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1. 发明申请

WO2005000443A1 METHOD AND APPARATUS FOR PERFORMING PLANAR ELECTROCHROMATOGRAPHY AT ELEVATED PRESSURE 审中-公开
标题翻译：用于在高压下执行平面电子成像的方法和装置
公开(公告)号：WO2005000443A1
公开(公告)日：2005-01-06
申请号：PCT/US2004/019438
申请日：2004-06-17
申请人： ADVANCED RESEARCH AND TECHNOLOGY INSTITUTE, INC. , PURDUE RESEARCH FOUNDATION , NUROK, David , SANTINI, Robert, E. , REPLOGLE, Randall, W. , HAWKINS, Gregory, L. , KOERS, James, M.
发明人： NUROK, David , SANTINI, Robert, E. , REPLOGLE, Randall, W. , HAWKINS, Gregory, L. , KOERS, James, M.
IPC分类号： B01D15/08
CPC分类号： G01N30/90 , G01N30/92 , G01N30/94 , G01N2030/285 , G01N2030/906 , G01N2030/0035
摘要： According to one aspect of the disclosure, there is provided an apparatus (210) for performing electrochromatography. The apparatus (210) includes a die block (222) which is movable to exert a pressure greater than atmospheric pressure on a chromatography sample plate during performance of an electrochromatography procedure. A method of performing electrochromatography is also disclosed.
摘要翻译：根据本公开的一个方面，提供了一种用于执行电色谱的装置（210）。该设备（210）包括一个模具块（222），该模块可在电色层析过程执行期间在色谱样品板上移动以施加大于大气压的压力。还公开了一种执行电色谱法的方法。

2. 发明申请

WO2004027535A1 FLOW CONTROL SYSTEM 审中-公开
标题翻译：流量控制系统
公开(公告)号：WO2004027535A1
公开(公告)日：2004-04-01
申请号：PCT/US2003/030008
申请日：2003-09-17
申请人： EKSIGENT TECHNOLOGIES, LLC , PAUL, Phillip, H. , REHM, Jason, E. , ARNOLD, Don Wesley
发明人： PAUL, Phillip, H. , REHM, Jason, E. , ARNOLD, Don Wesley
IPC分类号： G05D7/06
CPC分类号： G05D7/0682 , G01N30/32 , G01N30/34 , G01N2030/324 , G01N2030/326 , G05D7/0694 , G05D11/132 , G01N2030/285
摘要： Method and apparatus for providing liquid flow at a controlled rate less than 100 microliters/minute, and for varying the flow rate in a desired way. A liquid is driven through a conduit by pressure. The rate of flow of the liquid through the conduit is measured and compared to a desired value. The resulting information is then used to make any desirable changes in the driving pressure. In one embodiment, which is particularly suitable for a mixture of liquids to be supplied to a gradient liquid chromatography column, the rate of flow of each of two or more different liquids is controlled individually, and the liquids are then mixed together.
摘要翻译：以小于100微升/分钟的受控速率提供液体流量的方法和装置，以及以期望的方式改变流速。液体通过压力被驱动通过导管。测量液体通过导管的流速，并将其与期望值进行比较。然后使用所得到的信息来进行驱动压力的任何期望的改变。在一个特别适用于供应到梯度液相色谱柱的液体混合物的实施方案中，分别控制两种或多种不同液体中每种液体的流速，然后将液体混合在一起。

