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1. 发明授权

US06930305B2 Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring 有权
标题翻译：使用激光解吸和多反应监测对小分子进行高通量定量的方法和系统
公开(公告)号：US06930305B2
公开(公告)日：2005-08-16
申请号：US10400322
申请日：2003-03-27
申请人： Thomas R. Covey , John J. Corr , William H. Fisher , Chau Tung
发明人： Thomas R. Covey , John J. Corr , William H. Fisher , Chau Tung
IPC分类号： G01N27/62 , B01D59/44 , G01N21/00 , G01N27/64 , H01J49/00 , H01J49/10 , H01J49/16 , H01J49/40 , H01J49/42 , B01D54/44
CPC分类号： H01J49/4215 , H01J49/0031 , H01J49/004 , H01J49/0481 , H01J49/164
摘要： A mass spectrometry quantitation technique enables high-throughput quantitation of small molecules using a laser-desorption (e.g., MALDI) ion source coupled to a triple-quadrupole mass analyzer. The ions generated from the ion source are collisionally damped/cooled, and then quantitatively analyzed using the triple-quadrupole analyzer operated in the multiple-reaction-monitoring (MRM) mode. Significantly improved measurement sensitivity is obtained by applying laser pulses to the ion source at a high pulse rate of about 500 Hz or higher. This allows the data acquisition to be performed rapidly, and the speed of about one second for each sample point on the ion source target has been achieved.
摘要翻译：使用耦合到三重四极杆质谱仪的激光解吸（例如MALDI）离子源，质谱定量技术可实现小分子的高通量定量。从离子源产生的离子被碰撞阻尼/冷却，然后使用在多反应监测（MRM）模式中操作的三重四极杆分析器进行定量分析。通过以大约500Hz或更高的高脉冲速度向离子源施加激光脉冲，可以获得显着提高的测量灵敏度。这允许快速执行数据采集，并且已经实现了离子源目标上的每个采样点的约1秒的速度。

2. 发明授权

US4861988A Ion spray apparatus and method 失效
标题翻译：离子喷涂装置及方法
公开(公告)号：US4861988A
公开(公告)日：1989-08-29
申请号：US103056
申请日：1987-09-30
申请人： John D. Henion , Thomas R. Covey , Andries P. Bruins
发明人： John D. Henion , Thomas R. Covey , Andries P. Bruins
IPC分类号： G01N30/72 , H01J49/04
CPC分类号： H01J49/167 , G01N30/7246 , G01N30/7266 , H01J49/0445 , G01N30/7293
摘要： A device for interfacing between a microbore liquid chromatograph and a mass analyser. In such a device, liquid from the liquid chromatograph is sprayed through a stainless steel capillary tube into the atmospheric pressure ionization chamber of a mass spectrometer. A voltage of e.g., plus or minus 3 KV is applied to the stainless steel tube, and a nebulizing gas, e.g. nitrogen, is directed at high velocity past the tube tip through another tube encircling the stainless steel tube. The combination of the nebulizing gas and the electric potential disperses the liquid at room temperature into a fine mist providing an increased and more stable ion signal without thermal decomposition of the compounds being analysed.
摘要翻译：用于在微孔液相色谱仪和质量分析仪之间进行接口的装置。在这种装置中，来自液相色谱仪的液体通过不锈钢毛细管喷射到质谱仪的大气压电离室中。对不锈钢管施加例如加或减3KV的电压，以及雾化气体，例如，氮气以高速通过管尖通过环绕不锈钢管的另一个管。雾化气体和电位的组合将液体在室温下分散成细雾，提供增加和更稳定的离子信号，而不会分解化合物的热分解。

