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1. 发明申请

US20190164739A1 FREQUENCY AND AMPLITUDE SCANNED QUADRUPOLE MASS FILTER AND METHODS 审中-公开
公开(公告)号：US20190164739A1
公开(公告)日：2019-05-30
申请号：US16264023
申请日：2019-01-31
申请人： The Trustees of Indiana University
发明人： Martin F. Jarrold , Deven L. Shinholt , Staci N. Anthony , Andrew W. Alexander
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/4215 , H01J49/0031 , H01J49/427
摘要： A quadrupole mass filter and method for operating the filter are described. Sample ions, each having a mass-to-charge ratio, are passed to a quadrupole at least one AC voltage is applied thereto to separate the ions by incrementally varying a frequency of the at least one AC voltage within a first range of frequencies and, for each of at least some of the incremental frequencies in the first range of frequencies, incrementally varying an amplitude of the at least one AC voltage within a range of amplitudes, wherein each incremental frequency and incremental amplitude pair of the at least one AC voltage creates a different band pass filter in the quadrupole through which produced ions having a different corresponding mass-to-charge ratio pass to a detector.

2. 发明申请

US20180247803A1 MASS SPECTROMETRY BY DETECTING POSITIVELY AND NEGATIVELY CHARGED PARTICLES 审中-公开
公开(公告)号：US20180247803A1
公开(公告)日：2018-08-30
申请号：US15903728
申请日：2018-02-23
申请人： 908 Devices Inc.
发明人： Christopher D. Brown , Evgeny Krylov , Michael Goodwin , Kerin Gregory , Andrew J. Bartfay-Szabo
IPC分类号： H01J49/00 , H01J49/42 , H01J49/02
CPC分类号： H01J49/0095 , H01J49/0036 , H01J49/022 , H01J49/025 , H01J49/427
摘要： The disclosure features mass spectrometry systems and methods that include an ion source, an ion trap, a detector subsystem featuring first and second detector elements, and a controller electrically connected to the ion source, the ion trap, and the detector subsystem and configured so that during operation of the system, the controller: applies an electrical signal to the ion source to generate positively and negatively charged particles from sample particles in the system; applies an electrical signal to the ion trap to eject a plurality of particles from the ion trap through a common aperture of the ion trap, and determines information about the sample particles based on first and second electrical signals generated by the ejected particles.

3. 发明授权

US10043648B2 High duty cycle ion spectrometer 有权
公开(公告)号：US10043648B2
公开(公告)日：2018-08-07
申请号：US15640129
申请日：2017-06-30
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander Alekseevich Makarov
IPC分类号： H01J49/04 , H01J49/00 , H01J49/10 , H01J49/40 , H01J49/06 , H01J49/42 , G01N27/62
CPC分类号： H01J49/10 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/0481 , H01J49/06 , H01J49/063 , H01J49/401 , H01J49/4215 , H01J49/423 , H01J49/425 , H01J49/426 , H01J49/427 , H01J49/4295
摘要： An ion spectrometer is provided, comprising: an ion source, arranged to generate ions continuously with a first range of mass to charge ratios; and an ion trap, arranged to receive ions from the ion source along an axis, and to eject ions with a second range of mass to charge ratios orthogonally to that axis, the second range of mass to charge ratios being narrower than the first range of mass to charge ratios. In some embodiments, ions generated by the ion source continuously flow into the ion trap. Additionally or alternatively, ion optics receive ions ejected from the ion trap and cool the ions without substantial fragmentation. An ion analyser receives ions ejected from the ion trap or ion optics and separates the ions in accordance with at least one characteristic of the ions.

4. 发明申请

US20180151339A1 SEPARATING IONS IN AN ION TRAP 审中-公开
公开(公告)号：US20180151339A1
公开(公告)日：2018-05-31
申请号：US15568601
申请日：2016-04-25
申请人： MICROMASS UK LIMITED
发明人： Jason Lee WILDGOOSE , Keith RICHARDSON , David J. LANGRIDGE , Martin Raymond GREEN , Steven Derek PRINGLE
IPC分类号： H01J49/00 , H01J49/42 , G01N27/62
CPC分类号： H01J49/004 , G01N27/62 , H01J49/4235 , H01J49/427
摘要： A method is disclosed comprising: trapping ions in an ion trap (40); applying a first force on the ions within the ion trap in a first direction, said force having a magnitude that is dependent upon the value of a physicochemical property of the ions; applying a second force on these ions in the opposite direction so that the ions separate according to the physicochemical property value as a result of the first and second forces; and then pulsing or driving ions out of one or more regions of the ion trap.

