专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US12151997B2 Method for preparing an amine hydrochloride suspension 有权
公开(公告)号：US12151997B2
公开(公告)日：2024-11-26
申请号：US18143981
申请日：2023-05-05
申请人： Covestro Intellectual Property GmbH & Co. KG
发明人： Michael Merkel , Tim Loddenkemper , Frank Gerhartz , Stefan Hirschfeld
IPC分类号： C07C263/10 , C07C209/74 , C08G18/75
CPC分类号： C07C263/10 , C07C209/74 , C08G18/758
摘要： The invention relates to a method for preparing a suspension of a hydrochloride of an organic amine, comprising the following steps of (i) initially charging at least one organic solvent in a reaction vessel to form a liquid level, (ii) adding hydrogen chloride, (iii) adding the organic amine, wherein the organic amine is added below the liquid level present in the reaction vessel and steps (ii) and (iii) are at least partly carried out simultaneously. Furthermore, the present invention also relates to a method wherein the suspension obtained after step (iii) is reacted in a step (iv) with phosgene to obtain the organic isocyanate corresponding to the organic amine used, to the corresponding organic isocyanate and to the use of the organic isocyanate for producing polyisocyanates.

2. 发明公开

US20230271916A1 Method for Preparing an Amine Hydrochloride Suspension 审中-公开
公开(公告)号：US20230271916A1
公开(公告)日：2023-08-31
申请号：US18143981
申请日：2023-05-05
申请人： Covestro Intellectual Property GmbH & Co. KG
发明人： Michael Merkel , Tim Loddenkemper , Frank Gerhartz , Stefan Hirschfeld
IPC分类号： C07C263/10 , C07C209/74 , C08G18/75
CPC分类号： C07C263/10 , C07C209/74 , C08G18/758
摘要： The invention relates to a method for preparing a suspension of a hydrochloride of an organic amine, comprising the following steps of (i) initially charging at least one organic solvent in a reaction vessel to form a liquid level, (ii) adding hydrogen chloride, (iii) adding the organic amine, wherein the organic amine is added below the liquid level present in the reaction vessel and steps (ii) and (iii) are at least partly carried out simultaneously. Furthermore, the present invention also relates to a method wherein the suspension obtained after step (iii) is reacted in a step (iv) with phosgene to obtain the organic isocyanate corresponding to the organic amine used, to the corresponding organic isocyanate and to the use of the organic isocyanate for producing polyisocyanates.

3. 发明授权

US11691943B2 Preparation method of 4-(heptafluoro-2-propyl)-2-trifluoromethylaniline and application thereof 有权
公开(公告)号：US11691943B2
公开(公告)日：2023-07-04
申请号：US17686997
申请日：2022-03-04
申请人： JIANGXI TIANYU CHEMICAL CO., LTD.
发明人： Chaoqun Huang , Jintao Zhu , Liangming Luo , Rong Zhang
IPC分类号： C07C209/74 , B01J31/02 , C07C209/86 , C07C211/52
CPC分类号： C07C209/74 , B01J31/0239 , C07C209/86 , C07C211/52
摘要： The present disclosure provides a preparation method of 4-(heptafluoro-2-propyl)-2-trifluoromethylaniline and an application thereof. The preparation method comprises the following steps: reacting 2-aminobenzotrifluoride and 2-bromoheptafluoropropane in the presence of sodium formate or hydrates thereof and a SO2 reagent, so as to obtain 4-(heptafluoro-2-propyl)-2-trifluoromethylaniline. The present disclosure adds sodium formate or hydrate thereof and the SO2 reagent during the reaction of 2-aminobenzotrifluoride and 2-bromoheptafluoropropane. Under the cooperation of these two compounds, the yield of the reaction is high. And the purity of the product is high, the operation method is simple, the cost is relatively low, and the pH of the reaction doesn't need to be controlled.