3. 发明授权

US08779356B2 Method and system for providing a dual curtain gas to a mass spectrometry system 有权
标题翻译：用于向质谱系统提供双帘式气体的方法和系统
公开(公告)号：US08779356B2
公开(公告)日：2014-07-15
申请号：US13821148
申请日：2011-09-14
申请人： Thomas R. Covey , Stanislaw Potyrala , Bradley B. Schneider
发明人： Thomas R. Covey , Stanislaw Potyrala , Bradley B. Schneider
IPC分类号： H01J49/24 , B01D59/44
CPC分类号： H01J49/02 , H01J49/044
摘要： A system and method for mass spectrometry including a curtain gas chamber defined by a curtain plate having an aperture for receiving ions from an ion source and an orifice plate having an inlet into a mass spectrometer. At least one barrier separates the curtain chamber into a first curtain gas chamber region and a second curtain gas chamber region. At least one gas source provides a gas inflow into the second curtain gas chamber region and a gas outflow into the first curtain gas chamber region, a portion of the gas outflow directed out of the aperture. A heating element heats the gas inflow, a portion of the heated gas inflow directed into the inlet of the mass spectrometer wherein the portion of the heated gas inflow can be at a substantially higher temperature than the portion of the gas outflow.
摘要翻译：一种用于质谱的系统和方法，包括由具有用于从离子源接收离子的孔的幕板限定的帘式气室和具有入口进入质谱仪的孔板。至少一个屏障将幕帘室分隔成第一帘式气体室区域和第二帘式气体室区域。至少一个气体源提供气体流入第二帘式气体室区域，并且气体流入第一帘式气体室区域，一部分气体流出物被引导出孔。加热元件加热气体流入，一部分加热气体流入引导到质谱仪的入口，其中加热气体流入的部分可以处于比气体流出部分显着更高的温度。

4. 发明申请

US20100237233A1 ION OPTICS DRAIN FOR ION MOBILITY 有权
标题翻译：离子光学离子离子移动
公开(公告)号：US20100237233A1
公开(公告)日：2010-09-23
申请号：US12722863
申请日：2010-03-12
申请人： Thomas R. Covey , Bradley B. Schneider , John Vandermey
发明人： Thomas R. Covey , Bradley B. Schneider , John Vandermey
IPC分类号： H01J49/26 , H01J49/06
CPC分类号： H01J49/06 , H01J49/421 , H01J49/427
摘要： A sample analysis system incorporates an ion removal mechanism for removing residual ions from the sample analysis system. The ion removal mechanism can be included in an ion optics assembly, which connects an ion mobility filter to a mass analyzer. A sample to be analyzed by the sample analysis system may be entered into an ion mobility filter. The ion mobility filter filters the ions of the sample and passes the filtered group of ions to the ion optics assembly. The ion optics assembly transports the filtered group of ions to a mass analyzer where some or all of the ions in the group are detected. The ion removal mechanism then removes all or substantially all residual ions from the ion optics that were left over from the first filtered group before a second filtered group is passed through.
摘要翻译：样品分析系统包含用于从样品分析系统中去除残留离子的离子去除机构。离子去除机构可以包括在将离子迁移过滤器连接到质量分析器的离子光学组件中。可以将样品分析系统分析的样品输入离子迁移率过滤器。离子迁移率过滤器过滤样品的离子并将过滤的离子组通过离子光学组件。离子光学组件将过滤的离子组输送到质量分析器，其中检测到组中的一些或全部离子。然后离子去除机构在第二过滤组通过之前，从第一过滤组中留下的离子光学元件中除去所有或基本上所有残留的离子。

5. 发明授权

US5412208A Ion spray with intersecting flow 失效
标题翻译：离子喷雾与相交流
公开(公告)号：US5412208A
公开(公告)日：1995-05-02
申请号：US181529
申请日：1994-01-13
申请人： Thomas R. Covey , Joseph F. Anacleto
发明人： Thomas R. Covey , Joseph F. Anacleto
IPC分类号： G01N30/72 , H01J49/04 , H01J49/10
CPC分类号： H01J49/165 , G01N30/7246 , H01J49/044 , H01J49/0477
摘要： Liquid from a liquid chromatograph or other sample source, preferably assisted by a high velocity coaxial gas jet, is sprayed through a capillary tube producing a flow in a first direction of charged droplets. A flow of heated gas, in a second direction different from the first direction, intersects the droplet flow at a region upstream of an orifice. The flows mix turbulently, with the second flow helping to evaporate the droplets to produce ions and helping to move the evaporating droplets toward the orifice, providing a focusing effect. Ions are drawn through the orifice into a mass analyzer and analyzed. Alternatively the flows of liquid and heating gas can be directed toward each other and at right angles to the axis through the orifice, and the inhaling effect of the orifice can be used to draw droplets toward it, or a third gas flow can be used for this purpose. The heated intersecting gas flow typically provides an increase in sensitivity (ion counts per second) of between 10 and 100 times. Heating the droplet plume also allows controlled desaturation of ions and in increase in the number of charges on them, without degrading the ions.
摘要翻译：来自液相色谱仪或其它样品源的液体优选由高速同轴气体射流辅助，通过毛细管喷射，产生沿带电液滴的第一方向的流动。在与第一方向不同的第二方向上的加热气体流在孔口上游的区域处与液滴流相交。流动紊乱地混合，第二流有助于蒸发液滴以产生离子并帮助将蒸发的液滴移向孔口，从而提供聚焦效果。离子通过孔进入质量分析器并进行分析。或者，液体和加热气体的流动可以彼此指向并且通过孔口与轴线成直角，并且可以使用孔口的吸入效应来朝向其喷射液滴，或者可以使用第三气流这个目的加热的相交气流通常提供10至100倍的灵敏度（每秒离子计数）的增加。加热液滴羽流还允许控制离子的去饱和并增加其上的电荷数，而不降解离子。

