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1. 发明申请

US20070023676A1 Nanospray ionization device and method 有权
标题翻译：纳米喷雾电离装置及方法
公开(公告)号：US20070023676A1
公开(公告)日：2007-02-01
申请号：US11171976
申请日：2005-06-29
申请人： Paul Goodley , Timothy Joyce , Jerry Dowell
发明人： Paul Goodley , Timothy Joyce , Jerry Dowell
IPC分类号： H01J27/00
CPC分类号： H01J49/165 , H01J49/0468
摘要： The present invention provides an apparatus and method for use with a mass spectrometry system. The invention provides an ion source for providing radiative heating to an ionization region. The ion source includes a nanospray ionization device for producing ions and a conduit adjacent to the ionization device for receiving ions from the ionization device. The conduit includes a conductive material for providing indirect radiative heating to the ionization region. Direct radiative heating may also be provided using a heater in the conduit. The ion source may be used separately or in conjunction with the mass spectrometry system. When used in conjunction with a mass spectrometry system a detector may also be employed down stream from the device. A method for desolvating an analyte using the device is also disclosed.
摘要翻译：本发明提供了一种与质谱系统一起使用的装置和方法。本发明提供了一种用于向电离区域提供辐射加热的离子源。离子源包括用于产生离子的纳米喷雾离子化装置和与电离装置相邻的导管，用于从离子化装置接收离子。导管包括用于向电离区提供间接辐射加热的导电材料。也可以使用导管中的加热器来提供直接辐射加热。离子源可以单独使用或与质谱系统结合使用。当与质谱系统结合使用时，也可以从装置下游使用检测器。还公开了使用该装置对分析物进行脱溶剂的方法。

2. 发明申请

US20070001114A1 Apparatus and method for ion capture and production 审中-公开
标题翻译：用于离子捕获和制备的装置和方法
公开(公告)号：US20070001114A1
公开(公告)日：2007-01-04
申请号：US11172217
申请日：2005-06-29
申请人： Paul Goodley , Jean-Luc Truche , Jerry Dowell , Timothy Joyce
发明人： Paul Goodley , Jean-Luc Truche , Jerry Dowell , Timothy Joyce
IPC分类号： H01J49/10
CPC分类号： H01J49/0418
摘要： The present invention relates to an apparatus and method for producing ions. The apparatus may be used separately as an ion source or in combination with a mass spectrometry system. The ion source of the present invention provides an ionization device for producing ions, a substrate for capturing, storing and releasing ions produced by the ionization device, a conductive material in contact with the substrate for receiving an electrical pulse, and a voltage source electrically connected to the conductive material for applying an electrical pulse to the conductive material and substrate to release the ions captured by the substrate. Also disclosed is a method for storing and releasing ions using the disclosed apparatus.
摘要翻译：本发明涉及一种用于生产离子的装置和方法。该装置可以单独用作离子源或与质谱系统组合使用。本发明的离子源提供用于产生离子的离子化装置，用于捕获，存储和释放由离子化装置产生的离子的基板，与基板接触的用于接收电脉冲的导电材料和电连接的电压源涉及用于将电脉冲施加到导电材料和衬底以释放由衬底捕获的离子的导电材料。还公开了使用所公开的装置来存储和释放离子的方法。

3. 发明申请

US20070048745A1 Systems and methods for partitioned nanopore analysis of polymers 审中-公开
标题翻译：聚合物分隔纳米孔分析的系统和方法
公开(公告)号：US20070048745A1
公开(公告)日：2007-03-01
申请号：US11214546
申请日：2005-08-30
申请人： Timothy Joyce , Jerry Dowell
发明人： Timothy Joyce , Jerry Dowell
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N33/48721 , B82Y5/00 , C12Q1/6869 , C12Q2565/631 , C12Q2565/607
摘要： Devices, systems, and methods for nanopore analysis of polymers are provided. One exemplary device, among others, includes a substrate having a plurality of partitioned nanopores configured to receive a polymer sample. In addition, the device includes a plurality of sets of resonant tunneling electrodes adjacent the partitioned nanopore. At least one set of resonant tunneling electrodes is configured to detect tunneling current as monomers of a polymer in the polymer sample sequentially travel through at least one partitioned nanopore.
摘要翻译：提供了聚合物纳米孔分析的装置，系统和方法。一个示例性的装置，其中包括具有多个分隔纳米孔的基底，其被配置成接收聚合物样品。此外，该器件包括与分隔的纳米孔相邻的多组谐振隧穿电极。至少一组谐振隧道电极被配置为检测隧道电流，因为聚合物样品中的聚合物的单体顺序地穿过至少一个分隔的纳米孔。

