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1. 发明申请

US20220024852A1 PROCESS FOR MANUFACTURING ETHYLENEAMINE COMPOUNDS 有权
公开(公告)号：US20220024852A1
公开(公告)日：2022-01-27
申请号：US17310607
申请日：2020-02-13
申请人： NOURYON CHEMICALS INTERNATIONAL B.V.
发明人： Rolf Krister EDVINSSON , Antoon Jacob Berend TEN KATE , Michiel Jozef Thomas RAAIJMAKERS , Rens VENEMAN , Slavisa JOVIC , Lawien Feisal ZUBEIR , Eike Nicolas KANTZER , Ina EHLERS , Hendrik VAN DAM , Karl Fredrik LAKE
IPC分类号： C07C213/08 , C07C209/68 , C07C209/08
摘要： The present disclosure pertains to a process for manufacturing ethyleneamine compounds selected from the group of ethyleneamines and hydroxyethylethyleneamines wherein the process comprises two reaction sequences.

2. 发明授权

US11046637B2 Process for the manufacture of 1,1,1-trifluoro-2-chloroethaneand/or trifluoroethylamine 有权
公开(公告)号：US11046637B2
公开(公告)日：2021-06-29
申请号：US16517547
申请日：2019-07-20
申请人： Fujian Yongjing Technology Co., Ltd.
发明人： Hongjun Du , Wenting Wu
IPC分类号： C07C209/08 , C07C211/15 , B01J27/06
摘要： The invention relates to a new process for the manufacture of fluoroaryl compounds and derivatives thereof, in particular of fluorobenzenes and derivatives thereof, and especially wherein said manufacture relates to an environmentally friendly production of the said compounds. Thus, the present invention overcomes the disadvantages of the prior art processes, and in a surprisingly simple and beneficial manner, and as compared to the prior art processes, in particular, the invention provides a more efficient and energy saving processes, and also provides a more environmentally friendly process, for the manufacture of nuclear fluorinated aromatics, and preferably of nuclear fluorinated fluorobenzenes. Accordingly, in one aspect of the invention, an industrially beneficial process for preparing fluorobenzenes from halobenzene precursors using HF to form hydrogen halide is provided by the present invention. A beneficial and surprisingly simple use of chlorobenzene as an industrially interesting starting material in the manufacture of fluorobenzene is provided.

3. 发明授权

US10711033B2 Branched chain-containing aromatic compound 有权
公开(公告)号：US10711033B2
公开(公告)日：2020-07-14
申请号：US15274463
申请日：2016-09-23
申请人： AJINOMOTO CO., INC.
发明人： Daisuke Takahashi
IPC分类号： C07C43/225 , C07K1/06 , C07C43/23 , C07C235/42 , C07K5/093 , C07K5/113 , C07K7/06 , C07C41/09 , C07C209/08 , C07C217/58 , C07C231/14 , C07C233/25 , C07K5/068 , C07K5/078 , C07K5/097 , C07K5/103
摘要： The present invention provides a particular branched chain-containing aromatic compound. The branched chain-containing aromatic compound of the present invention is easily-soluble in isopropyl acetate superior in liquid-separation operability, and can be used for a production method of peptide and the like, which provides a final product simply by extraction separation, without crystallization and isolation of each intermediate in each step.

4. 发明授权

US10500577B2 Oxalic amide ligands, and uses thereof in copper-catalyzed coupling reaction of aryl halides 有权
公开(公告)号：US10500577B2
公开(公告)日：2019-12-10
申请号：US15746646
申请日：2016-04-15
申请人： CE Pharm CO., LTD
发明人： Dawei Ma , Wei Zhou , Mengyang Fan , Haibo Wu , Junli Yin , Shanghua Xia
IPC分类号： C07D207/325 , B01J31/22 , C07C231/02 , C07C233/56 , C07B41/02 , C07B43/04 , C07B45/06 , C07C41/26 , C07C45/64 , C07C209/08 , C07C209/10 , C07C213/02 , C07C213/08 , C07C221/00 , C07C231/12 , C07C231/14 , C07C253/30 , C07C315/04 , C07C319/14 , C07C319/20 , C07D207/06 , C07D207/14 , C07D207/335 , C07D209/86 , C07D213/40 , C07D213/65 , C07D213/73 , C07D213/89 , C07D215/20 , C07D215/38 , C07D215/40 , C07D217/22 , C07D231/12 , C07D233/60 , C07D239/42 , C07D241/18 , C07D241/20 , C07D241/42 , C07D263/56 , C07D277/64 , C07D277/66 , C07D295/00 , C07D295/096 , C07D295/135 , C07D307/22 , C07D307/52 , C07D307/81 , C07D317/28 , C07D317/58 , C07D317/64 , C07D317/66 , C07D333/20 , C07D335/16 , C07D471/04 , C07D495/04 , C07D333/58 , C07D213/74 , C07D223/12 , C07D223/22 , C07D333/36 , C07D333/54 , C07D239/545 , C07D207/27 , C07D209/08 , C07D211/72
CPC分类号： B01J31/2243 , B01J31/22 , C07B41/02 , C07B43/04 , C07B45/06 , C07C41/26 , C07C45/64 , C07C209/08 , C07C209/10 , C07C213/02 , C07C213/08 , C07C221/00 , C07C231/02 , C07C231/12 , C07C231/14 , C07C233/56 , C07C253/30 , C07C315/04 , C07C319/14 , C07C319/20 , C07D207/06 , C07D207/14 , C07D207/27 , C07D207/325 , C07D207/335 , C07D209/08 , C07D209/86 , C07D211/72 , C07D213/40 , C07D213/65 , C07D213/73 , C07D213/74 , C07D213/89 , C07D215/20 , C07D215/38 , C07D215/40 , C07D217/22 , C07D223/12 , C07D223/22 , C07D231/12 , C07D233/60 , C07D239/42 , C07D239/545 , C07D241/18 , C07D241/20 , C07D241/42 , C07D263/56 , C07D277/64 , C07D277/66 , C07D295/00 , C07D295/096 , C07D295/135 , C07D307/22 , C07D307/52 , C07D307/81 , C07D317/28 , C07D317/58 , C07D317/64 , C07D317/66 , C07D333/20 , C07D333/36 , C07D333/54 , C07D333/58 , C07D335/16 , C07D471/04 , C07D495/04 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2531/16
摘要： The present invention provides oxalic amide ligands and uses thereof in copper-catalyzed coupling reaction of aryl halides. Specifically, the present invention provides a use of a compound represented by formula I, wherein definitions of each group are described in the specification. The compound represented by formula I can be used as a ligand in copper-catalyzed coupling reaction of aryl halides for the formation of C—N, C—O and C—S bonds.

