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1. 发明申请

US20070221839A1 Analytical system and method 审中-公开
标题翻译：分析系统和方法
公开(公告)号：US20070221839A1
公开(公告)日：2007-09-27
申请号：US11388686
申请日：2006-03-24
申请人： Paul Goodley , Bernd Glatz
发明人： Paul Goodley , Bernd Glatz
IPC分类号： H01J49/04
CPC分类号： G01N30/7266 , B01L3/0268 , B01L3/502707 , B01L3/502753 , B01L2300/0816 , B01L2300/161 , B01L2400/027 , B01L2400/0622 , G01N30/6095 , H01J49/0018 , H01J49/0431 , H01J49/165
摘要： The invention provides an analytical system having a separating system and a liquid chromatography chip. The liquid chromatography chip has an emitter that includes a material that prevents charge buildup on the emitter surface. Methods of using the analytical system, chip and emitter are also disclosed.
摘要翻译：本发明提供了一种具有分离系统和液相色谱芯片的分析系统。液相色谱芯片具有包括防止发射体表面电荷积累的材料的发射极。还公开了使用分析系统，芯片和发射器的方法。

2. 发明申请

US20070023676A1 Nanospray ionization device and method 有权
标题翻译：纳米喷雾电离装置及方法
公开(公告)号：US20070023676A1
公开(公告)日：2007-02-01
申请号：US11171976
申请日：2005-06-29
申请人： Paul Goodley , Timothy Joyce , Jerry Dowell
发明人： Paul Goodley , Timothy Joyce , Jerry Dowell
IPC分类号： H01J27/00
CPC分类号： H01J49/165 , H01J49/0468
摘要： The present invention provides an apparatus and method for use with a mass spectrometry system. The invention provides an ion source for providing radiative heating to an ionization region. The ion source includes a nanospray ionization device for producing ions and a conduit adjacent to the ionization device for receiving ions from the ionization device. The conduit includes a conductive material for providing indirect radiative heating to the ionization region. Direct radiative heating may also be provided using a heater in the conduit. The ion source may be used separately or in conjunction with the mass spectrometry system. When used in conjunction with a mass spectrometry system a detector may also be employed down stream from the device. A method for desolvating an analyte using the device is also disclosed.
摘要翻译：本发明提供了一种与质谱系统一起使用的装置和方法。本发明提供了一种用于向电离区域提供辐射加热的离子源。离子源包括用于产生离子的纳米喷雾离子化装置和与电离装置相邻的导管，用于从离子化装置接收离子。导管包括用于向电离区提供间接辐射加热的导电材料。也可以使用导管中的加热器来提供直接辐射加热。离子源可以单独使用或与质谱系统结合使用。当与质谱系统结合使用时，也可以从装置下游使用检测器。还公开了使用该装置对分析物进行脱溶剂的方法。

3. 发明申请

US20050139766A1 Micro matrix ion generator for analyzers 有权
公开(公告)号：US20050139766A1
公开(公告)日：2005-06-30
申请号：US11065516
申请日：2005-02-23
申请人： Paul Goodley , Jean-Luc Truche
发明人： Paul Goodley , Jean-Luc Truche
IPC分类号： H01J49/04 , B01D59/44 , H01J49/00
CPC分类号： H01J49/167 , H01J49/0018 , H01J49/04
摘要： A source of ions for an analyzer includes a reservoir for containing a liquid, a manifold having a plurality of nozzles, a conduit connecting the reservoir to the manifold and a counter electrode having a potential different between the counter electrode and the nozzles to enable liquid to be ejected from the nozzles in droplets and to enable ions to be ejected from the droplets.

4. 发明申请

US20070235642A1 Curved conduit ion sampling device and method 失效
标题翻译：曲线管离子采样装置及方法
公开(公告)号：US20070235642A1
公开(公告)日：2007-10-11
申请号：US11398163
申请日：2006-04-05
申请人： Jean-Luc Truche , Paul Goodley , Steven Fischer , Jian Bal
发明人： Jean-Luc Truche , Paul Goodley , Steven Fischer , Jian Bal
IPC分类号： H01J49/00
CPC分类号： H01J49/062
摘要： An ion sampling apparatus for use in a mass spectrometry system. The ion sampling apparatus includes a target support for receiving a sample, an irradiation source for emitting energetic radiation or particles toward the target support, and a conduit having a curved end and a longitudinal axis, the curved end having an inlet with a central axis, the conduit being adjacent to the target support. The longitudinal axis of the conduit and the central axis of the inlet intersect to define an angle that is between about 20 degrees and about 210 degrees.
摘要翻译：用于质谱系统的离子取样装置。离子采样设备包括用于接收样品的目标支撑体，用于向目标支撑体发射能量辐射或颗粒的辐射源，以及具有弯曲端部和纵向轴线的导管，该弯曲端部具有带有中心轴线的入口，导管与目标支撑件相邻。导管的纵向轴线和入口的中心轴线相交以限定约20度至约210度之间的角度。

