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1. 发明公开

US20240203720A1 MULTIPLEXED ELECTROSPRAY IONIZATION SOURCES USING ORTHOGONAL INJECTION INTO AN ELECTRODYNAMIC ION FUNNEL 审中-公开
公开(公告)号：US20240203720A1
公开(公告)日：2024-06-20
申请号：US18287357
申请日：2022-04-15
申请人： Purdue Research Foundation
发明人： Julia Laskin , Pei Su , Carlos Larriba , Xi Chen
IPC分类号： H01J49/06 , H01J49/04 , H01J49/10 , H01J49/16
CPC分类号： H01J49/066 , H01J49/0468 , H01J49/107 , H01J49/165
摘要： The invention generally relates to systems and methods for systems and methods for multiplexed electrospray ionization. In certain embodiments, electrospray ionization sources orthogonally inject ions into an ion funnel with at least two of the sources injecting on the same side of the ion funnel.

2. 发明申请

US20190244799A1 SYSTEMS INCLUDING A CELL ANALYZER COUPLED TO A MASS SPECTROMETER AND METHODS USING THE SYSTEMS 审中-公开
公开(公告)号：US20190244799A1
公开(公告)日：2019-08-08
申请号：US16209130
申请日：2018-12-04
申请人： PERKINELMER HEALTH SCIENCES CANADA, INC.
发明人： Chady Stephan , Ruth Merrifield
IPC分类号： H01J49/10 , H01J49/04 , G01N30/72 , H01J49/16
CPC分类号： H01J49/107 , G01N30/7273 , H01J49/045 , H01J49/049 , H01J49/167
摘要： Certain configurations of systems comprising a cell analyzer and a mass spectrometer are described. In some embodiments, the system can be used to determine both a cell phenotype or cellular response and an amount of at least one elemental species in the cell. The phenotype or other cellular characteristic and elemental content of each cell in a cell population can be determined and correlated.

3. 发明授权

US10304667B1 Apparatus and method for cleaning an inlet of a mass spectrometer 有权
公开(公告)号：US10304667B1
公开(公告)日：2019-05-28
申请号：US15842729
申请日：2017-12-14
申请人： Thermo Finnigan LLC
发明人： Steven L. Reeber , Cornelia L. Boeser
IPC分类号： H01J49/04 , H01J37/32 , H01J49/26 , H01J49/10
CPC分类号： H01J37/32862 , H01J49/0031 , H01J49/04 , H01J49/0404 , H01J49/107 , H01J49/24 , H01J49/26
摘要： A method of removing sample residue from a surface of a mass spectrometer inlet, with the surface being adjacent to an ion passageway, is provided. A pendent droplet of a cleaning solvent is formed at a tip of a capillary, with the tip being spaced apart from the surface. The pendent droplet detaches from the tip and contacts the surface. The surface is heated to a temperature T at least 50° C. above the boiling point of the least volatile component of the cleaning solvent.

4. 发明申请

US20180372696A1 LIQUID SAMPLE ANALYSIS SYSTEM 审中-公开
公开(公告)号：US20180372696A1
公开(公告)日：2018-12-27
申请号：US15780829
申请日：2015-12-04
申请人： SHIMADZU CORPORATION
发明人： Kazuma MAEDA
IPC分类号： G01N30/72 , H01J49/04 , H01J49/10
CPC分类号： G01N30/724 , G01N27/62 , G01N30/72 , G01N30/7273 , G01N2030/027 , G01N2030/626 , H01J49/0031 , H01J49/0431 , H01J49/044 , H01J49/0445 , H01J49/107 , H01J49/165
摘要： A liquid sample analyzing system including an ion analyzer having a first ion source receiving a target sample and a second ion source receiving a reference sample; a liquid sample introduction mechanism 3 including a passage-switching section introducing reference samples into the second ion source; and a controller for repeatedly performing a series of steps in the ion analyzer, the steps including: a pre-measurement step for initiating a measurement; a measurement step for introducing a target sample into the first ion source and performing a measurement on an ion originating from the target sample along with an ion originating from a reference sample introduced into the second ion source by the liquid sample introduction mechanism; and a post-measurement step where the liquid sample introduction mechanism operates concurrently with the predetermined post-measurement step to switch the passage-switching section to a passage having a reference sample for the next analysis.

5. 发明申请

US20180190478A1 INORGANIC AND ORGANIC MASS SPECTROMETRY SYSTEMS AND METHODS OF USING THEM 审中-公开
公开(公告)号：US20180190478A1
公开(公告)日：2018-07-05
申请号：US15845419
申请日：2017-12-18
申请人： PERKINELMER HEALTH SCIENCES CANADA, INC.
发明人： Tak Shun Cheung , Chui Ha Cindy Wong , Hamid Badiei , William Fisher
IPC分类号： H01J49/00 , H01J49/10 , H01J49/42
CPC分类号： H01J49/009 , H01J49/107 , H01J49/4225
摘要： Certain configurations of systems and methods that can detect inorganic ions and organic ions in a sample are described. In some configurations, the system may comprise one, two, three or more mass spectrometer cores. In some instances, the mass spectrometer cores can utilize common components such as gas controllers, processors, power supplies and vacuum pumps. In certain configurations, the systems can be designed to detect both inorganic and organic analytes comprising a mass from about three atomic mass units, four atomic mass units or five atomic mass units up to a mass of about two thousand atomic mass units.