5. 发明授权

US10246412B2 Chemical film on substrate and method of forming the same, method of forming paracyclophane containing functional ground with disulfide bond 有权
公开(公告)号：US10246412B2
公开(公告)日：2019-04-02
申请号：US15185003
申请日：2016-06-16
申请人： MAY-HWA ENTERPRISE CORPORATION
发明人： Hsien-Yeh Chen , Zhen-Yu Guan , Chih-Yu Wu
IPC分类号： C07C319/22 , C07C17/16 , C07C29/14 , C07C45/30 , C07C209/08 , C09D165/04 , C07C45/45 , C07C22/04
摘要： The present invention provides a method of forming paracyclyophane containing disulfide functional group. The paracyclophane is prepared by adding 3,3′-dithiodipropionic acid (DPDPA) and N-ethyl-N′-(3-(dimethylamino)propyl)carbodiimide (EDC) into 4-aminomethyl [2,2] paracyclophane. The present invention further provides a chemical film and a method of forming the same. The chemical film contains poly-p-xylylene with disulfide functional group and is formed on a substrate by a chemical vapor deposition process.

6. 发明授权

US10221134B2 Processes to produce brivaracetam 有权
公开(公告)号：US10221134B2
公开(公告)日：2019-03-05
申请号：US15575373
申请日：2016-05-24
申请人： ESTEVE QUIMICA S.A.
发明人： Peng Wang , Pixu Li , Qiang Wei , Yuanhua Liu
IPC分类号： C07D207/27 , A61K31/4015 , C07C53/19 , C07C53/50 , C07C67/307 , C07C69/63 , C07C71/00 , C07C209/08 , C07C231/14 , C07C233/05 , C07C237/06
摘要： The present invention provides a scalable synthesis of enantiomerically pure brivaracetam, and related derivatives.

7. 发明授权

US09040751B2 Method for producing ring-halogenated N,N-dialkylbenzylamines 有权
标题翻译：环状卤代N，N-二烷基苄胺的制备方法
公开(公告)号：US09040751B2
公开(公告)日：2015-05-26
申请号：US14236163
申请日：2012-08-01
申请人： Jordan Hartwig
发明人： Jordan Hartwig
IPC分类号： C07C209/00 , C07C209/10 , C07C209/08 , C07C221/00
CPC分类号： C07C209/10 , C07C209/08 , C07C221/00 , C07C211/29
摘要： The invention relates to a method for preparing ring-halogenated N,N-dialkylbenzylamines and intermediates obtainable therefrom for preparing agrochemicals and pharmaceutically active ingredients.
摘要翻译：本发明涉及一种制备环状卤代N，N-二烷基苄胺的方法及其制备方法，用于制备农药和药物活性成分。