5. 发明授权

US09892903B1 Systems and methods for coupling a laser beam to a mass spectrometer 有权
公开(公告)号：US09892903B1
公开(公告)日：2018-02-13
申请号：US15389377
申请日：2016-12-22
申请人： Thermo Finnigan LLC
发明人： Jesse D. Canterbury
IPC分类号： H01J49/00 , H01J49/42 , H01J49/06
CPC分类号： H01J49/427 , H01J49/0059 , H01J49/061
摘要： A mass spectrometry system includes a laser source, a trapping volume, first and second beam deflectors, and a deflector controller. The first and second beam deflectors are arranged on a path from the laser source to the trapping volume. The first beam deflector is configured to oscillate in a first direction at a first frequency and the second beam deflector configured to oscillate in a second direction orthogonal to the first direction at a second frequency. The deflector controller is configured to scan a scanned area within the trapping volume with the laser by controlling the oscillation of the first and second beam deflectors to cause ions trapped within the trapping volume to fragment into fragment ions. The scanned area has a first dimension defined by the oscillation in first direction and a second dimension defined by the oscillation in the second direction.

6. 发明申请

US20170213716A1 Method for Separating Ions According to a Physicochemical Property 有权
公开(公告)号：US20170213716A1
公开(公告)日：2017-07-27
申请号：US15125396
申请日：2015-03-10
申请人： Micromass UK Limited
发明人： Jason Lee Wildgoose
IPC分类号： H01J49/42 , H01J49/40 , H01J49/06 , G01N27/62
CPC分类号： H01J49/427 , G01N27/622 , H01J49/062 , H01J49/408
摘要： A method of separating ions according to a physicochemical property is disclosed. The method comprises causing ions to perform a plurality of cycles along or around an ion guiding path such that the ions separate according to said physicochemical property. The ions are ejected from an ion exit region by applying a force to the ions such that only having a physicochemical property value that is either above or below a threshold value are ejected as they pass through the exit region, but ions having a physicochemical property value either below or above said threshold value, respectively, remain within the ion guiding path. The force applied to the ions within the exit region is varied with time such that the physicochemical property value of the ions ejected from the ion guiding region varies with time.

7. 发明授权

US09564307B2 Constraining arcuate divergence in an ion mirror mass analyser 有权
标题翻译：在离子镜质量分析仪中限制弓形散度
公开(公告)号：US09564307B2
公开(公告)日：2017-02-07
申请号：US14945305
申请日：2015-11-18
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander A. Makarov
IPC分类号： H01J49/40 , H01J49/42
CPC分类号： H01J49/405 , H01J49/4245 , H01J49/425 , H01J49/427
摘要： A charged particle analyzer apparatus comprising two opposing ion mirrors each mirror comprising inner and outer field-defining electrode systems elongated along an axis z, the outer system surrounding the inner, whereby when the electrode systems are electrically biased the mirrors create an electrical field comprising opposing electrical fields along z; and at least one arcuate focusing lens for constraining the arcuate divergence of a beam of charged particles within the analyzer while the beam orbits around the axis z, the analyzer further comprising a disc having two faces at least partly spanning the space between the inner and outer field defining electrode systems and lying in a plane perpendicular to the axis z, the disc having resistive coating upon both faces. A mass spectrometer system comprising a plurality of the charged particle analyzers arranged as a parallel array.
摘要翻译：一种带电粒子分析仪装置，包括两个相对的离子镜，每个反射镜包括沿着轴线z延伸的内部和外部场限定电极系统，外部系统围绕内部，由此当电极系统被电偏置时，反射镜产生电场，包括相对 z电场; 以及至少一个弧形聚焦透镜，用于约束分束器内的带电粒子束的弓形发散，同时光束围绕轴线z运动，分析器还包括具有至少部分跨越内外两者之间的空间的两个面的圆盘场定义电极系统并且位于垂直于轴线z的平面中，该盘在两个面上具有电阻涂层。一种质谱仪系统，包括多个被布置成平行阵列的带电粒子分析器。

