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1. 发明授权

US08779356B2 Method and system for providing a dual curtain gas to a mass spectrometry system 有权
标题翻译：用于向质谱系统提供双帘式气体的方法和系统
公开(公告)号：US08779356B2
公开(公告)日：2014-07-15
申请号：US13821148
申请日：2011-09-14
申请人： Thomas R. Covey , Stanislaw Potyrala , Bradley B. Schneider
发明人： Thomas R. Covey , Stanislaw Potyrala , Bradley B. Schneider
IPC分类号： H01J49/24 , B01D59/44
CPC分类号： H01J49/02 , H01J49/044
摘要： A system and method for mass spectrometry including a curtain gas chamber defined by a curtain plate having an aperture for receiving ions from an ion source and an orifice plate having an inlet into a mass spectrometer. At least one barrier separates the curtain chamber into a first curtain gas chamber region and a second curtain gas chamber region. At least one gas source provides a gas inflow into the second curtain gas chamber region and a gas outflow into the first curtain gas chamber region, a portion of the gas outflow directed out of the aperture. A heating element heats the gas inflow, a portion of the heated gas inflow directed into the inlet of the mass spectrometer wherein the portion of the heated gas inflow can be at a substantially higher temperature than the portion of the gas outflow.
摘要翻译：一种用于质谱的系统和方法，包括由具有用于从离子源接收离子的孔的幕板限定的帘式气室和具有入口进入质谱仪的孔板。至少一个屏障将幕帘室分隔成第一帘式气体室区域和第二帘式气体室区域。至少一个气体源提供气体流入第二帘式气体室区域，并且气体流入第一帘式气体室区域，一部分气体流出物被引导出孔。加热元件加热气体流入，一部分加热气体流入引导到质谱仪的入口，其中加热气体流入的部分可以处于比气体流出部分显着更高的温度。

2. 发明申请

US20100237233A1 ION OPTICS DRAIN FOR ION MOBILITY 有权
标题翻译：离子光学离子离子移动
公开(公告)号：US20100237233A1
公开(公告)日：2010-09-23
申请号：US12722863
申请日：2010-03-12
申请人： Thomas R. Covey , Bradley B. Schneider , John Vandermey
发明人： Thomas R. Covey , Bradley B. Schneider , John Vandermey
IPC分类号： H01J49/26 , H01J49/06
CPC分类号： H01J49/06 , H01J49/421 , H01J49/427
摘要： A sample analysis system incorporates an ion removal mechanism for removing residual ions from the sample analysis system. The ion removal mechanism can be included in an ion optics assembly, which connects an ion mobility filter to a mass analyzer. A sample to be analyzed by the sample analysis system may be entered into an ion mobility filter. The ion mobility filter filters the ions of the sample and passes the filtered group of ions to the ion optics assembly. The ion optics assembly transports the filtered group of ions to a mass analyzer where some or all of the ions in the group are detected. The ion removal mechanism then removes all or substantially all residual ions from the ion optics that were left over from the first filtered group before a second filtered group is passed through.
摘要翻译：样品分析系统包含用于从样品分析系统中去除残留离子的离子去除机构。离子去除机构可以包括在将离子迁移过滤器连接到质量分析器的离子光学组件中。可以将样品分析系统分析的样品输入离子迁移率过滤器。离子迁移率过滤器过滤样品的离子并将过滤的离子组通过离子光学组件。离子光学组件将过滤的离子组输送到质量分析器，其中检测到组中的一些或全部离子。然后离子去除机构在第二过滤组通过之前，从第一过滤组中留下的离子光学元件中除去所有或基本上所有残留的离子。

3. 发明申请

US20130264493A1 METHOD AND SYSTEM FOR PROVIDING A DUAL CURTAIN GAS TO A MASS SPECTROMETRY SYSTEM 有权
标题翻译：用于向双光谱提供质谱系统的方法和系统
公开(公告)号：US20130264493A1
公开(公告)日：2013-10-10
申请号：US13821148
申请日：2011-09-14
申请人： Thomas R. Covey , Stanislaw Potyrala , Bradley B. Schneider
发明人： Thomas R. Covey , Stanislaw Potyrala , Bradley B. Schneider
IPC分类号： H01J49/02
CPC分类号： H01J49/02 , H01J49/044
摘要： A system and method for mass spectrometry including a curtain gas chamber defined by a curtain plate having an aperture for receiving ions from an ion source and an orifice plate having an inlet into a mass spectrometer. At least one barrier separates the curtain chamber into a first curtain gas chamber region and a second curtain gas chamber region. At least one gas source provides a gas inflow into the second curtain gas chamber region and a gas outflow into the first curtain gas chamber region, a portion of the gas outflow directed out of the aperture. A heating element heats the gas inflow, a portion of the heated gas inflow directed into the inlet of the mass spectrometer wherein the portion of the heated gas inflow can be at a substantially higher temperature than the portion of the gas outflow.
摘要翻译：一种用于质谱的系统和方法，包括由具有用于从离子源接收离子的孔的幕板限定的帘式气室和具有入口进入质谱仪的孔板。至少一个屏障将幕帘室分隔成第一帘式气体室区域和第二帘式气体室区域。至少一个气体源提供气体流入第二帘式气体室区域，并且气体流入第一帘式气体室区域，一部分气体流出物被引导出孔。加热元件加热气体流入，一部分加热气体流入引导到质谱仪的入口，其中加热气体流入的部分可以处于比气体流出部分显着更高的温度。