3. 发明申请

WO01067080A1 PARALLEL ARRAY OF INDEPENDENT THERMOSTATS FOR COLUMN SEPARATIONS 审中-公开
标题翻译：用于柱分离的独立恒温器的平行阵列
公开(公告)号：WO01067080A1
公开(公告)日：2001-09-13
申请号：PCT/US2001/007329
申请日：2001-03-07
IPC分类号： B01L3/00 , B01L7/00 , G01N27/447 , G01N30/28 , G01N30/30 , G01N30/46 , G01N27/26
CPC分类号： B01L7/54 , B01J2219/00452 , B01J2219/00585 , B01J2219/00587 , B01J2219/00698 , B01J2219/00702 , B01J2219/00707 , B01L3/5027 , B01L7/00 , B01L7/52 , B01L7/5255 , B01L2300/18 , B01L2300/1883 , B01L2400/0415 , G01N27/44704 , G01N27/44708 , G01N27/44782 , G01N30/30 , G01N2030/285 , G01N2030/3007 , G01N30/466
摘要： A thermostat array including an array of two or more capillary columns (10) or two or more channels in a microfabricated device is disclosed. A heat conductive material (12) surrounds each individual column or channel in array, each individual column or channel being thermally insulated from every other individual column or channel. One or more independently controlled heating or cooling elements (14) is positioned adjacent to individual columns or channels within the heat conductive material, each heating or cooling element being connected to a source of heating or cooling, and one or more independently controlled temperature sensing elements (16) is positioned adjacent to the individual columns or channels within the heat conductive material. Each temperature sensing element is connected to a temperature controller.
摘要翻译：公开了一种包括两个或多个毛细管柱（10）的阵列或微加工装置中的两个或更多个通道的恒温器阵列。导热材料（12）围绕阵列中的每个单独的柱或通道，每个单独的柱或通道与每隔一个单独的柱或通道热绝缘。一个或多个独立控制的加热或冷却元件（14）邻近于导热材料内的各个柱或通道定位，每个加热或冷却元件连接到加热或冷却源，以及一个或多个独立控制的温度感测元件（16）定位成与导热材料内的各列或通道相邻。每个温度感测元件连接到温度控制器。

4. 发明申请

WO01053819A1 SEPARATION MEDIA, MULTIPLE ELECTROSPRAY NOZZLE SYSTEM AND METHOD 审中-公开
标题翻译：分离介质，多电极喷雾系统和方法
公开(公告)号：WO01053819A1
公开(公告)日：2001-07-26
申请号：PCT/US2001/001785
申请日：2001-01-18
IPC分类号： G01N27/62 , B01D15/08 , B01D57/02 , B01D59/44 , B01J20/281 , B01J20/283 , B01J20/285 , B03C5/00 , B05B5/043 , G01N1/10 , G01N21/33 , G01N21/53 , G01N21/64 , G01N27/447 , G01N30/28 , G01N30/46 , G01N30/52 , G01N30/60 , G01N30/72 , G01N30/74 , G01N30/88 , G01N37/00 , H01J49/00 , H01J49/04 , H01J49/10 , G01N27/26 , B32B31/00 , H01J49/14 , G01N27/477
CPC分类号： G01N30/466 , B01J20/261 , B01J20/267 , B01J20/281 , B01J20/285 , B01J2220/54 , B01J2220/82 , G01N27/44717 , G01N30/463 , G01N30/467 , G01N30/48 , G01N30/6095 , G01N30/7266 , G01N2030/285 , G01N2030/528 , H01J49/0018 , H01J49/167
摘要： A microfabricated silicon chip with a separation material, such as in situ prepared porous polymer monoliths (254) in its microchannels is disclosed. The polymer monoliths are liquid-permeable and serve as microcolumns for liquid chromatography, which are prepared by in situ radical polymerization of a mixture containing vinyl monomers and solvents (porogen) in the microchannels. A method and system are disclosed to generate one or more electrospray plumes from one or more nozzles that provide an ion intensity as measured by a mass spectrometer that is approximately proportional to the number of electrospray plumes formed for analyses contained within the fluid. A plurality of electrospray devices (250) can be used in the form of an array of miniaturized separate electrospray devices for the purpose of generating multiple electrospray plumes from multiple nozzles (242) for the same fluid for analysis.
摘要翻译：公开了一种具有分离材料的微制造硅芯片，例如其微通道中原位制备的多孔聚合物整料（254）。聚合物整料是液体可渗透的，用作液相色谱的微柱，其通过在微通道中含有乙烯基单体和溶剂（致孔剂）的混合物的原位自由基聚合制备。公开了一种方法和系统，以从一个或多个喷嘴产生一个或多个电喷雾羽流，其提供与质量分析仪测量的离子强度，其大小与为流体中包含的分析形成的电喷雾羽流的数量成比例。多个电喷射装置（250）可以以小型化的独立电喷雾装置阵列的形式使用，用于从用于分析的相同流体的多个喷嘴（242）产生多个电喷雾羽流。