4. 发明申请

US20060097149A1 Nanowire target support and method 失效
标题翻译：纳米线目标支持和方法
公开(公告)号：US20060097149A1
公开(公告)日：2006-05-11
申请号：US10971164
申请日：2004-10-22
申请人： Timothy Joyce
发明人： Timothy Joyce
IPC分类号： H01J49/00
CPC分类号： H01J49/164 , H01J49/0418
摘要： The invention provides an apparatus that produces analyte ions for detection by a detector. The apparatus includes a matrix based ion source having a nanowire target substrate for producing analyte ions, an ion transport system adjacent to the matrix based ion source for transporting analyte ions from the matrix based ion source; and an ion detector downstream from the ion transport system for detecting the analyte ions. The invention also provides a method for producing and detecting the analyte ions.
摘要翻译：本发明提供一种生成分析物离子以供检测器检测的装置。该装置包括具有用于产生分析物离子的纳米线靶基质的基于基质的离子源，与基于基质的离子源相邻的离子传输系统，用于将基于离子源的离子源输送到分析物离子; 以及离子传感系统下游的用于检测分析物离子的离子检测器。本发明还提供了一种用于产生和检测分析物离子的方法。

5. 发明申请

US20060081775A1 Ionization chambers for mass spectrometry 失效
公开(公告)号：US20060081775A1
公开(公告)日：2006-04-20
申请号：US10966191
申请日：2004-10-15
申请人： Timothy Joyce , Jennifer Lu
发明人： Timothy Joyce , Jennifer Lu
IPC分类号： H01J49/10
CPC分类号： H01J49/147 , B82Y10/00
摘要： An ionization chamber for a mass spectrometry system is described. The ionization chamber comprises a housing defining an ionization region, and the housing comprises a carbon nanotube material.

6. 发明申请

US20060019259A1 Characterization of biopolymers by resonance tunneling and fluorescence quenching 审中-公开
标题翻译：通过共振隧道和荧光猝灭表征生物聚合物
公开(公告)号：US20060019259A1
公开(公告)日：2006-01-26
申请号：US10898586
申请日：2004-07-22
申请人： Timothy Joyce
发明人： Timothy Joyce
IPC分类号： C12Q1/68 , C12M3/04
CPC分类号： G01N33/6818 , C12Q1/6869 , G01N33/48721 , C12Q2565/631 , C12Q2565/607
摘要： The present invention provides a method and apparatus for determining the identity of a monomeric residue of a biopolymer. The apparatus comprises a substrate having a nanopore, a potential-producing element for producing a ramped potential across electrodes adjacent to the nanopore, and a quenchable excitable moiety adjacent to the nanopore. As a biopolymer passes through the nanopore, the identity of monomeric residues of a biopolymer may be determined by detecting changes in (a) current across the electrodes and (b) a signal of the quenchable excitable molecule. The subject method and apparatus find use in determining the identity of a plurality of monomeric residues of a biopolymer, and, as such, may be employed in a variety of diagnostic and research applications.
摘要翻译：本发明提供了用于测定生物聚合物的单体残基的身份的方法和装置。该装置包括具有纳米孔的底物，用于在邻近纳米孔的电极之间产生斜坡电位的潜在产生元件和与该纳米孔相邻的可淬火的可兴奋部分。当生物聚合物通过纳米孔时，生物聚合物的单体残基的身份可以通过检测（a）跨越电极的电流的变化和（b）可淬灭的可激发分子的信号来确定。本发明的方法和装置用于确定生物聚合物的多个单体残基的身份，并且因此可用于多种诊断和研究应用。

7. 发明申请

US20060243917A1 Apparatus and method for sensor control and feedback 有权
公开(公告)号：US20060243917A1
公开(公告)日：2006-11-02
申请号：US11471954
申请日：2006-06-21
申请人： Steven Fischer , Darrell Gourley , Glen Ingle , Timothy Joyce
发明人： Steven Fischer , Darrell Gourley , Glen Ingle , Timothy Joyce
IPC分类号： H01J27/24
CPC分类号： H01J49/04 , H01J49/10 , H01J49/107 , H01J49/165
摘要： The present invention relates to an apparatus and method for use with a mass spectrometry system. The invention provides an ion source, infrared emitter and sensor with closed control feedback loop coupled to the infrared emitter. Methods of control and heating using the apparatus of the present invention are also disclosed.