4. 发明授权

US08513600B2 Method and system for vacuum driven mass spectrometer interface with adjustable resolution and selectivity 有权
公开(公告)号：US08513600B2
公开(公告)日：2013-08-20
申请号：US13541414
申请日：2012-07-03
申请人： Bradley B. Schneider , Thomas R. Covey
发明人： Bradley B. Schneider , Thomas R. Covey
IPC分类号： H01J49/24 , H01J49/04
CPC分类号： H01J49/26 , G01N27/622 , H01J49/004 , H01J49/0404 , H01J49/0468 , H01J49/24
摘要： A mass spectrometer system and method of operating same are provided. The system comprises an ion conduit for receiving ions; a boundary member defining a curtain gas chamber containing the ion conduit; a curtain gas supply for providing a curtain gas to an inlet of the ion conduit to provide a gas flow into the conduit, and a curtain gas outflow out of a curtain gas chamber inlet; a mass spectrometer at least partially sealed to, and in fluid communication with, the conduit for receiving the ions from the conduit; a vacuum chamber surrounding the mass spectrometer operable to draw the gas flow including the ions through the conduit and into the vacuum chamber; and, a gas outlet for drawing a gas outflow from the gas flow located between the conduit and the mass spectrometer to increase the gas flow rate through the conduit.

5. 发明授权

US07259371B2 Method and apparatus for improved sensitivity in a mass spectrometer 有权
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：US07259371B2
公开(公告)日：2007-08-21
申请号：US11315788
申请日：2005-12-22
申请人： Bruce A. Collings , Thomas R. Covey , Mircea Guna , Hassan Javaheri , Alexandre V. Loboda , Bradley B. Schneider , Bruce A. Thomson
发明人： Bruce A. Collings , Thomas R. Covey , Mircea Guna , Hassan Javaheri , Alexandre V. Loboda , Bradley B. Schneider , Bruce A. Thomson
IPC分类号： H01J49/00
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, at least one ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以至基本上径向限制超音速自由射流膨胀的至少一个离子导向器可以将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

6. 发明授权

US08350212B2 Ion optics drain for ion mobility 有权
标题翻译：用于离子迁移率的离子光学排水
公开(公告)号：US08350212B2
公开(公告)日：2013-01-08
申请号：US12722863
申请日：2010-03-12
申请人： Thomas R. Covey , Bradley B. Schneider , John Vandermey
发明人： Thomas R. Covey , Bradley B. Schneider , John Vandermey
IPC分类号： H01J49/26
CPC分类号： H01J49/06 , H01J49/421 , H01J49/427
摘要： A sample analysis system incorporates an ion removal mechanism for removing residual ions from the sample analysis system. The ion removal mechanism can be included in an ion optics assembly, which connects an ion mobility filter to a mass analyzer. A sample to be analyzed by the sample analysis system may be entered into an ion mobility filter. The ion mobility filter filters the ions of the sample and passes the filtered group of ions to the ion optics assembly. The ion optics assembly transports the filtered group of ions to a mass analyzer where some or all of the ions in the group are detected. The ion removal mechanism then removes all or substantially all residual ions from the ion optics that were left over from the first filtered group before a second filtered group is passed through.
摘要翻译：样品分析系统包含用于从样品分析系统中去除残留离子的离子去除机构。离子去除机构可以包括在将离子迁移过滤器连接到质量分析器的离子光学组件中。可以将样品分析系统分析的样品输入离子迁移率过滤器。离子迁移率过滤器过滤样品的离子并将过滤的离子组通过离子光学组件。离子光学组件将过滤的离子组输送到质量分析器，其中检测到组中的一些或全部离子。然后离子去除机构在第二过滤组通过之前，从第一过滤组中留下的离子光学元件中除去所有或基本上所有残留的离子。