5. 发明申请

WO1997004297A1 MICROSCALE FLUID HANDLING SYSTEM 审中-公开
标题翻译：微型流体处理系统
公开(公告)号：WO1997004297A1
公开(公告)日：1997-02-06
申请号：PCT/US1996011985
申请日：1996-07-19
申请人： NORTHEASTERN UNIVERSITY
发明人： NORTHEASTERN UNIVERSITY , KARGER, Barry, L. , FORET, Frantisek , ZAVRACKY, Paul, M. , MCGRUER, E., Nicol , XUE, Qifeng , DUNAYEVSKIY, Yuriy, M.
IPC分类号： G01N01/14
CPC分类号： H01J49/165 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/0093 , B01J2219/00932 , B01L3/0268 , B01L3/502715 , B01L2300/0803 , B01L2300/0816 , B01L2400/027 , B01L2400/0421 , B33Y80/00 , G01N30/466 , G01N30/6095 , G01N30/7266 , G01N2030/027 , G01N2030/285 , G01N2030/628 , G01N2035/1044 , H01J49/0445 , Y10T436/117497 , Y10T436/14 , Y10T436/142222 , Y10T436/143333 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , G01N30/34
摘要： A microscale fluid handling system (10) that permits the efficient transfer of nanoliter to picoliter quantities of a fluid sample from the spatially concentrated environment of a microfabricated chip to "off-chip" analytical or collection devices (23) for further off-chip sample manipulation and analysis is disclosed. The fluid handling system (10) is fabricated in the form of one or more channels (12), in any suitable format, provided in a microchip body or substrate of silica, polymer or other suitable non-conductive material, or of stainless steel, noble metal, silicon or other suitable conductive or semi-conductive material. The microchip fluid handling system (10) includes one or more exit ports (16) integral with the end of one or more of the channels (12) for consecutive or simultaneous off-chip analysis or collection of the sample. The exit port or ports (16) may be configured, for example, as an electrospray interface for transfer of a fluid sample to a mass spectrometer (23).
摘要翻译：微量流体处理系统（10），其允许将纳升酯有效转移至微胶囊数量的流体样品，从微细堆芯片的空间集中环境到“片外”分析或收集装置（23），用于进一步的片外样品披露了操作和分析。液体处理系统（10）以一种或多种通道（12）的形式制成，其格局为任何合适的格式，设置在硅片，聚合物或其它合适的非导电材料或不锈钢的微芯片体或基底中，贵金属，硅或其他合适的导电或半导体材料。微芯片流体处理系统（10）包括与一个或多个通道（12）的端部成一体的一个或多个出口（16），用于连续或同时片外分析或收集样品。出口或端口（16）可以被配置为例如用于将流体样品转移到质谱仪（23）的电喷雾界面。