6. 发明授权

US4994165A Liquid junction coupling for capillary zone electrophoresis/ion spray spectrometry 失效
标题翻译：用于毛细管区带电泳/离子喷射光谱法的液体接头
公开(公告)号：US4994165A
公开(公告)日：1991-02-19
申请号：US311500
申请日：1989-02-16
申请人： Edgar D. Lee , Thomas R. Covey , John D. Henion
发明人： Edgar D. Lee , Thomas R. Covey , John D. Henion
IPC分类号： G01N27/447 , H01J49/04
CPC分类号： H01J49/0431 , G01N27/44717 , H01J49/165 , G01N27/4473
摘要： An improved capillary zone electrophoresis (CZE)/ mass spectrometer interface comprises a liquid junction adapted to makeup the volume/flow rate of the CZE column eluent stream to be more compatible with the ion spray LC/MS interface flow rates required by mass spectrometer detectors in on-line separation/detection systems for variouscompositions and mixtures including biological fluids and environmental samples. Analytes eluting from the CZE capillary column are diluted with a suitable buffer thereby adjusting the volume and flow rates to prevent flow and pressure discrepanies which would otherwise result in peak broadening.The new liquid junction system for CZE/MS and CZE/MS/MS is useful in separating, detecting and analyzing compositions and mixtures such as amino acids, pesticides, peptides, mucleotides, sulfonated azo dyes and enzymatic digests such as tryptic digest of recombinant bovine somatotropan. Detection can be carried out in both positive and negative ion modes. High separation efficiencies ranging from 50,000 to 1,000,000 theoretical plates and peak asymmetries of 1.2 to 1.8 for tryptic digest are achieved.
摘要翻译：改进的毛细管区带电泳（CZE）/质谱仪界面包括适于补充CZE柱洗脱液流的体积/流速的液体接头，以便与质谱仪检测器所需的离子喷雾LC / MS界面流速更相容用于各种组合物和混合物的在线分离/检测系统，包括生物流体和环境样品。从CZE毛细管柱洗脱的分析物用合适的缓冲液稀释，由此调节体积和流速，以防止否则会导致峰值变宽的流动和压力差异。用于CZE / MS和CZE / MS / MS的新型液体接头系统可用于分离，检测和分析组合物和混合物，如氨基酸，农药，肽，核苷酸，磺化偶氮染料和酶消化物，如重组牛胰蛋白酶消化生长激素检测可以在正离子和负离子两种模式下进行。实现了50,000至1,000,000理论塔板的高分离效率和胰蛋白酶消化物的峰值不对称性为1.2至1.8。