5. 发明申请

US20070164231A1 Apparatus and method for ion calibrant introduction 有权
标题翻译：离子校准物引入装置及方法
公开(公告)号：US20070164231A1
公开(公告)日：2007-07-19
申请号：US11333860
申请日：2006-01-17
申请人： Jean-Luc Truche , Jian Bai , Paul Goodley
发明人： Jean-Luc Truche , Jian Bai , Paul Goodley
IPC分类号： H01J27/00
CPC分类号： H01J49/107 , H01J49/0009
摘要： The present invention relates to an apparatus and method for introducing calibrant ions into a conduit, ion source and/or mass spectrometry system.
摘要翻译：本发明涉及将校准物离子引入导管，离子源和/或质谱系统中的装置和方法。

6. 发明申请

US20070017869A1 Liquid chromatography chip with flexible interface 失效
标题翻译：液相色谱芯片具有灵活的界面
公开(公告)号：US20070017869A1
公开(公告)日：2007-01-25
申请号：US11187084
申请日：2005-07-22
申请人： Paul Goodley
发明人： Paul Goodley
IPC分类号： B01D15/08
CPC分类号： G01N30/6095 , G01N30/6004 , G01N30/7266 , G01N2030/8417
摘要： A liquid chromatography chip may include an analytical column. After an analyte has traveled through an analytical column defined by the chromatography chip, the analyte is routed, either directly or indirectly, to a port defined by the chromatogrpahy chip, instead of to a spray tip on-board the chromatography chip. The port may be in fluid communication with a tube or conduit that may, in turn, be coupled to another device. Such an arrangement provides for flexible interface of the chromatography chip to another device.
摘要翻译：液相色谱芯片可以包括分析柱。分析物经过色谱芯片定义的分析柱后，直接或间接地将分析物路由到由色谱芯片定义的端口，而不是色谱芯片上的喷嘴。端口可以与管或导管流体连通，管或导管又可以耦合到另一装置。这种布置提供了色谱芯片与另一器件的柔性接口。

7. 发明授权

US4580554A Traction device 失效
标题翻译：牵引装置
公开(公告)号：US4580554A
公开(公告)日：1986-04-08
申请号：US555814
申请日：1983-11-28
申请人： Paul Goodley
发明人： Paul Goodley
IPC分类号： A61H1/02 , A61F5/00
CPC分类号： A61H1/0229 , A61H1/0218 , A61H2201/1621 , A61H2203/0456
摘要： A traction device in which the user himself applies the traction force. A harness runs under the user's body to the dorsal and lumbar region thereof. A strap is attached to the harness and is used to apply traction thereto, the opposite ends of the strap being attached to the ends of a traction bar. The traction bar has attachment means at its center and to the left and right of center, a line or cable being selectively attached to one of these attachment means. This line fits through a suitable fitting and is attached to a force indicator device which is within the user's view. A line runs from the indicator device to a force input drive member adapted to be engaged by the user's feet or hands. In using the device, the user applies the desired amount of force to the force input drive member, as indicated on the indicator device, this force being delivered to a selected portion of the user's back through a suitable applicator member.
摘要翻译：牵引装置，其中使用者自己施加牵引力。线束在使用者的身体下方运行到其背部和腰部区域。带子附接到线束并用于对其施加牵引力，带的相对端附接到牵引杆的端部。牵引杆在其中心和中心的左侧和右侧具有附接装置，线或电缆选择性地连接到这些连接装置中的一个上。该线适合通过合适的配件并附接到用户视野内的力指示器装置。线从指示器装置延伸到适于由使用者的脚或手接合的力输入驱动构件。在使用该装置时，使用者将如图所示的力输入驱动构件所需的力量施加到指示器装置上，该力通过合适的施加器构件输送到用户的背部的选定部分。

