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    • 1. 发明申请
    • Nanowire target support and method
    • 纳米线目标支持和方法
    • US20060097149A1
    • 2006-05-11
    • US10971164
    • 2004-10-22
    • Timothy Joyce
    • Timothy Joyce
    • H01J49/00
    • H01J49/164H01J49/0418
    • The invention provides an apparatus that produces analyte ions for detection by a detector. The apparatus includes a matrix based ion source having a nanowire target substrate for producing analyte ions, an ion transport system adjacent to the matrix based ion source for transporting analyte ions from the matrix based ion source; and an ion detector downstream from the ion transport system for detecting the analyte ions. The invention also provides a method for producing and detecting the analyte ions.
    • 本发明提供一种生成分析物离子以供检测器检测的装置。 该装置包括具有用于产生分析物离子的纳米线靶基质的基于基质的离子源,与基于基质的离子源相邻的离子传输系统,用于将基于离子源的离子源输送到分析物离子; 以及离子传感系统下游的用于检测分析物离子的离子检测器。 本发明还提供了一种用于产生和检测分析物离子的方法。
    • 3. 发明申请
    • Characterization of biopolymers by resonance tunneling and fluorescence quenching
    • 通过共振隧道和荧光猝灭表征生物聚合物
    • US20060019259A1
    • 2006-01-26
    • US10898586
    • 2004-07-22
    • Timothy Joyce
    • Timothy Joyce
    • C12Q1/68C12M3/04
    • G01N33/6818C12Q1/6869G01N33/48721C12Q2565/631C12Q2565/607
    • The present invention provides a method and apparatus for determining the identity of a monomeric residue of a biopolymer. The apparatus comprises a substrate having a nanopore, a potential-producing element for producing a ramped potential across electrodes adjacent to the nanopore, and a quenchable excitable moiety adjacent to the nanopore. As a biopolymer passes through the nanopore, the identity of monomeric residues of a biopolymer may be determined by detecting changes in (a) current across the electrodes and (b) a signal of the quenchable excitable molecule. The subject method and apparatus find use in determining the identity of a plurality of monomeric residues of a biopolymer, and, as such, may be employed in a variety of diagnostic and research applications.
    • 本发明提供了用于测定生物聚合物的单体残基的身份的方法和装置。 该装置包括具有纳米孔的底物,用于在邻近纳米孔的电极之间产生斜坡电位的潜在产生元件和与该纳米孔相邻的可淬火的可兴奋部分。 当生物聚合物通过纳米孔时,生物聚合物的单体残基的身份可以通过检测(a)跨越电极的电流的变化和(b)可淬灭的可激发分子的信号来确定。 本发明的方法和装置用于确定生物聚合物的多个单体残基的身份,并且因此可用于多种诊断和研究应用。
    • 8. 发明申请
    • Nanospray ionization device and method
    • 纳米喷雾电离装置及方法
    • US20070023676A1
    • 2007-02-01
    • US11171976
    • 2005-06-29
    • Paul GoodleyTimothy JoyceJerry Dowell
    • Paul GoodleyTimothy JoyceJerry Dowell
    • H01J27/00
    • H01J49/165H01J49/0468
    • The present invention provides an apparatus and method for use with a mass spectrometry system. The invention provides an ion source for providing radiative heating to an ionization region. The ion source includes a nanospray ionization device for producing ions and a conduit adjacent to the ionization device for receiving ions from the ionization device. The conduit includes a conductive material for providing indirect radiative heating to the ionization region. Direct radiative heating may also be provided using a heater in the conduit. The ion source may be used separately or in conjunction with the mass spectrometry system. When used in conjunction with a mass spectrometry system a detector may also be employed down stream from the device. A method for desolvating an analyte using the device is also disclosed.
    • 本发明提供了一种与质谱系统一起使用的装置和方法。 本发明提供了一种用于向电离区域提供辐射加热的离子源。 离子源包括用于产生离子的纳米喷雾离子化装置和与电离装置相邻的导管,用于从离子化装置接收离子。 导管包括用于向电离区提供间接辐射加热的导电材料。 也可以使用导管中的加热器来提供直接辐射加热。 离子源可以单独使用或与质谱系统结合使用。 当与质谱系统结合使用时,也可以从装置下游使用检测器。 还公开了使用该装置对分析物进行脱溶剂的方法。