6. 发明申请

WO1997001085A1 FLOW-THROUGH SAMPLING CELL AND USE THEREOF 审中-公开
标题翻译：流通采样细胞及其用途
公开(公告)号：WO1997001085A1
公开(公告)日：1997-01-09
申请号：PCT/SE1996000750
申请日：1996-06-07
申请人： PHARMACIA AB , WALLMAN, Lars , DROTT, Johan , NILSSON, Johan , LAURELL, Thomas , NILSSON, Staffan
发明人： PHARMACIA AB
IPC分类号： G01N01/10
CPC分类号： B01L3/0268 , B01F13/0059 , B01F15/0241 , B01F15/0255 , B01L3/502715 , B01L2200/0605 , B01L2400/0439 , B01L2400/0487 , G01N1/10 , G01N2030/162 , G01N2030/285 , G01N2035/00237 , G01N2035/1041
摘要： A sampling cell of flow-through type and use of such a sampling cell. The sampling cell is preferably manufactured by etching of silicon wafers. It is especially useful for continuous picovolume sampling in an analytical flow. The pressure pulse generating means (9) generate pressure pulses directly into a flow channel (3). The flow channel (3) is preferably formed by a first basin (4) in a first structure (1) and a second basin (5) in a second structure (2). In a first embodiment the pressure pulse generating means (9) comprise at least one piezo-ceramic disc and/or devices acting by way of magnetostrictive, electrostatical or electromechanical forces and/or devices acting by way of thermal expansion. Method of directing samples from a flow-through sampling cell by establishing a difference in electrical potential between the liquid in the flow-through sampling cell and the object to which said samples are to be directed. Use of a flow-through sampling cell for coating of surfaces, especially for achieving biospecific surfaces, for extracting samples from a continuous liquid flow, for extracting a precise sample amount by collecting a defined number of samples or for injecting samples for electrophoresis, especially capillary electrophoresis, and for electrochromatography.
摘要翻译：流通型采样单元和这种采样单元的使用。采样单元优选通过蚀刻硅晶片来制造。它对于在分析流程中连续的皮考冒泡采样是特别有用的。压力脉冲发生装置（9）直接产生压力脉冲到流动通道（3）中。流动通道（3）优选地由第一结构（1）中的第一盆（4）和第二结构（2）中的第二盆（5）形成。在第一实施例中，压力脉冲产生装置（9）包括至少一个压电陶瓷盘和/或通过磁致伸缩，静电或机电力作用的装置和/或通过热膨胀作用的装置。通过建立流通采样池中的液体与所述样品将被引导到的物体之间的电位差来从流通取样池引导样品的方法。使用流通采样池用于涂覆表面，特别是用于实现生物特异性表面，用于从连续液体流中提取样品，通过收集限定数量的样品或用于注射样品用于电泳，特别是毛细管电泳和电色谱。

7. 发明申请

WO1995010344A1 BEADED CAPILLARIES FOR CAPILLARY ELECTROPHORESIS AND CHROMATOGRAPHIC SEPARATIONS 审中-公开
标题翻译：用于毛细管电泳和色谱分离的珠状毛毡
公开(公告)号：WO1995010344A1
公开(公告)日：1995-04-20
申请号：PCT/US1994011430
申请日：1994-10-14
申请人： SARASEP, INC.
发明人： SARASEP, INC. , GJERDE, Douglas, T. , YENGOYAN, Leon
IPC分类号： B01D15/08
CPC分类号： B01J20/281 , B01J2220/54 , G01N27/44752 , G01N30/02 , G01N30/08 , G01N30/48 , G01N30/56 , G01N2030/285 , B01D15/36
摘要： A capillary having beads bound to the inside wall thereof is useful in capillary electrophoresis and capillary liquid chromatography. The beads may be ion exchange resin beads, chelating resin beads, reverse phase beads or beads having affinity sites. The beaded capillary allows control of direction and magnitude of electroosmotic flow through the capillary.
摘要翻译：具有与其内壁结合的珠粒的毛细管可用于毛细管电泳和毛细管液相色谱。珠可以是离子交换树脂珠，螯合树脂珠，反相珠或具有亲和位点的珠。珠状毛细管允许控制通过毛细管的电渗流的方向和大小。

8. 发明申请

WO1991013346A1 ON-CAPILLARY GAP JUNCTION FOR FLUORESCENCE DETECTION IN CAPILLARY ELECTROPHORESIS 审中-公开
标题翻译：用于毛细管电泳中荧光检测的毛细孔隙结
公开(公告)号：WO1991013346A1
公开(公告)日：1991-09-05
申请号：PCT/US1991001274
申请日：1991-02-27
申请人： APPLIED BIOSYSTEMS, INC.
发明人： APPLIED BIOSYSTEMS, INC. , MORING, Stephen, E.
IPC分类号： G01N27/26
CPC分类号： G01N27/44717 , G01N27/44721 , G01N27/44773 , G01N30/02 , G01N30/60 , G01N2030/285 , G01N2030/8435 , B01D15/3842
摘要： A junction reactor (50) that aligns a pair of capillaries (513, 514) substantially collinearly, end-to-end that allows a small gap (512) to be produced between these two ends. An applied voltage difference between the other ends of these two capillaries producces in the gap (512) electric fields lines that extend across the gap (512). Empirical evidence shows that the gap (512) introduces only a small reduction in resolution of an electrophoretic or electrochromatographic separation. The gap (512) enables sample liquid to be coupled between capillaries (513, 514) of different internal diameters and enables on-capillary reactions such as attaching a fluorescent tag to a sample components.