6. 发明授权

US09852897B2 Hybrid ion source, mass spectrometer, and ion mobility device 有权
公开(公告)号：US09852897B2
公开(公告)日：2017-12-26
申请号：US14442199
申请日：2013-11-07
申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION
发明人： Hideki Hasegawa , Hiroyuki Satake , Masao Suga , Yuichiro Hashimoto
IPC分类号： H01J49/10 , G01N27/62 , H01J49/16
CPC分类号： H01J49/107 , G01N27/62 , H01J49/165 , H01J49/168
摘要： Provided is an ion source achieving high sensitivity and high robustness while executing a plurality of types of ionization schemes. To this end, a hybrid ion source (1) includes: a chamber (24); a first ion source (2) to spray a sample solution (5) for ionization; a second ion source (3) to ionize droplets and/or a gas component sprayed from the first ion source (2); a first electrode (11) to introduce a first ion (7) generated by the first ion source (2), and a second ion generated by the second ion source (3); and an exhaust pump (27) that generates air flow (26) in a direction from a first space area (23) where the first ion (7) is generated to a second space area (19) in the second ion source (3) where the second ion is generated.

7. 发明申请

US20170309463A1 SYSTEMS AND METHODS FOR TRACE CHEMICAL DETECTION USING DUAL PHOTOIONIZATION SOURCES 审中-公开
公开(公告)号：US20170309463A1
公开(公告)日：2017-10-26
申请号：US15135679
申请日：2016-04-22
申请人： Morpho Detection, LLC
发明人： Andrey N. Vilkov
IPC分类号： H01J49/16 , G01N27/62 , H01J49/04 , H01J49/26
CPC分类号： H01J49/161 , G01N27/622 , G01N27/628 , H01J49/0409 , H01J49/107 , H01J49/162 , H01J49/26
摘要： A dual source ionizer is provided. The dual source ionizer includes a first photoionization source configured to emit low flux ultraviolet (UV) light to generate primarily NO3− ions, and a second photoionization source configured to emit high flux UV light to generate primarily ions other than NO3− ions.

8. 发明申请

US20170191962A9 SYSTEM AND METHOD FOR TRACE DETECTION USING DUAL IONIZATION SOURCES 有权
公开(公告)号：US20170191962A9
公开(公告)日：2017-07-06
申请号：US14666856
申请日：2015-03-24
申请人： MORPHO DETECTION, LLC
发明人： Andrey N. Vilkov , Jack A. Syage
IPC分类号： G01N27/62 , G01N33/00 , G01N33/22 , H01J37/08 , H01J49/10
CPC分类号： G01N27/622 , G01N33/0036 , G01N33/227 , H01J37/08 , H01J49/107
摘要： A dual source ionizer includes a first ionization source and a second ionization source. The first ionization source is configured to generate a first electric field. The first electric field has a first field strength that is insufficient to form NOx− ions. The second ionization source is configured to generate a second electric field. The second electric field has a second field strength that is sufficient to form ozone and the NOx− ions.

9. 发明授权

US09666422B2 Analyzer 有权
公开(公告)号：US09666422B2
公开(公告)日：2017-05-30
申请号：US14891123
申请日：2014-08-29
申请人： ATONARP INC.
发明人： Prakash Sreedhar Murthy
IPC分类号： H01J49/02 , H01J49/00 , H01J49/14 , H01J49/10
CPC分类号： H01J49/0031 , H01J49/025 , H01J49/06 , H01J49/107 , H01J49/147
摘要： There is provided an analyzer including: an ionizer unit that ionizes molecules to be analyzed; a filter unit that selectively passes ions generated by the ionizer unit; and a detection unit that detects ions that have passed the filter unit. The detection unit includes a plurality of detection elements disposed in a matrix, and the analyzer further includes a first reconfiguration unit that switches between detection patterns including detection elements to be enabled for detection out of the plurality of detection elements. The ionizer unit includes a plurality of ion sources, and the analyzer further includes a driving control unit that switches the connections of the plurality of ion sources based on changes in characteristics of the ion sources.

10. 发明授权

US09589776B2 Ruggedized advanced identification mass spectrometer 有权
标题翻译：坚固的高级识别质谱仪
公开(公告)号：US09589776B2
公开(公告)日：2017-03-07
申请号：US15070433
申请日：2016-03-15
申请人： SRI INTERNATIONAL
发明人： Ashish Chaudhary , Friso Van Amerom , R. Timothy Short
IPC分类号： H01J49/00 , H01J49/24
CPC分类号： H01J49/0027 , H01J49/0013 , H01J49/004 , H01J49/0054 , H01J49/0059 , H01J49/107 , H01J49/24
摘要： A dual-ionization mass spectrometer includes a first mass spectrometer module forming a hard ionization mass spectrometer, a second mass spectrometer forming a soft ionization mass spectrometer, a vacuum ultraviolet light source positioned between the first and second modules, a housing encompassing the first and second sets of plates and the light source, and an inlet positioned to receive a sample of an analyte and provide it to at least one of the sets of plates. A method of detecting a substance includes receiving a sample of an analyte into a housing through an inlet, performing soft ionization mass spectrometry on the sample with a soft ionization mass spectrometer in the housing, performing hard ionization spectrometry on the sample with a hard ionization spectrometer in the housing if needed, and generating a detection result from at least one of the soft ionization spectrometry and the hard ionization spectrometry.
摘要翻译：双电离质谱仪包括形成硬电离质谱仪的第一质谱模块，形成软电离质谱仪的第二质谱仪，位于第一和第二模块之间的真空紫外光源，包含第一和第二一组板和光源，以及定位成接收分析物样品并将其提供给至少一组板的入口。检测物质的方法包括通过入口将分析物的样品接收到壳体中，通过壳体中的软质电离质谱仪对样品进行软质电离质谱分析，用硬质电离光谱仪对样品进行硬质离子化分光光度法如果需要，在壳体中，并且从至少一种软电离光谱法和硬质电离光谱法产生检测结果。

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