7. 发明申请

US20130264493A1 METHOD AND SYSTEM FOR PROVIDING A DUAL CURTAIN GAS TO A MASS SPECTROMETRY SYSTEM 有权
标题翻译：用于向双光谱提供质谱系统的方法和系统
公开(公告)号：US20130264493A1
公开(公告)日：2013-10-10
申请号：US13821148
申请日：2011-09-14
申请人： Thomas R. Covey , Stanislaw Potyrala , Bradley B. Schneider
发明人： Thomas R. Covey , Stanislaw Potyrala , Bradley B. Schneider
IPC分类号： H01J49/02
CPC分类号： H01J49/02 , H01J49/044
摘要： A system and method for mass spectrometry including a curtain gas chamber defined by a curtain plate having an aperture for receiving ions from an ion source and an orifice plate having an inlet into a mass spectrometer. At least one barrier separates the curtain chamber into a first curtain gas chamber region and a second curtain gas chamber region. At least one gas source provides a gas inflow into the second curtain gas chamber region and a gas outflow into the first curtain gas chamber region, a portion of the gas outflow directed out of the aperture. A heating element heats the gas inflow, a portion of the heated gas inflow directed into the inlet of the mass spectrometer wherein the portion of the heated gas inflow can be at a substantially higher temperature than the portion of the gas outflow.
摘要翻译：一种用于质谱的系统和方法，包括由具有用于从离子源接收离子的孔的幕板限定的帘式气室和具有入口进入质谱仪的孔板。至少一个屏障将幕帘室分隔成第一帘式气体室区域和第二帘式气体室区域。至少一个气体源提供气体流入第二帘式气体室区域，并且气体流入第一帘式气体室区域，一部分气体流出物被引导出孔。加热元件加热气体流入，一部分加热气体流入引导到质谱仪的入口，其中加热气体流入的部分可以处于比气体流出部分显着更高的温度。

8. 发明授权

US08513600B2 Method and system for vacuum driven mass spectrometer interface with adjustable resolution and selectivity 有权
公开(公告)号：US08513600B2
公开(公告)日：2013-08-20
申请号：US13541414
申请日：2012-07-03
申请人： Bradley B. Schneider , Thomas R. Covey
发明人： Bradley B. Schneider , Thomas R. Covey
IPC分类号： H01J49/24 , H01J49/04
CPC分类号： H01J49/26 , G01N27/622 , H01J49/004 , H01J49/0404 , H01J49/0468 , H01J49/24
摘要： A mass spectrometer system and method of operating same are provided. The system comprises an ion conduit for receiving ions; a boundary member defining a curtain gas chamber containing the ion conduit; a curtain gas supply for providing a curtain gas to an inlet of the ion conduit to provide a gas flow into the conduit, and a curtain gas outflow out of a curtain gas chamber inlet; a mass spectrometer at least partially sealed to, and in fluid communication with, the conduit for receiving the ions from the conduit; a vacuum chamber surrounding the mass spectrometer operable to draw the gas flow including the ions through the conduit and into the vacuum chamber; and, a gas outlet for drawing a gas outflow from the gas flow located between the conduit and the mass spectrometer to increase the gas flow rate through the conduit.

9. 发明授权

US07259371B2 Method and apparatus for improved sensitivity in a mass spectrometer 有权
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：US07259371B2
公开(公告)日：2007-08-21
申请号：US11315788
申请日：2005-12-22
申请人： Bruce A. Collings , Thomas R. Covey , Mircea Guna , Hassan Javaheri , Alexandre V. Loboda , Bradley B. Schneider , Bruce A. Thomson
发明人： Bruce A. Collings , Thomas R. Covey , Mircea Guna , Hassan Javaheri , Alexandre V. Loboda , Bradley B. Schneider , Bruce A. Thomson
IPC分类号： H01J49/00
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, at least one ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以至基本上径向限制超音速自由射流膨胀的至少一个离子导向器可以将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

10. 发明授权

US07098452B2 Atmospheric pressure charged particle discriminator for mass spectrometry 有权
公开(公告)号：US07098452B2
公开(公告)日：2006-08-29
申请号：US10778424
申请日：2004-02-13
申请人： Bradley Schneider , Thomas R. Covey
发明人： Bradley Schneider , Thomas R. Covey
IPC分类号： H01J49/04
CPC分类号： H01J49/06 , H01J49/044
摘要： An apparatus and method for performing mass spectroscopy uses an ion interface to provide the function of removing undesirable particulates from an ion stream from an atmospheric pressure ion source, such as an electrospray source or a MALDI source, before the ion stream enters a vacuum chamber containing the mass spectrometer. The ion interface includes an entrance cell with a bore that may be heated for desolvating charged droplets when the ion source is an electrospray source, and a particle discrimination cell with a bore disposed downstream of the bore of the entrance cell and before an aperture leading to the vacuum chamber. The particle discrimination cell creates gas dynamic and electric field conditions that enables separation of undesirable charged particulates from the ion stream.

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