30/6043 , G01N30/6047 , G01N30/606 , G01N30/6095 , G01N30/88 , G01N2030/085 , G01N2030/146 , G01N2030/285 , G01N2030/565 , G01N2030/8881 , G01N30/06
摘要： Systems and methods are provided for preparing samples for chromatographic separations and then chromatographically separating the prepared samples, preferably in a high-throughput fashion utilizing multiple parallel first (fluid) processing regions in fluid communication with multiple parallel second (fluid) processing regions wherein the each second processing region includes a chromatography column. One or more common fluid supplies may be utilized in each of the sample preparation and separation steps to minimize the number of requisite fluid connections and external components such as pumps, reservoirs, pulse dampers, flow controllers, and the like.
摘要翻译：提供了用于制备用于色谱分离的样品的系统和方法，然后以优选以高通量方式色谱分离制备的样品，利用与多个平行的第二（流体）处理区域流体连通的多个平行的第一（流体）处理区域，其中，第二处理区域包括色谱柱。可以在每个样品制备和分离步骤中使用一种或多种常见的流体供应，以使需要的流体连接和外部组件（例如泵，储存器，脉冲阻尼器，流量控制器等）的数量最小化。

9. 发明申请

WO2003045559A3 MICROFLUIDIC DEVICES WITH DISTRIBUTING INPUTS 审中-公开
公开(公告)号：WO2003045559A3
公开(公告)日：2003-06-05
申请号：PCT/US2002/017957
申请日：2002-06-06
申请人： NANOSTREAM, INC.
发明人： O'CONNOR, Stephen, D. , KARP, Christoph, D. , DANTSKER, Eugene
IPC分类号： B01L3/00
摘要： Microfluidic devices having a plurality of functional features for performing one or more fluidic operations in parallel are provided. Reagents, samples or other fluids common to multiple functional features ("common fluids") may be input into a microfluidic device or system through one or more distributing inputs that divide and distribute the common fluids as desired. The use of a multi-layer fabrication technique allows multiple distributing inputs to distribute to multiple functional features in a microfluidic device without undesirable fluid channel intersections.

10. 发明申请

WO2002068823A1 UNI-DIRECTIONAL FLOW MICROFLUIDIC COMPONENTS 审中-公开
公开(公告)号：WO2002068823A1
公开(公告)日：2002-09-06
申请号：PCT/US2001/042916
申请日：2001-11-05
申请人： NANOSTREAM INC. , KARP, Christoph, D.
发明人： KARP, Christoph, D.
IPC分类号： F04B43/04
CPC分类号： F04B53/1047 , F04B43/043 , Y10T137/7895
摘要： Microfluidic fluid control devices are provided. One microfluidic fluid control device can be used as a uni-directional valve within a microfluidic system. The invention also provides a microfluidic pump mechanism having two uni-directional valves separated by an expandable reservoir. Such devices may be formed in multiple layers and utilize flexible membranes.
摘要翻译：提供微流体控制装置。一个微流体流体控制装置可用作微流体系统内的单向阀。本发明还提供一种微流体泵机构，其具有由可扩张的储存器分开的两个单向阀。这样的装置可以形成多层并且利用柔性膜。

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