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1. 发明申请

US20180170859A1 A NOVEL PROCESS FOR THE PREPARATION OF TERIFLUNOMIDE 审中-公开
公开(公告)号：US20180170859A1
公开(公告)日：2018-06-21
申请号：US15736981
申请日：2016-06-16
申请人： BIOCON LIMITED
发明人： Venkata Raghavendracharyulu Palle , Ramakrishna Parameshwar Bhat , Mariappan Kaliappan , Jithendra R. Babu , Rajmahendra Shanmughasamy
IPC分类号： C07C255/23 , C07C253/14 , C07D261/08
CPC分类号： C07C255/23 , C07C253/00 , C07C253/14 , C07D261/08 , G01N23/20075 , G01N25/4866 , G01R33/46
摘要： The present invention provides a process for the preparation of Teriflunomide (Formula-I). The present invention describes the synthesis of Teriflunomide without isolating the intermediate Leflunomide. Teriflunomide is prepared from 5-Methyl isoxazole-4-carboxylic acid by converting to its acid chloride and coupling with 4-trifluoromethyl aniline to obtain Leflunomide (which is not isolated) followed by ring opening reaction using aq. Sodium Hydroxide to form Teriflunomide. In other words, the process is telescoped from 5-methylisoxazole-4-carbonyl chloride.

2. 发明申请

US20160254456A1 Materials for Electronic Devices 审中-公开
标题翻译：电子设备材料
公开(公告)号：US20160254456A1
公开(公告)日：2016-09-01
申请号：US15029067
申请日：2014-04-29
申请人： MERCK PATENT GMBH
发明人： Holger Heil , Lara-Isabel Rodriguez , Beate Burkhart , Amandine Darsy
IPC分类号： H01L51/00 , C07C1/30 , C07C13/72 , C07D307/77 , C07F7/08 , C07D209/80 , C07D311/78 , C07C255/52 , C07C253/14 , C07C255/51 , C07D307/91 , C07C25/22 , C07C17/20 , C07C22/08 , C07D213/06 , C07C211/61 , C07C209/10 , C07D209/86 , C09K11/06 , C07C13/62
CPC分类号： H01L51/0056 , C07C1/30 , C07C13/62 , C07C13/72 , C07C17/206 , C07C17/263 , C07C22/08 , C07C25/22 , C07C209/10 , C07C211/61 , C07C253/14 , C07C255/51 , C07C255/52 , C07C2602/08 , C07C2603/18 , C07C2603/54 , C07C2603/94 , C07C2603/97 , C07D209/80 , C07D209/82 , C07D209/86 , C07D213/06 , C07D307/77 , C07D307/91 , C07D311/78 , C07D311/80 , C07D335/10 , C07D409/14 , C07F5/025 , C07F7/0807 , C07F7/081 , C07F7/083 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1022 , C09K2211/1029 , C09K2211/1088 , C09K2211/1096 , H01L51/0058 , H01L51/006 , H01L51/0061 , H01L51/0067 , H01L51/0071 , H01L51/0072 , H01L51/0073 , H01L51/0094 , H01L51/5012 , H01L51/5056 , Y02E10/549
摘要： The invention relates to compounds with benzindenofluorene base bodies and to the use thereof in electronic devices, in particular in organic electroluminescent devices.
摘要翻译：本发明涉及具有苯二烯芴基体的化合物及其在电子器件中的用途，特别是在有机电致发光器件中。

