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1. 发明申请

WO2011127044A2 METHOD OF PACKING CHROMATOGRAPHIC COLUMNS 审中-公开
标题翻译：包装色谱柱的方法
公开(公告)号：WO2011127044A2
公开(公告)日：2011-10-13
申请号：PCT/US2011031234
申请日：2011-04-05
申请人： PURDUE RESEARCH FOUNDATION , WIRTH MARY JEAN , RANASINGHE KODITHUWAKKUGE SAMPATH , YERNENI CHARU , BIRDSALL ROBERT
发明人： WIRTH MARY JEAN , RANASINGHE KODITHUWAKKUGE SAMPATH , YERNENI CHARU , BIRDSALL ROBERT
IPC分类号： G01N30/60
CPC分类号： B01D15/206 , B01D15/168 , B01D15/305 , B01D15/325 , B01J20/283 , G01N30/56 , G01N2030/562 , G01N2030/565 , G01N2030/8831
摘要： Improved methods for packing a chromatographic column and columns packed by these methods are provided. The methods include introducing a packing material into a chromatographic column, while simultaneously ultrasonicating and applying pressure to the packing material to form a packed column with radial homogeneity.
摘要翻译：提供了通过这些方法包装色谱柱和色谱柱的改进方法。所述方法包括将包装材料引入色谱柱，同时对包装材料进行超声波和施加压力以形成具有径向均匀性的填充柱。

2. 发明申请

WO2010030178A1 LCMS TECHNOLOGY AND ITS USES 审中-公开
标题翻译： LCMS技术及其用途
公开(公告)号：WO2010030178A1
公开(公告)日：2010-03-18
申请号：PCT/NL2009/050539
申请日：2009-09-09
申请人： DE STAAT DER NEDERLANDEN, VERT. DOOR DE MINISTER VAN VWS , VAN ELS, Cécile, Antoinette, Carola, Maria , SOETHOUT, Ernst, Christiaan , DE JONG, Adrianus, Petrus, Josephus, Maria , MEIRING, Hugo, Derk
发明人： VAN ELS, Cécile, Antoinette, Carola, Maria , SOETHOUT, Ernst, Christiaan , DE JONG, Adrianus, Petrus, Josephus, Maria , MEIRING, Hugo, Derk
IPC分类号： G01N30/56 , G01N30/60 , G01N30/72 , G01N30/46 , C07K16/00 , F16L19/00 , H01J49/16
CPC分类号： G01N30/7266 , G01N30/463 , G01N30/56 , G01N30/6039 , G01N2030/562 , G01N2030/565 , H01J49/167
摘要： The present invention relates to an improved LCMS technology and its uses in methods for the selective identification and characterization of immunogenic pathogen associated epitopes, and the use thereof in vaccine development. One way of bridging the knowledge gap on T cell epitopes is to apply a new platform technology, ''immunoproteomics'', to directly assess the epitope display at the surface of antigen presenting cells by nanoscale mass spectrometry of extracted peptide samples. This is the only methodology that can provide unbiased insight into epitope features such as the exact molecular nature, diversity, abundance, dynamics and PTM of T cell epitopes originating from pathogen-derived proteins. Therefore, this platform technology and immunoproteomics should become an intrinsic part of vaccinology.
摘要翻译：本发明涉及一种改进的LCMS技术及其在免疫原性病原体相关表位的选择性鉴定和鉴定方法中的用途及其在疫苗开发中的应用。弥补T细胞表位上的知识差距的一个方法是应用新的平台技术“免疫蛋白组学”，通过提取的肽样品的纳米级质谱直接评估抗原呈递细胞表面的表位显示。这是唯一可以提供无偏见的表位特征的方法，例如源自病原体衍生蛋白的T细胞表位的确切分子性质，多样性，丰度，动力学和PTM。因此，这种平台技术和免疫蛋白组学应该成为疫苗学的内在组成部分。

3. 发明申请

WO2009093958A1 METHOD FOR REMOVING AIR FROM A CHROMATOGRAPHY COLUMN 审中-公开
标题翻译：从色谱柱中去除空气的方法
公开(公告)号：WO2009093958A1
公开(公告)日：2009-07-30
申请号：PCT/SE2009/000024
申请日：2009-01-22
申请人： GE HEALTHCARE BIO-SCIENCES AB , AGREN, Tomas
发明人： AGREN, Tomas
IPC分类号： G01N30/60 , B01D15/22
CPC分类号： B01D15/22 , G01N30/56 , G01N30/6021 , G01N2030/565
摘要： The invention relates to a method for removing air from the bed space of a chromatography column. The method involves use a chromatography column having an inner wall which comprises at least one elongate groove through which air can pass from the bed space to a chamber above an adapter assembly.
摘要翻译：本发明涉及从层析柱的床空间除去空气的方法。该方法包括使用具有内壁的色谱柱，所述内壁包括至少一个细长槽，空气可通过该槽从床空间通过适配器组件上方的室。

