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1. 发明申请

US20070023676A1 Nanospray ionization device and method 有权
标题翻译：纳米喷雾电离装置及方法
公开(公告)号：US20070023676A1
公开(公告)日：2007-02-01
申请号：US11171976
申请日：2005-06-29
申请人： Paul Goodley , Timothy Joyce , Jerry Dowell
发明人： Paul Goodley , Timothy Joyce , Jerry Dowell
IPC分类号： H01J27/00
CPC分类号： H01J49/165 , H01J49/0468
摘要： The present invention provides an apparatus and method for use with a mass spectrometry system. The invention provides an ion source for providing radiative heating to an ionization region. The ion source includes a nanospray ionization device for producing ions and a conduit adjacent to the ionization device for receiving ions from the ionization device. The conduit includes a conductive material for providing indirect radiative heating to the ionization region. Direct radiative heating may also be provided using a heater in the conduit. The ion source may be used separately or in conjunction with the mass spectrometry system. When used in conjunction with a mass spectrometry system a detector may also be employed down stream from the device. A method for desolvating an analyte using the device is also disclosed.
摘要翻译：本发明提供了一种与质谱系统一起使用的装置和方法。本发明提供了一种用于向电离区域提供辐射加热的离子源。离子源包括用于产生离子的纳米喷雾离子化装置和与电离装置相邻的导管，用于从离子化装置接收离子。导管包括用于向电离区提供间接辐射加热的导电材料。也可以使用导管中的加热器来提供直接辐射加热。离子源可以单独使用或与质谱系统结合使用。当与质谱系统结合使用时，也可以从装置下游使用检测器。还公开了使用该装置对分析物进行脱溶剂的方法。

2. 发明授权

US07135689B2 Apparatus and method for ion production enhancement 有权
公开(公告)号：US07135689B2
公开(公告)日：2006-11-14
申请号：US11041118
申请日：2005-01-21
申请人： Jean-Luc Truche , Jian Bai , Timothy Joyce
发明人： Jean-Luc Truche , Jian Bai , Timothy Joyce
IPC分类号： H01J27/00
CPC分类号： H01J49/164 , H01J49/0477
摘要： The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.

3. 发明申请

US20060210995A1 Nanopore analysis systems and methods of using nanopore devices 审中-公开
标题翻译：纳米孔分析系统和使用纳米孔装置的方法
公开(公告)号：US20060210995A1
公开(公告)日：2006-09-21
申请号：US11080183
申请日：2005-03-15
申请人： Timothy Joyce
发明人： Timothy Joyce
IPC分类号： C12Q1/68 , G06F19/00 , C12M1/34
CPC分类号： G01N33/48721 , B01L3/5027 , B82Y15/00 , C12Q1/6825 , C12Q1/6869 , C12Q2565/631
摘要： Systems and methods for nanopore analysis are provided.
摘要翻译：提供了纳米孔分析的系统和方法。

4. 发明申请

US20060207880A1 Microfluidic devices and methods of using microfluidic devices 审中-公开
标题翻译：微流体装置和使用微流体装置的方法
公开(公告)号：US20060207880A1
公开(公告)日：2006-09-21
申请号：US11080184
申请日：2005-03-15
申请人： Timothy Joyce , Jennifer Lu
发明人： Timothy Joyce , Jennifer Lu
IPC分类号： C07K1/26 , G01N27/00
CPC分类号： G01N27/4473 , B01L3/502746 , B01L2200/0663 , B01L2300/0645 , B01L2300/0861 , B01L2400/0421 , B01L2400/084 , C12Q2565/629 , G01N2035/00514
摘要： Microfluidic devices, systems and methods of their use are provided.
摘要翻译：提供微流体装置，其使用的系统和方法。

5. 发明申请

US20060086626A1 Nanostructure resonant tunneling with a gate voltage source 审中-公开
标题翻译：纳米结构谐振隧道与栅极电压源
公开(公告)号：US20060086626A1
公开(公告)日：2006-04-27
申请号：US10971475
申请日：2004-10-22
申请人： Timothy Joyce
发明人： Timothy Joyce
IPC分类号： G01N33/487 , G01F1/64
CPC分类号： G01N33/48721 , B82Y5/00 , B82Y10/00 , B82Y15/00 , C12Q1/6869 , C12Q2565/631
摘要： The invention provides an apparatus and method for sequencing and identifying a biopolymer. The invention provides a first nanostructure electrode, a second nanostructure electrode, a first gate electrode, a second gate electrode, a gate voltage source and a potential means. The gate electrodes may be ramped by a voltage source to search and determine a resonance level between the first nanostructure electrode, biopolymer and second nanostructure electrode. The potential means that is in electrical connection with the first nanostructure electrode and the second nanostructure electrode is maintained at a fixed voltage. A method of biopolymer sequencing and identification is also disclosed.
摘要翻译：本发明提供了用于测序和鉴定生物聚合物的装置和方法。本发明提供了第一纳米结构电极，第二纳米结构电极，第一栅电极，第二栅电极，栅极电压源和电位装置。栅电极可以通过电压源斜坡来搜索并确定第一纳米结构电极，生物聚合物和第二纳米结构电极之间的共振水平。与第一纳米结构电极和第二纳米结构电极电连接的电位保持在固定电压。还公开了生物聚合物测序和鉴定的方法。

6. 发明申请

US20050161613A1 Apparatus and method for ion production enhancement 有权
公开(公告)号：US20050161613A1
公开(公告)日：2005-07-28
申请号：US11041118
申请日：2005-01-21
申请人： Jean-Luc Truche , Jian Bai , Timothy Joyce
发明人： Jean-Luc Truche , Jian Bai , Timothy Joyce
IPC分类号： H01J49/04 , H01J49/16 , H01J27/00
CPC分类号： H01J49/164 , H01J49/0477
摘要： The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.