5. 发明授权

US09067869B2 Method for preparing difluoroacetonitrile and the derivatives thereof 有权
标题翻译：二氟乙腈及其衍生物的制备方法
公开(公告)号：US09067869B2
公开(公告)日：2015-06-30
申请号：US14003118
申请日：2012-03-08
申请人： Olivier Buisine
发明人： Olivier Buisine
IPC分类号： C07C253/14 , C07C51/08
CPC分类号： C07C253/14 , C07C51/08 , C07C255/10
摘要： The present invention relates to a method for preparing difluoracetonitrile and the derivatives thereof. The method for preparing difluoroacetonitrile according to the invention is characterized in that it includes reacting halogenodifluoromethane and a source of cyanide anions in an alkaline medium. The invention also relates to the use of difluoroacetonitrile as an intermediate in the manufacture of difluoroacetic acid and the salts, esters, or amide thereof.
摘要翻译：本发明涉及二氟乙腈及其衍生物的制备方法。根据本发明的制备二氟乙腈的方法的特征在于其包括在碱性介质中使卤代二氟甲烷和氰化物阴离子源反应。本发明还涉及二氟乙腈作为制备二氟乙酸及其盐，酯或酰胺的中间体的用途。

6. 发明申请

US20150152126A1 PHOSPHINE LIGANDS FOR CATALYTIC REACTIONS 有权
标题翻译：用于催化反应的磷酸盐配体
公开(公告)号：US20150152126A1
公开(公告)日：2015-06-04
申请号：US14611943
申请日：2015-02-02
申请人： AbbVie Inc.
发明人： Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
IPC分类号： C07F9/6568 , C07D209/42 , C07D213/76 , C07D239/54 , C07C41/01 , C07C273/18 , C07C253/30 , C07C201/10 , C07D209/34 , C07F5/02 , C07C17/093 , C07D295/033 , C07C319/14 , C07C45/71 , C07C253/14 , C07F9/40 , B01J31/24 , C07C1/30 , C07C303/36
CPC分类号： B01J31/2423 , B01J31/189 , B01J31/2419 , B01J31/2438 , B01J31/2466 , B01J31/2485 , B01J31/249 , B01J2231/4211 , B01J2231/4227 , B01J2231/4277 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2231/44 , B01J2531/0205 , B01J2531/0266 , B01J2531/0288 , B01J2531/824 , B01J2540/10 , B01J2540/40 , C07C1/26 , C07C1/30 , C07C1/321 , C07C17/093 , C07C17/2635 , C07C17/361 , C07C41/01 , C07C41/30 , C07C45/61 , C07C45/68 , C07C45/71 , C07C201/10 , C07C253/14 , C07C253/30 , C07C273/1854 , C07C273/1863 , C07C303/36 , C07C303/40 , C07C319/14 , C07C2531/24 , C07C2531/26 , C07D209/12 , C07D209/34 , C07D209/42 , C07D213/76 , C07D239/54 , C07D265/30 , C07D295/033 , C07F1/02 , C07F5/025 , C07F5/04 , C07F9/4021 , C07F9/4841 , C07F9/505 , C07F9/5072 , C07F9/509 , C07F9/572 , C07F9/65031 , C07F9/65583 , C07F9/65683 , C07F9/657163 , Y02P20/52 , C07C275/28 , C07C311/08 , C07C311/21 , C07C311/29 , C07C255/10 , C07C321/30 , C07C205/45 , C07C15/06 , C07C49/784
摘要： The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.
摘要翻译：本公开涉及：（a）磷酸基配体; （b）包含磷酸基配体的催化剂组合物; 和（c）在结合形成反应中使用这种磷酸基配体和催化剂组合物的方法。

7. 发明申请

US20120309931A1 PROCESS FOR THE SYNTHESIS OF 3-HYDROXYGLUTARONITRILE 有权
标题翻译： 3-羟基吡喃酮的合成方法
公开(公告)号：US20120309931A1
公开(公告)日：2012-12-06
申请号：US13584904
申请日：2012-08-14
申请人： JELENA CIRAKOVIC
发明人： JELENA CIRAKOVIC
IPC分类号： C07C253/14 , C08G69/28 , C08G73/06 , C08G73/10 , C08G18/70 , C07C253/00 , C07D213/73
CPC分类号： C07C253/14 , C07C255/12
摘要： A high yield and high productivity processes for preparing 3-hydroxyglutaronitrile by reacting an epihalohydrin or a 4-halo-3-hydroxy-butanenitrile, or analogous compound containing a different leaving group, with cyanide (CN—) in the presence of water and an ionic liquid. The use of an ionic liquid as a cosolvent with water results in increased productivity and selectivity.
摘要翻译：通过使表卤代醇或4-卤代-3-羟基丁腈或含有不同离去基团的类似化合物与氰化物（CN-）在水存在下反应制备3-羟基戊二腈的高产率和高生产率方法，离子液体。使用离子液体作为助溶剂与水导致提高的生产率和选择性。