4. 发明申请

WO2009052144A2 AN INTEGRATED MICROFLUIDIC NOZZLE DEVICE FOR CHROMATOGRAPHIC SAMPLE PREPARATION FOR MASS SPECTROMETRY APPLICATIONS 审中-公开
标题翻译：用于色谱样品制备的集成微流化床喷嘴装置用于质谱分析
公开(公告)号：WO2009052144A2
公开(公告)日：2009-04-23
申请号：PCT/US2008079939
申请日：2008-10-15
申请人： PHOENIX S & T INC , STAATS SAU LAN TANG
发明人： STAATS SAU LAN TANG
CPC分类号： G01N30/7266 , B01L3/0268 , B01L3/502715 , B01L3/502753 , B01L3/565 , B01L2200/027 , B01L2300/0816 , B01L2300/0829 , B01L2300/0838 , B01L2400/0415 , B01L2400/0487 , B01L2400/0633 , B01L2400/065 , G01N30/467 , G01N30/56 , G01N30/6095 , G01N2030/528 , G01N2030/565 , H01J49/00
摘要： In accordance with one aspect of the present invention, a low-cost injection-molded plastic microfluidic device that performs the multiplexing of affinity or chromatographic sample cleanup and enrichment methods and the detection by nanospray mass spectrometry of analytes such as biomarkers in a single package to conserve sample, and processes body fluids with HPLC grade and even next- generation chromatographic resins such as nanoparticles to maximize the sensitivity of the detection.
摘要翻译：根据本发明的一个方面，一种低成本的注塑成型的塑料微流体装置，其执行亲和或多色谱样品净化和富集方法的复用以及通过纳米喷雾质谱法检测单个包装中诸如生物标记的分析物到保存样品，并使用HPLC级甚至下一代色谱树脂（如纳米颗粒）处理体液，以最大限度地提高检测的灵敏度。

5. 发明申请

WO2009032903A1 CHROMATOGRAPHY APPARATUS AND METHOD 审中-公开
标题翻译：色谱装置和方法
公开(公告)号：WO2009032903A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/075221
申请日：2008-09-04
申请人： Q LABTECH LLC , QIAN, Weimin
发明人： QIAN, Weimin
IPC分类号： G01J3/28 , G01R19/00
CPC分类号： G01N30/56 , G01N2030/565
摘要： Disclosed is a closed sample preparation system and column packing system for chromatography that includes a first container, a first adaptor portion having a first adapter air pathway, wherein the first adaptor portion is in sealed association with the first container, an exit port from the first container and the exit port being configured to allow fluid flow from the first container, a second container having an opening, a second adaptor portion having a second adapter air pathway, wherein the second adaptor portion is in sealed association with the second container, a fluid connection between the exit port and the second adapter air pathway, and a filter disposed within the second container, wherein the opening of the second container is configured to allow fluid flow from the second container.
摘要翻译：公开了一种封闭的样品制备系统和用于色谱的柱填充系统，其包括第一容器，具有第一适配器空气通路的第一适配器部分，其中第一适配器部分与第一容器密封相关联，容器和出口被配置为允许来自第一容器的流体流动，具有开口的第二容器，具有第二适配器空气通道的第二适配器部分，其中第二适配器部分与第二容器密封，流体出口和第二适配器空气路径之间的连接以及设置在第二容器内的过滤器，其中第二容器的开口被配置成允许流体从第二容器流出。