8. 发明授权

US08952197B2 Processes for the preparation of 5-HT2C receptor agonists 有权
标题翻译：制备5-HT 2C受体激动剂的方法
公开(公告)号：US08952197B2
公开(公告)日：2015-02-10
申请号：US13378797
申请日：2010-06-17
申请人： John A. DeMattei , Carlos Marlon , Ryan O. Castro , Tsung-Hsun Chuang , Mark Allen Hadd , Xiao-Xiong Lu , Mark Macias , Stephen M. Shaw
发明人： John A. DeMattei , Carlos Marlon , Ryan O. Castro , Tsung-Hsun Chuang , Mark Allen Hadd , Xiao-Xiong Lu , Mark Macias , Stephen M. Shaw
IPC分类号： C07C209/00 , C07C213/08 , C07C17/16 , C07C209/08 , C07C209/74 , C07C211/29
CPC分类号： C07C209/74 , C07C17/04 , C07C17/16 , C07C209/08 , C07C211/29 , C07C213/00 , C07C213/08 , C07C215/08
摘要： The present invention relates to processes and intermediates useful in the preparation of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (lorcaserin), a serotonin (5-HT) receptor modulator that is useful in the treatment of for example, central nervous system disorders, such as obesity.
摘要翻译：本发明涉及可用于制备（R）-8-氯-1-甲基-2,3,4,5-四氢-1H-3-苯并吖庚因（氯卡色林），5-羟色胺（5-HT）的方法和中间体）受体调节剂，其可用于治疗例如中枢神经系统疾病，例如肥胖症。

9. 发明授权

US07807850B2 Preparation of 2R,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-P-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines 有权
标题翻译：制备2R，3S-N-异丁基-N-（2-羟基-3-氨基-4-苯基丁基）-P-硝基苯磺酰胺盐酸盐和2-羟基-1,3-二胺的其它衍生物
公开(公告)号：US07807850B2
公开(公告)日：2010-10-05
申请号：US12190713
申请日：2008-08-13
申请人： Aslam A. Malik , Hasan Palandoken , Joy A. Stringer , Roland P. Carlson , John Leach , Thomas G. Archibald , Robert G. Miotke
发明人： Aslam A. Malik , Hasan Palandoken , Joy A. Stringer , Roland P. Carlson , John Leach , Thomas G. Archibald , Robert G. Miotke
IPC分类号： C07C303/36 , C07C303/40 , C07C303/00 , C07C209/08 , C07C271/20
CPC分类号： C07C269/06 , C07C303/40 , C07C311/18 , C07C271/20
摘要： The present invention provides a new process for the preparation of 2R,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbuty1)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2R,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2R,3S-derivative, but also the 2S,3S-, 2S,2R- and the 2R,3R-derivatives.
摘要翻译：本发明提供了制备2R，3S-N-异丁基-N-（2-羟基-3-氨基-4-苯基丁-1-） - 对硝基苯磺酰胺盐酸盐的新方法，其中该化合物直接由氯甲基醇制备。重要的是，本发明的方法导致2R，3S-N-异丁基-N-（2-羟基-3-氨基-4-苯基丁基） - 对硝基苯磺酰胺盐酸盐的产率较高，而不损及其纯度。本发明的方法不仅可用于制备2R，3S-衍生物，而且可制备2S，3S-，2S，2R-和2R，3R-衍生物。

10. 发明申请

US20090281325A1 METHOD FOR SELECTIVELY PRODUCING PRIMARY AMINE COMPOUND 失效
标题翻译：选择生产主要胺化合物的方法
公开(公告)号：US20090281325A1
公开(公告)日：2009-11-12
申请号：US12097234
申请日：2006-12-14
申请人： Naoyuki Takano , Kazuyuki Tanaka , Shinzo Seko
发明人： Naoyuki Takano , Kazuyuki Tanaka , Shinzo Seko
IPC分类号： C07D213/38 , C07C209/08
CPC分类号： C07C209/62 , C07C213/02 , C07D213/26 , C07D213/38 , C07D251/04 , C07C211/27 , C07C211/29 , C07C217/58
摘要： Disclosed is a method for producing a primary amine compound represented by the formula (3): wherein, Ar is as defined below , which is characterized in that a halogen compound represented by the formula (1): wherein, Ar represents an unsubstituted aromatic group such as a phenyl group, a naphthyl group, a pyridyl group, a furyl group, a thienyl group, a pyrrolyl group, an oxazolyl group, an isoxazolyl group or a pyrimidinyl group, or an aromatic group obtained by substituting such an unsubstituted aromatic group with 1-3 substituents; and X represents a halogen atom, ammonia and formaldehyde are reacted with each other, thereby obtaining a hexahydrotriazine compound represented by the formula (2): wherein, Ar is as defined above, and then the thus-obtained hexahydrotriazine compound is decomposed. By this method, a primary amine compound can be commercially advantageously produced by using a low-cost ammonia while suppressing production of a secondary amine as a by-product.
摘要翻译：公开了一种由式（3）表示的伯胺化合物的制备方法：其中Ar如下所定义，其特征在于由式（1）表示的卤素化合物：其中Ar表示未取代的芳族基团苯基，萘基，吡啶基，呋喃基，噻吩基，吡咯基，恶唑基，异恶唑基或嘧啶基，或通过取代这些未取代的芳基取代的芳基具有1-3个取代基; X表示卤素原子，氨和甲醛彼此反应，得到式（2）表示的六氢三嗪化合物：其中，Ar如上定义，然后将由此得到的六氢三嗪化合物分解。通过这种方法，可以通过使用低成本氨同时抑制作为副产物的仲胺的生产，商业上有利地生产伯胺化合物。

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