8. 发明申请

US20060062194A1 Integration of remote microcell with CDMA infrastructure 有权
公开(公告)号：US20060062194A1
公开(公告)日：2006-03-23
申请号：US11261251
申请日：2005-10-28
申请人： Brian Fiut , Timothy Joyce
发明人： Brian Fiut , Timothy Joyce
IPC分类号： H04B7/216
CPC分类号： H04B7/2609 , H04B7/2628 , H04B2201/70702 , H04W4/18 , H04W24/00
摘要： A method of interconnecting a CDMA cellsite having signal advancing capabilities with at least one remote microcell without re-synchronization capabilities. The method of the present invention sufficiently advances the signal to compensate for the time delay induced by communication signal travel over a fiber optic connection between a base station cellsite and a remote microcell.

9. 发明申请

US20060014293A1 Lock mass ions for use with derivatized peptides for de novo sequencing using tandem mass spectrometry 审中-公开
标题翻译：使用串联质谱法将质子离子锁定用于衍生肽进行从头测序
公开(公告)号：US20060014293A1
公开(公告)日：2006-01-19
申请号：US10938690
申请日：2004-09-10
申请人： Timothy Joyce , Barry Boyes , Gordon Nicol , Hongbin Liu
发明人： Timothy Joyce , Barry Boyes , Gordon Nicol , Hongbin Liu
IPC分类号： G01N33/00
CPC分类号： G01N33/6851 , G01N33/6842 , G01N33/6848 , H01J49/0031 , Y10T436/24
摘要： Multiple derivatization by chemical reactions of analytes for mass spectrometry is disclosed. The derivatizations enhance the use of MS techniques for analyzing protein samples, particularly when the sequence of a polypeptide is determined by tandem MS/MS. Accurate mass analysis techniques are described for use in sequencing polypeptides, together with the use of sequencing data in protein analysis. An apparatus and method for calibrating a mass spectrometer by internally introducing calibration masses at a post-source stage of the mass spectrometer is also provided. Lock mass ions mix with the derivatized polypeptide analyte ions prior to mass analysis.
摘要翻译：公开了通过化学反应进行质谱分析的多重衍生化。衍生化增强了MS技术用于分析蛋白质样品的用途，特别是当通过串联MS / MS测定多肽的序列时。描述了准确的质量分析技术用于测序多肽，以及在蛋白质分析中使用测序数据。还提供了通过在质谱仪的后源阶段内部引入校准质量来校准质谱仪的装置和方法。在质量分析之前，将质子离子与衍生的多肽分析物离子混合。

10. 发明申请

US20050151090A1 Apparatus and method for ion production enhancement 有权
标题翻译：用于离子生产增强的装置和方法
公开(公告)号：US20050151090A1
公开(公告)日：2005-07-14
申请号：US11015190
申请日：2004-12-16
申请人： Jean-Luc Truche , Jian Bai , Timothy Joyce
发明人： Jean-Luc Truche , Jian Bai , Timothy Joyce
IPC分类号： H01J49/04 , H01J49/16 , H01J27/00
CPC分类号： H01J49/164 , H01J49/0477
摘要： The present invention relates to an apparatus and method for use with a mass spectrometer. The ion enhancement system of the present invention is used to direct a heated gas toward ions produced by a matrix based ion source and detected by a detector. The ion enhancement system is interposed between the ion source and the detector. The analyte ions that contact the heated gas are enhanced and an increased number of ions are more easily detected by a detector. The method of the invention comprises producing analyte ions from a matrix based ion source, enhancing the analyte ions with an ion enhancement system and detecting the enhanced analyte ions with a detector.
摘要翻译：本发明涉及一种与质谱仪一起使用的装置和方法。本发明的离子增强系统用于将加热气体引导到由基于基质的离子源产生的离子并由检测器检测。离子增强系统介于离子源和检测器之间。接触加热气体的分析物离子增强，并且更多的离子更容易被检测器检测。本发明的方法包括从基于基质的离子源产生分析物离子，用离子增强系统增强分析物离子并用检测器检测增强的分析物离子。

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