6. 发明申请

WO03045559A8 MICROFLUIDIC DEVICES WITH DISTRIBUTING INPUTS 审中-公开
标题翻译：具有分布式输入的微流体装置
公开(公告)号：WO03045559A8
公开(公告)日：2004-09-02
申请号：PCT/US0217957
申请日：2002-06-06
申请人： NANOSTREAM INC
发明人： O'CONNOR STEPHEN D , KARP CHRISTOPH D , DANTSKER EUGENE
IPC分类号： G01N31/20 , B01F5/06 , B01F13/00 , B01J19/00 , B01L3/00 , B29C65/00 , B81B1/00 , B81C3/00 , G01N27/447 , G01N30/56 , G01N30/60 , G01N37/00
CPC分类号： B01F5/064 , B01F13/0059 , B01F15/0264 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/00869 , B01J2219/00891 , B01J2219/00997 , B01L3/5027 , B01L3/502707 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , B29C65/02 , B29C66/02 , B29C66/026 , B29C66/71 , B29K2023/00 , B29K2023/12 , B29L2031/756 , B81B2201/058 , B81C3/008 , G01N30/6095 , G01N2030/565 , Y10T137/206 , Y10T137/212 , Y10T137/2196 , Y10T137/2224 , Y10T137/8359 , B29C2035/0827 , B29K2067/00
摘要： Microfluidic devices having a plurality of functional features for performing one or more fluidic operations in parallel are provided. Reagents, samples or other fluids common to multiple functional features ("common fluids") may be input into a microfluidic device or system through one or more distributing inputs that divide and distribute the common fluids as desired. The use of a multi-layer fabrication technique allows multiple distributing inputs to distribute to multiple functional features in a microfluidic device without undesirable fluid channel intersections.
摘要翻译：提供具有用于并行执行一个或多个流体操作的多个功能特征的微流体装置。可以通过一个或多个分配输入将多个功能特征（“普通流体”）共同的试剂，样品或其它流体输入到微流体装置或系统中，根据需要分配和分配普通流体。使用多层制造技术允许多个分配输入分配到微流体装置中的多个功能特征，而不需要不需要的流体通道交叉。

7. 发明申请

WO2003045559A2 MICROFLUIDIC DEVICES WITH DISTRIBUTING INPUTS 审中-公开
标题翻译：具有分布式输入的微流体装置
公开(公告)号：WO2003045559A2
公开(公告)日：2003-06-05
申请号：PCT/US2002/017957
申请日：2002-06-06
申请人： NANOSTREAM, INC.
发明人： O'CONNOR, Stephen, D. , KARP, Christoph, D. , DANTSKER, Eugene
IPC分类号： B01L3/00
CPC分类号： B01F5/064 , B01F13/0059 , B01F15/0264 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/00869 , B01J2219/00891 , B01J2219/00997 , B01L3/5027 , B01L3/502707 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , B29C65/02 , B29C66/02 , B29C66/026 , B29C66/71 , B29K2023/00 , B29K2023/12 , B29L2031/756 , B81B2201/058 , B81C3/008 , G01N30/6095 , G01N2030/565 , Y10T137/206 , Y10T137/212 , Y10T137/2196 , Y10T137/2224 , Y10T137/8359 , B29C2035/0827 , B29K2067/00
摘要： Microfluidic devices having a plurality of functional features for performing one or more fluidic operations in parallel are provided. Reagents, samples or other fluids common to multiple functional features ("common fluids") may be input into a microfluidic device or system through one or more distributing inputs that divide and distribute the common fluids as desired. The use of a multi-layer fabrication technique allows multiple distributing inputs to distribute to multiple functional features in a microfluidic device without undesirable fluid channel intersections.
摘要翻译：提供具有用于并行执行一个或多个流体操作的多个功能特征的微流体装置。可以通过一个或多个分配输入将多个功能特征（“普通流体”）共同的试剂，样品或其它流体输入到微流体装置或系统中，根据需要分配和分配普通流体。使用多层制造技术允许多个分配输入分配到微流体装置中的多个功能特征，而不需要不需要的流体通道交叉。

8. 发明申请

WO00025128A1 METHOD AND APPARATUS FOR PACKED COLUMN SEPARATIONS AND PURIFICATIONS 审中-公开
标题翻译：包装柱分离和纯化的方法和装置
公开(公告)号：WO00025128A1
公开(公告)日：2000-05-04
申请号：PCT/US1999/023384
申请日：1999-10-06
IPC分类号： G01N30/56 , G01N30/60 , G01N35/00 , G01N35/08
CPC分类号： G01N30/56 , B01L2200/0668 , B01L2300/0877 , G01N30/6004 , G01N35/0098 , G01N35/085 , G01N2030/565
摘要： A column chamber is packed or emptied by switching a bleeding end valve at the column outlet. The column chamber is packed by filling a slurry consisting of the matrix and some fluid through the column inlet while the end valve at the column outlet is in a first position, passing fluid but blocking the passage of matrix. The column chamber is emptied by switching the end valve into a second, open, position. One embodiment comprises a valve switched by turning a rod in the actuator port. A method of purifying and a system of column-based operations are also described.
摘要翻译：通过在柱出口处切换出血端阀来填充或排空柱室。通过填充由基质和一些流体组成的浆料通过柱入口填充柱室，而塔出口处的端阀处于第一位置，通过流体但阻止基体的通过。通过将终止阀切换到第二个打开的位置来清空柱室。一个实施例包括通过转动致动器端口中的杆来切换阀。还描述了净化方法和基于列的操作的系统。