8. 发明授权

US08247570B2 Process for preparing 2-amino-5-cyanobenzoic acid derivatives 有权
标题翻译：制备2-氨基-5-氰基苯甲酸衍生物的方法
公开(公告)号：US08247570B2
公开(公告)日：2012-08-21
申请号：US12809072
申请日：2008-12-17
申请人： Donald J. Dumas , Albert Loren Casalnuovo
发明人： Donald J. Dumas , Albert Loren Casalnuovo
IPC分类号： C07D401/00
CPC分类号： C07D401/04 , C07C253/14 , C07D231/14 , C07D231/16 , C07C255/58
摘要： Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with a metal cyanide reagent, a copper(I) salt reagent, an iodide salt reagent and at least one compound of Formula 3 wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; X is Br or Cl; and R5, R6, R7, R8 and R9 are as defined in the disclosure. Also disclosed is a method for preparing a compound of Formula 4 wherein R12, R13, R14 and Z are as defined in the disclosure, using a compound of Formula 1 characterized by preparing the compound of Formula 1 by the method disclosed above or using a compound of Formula 1 prepared by the method disclosed above.
摘要翻译：公开了一种制备式1化合物的方法，包括使式2化合物与金属氰化物试剂，铜（I）盐试剂，碘化物盐试剂和至少一种式3化合物（其中R1是NHR3或OR4）接触 ; R2是CH3或Cl; R3是H，C1-C4烷基，环丙基，环丙基环丙基，环丙基甲基或甲基环丙基; R4是H或C1-C4烷基; X是Br或Cl; 并且R5，R6，R7，R8和R9如本公开所定义。还公开了制备式4化合物的方法，其中R 12，R 13，R 14和Z如本公开所定义，使用式1的化合物，其特征在于通过上述方法制备式1化合物或使用化合物通过上述方法制备。