4. 发明申请

US20180011402A1 RESIN, PHOTOSENSITIVE RESIN COMPOSITION, ELECTRONIC COMPONENT AND DISPLAY DEVICE USING THE SAME 审中-公开
公开(公告)号：US20180011402A1
公开(公告)日：2018-01-11
申请号：US15545912
申请日：2016-01-25
申请人： TORAY INDUSTRIES, INC.
发明人： Tomoyuki YUBA , Yuki MASUDA , Jiake JIN , Ping LI
IPC分类号： G03F7/023 , G03F7/16 , H01L27/12 , H01L23/31 , H01L23/29 , G03F7/40 , G03F7/32 , G03F7/20 , C07C25/18 , C08G73/22 , C08G73/10 , C07D263/56 , C07C231/02 , C07C215/80 , C07C209/74 , H05K1/02 , H01L27/32
CPC分类号： G03F7/0233 , C07C25/18 , C07C41/22 , C07C67/307 , C07C209/74 , C07C211/56 , C07C213/00 , C07C215/80 , C07C231/02 , C07C231/12 , C07C269/06 , C07D209/48 , C07D263/56 , C07D263/62 , C08G69/32 , C08G73/1017 , C08G73/1039 , C08G73/1042 , C08G73/106 , C08G73/1075 , C08G73/1082 , C08G73/22 , C09D179/04 , C09D179/08 , G03F7/037 , G03F7/162 , G03F7/168 , G03F7/2004 , G03F7/322 , G03F7/40 , H01L21/027 , H01L23/293 , H01L23/3157 , H01L23/3171 , H01L27/1248 , H01L27/3258 , H01L2224/11 , H01L2224/16145 , H01L2224/32145 , H01L2224/48463 , H01L2224/73204 , H01L2224/73265 , H05K1/0298 , H05K3/3452 , C07C233/80 , C07C233/43 , C07C271/28 , C07C43/225 , C07C69/76 , H01L2924/00
摘要： A resin having a small linear thermal expansion coefficient and a low absorbance is provided. The resin is characterized by including at least one structure selected from structures represented by the following general formulae (1) and (2):

5. 发明授权

US09859502B2 Materials for electronic devices 有权
公开(公告)号：US09859502B2
公开(公告)日：2018-01-02
申请号：US15030565
申请日：2014-09-24
申请人： Merck Patent GmbH
发明人： Arne Buesing , Irina Martynova , Frank Voges , Jonas Valentin Kroeber
IPC分类号： H01L51/00 , C09K11/06 , H05B33/10 , C07C211/54 , C07C211/61 , C07D307/91 , C07C209/74 , C09K11/02 , H01L51/50
CPC分类号： H01L51/006 , C07C209/74 , C07C211/54 , C07C211/61 , C07C2603/18 , C07C2603/52 , C07C2603/90 , C07C2603/97 , C07D307/91 , C09K11/025 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/185 , H01L51/0054 , H01L51/0055 , H01L51/0056 , H01L51/0058 , H01L51/0061 , H01L51/0073 , H01L51/5012 , H01L51/5056 , H01L51/506 , H01L51/5088 , H01L51/5096 , H05B33/10 , Y02E10/549
摘要： The invention relates to compounds according to formula (1), said compounds being suitable for use in electronic devices, in particular in organic electroluminescent devices.