9. 发明申请

WO99029389A1 METHOD FOR CHARGING THE PARTICLE BED SPACE OF A CHROMATOGRAPH 审中-公开
标题翻译：方法用于装载TEILCHENBETTRAUMS色谱仪
公开(公告)号：WO99029389A1
公开(公告)日：1999-06-17
申请号：PCT/AT1998/000300
申请日：1998-12-10
IPC分类号： B01D15/00 , B01D15/08 , G01N30/56
CPC分类号： B01D15/206 , B01D15/1892 , G01N30/56 , G01N2030/565
摘要： The invention relates to a method for charging the space of a particle bed in an annular chromatograph. Said method is characterised in that the particulate material is fed as a suspension in a fluid under pressure and in that the bed particle space is vibrated, preferably in an intermittent manner.
摘要翻译：提出一种方法，用于馈送Teilchenbettraums有填充，其特征在于，所述颗粒材料被引入作为在压力下在液体中的悬浮液，将Teilchenbettraum，优选间歇地振荡的环形色谱仪。

10. 发明申请

WO1997032207A1 COLLAPSIBLE APPARATUS FOR COMPRESSING PACKING MATERIAL IN LIQUID CHROMATOGRAPHY COLUMNS AND METHODS OF USE 审中-公开
标题翻译：用于压缩液相色谱柱中的包装材料的可消除装置及其使用方法
公开(公告)号：WO1997032207A1
公开(公告)日：1997-09-04
申请号：PCT/US1997003227
申请日：1997-02-28
申请人： VARIAN ASSOCIATES, INC.
发明人： VARIAN ASSOCIATES, INC. , HATCH, Richard, G. , FAN, Chiko
IPC分类号： G01N30/56
CPC分类号： G01N30/56 , B01D15/20 , B01D15/206 , B01D15/22 , G01N30/6004 , G01N30/6047 , G01N2030/522 , G01N2030/565
摘要： Longitudinally collapsible apparatus for compacting packing material within a tubular liquid chromatography column. The apparatus includes a first support member, a second support member and a movable support member. The movable support member is releasably connectable to the second support member for support thereby. When released from the second support member, the movable member is adapted to ride on guide members extending between the first and second support members. A compression mechanism is supported on the movable support member to move therewith to a longitudinally collapsed position for the apparatus. The compression mechanism comprises a reversible drive for an axially movable rod carrying a movable piston. With the movable support member secured to the second support member, the piston of the compression mechanism is movable in an end of the tubular column when the column is supported on the first support member. Movement of the movable piston within the column axially compresses a column packing material as the piston is driven towards an opposite end of the column. The piston also is releasably connectable to the tubular column to raise and lower the column when the apparatus extends in a vertical direction and when it is desired to insert an end piston into or remove the end piston from the opposite end of the column or when it is desired to change an adapter ring on the first support member to receive a column of a different diameter for packing by the apparatus.
摘要翻译：用于压缩管状液相色谱柱内的包装材料的纵向可折叠装置。该装置包括第一支撑构件，第二支撑构件和可动支撑构件。可移动支撑构件可释放地连接到用于支撑的第二支撑构件。当从第二支撑构件释放时，可移动构件适于骑在在第一和第二支撑构件之间延伸的引导构件上。压缩机构被支撑在可移动支撑构件上以随着其移动到用于装置的纵向收缩位置。压缩机构包括用于承载活动活塞的可轴向移动的杆的可逆驱动。当可移动支撑件固定到第二支撑构件上时，当柱被支撑在第一支撑构件上时，压缩机构的活塞可在管柱的端部移动。当活塞朝向柱的相对端驱动时，柱内的可移动活塞的移动轴向压缩柱填充材料。当装置在垂直方向上延伸时，以及当期望将端部活塞从柱的相对端插入或移出末端活塞时，或者当其移动时，活塞还可释放地连接到管状柱以升高和降低柱期望改变第一支撑构件上的适配环以接收不同直径的柱，以便由该装置包装。

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