9. 发明申请

WO2008061222A9 METHOD AND SYSTEM FOR SEPARATING ANALYTES 审中-公开
标题翻译：用于分离分析的方法和系统
公开(公告)号：WO2008061222A9
公开(公告)日：2008-07-24
申请号：PCT/US2007084940
申请日：2007-11-16
申请人： UNIV INDIANA RES & TECH CORP , UNIV CALIFORNIA , NUROK DAVID , NOVOTNY ALLYSON L , STACHOWIAK TIMOTHY , SVEC FRANTISEK
发明人： NUROK DAVID , NOVOTNY ALLYSON L , STACHOWIAK TIMOTHY , SVEC FRANTISEK
IPC分类号： B01D15/08
CPC分类号： G01N30/92 , B01D15/38 , B01J20/261 , B01J20/285 , B01J2220/82 , G01N27/44747 , G01N2030/285 , G01N2030/906
摘要： A method and device for performing chromatography includes placing a monolithic polymer layer in contact with a liquid mobile phase. The monolithic polymer layer may be neutral, positively charged, or negatively charged. A first electrode and second electrode are coupled to the monolithic polymer layer. An electrical potential is created between the first electrode and the second electrode. In some embodiments, the monolithic polymer layer may be placed in a sealed chamber, which may have a pressure greater than atmospheric pressure. Additionally, in some embodiments, the mobile phase is advanced through the monolithic polymer layer via one of a number of forced flow techniques.
摘要翻译：用于进行色谱分析的方法和装置包括将单片聚合物层放置成与液体流动相接触。单块聚合物层可以是中性的，带正电的或带负电荷的。第一电极和第二电极连接到单片聚合物层。在第一电极和第二电极之间产生电势。在一些实施例中，单片聚合物层可以放置在密封室中，该密封室可以具有大于大气压的压力。另外，在一些实施方式中，流动相经由单片聚合物层经由多种强制流动技术之一被推进。

10. 发明申请

WO2005001806A1 SYSTEM AND METHOD FOR ELECTRONIC PRESENTATIONS 审中-公开
标题翻译：电子陈述的系统和方法
公开(公告)号：WO2005001806A1
公开(公告)日：2005-01-06
申请号：PCT/US2004/016860
申请日：2004-05-28
申请人： LEARNING TREE INTERNATIONAL, INC. , O'NEAL, David, Sheldon , SMITH, Sean, Dare , ACKERMAN, Stuart
发明人： O'NEAL, David, Sheldon , SMITH, Sean, Dare , ACKERMAN, Stuart
IPC分类号： G09G5/00
CPC分类号： G06F3/1431 , B01L2300/041 , B01L2400/0415 , G01N30/56 , G01N30/6095 , G01N2030/285 , G01N2030/565 , G06F3/0481 , G09B5/00 , G09B5/02 , G09B5/08 , H04N5/74
摘要： An electronic presentation system and method provides multiple display screens for presentation materials as well as permits dynamic annotations to presentation materials that do not permanently alter the presentation materials. The presentation materials can easily be directed to any one of the display screens and any annotations can be saved for future use or simply deleted. A single interface screen allows simple annotation of either the left or right screen images while a zoom feature allows slides to be presented in a variety of different ways. Additional features include tracking and displaying an indication of how a presentation is progressing relative to a pre-set timeline, identifying and tracking slides of a presentation which need correction or updating, and permitting a presenter to annotate slides of a presentation while located remotely from the presentation system.
摘要翻译：电子演示系统和方法为演示材料提供多个显示屏幕，并且允许动态注释不永久地改变演示材料的演示材料。演示材料可以轻松地被引导到任何一个显示屏幕，并且可以保存任何注释以供将来使用或简单地删除。单个界面屏幕允许左或右屏幕图像的简单注释，而缩放功能允许幻灯片以各种不同的方式呈现。附加功能包括跟踪和显示演示文稿相对于预设时间表如何进行的指示，识别和跟踪需要更正或更新的演示文稿的幻灯片，并允许演示者在远离演示系统。

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