9. 发明授权

US08212075B2 Process for preparing 2-amino-5-cyanobenzoic acid derivatives 有权
标题翻译：制备2-氨基-5-氰基苯甲酸衍生物的方法
公开(公告)号：US08212075B2
公开(公告)日：2012-07-03
申请号：US12741635
申请日：2008-11-07
申请人： Vladimir Grushin , Albert Loren Casalnuovo
发明人： Vladimir Grushin , Albert Loren Casalnuovo
IPC分类号： C07C231/12
CPC分类号： C07C253/14 , C07D231/14 , C07D401/04 , C07F17/02 , C07C255/58
摘要： Disclosed is a method for preparing a compound of Formula 1 comprising contacting a compound of Formula 2 with at least one alkali metal cyanide of Formula 3 and a compound of Formula 4. wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-C4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; R4 is H or C1-C4 alkyl; X is Br, Cl or I; and R5, R6, R7, R8, R9 and R10 are as defined in the disclosure.Also disclosed is a method for preparing a compound of Formula 4 wherein R9 and R10 together are a cycloalkadiene bidentate ligand, comprising contacting a compound of Formula 5 wherein Y is Cl, Br or I, with a cycloalkadiene bidentate ligand, at least one metal reducing agent and a nitrile solvent.Also disclosed is a method for preparing a compound of Formula 1 comprising preparing a compound of Formula 4 by contacting a compound of Formula 5 with a cycloalkadiene bidentate ligand and at least one metal reducing agent, and then contacting the reaction mixture comprising the compound of Formula 4 with a compound of Formula 2 and at least one alkali metal cyanide of Formula 3; and further disclosed is a method for preparing a compound of Formula 6 wherein R15, R16, R17 and Z are as defined in the disclosure using a compound of Formula 1, characterized by preparing the compound of Formula 1 by a method disclosed above.
摘要翻译：公开了制备式1化合物的方法，包括使式2的化合物与至少一种式3的碱金属氰化物和式4的化合物接触，其中R 1是NHR 3或OR 4; R2是CH3或Cl; R3是H，C1-C4烷基，环丙基，环丙基环丙基，环丙基甲基或甲基环丙基; R4是H或C1-C4烷基; X是Br，Cl或I; 并且R5，R6，R7，R8，R9和R10如本公开所定义。还公开了制备式4化合物的方法，其中R 9和R 10一起是环二烯二齿配体，包括使式5的化合物，其中Y是Cl，Br或I与环二烯二齿配体，至少一种金属还原助剂和腈溶剂。还公开了制备式1化合物的方法，包括通过使式5的化合物与环二烯二齿配体和至少一种金属还原剂接触来制备式4的化合物，然后使包含式 4与式2的化合物和至少一种式3的碱金属氰化物反应; 并且进一步公开了制备式6化合物的方法，其中R 15，R 16，R 17和Z如本公开中所定义，使用式1化合物，其特征在于通过上述方法制备式1化合物。

10. 发明申请

US20110245520A1 METHOD OF MAKING FLUORINATED ALKOXY CARBOXYLIC ACIDS AND PRECURSORS THEREOF 有权
标题翻译：制备氟化烷氧基羧酸及其前体的方法
公开(公告)号：US20110245520A1
公开(公告)日：2011-10-06
申请号：US13133734
申请日：2009-11-24
申请人： Tilman Zipplies , Klaus Hintzer , Oleg Shyshkov
发明人： Tilman Zipplies , Klaus Hintzer , Oleg Shyshkov
IPC分类号： C07C247/04 , C07C51/08
CPC分类号： C07C255/13 , C07C51/08 , C07C59/135 , C07C67/08 , C07C69/708 , C07C247/04 , C07C253/14
摘要： A method for preparing saturated partially fluorinated alkoxy carboxylic acids or salts thereof by treating a compound: (II), where Rf represents a fluorinated, linear or branched alkyl residue interruptible by one or more oxygen atoms, n is 0 or 1, with a Z-anion in a reaction medium comprising water and an organic solvent, where the Z-anion is selected from CN—, SCN— and OCN— or combinations thereof. A method of making partially fluorinated ethers of the general formula (I) wherein Rf is defined as above, n is 0 or 1, and Z is nitrile (—CN), azide (—N3), thiocyanate (—SCN) or cyanate (—OCN) group, said method comprising treating a fluorinated olefin of the general formula (II) wherein the Z-anion is CN—, OCN—, SCN— or N3−. A compound of the general formula (I) as previously described where Z is selected from SCN, OCN and N3.
摘要翻译：通过处理化合物（II）制备饱和部分氟化的烷氧基羧酸或其盐的方法，其中Rf表示可被一个或多个氧原子中断的氟化的直链或支链烷基，n为0或1，Z为阴离子在包含水和有机溶剂的反应介质中，其中Z-阴离子选自CN-，SCN-和OCN-或其组合。制备通式（I）的部分氟化醚的方法，其中Rf定义如上，n为0或1，Z为腈（-CN），叠氮化物（-N 3），硫氰酸酯（-SCN）或氰酸酯 -OCN）基团，所述方法包括处理通式（II）的氟化烯烃，其中Z-阴离子是CN-，OCN-，SCN-或N 3 - 。其中Z选自SCN，OCN和N 3，如前所述的通式（I）的化合物。

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