6. 发明授权

US09446995B2 Synthesis of therapeutic and diagnostic drugs centered on regioselective and stereoselective ring opening of aziridinium ions 有权
标题翻译：以吖啶鎓离子的区域选择性和立体选择性开环为中心的治疗和诊断药物的合成
公开(公告)号：US09446995B2
公开(公告)日：2016-09-20
申请号：US13896524
申请日：2013-05-17
申请人： Hyun-Soon Chong
发明人： Hyun-Soon Chong
IPC分类号： C07C253/14 , C07C209/08 , C07C209/74 , C07C213/00 , C07C209/10 , C07C319/04 , C07C247/10 , C07C327/06 , C07D221/10 , C07B43/00 , C07B43/04 , C07C331/28 , C07C227/18 , C07D255/02 , C07D217/04 , C07D209/16 , C07C209/62 , C07D265/32 , C07D207/404
CPC分类号： C07B43/04 , C07B43/00 , C07B2200/07 , C07C209/08 , C07C209/10 , C07C209/62 , C07C209/74 , C07C213/00 , C07C227/18 , C07C247/10 , C07C253/14 , C07C319/04 , C07C327/06 , C07C331/28 , C07C2102/08 , C07C2602/08 , C07D207/404 , C07D209/16 , C07D217/04 , C07D221/10 , C07D255/02 , C07D265/32 , C07C229/16 , C07C211/27 , C07C229/34 , C07C255/42 , C07C211/29 , C07C215/30 , C07C211/49 , C07C219/22 , C07C323/29
摘要： Stereoselective and regioselective synthesis of compounds via nucleophilic ring opening reactions of aziridinium ions for use in stereoselective and regioselective synthesis of therapeutic and diagnostic compounds.
摘要翻译：通过用于立体选择性和区域选择性合成治疗和诊断化合物的吖啶鎓离子的亲核开环反应的化合物的立体选择性和区域选择性合成。

7. 发明授权

US09193667B2 Process for the selective meta-chlorination of alkylanilines 有权
标题翻译：烷基苯胺的选择性间氯化方法
公开(公告)号：US09193667B2
公开(公告)日：2015-11-24
申请号：US13817972
申请日：2011-08-16
申请人： Nikolaus Bieler , Stefan Ellinger , Martina Furrer , Viktor Ladnak , Constanze Müller , Leo Schmid , Cornelia Zur Täschler
发明人： Nikolaus Bieler , Stefan Ellinger , Martina Furrer , Viktor Ladnak , Constanze Müller , Leo Schmid , Cornelia Zur Täschler
IPC分类号： C07C209/00 , C07C209/74
CPC分类号： C07C209/74 , Y02P20/582 , C07C211/52
摘要： A process for the chlorination of alkylanilines is provided allowing a highly selective chlorination in the meta-position of the aromatic ring. This is achieved by reacting a mixture comprising the alkylaniline and sulfuric acid with chlorine. This process allows a meta-chlorination with a selectivity of more than 90%.
摘要翻译：提供烷基苯胺的氯化方法，允许在芳环的间位进行高度选择性氯化。这是通过使包含烷基苯胺和硫酸的混合物与氯反应来实现的。该方法允许以大于90％的选择性进行间氯化。

8. 发明授权

US09126905B2 Process for manufacturing fluoroaromatics 有权
标题翻译：氟代芳族化合物的制备方法
公开(公告)号：US09126905B2
公开(公告)日：2015-09-08
申请号：US14415265
申请日：2013-07-08
申请人： BASF SE
发明人： Michael Rack , Maximilian Dochnahl , Volker Maywald , Bernd Wolf , Joachim Gebhardt , Timo Frassetto , Uwe Josef Vogelbacher , Roland Götz
IPC分类号： C07C37/62 , C07C37/76 , C07C17/35 , C07C17/093 , C07C41/22 , C07C51/363 , C07C209/74 , C07D213/73
CPC分类号： C07C37/62 , C07C17/093 , C07C17/35 , C07C37/76 , C07C41/22 , C07C51/363 , C07C209/74 , C07C245/20 , C07D213/73 , C07C39/27
摘要： The present invention relates to a process for manufacturing fluoroaromatics of formula (I), A-F (I) comprising step a) diazotization of aminoaromatics of formula (II) in anhydrous HF with an aqueous solution of a diazotizing agent; followed by step b) thermic decomposition of the diazonium salt of formula (III) resulting from step a); wherein the variables are defined according to the description.
摘要翻译：本发明涉及一种制备式（I）的氟代芳族化合物的方法，A-F（I）包括步骤a）将式（II）的氨基芳族化合物在无水HF中的重氮化与重氮化剂的水溶液重氮化; 然后步骤b）由步骤a）得到的式（III）的重氮盐的热分解; 其中根据描述定义变量。