7. 发明申请

US20060243917A1 Apparatus and method for sensor control and feedback 有权
公开(公告)号：US20060243917A1
公开(公告)日：2006-11-02
申请号：US11471954
申请日：2006-06-21
申请人： Steven Fischer , Darrell Gourley , Glen Ingle , Timothy Joyce
发明人： Steven Fischer , Darrell Gourley , Glen Ingle , Timothy Joyce
IPC分类号： H01J27/24
CPC分类号： H01J49/04 , H01J49/10 , H01J49/107 , H01J49/165
摘要： The present invention relates to an apparatus and method for use with a mass spectrometry system. The invention provides an ion source, infrared emitter and sensor with closed control feedback loop coupled to the infrared emitter. Methods of control and heating using the apparatus of the present invention are also disclosed.

8. 发明申请

US20060062194A1 Integration of remote microcell with CDMA infrastructure 有权
公开(公告)号：US20060062194A1
公开(公告)日：2006-03-23
申请号：US11261251
申请日：2005-10-28
申请人： Brian Fiut , Timothy Joyce
发明人： Brian Fiut , Timothy Joyce
IPC分类号： H04B7/216
CPC分类号： H04B7/2609 , H04B7/2628 , H04B2201/70702 , H04W4/18 , H04W24/00
摘要： A method of interconnecting a CDMA cellsite having signal advancing capabilities with at least one remote microcell without re-synchronization capabilities. The method of the present invention sufficiently advances the signal to compensate for the time delay induced by communication signal travel over a fiber optic connection between a base station cellsite and a remote microcell.

9. 发明申请

US20060014293A1 Lock mass ions for use with derivatized peptides for de novo sequencing using tandem mass spectrometry 审中-公开
标题翻译：使用串联质谱法将质子离子锁定用于衍生肽进行从头测序
公开(公告)号：US20060014293A1
公开(公告)日：2006-01-19
申请号：US10938690
申请日：2004-09-10
申请人： Timothy Joyce , Barry Boyes , Gordon Nicol , Hongbin Liu
发明人： Timothy Joyce , Barry Boyes , Gordon Nicol , Hongbin Liu
IPC分类号： G01N33/00
CPC分类号： G01N33/6851 , G01N33/6842 , G01N33/6848 , H01J49/0031 , Y10T436/24
摘要： Multiple derivatization by chemical reactions of analytes for mass spectrometry is disclosed. The derivatizations enhance the use of MS techniques for analyzing protein samples, particularly when the sequence of a polypeptide is determined by tandem MS/MS. Accurate mass analysis techniques are described for use in sequencing polypeptides, together with the use of sequencing data in protein analysis. An apparatus and method for calibrating a mass spectrometer by internally introducing calibration masses at a post-source stage of the mass spectrometer is also provided. Lock mass ions mix with the derivatized polypeptide analyte ions prior to mass analysis.
摘要翻译：公开了通过化学反应进行质谱分析的多重衍生化。衍生化增强了MS技术用于分析蛋白质样品的用途，特别是当通过串联MS / MS测定多肽的序列时。描述了准确的质量分析技术用于测序多肽，以及在蛋白质分析中使用测序数据。还提供了通过在质谱仪的后源阶段内部引入校准质量来校准质谱仪的装置和方法。在质量分析之前，将质子离子与衍生的多肽分析物离子混合。

10. 发明申请

US20050151090A1 Apparatus and method for ion production enhancement 有权
标题翻译：用于离子生产增强的装置和方法
公开(公告)号：US20050151090A1
公开(公告)日：2005-07-14
申请号：US11015190
申请日：2004-12-16
申请人： Jean-Luc Truche , Jian Bai , Timothy Joyce
发明人： Jean-Luc Truche , Jian Bai , Timothy Joyce
IPC分类号： H01J49/04 , H01J49/16 , H01J27/00
CPC分类号： H01J49/164 , H01J49/0477
摘要： The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.
摘要翻译：本发明涉及一种与质谱仪一起使用的装置和方法。本发明的离子增强系统用于将加热气体引导到由基于基质的离子源产生的离子并由检测器检测。离子增强系统介于离子源和检测器之间。接触加热气体的分析物离子增强，并且更多的离子更容易被检测器检测。本发明的方法包括从基于基质的离子源产生分析物离子，用离子增强系统增强分析物离子并用检测器检测增强的分析物离子。

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