8. 发明申请

US20160336164A1 Systems and Methods for Ion Isolation 有权
标题翻译：离子隔离系统与方法
公开(公告)号：US20160336164A1
公开(公告)日：2016-11-17
申请号：US14709387
申请日：2015-05-11
申请人： Thermo Finnigan LLC
发明人： Philip M. REMES , Jae C. SCHWARTZ
IPC分类号： H01J49/42 , H01J49/00
CPC分类号： H01J49/427 , H01J49/0027 , H01J49/0031 , H01J49/4205 , H01J49/423
摘要： A mass spectrometer includes a radio frequency ion trap and a controller. The controller is configured to cause an ion population to be injected into the radio frequency ion trap and supply an isolation waveform to the radio frequency ion trap. The isolation waveform has at least one notch at a target mass-to-charge ratio and a frequency profile determined to eject unwanted ions at a plurality of frequencies in a substantially similar amount of time.
摘要翻译：质谱仪包括射频离子阱和控制器。控制器被配置为使离子群体注入射频离子阱并向射频离子阱提供隔离波形。隔离波形在目标质荷比下具有至少一个切口，并且确定了以基本相似的时间量在多个频率处喷射不想要的离子的频率分布。

9. 发明授权

US09472387B2 Systems and methods for identifying precursor ions from product ions using arbitrary transmission windowing 有权
标题翻译：使用任意透射窗口从产物离子中鉴定前体离子的系统和方法
公开(公告)号：US09472387B2
公开(公告)日：2016-10-18
申请号：US15089529
申请日：2016-04-02
申请人： DH Technologies Development Pte. Ltd.
发明人： Nic G. Bloomfield , Frank Londry
IPC分类号： H01J49/00 , H01J49/06
CPC分类号： H01J49/0036 , H01J49/0027 , H01J49/004 , H01J49/061 , H01J49/40 , H01J49/4215 , H01J49/427
摘要： Ions are separated from a sample over time and filtered. The precursor ions produced at each step are fragmented. Resulting product ions are analyzed using a mass analyzer, producing a product ion spectrum for each step of the transmission window and a plurality of product ion spectra for the mass range for the each scan. The plurality of product ion spectra are received, producing a plurality of multi-scan product ion spectra. At least one product ion is selected from the plurality of multi-scan product ion spectra that is present at least two or more times in product ion spectra from each of two or more scans. A known separation profile of a precursor ion is fit to intensities from the at least one product ion in the plurality of multi-scan product ion spectra to reconstruct a separation profile of a precursor ion of the at least one product ion.
摘要翻译：离子与样品随时间分离并过滤。在每个步骤产生的前体离子是碎裂的。使用质量分析仪分析所得产物离子，产生用于传输窗口的每个步骤的产物离子谱和用于每次扫描的质量范围的多个产物离子光谱。接收多个产物离子光谱，产生多个多扫描产物离子光谱。从多个多扫描产物离子光谱中选择至少一个产物离子，所述离子谱在两次或更多次扫描中的每一次的产物离子谱中至少存在两次或更多次。前体离子的已知分离曲线适合于多个多扫描产物离子光谱中的至少一种产物离子的强度，以重建至少一种产物离子的前体离子的分离曲线。

10. 发明申请

US20160225603A1 ION EJECTION FROM A QUADRUPOLE ION TRAP 有权
标题翻译：离子离子由四倍子离子捕获
公开(公告)号：US20160225603A1
公开(公告)日：2016-08-04
申请号：US15093152
申请日：2016-04-07
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Christian Albrecht HOCK , Dmitry GRINFELD , Richard HEMING
IPC分类号： H01J49/42 , H01J49/40
CPC分类号： H01J49/427 , H01J49/0031 , H01J49/0481 , H01J49/063 , H01J49/282 , H01J49/40 , H01J49/4225 , H01J49/424 , H01J49/4245
摘要： A method of ejecting ions to be analyzed from a quadrupole ion trap in which a trapping field is created by one or more RF voltages applied to one or more electrodes of the trap, the method comprising the steps of cooling the ions to be analyzed within the quadrupole ion trap until the ions are thermalized, reducing the amplitude of one or more RF voltages applied to the quadrupole ion trap and applying the reduced amplitude RF voltages for one half cycle after the one or more RF voltages have reached a zero crossing point, turning off the RF voltages applied to the quadrupole ion trap, and ejecting the ions to be analyzed from the quadrupole ion trap.
摘要翻译：从四极离子阱中排出要分析的离子的方法，其中通过施加到阱的一个或多个电极的一个或多个RF电压产生捕获场，该方法包括以下步骤：将待分析的离子冷却在四极离子阱，直到离子被热化，减少施加到四极离子阱的一个或多个RF电压的幅度，并且在一个或多个RF电压已经达到过零点之后将减小幅度的RF电压施加一个半周期，转动关闭施加到四极离子阱的RF电压，并从四极离子阱中喷射待分析的离子。

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