8. 发明申请

US20070228271A1 Method and apparatus for surface desorption ionization by charged particles 有权
标题翻译：带电粒子表面解吸电离的方法和装置
公开(公告)号：US20070228271A1
公开(公告)日：2007-10-04
申请号：US11398305
申请日：2006-04-04
申请人： Jean-Luc Truche , Paul Goodley , Gregor Overney
发明人： Jean-Luc Truche , Paul Goodley , Gregor Overney
IPC分类号： H01J49/14
CPC分类号： H01J49/142
摘要： An apparatus and method for generating analyte ions from a sample. An ion generating device is provided having a chamber with an outlet and a surface having a material and means for applying a high velocity gas flow through the chamber toward the outlet such that charged particles are produced by physical interaction between the high velocity gas and the material. The charged particles then induce the generation of primary ions by interaction with molecules of the high velocity gas. The primary ions are emitted from the outlet of the ion generating device toward a sample-bearing surface and analyte ions are generated by impact of the primary ions on the analyte sample on the surface.
摘要翻译：一种用于从样品中产生分析物离子的装置和方法。提供一种离子产生装置，其具有具有出口的腔室和具有材料的表面，以及用于将高速气流经由腔室朝向出口施加的装置，使得通过高速气体和材料之间的物理相互作用产生带电粒子。带电粒子然后通过与高速气体分子的相互作用诱导产生初级离子。主要离子从离子产生装置的出口朝向样品承载表面发射，分析物离子通过主离子冲击表面上的分析物样品而产生。

9. 发明申请

US20060208186A1 Nanospray ion source with multiple spray emitters 审中-公开
标题翻译：具有多个喷射发射体的纳米喷雾离子源
公开(公告)号：US20060208186A1
公开(公告)日：2006-09-21
申请号：US11081325
申请日：2005-03-15
申请人： Paul Goodley , Harvey Loucks , Michael Flanagan
发明人： Paul Goodley , Harvey Loucks , Michael Flanagan
IPC分类号： H01J49/10
CPC分类号： H01J49/10
摘要： The present invention provides an apparatus and method for use with a mass spectrometer. The invention provides a mass spectrometer system for non-pneumatic ion production, including a non-pneumatic nanospray ionization source. The nanospray ionization source has a first non-pneumatic ion spray emitter for producing ions; a conduit adjacent to the ion spray emitter, the conduit having an aperture designed for receiving ions from the ion spray emitter; a first electrode for directing the ions from the ion spray emitter toward the aperture of the capillary; and a conduit electrode for directing ions into the conduit; and detector down stream from the capillary for detecting ions produced by the non-pneumatic nanospray ionization source. The invention also provides a non-pneumatic nanospray ionization source, comprising a first non-pneumatic ion spray emitter for producing ions; a conduit adjacent to the ion spray emitter, the conduit having an aperture designed for receiving ions from the ion spray emitter; a first electrode for directing ions from the ion spray emitter toward the aperture of the conduit and a conduit electrode for directing ions into the conduit. Also disclosed is a method for producing ions using a nanospray ionization source.
摘要翻译：本发明提供了一种与质谱仪一起使用的装置和方法。本发明提供了一种用于非气动离子生产的质谱仪系统，包括非气动纳米喷雾电离源。纳米喷雾电离源具有用于产生离子的第一非气动离子喷射发射体; 邻近离子喷射发射器的导管，导管具有设计用于接收离子喷射发射器的离子的孔; 用于将离子从离子喷射器引导到毛细管的孔的第一电极; 以及用于将离子引导到导管中的导管电极; 并从毛细管下游探测由非气动纳米喷雾电离源产生的离子。本发明还提供一种非气动纳米喷雾电离源，包括用于产生离子的第一非气动离子喷射发射体; 邻近离子喷射发射器的导管，导管具有设计用于接收离子喷射发射器的离子的孔; 用于将离子从离子喷射器引导到导管的孔的第一电极和用于将离子引导到导管中的导管电极。还公开了使用纳米喷雾电离源产生离子的方法。

10. 发明申请

US20050092855A1 Electrospray ion source for mass spectroscopy 有权
标题翻译：电喷雾离子源进行质谱分析
公开(公告)号：US20050092855A1
公开(公告)日：2005-05-05
申请号：US10699448
申请日：2003-10-31
申请人： Ganggiang Li , Paul Goodley , Hongfeng Yin
发明人： Ganggiang Li , Paul Goodley , Hongfeng Yin
IPC分类号： G01N27/62 , B05B5/00 , H01J49/04 , H01J49/10 , H01J49/14 , H01J49/16
CPC分类号： H01J49/167
摘要： The invention provides an electrospray apparatus with an auxiliary electrode, and a method of using.
摘要翻译：本发明提供一种具有辅助电极的电喷射装置及其使用方法。

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