9. 发明授权

US09035101B2 Method for preparing 3-trifluoromethyl chalcones 有权
标题翻译：制备3-三氟甲基查尔酮的方法
公开(公告)号：US09035101B2
公开(公告)日：2015-05-19
申请号：US14041938
申请日：2013-09-30
申请人： E.I. du Pont de Nemours and Company
发明人： Gary David Annis
IPC分类号： C07C45/70 , C07C49/80 , C07C17/35 , C07C25/13 , C07C67/343 , C07C205/45 , C07C231/12 , C07D213/40 , C07D249/08 , C07D249/10 , C07D261/04 , C07D277/28 , C07C209/74 , C07C45/45
CPC分类号： C07D261/04 , C07C17/35 , C07C25/13 , C07C45/455 , C07C45/70 , C07C49/80 , C07C49/813 , C07C67/343 , C07C205/45 , C07C209/74 , C07C231/12 , C07C231/14 , C07C235/84 , C07D213/40 , C07D231/12 , C07D231/14 , C07D231/16 , C07D249/08 , C07D249/10 , C07D277/28 , C07C69/94 , C07C69/76 , C07C211/56
摘要： Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water. Also disclosed is a method for preparing a compound of Formula 2 comprising (1) forming a reaction mixture comprising a Grignard reagent derived from contacting a compound of Formula 5 wherein X is Cl, Br or I with magnesium metal or an alkylmagnesium halide in the presence of an ethereal solvent, and then (2) contacting the reaction mixture with a compound of Formula 6 wherein Y is OR11 or NR12R13, and R11, R12 and R13 are as defined in the disclosure. Further disclosed is a method for preparing a compound of Formula 7 wherein Q and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.
摘要翻译：公开了一种制备式1化合物的方法，其中Q和Z如本公开中所定义，包括从包含式2化合物，式3化合物，包含至少一种选自由式4的碱土金属氢氧化物组成的组，其中M是Ca，Sr或Ba，式4a的碱金属碳酸盐，其中M1是Li，Na或K，1,5-二氮杂双环[4.3.0]壬-5-烯和 1,8-二氮杂双环[5.4.0]十一碳-7-烯，以及能够与水形成低沸点共沸物的非质子传递溶剂。还公开了制备式2化合物的方法，其包括（1）形成反应混合物，该反应混合物包含衍生自在存在下使式5的化合物（其中X为Cl，Br或I）与镁金属或烷基卤化镁接触的格利雅试剂的醚溶剂，然后（2）使反应混合物与式6化合物（其中Y是OR 11或NR 12 R 13）和R 11，R 12和R 13如本公开所定义。进一步公开的是制备式7化合物的方法，其中Q和Z如本公开所定义，使用式1的化合物，其特征在于通过上述方法制备式1化合物或使用制备的式1化合物通过上述方法。

10. 发明申请

US20150057452A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS 审中-公开
标题翻译：选择性雄激素受体调节剂
公开(公告)号：US20150057452A1
公开(公告)日：2015-02-26
申请号：US14390735
申请日：2013-04-04
申请人： Catylix, Inc.
发明人： James David Rozzell , Raymond McCague
IPC分类号： C07C255/60 , C07C317/46 , C07C315/02 , C07D233/86 , C07C17/32 , C07C253/14 , C07C209/74 , C07C201/08 , C07C209/36 , C07C253/30 , C07C319/20
CPC分类号： C07C255/60 , C07C17/32 , C07C201/08 , C07C209/365 , C07C209/74 , C07C253/14 , C07C253/30 , C07C315/02 , C07C317/46 , C07C319/20 , C07D233/86
摘要： Compounds having therapeutic potential as androgen receptor modulators, and methods of making such compounds, are provided. The compounds are structurally related to bicalutamide but bear at least one difluoromethyl or C2 to C5 perfluoroalkyl group instead of a trifluoromethyl group.
摘要翻译：提供具有作为雄激素受体调节剂的治疗潜力的化合物，以及制备这些化合物的方法。这些化合物在结构上与比卡鲁胺有关，但至少含有一个二氟甲基或C2至C5全氟烷基而不是三氟甲基。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式