7. 发明申请

US20110183431A1 MASS ANALYSIS SYSTEM WITH LOW PRESSURE DIFFERENTIAL MOBILITY SPECTROMETER 审中-公开
标题翻译：具有低压差分移动光谱仪的质量分析系统
公开(公告)号：US20110183431A1
公开(公告)日：2011-07-28
申请号：US13016257
申请日：2011-01-28
申请人： Thomas R. Covey , Bradley B. Schneider
发明人： Thomas R. Covey , Bradley B. Schneider
IPC分类号： G01N27/00 , H01J49/26
CPC分类号： H01J49/26 , G01N27/624 , H01J49/004 , Y10T436/24
摘要： A mass analysis system including a low pressure dissociation region and a differential mobility spectrometer. The differential mobility spectrometer including at least one pair of filter electrodes defining an ion flow path where the filter electrodes generate an electric field for passing through a selected portion of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, an ion inlet that receives sample ions that have passed through the low pressure dissociation region, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions.
摘要翻译：质量分析系统，包括低压解离区域和差动迁移谱仪。差动迁移谱仪包括至少一对限定离子流动路径的过滤电极对，其中过滤电极基于样品离子的迁移率特性产生用于通过选定部分样品离子的电场。差分迁移率光谱仪还包括电压源，其向至少一个滤光器电极提供DC和RF电压以产生电场;接收经过低压解离区域的样品离子的离子入口和离子出口其输出所选择的样本离子部分。质谱仪接收样品离子的部分或全部选定部分。

8. 发明授权

US07863558B2 Radio frequency ion guide 有权
标题翻译：射频离子导向
公开(公告)号：US07863558B2
公开(公告)日：2011-01-04
申请号：US11703756
申请日：2007-02-08
申请人： Bradley B. Schneider , Thomas R. Covey
发明人： Bradley B. Schneider , Thomas R. Covey
IPC分类号： H01J49/04
CPC分类号： H01J49/062
摘要： An ion guide with two or more ion focusing elements and a gas channeling sleeve is described. An ion transport space within the gas channeling sleeve is in fluid communication with a pumping port. A suction device is used to suction gas out of the ion transport space through the pumping port establishing a gas flow. Ions in the ion transport space are transported from an ion entry end to an ion exit end of the ion guide by the gas flow. Several examples include a multipole ion guide in which rods are used as ion focusing elements. The gas channeling sleeve is fitted about the rods. In another example, toroidal or ring shaped ion focusing elements are used as ion focusing elements. In another example, a set of ion focusing rings are mounted between insulators to form a cylinder with a gas impermeable side wall. The cylinder is itself used as the gas channeling sleeve.
摘要翻译：描述了具有两个或更多离子聚焦元件和气体导引套筒的离子导向器。气体通道套管内的离子传输空间与泵送口流体连通。抽吸装置用于通过建立气流的泵送端口将气体排出离子传输空间。离子传输空间中的离子通过气流从离子入口端输送到离子导向器的离子出口端。几个实例包括其中杆用作离子聚焦元件的多极离子导向器。气体通道套筒围绕杆安装。在另一示例中，使用环形或环形离子聚焦元件作为离子聚焦元件。在另一示例中，一组离子聚焦环安装在绝缘体之间以形成具有不透气侧壁的圆筒。气缸本身用作气体导引套筒。

9. 发明授权

US07679053B2 Multiple sample sources for use with mass spectrometers, and apparatus, devices, and methods therefor 有权
标题翻译：用于质谱仪的多个样品源及其装置，装置及方法
公开(公告)号：US07679053B2
公开(公告)日：2010-03-16
申请号：US11860899
申请日：2007-09-25
申请人： Bradley B. Schneider , Thomas R. Covey
发明人： Bradley B. Schneider , Thomas R. Covey
IPC分类号： H01J49/00
CPC分类号： H01J49/107 , H01J49/0009 , H01J49/0095 , H01J49/067 , H01J49/165
摘要： A method for introducing samples through a boundary member partially defining a chamber at an entrance point coaxial to a sampling inlet of a mass spectrometer is described. Field-free conditions can be established in at least one region of the chamber. The sample can be introduced adjacent to the sampling inlet, and introducing at least a second sample can be introduced through at least one other entrance point in the chamber not adjacent to the sampling inlet. An apparatus having a sampling inlet and a boundary member partially defining a chamber is also described. Field-free conditions can be established in at least one region of the chamber, and there can be a first aperture in the boundary member through which a source emits sample. Related devices, uses and mass spectrometers are also described.
摘要翻译：描述了通过在与质谱仪的取样入口同轴的入口处部分地限定腔室的边界构件引入样品的方法。可以在室的至少一个区域建立无场的条件。可以将样品引入到采样入口附近，并且引入至少第二样品可以通过不与采样入口相邻的室中的至少一个其它入口引入。还描述了具有采样入口和部分地限定腔室的边界构件的装置。可以在室的至少一个区域中建立无场条件，并且在边界构件中可以有一个第一孔，源通过该孔发射样品。还描述了相关的装置，用途和质谱仪。

10. 发明授权

US07405397B2 Laser desorption ion source with ion guide coupling for ion mass spectroscopy 有权
标题翻译：激光解吸离子源与离子导向耦合离子质谱法
公开(公告)号：US07405397B2
公开(公告)日：2008-07-29
申请号：US11317368
申请日：2005-12-22
申请人： Thomas R. Covey , Hassan Javaheri , Bradley B. Schneider
发明人： Thomas R. Covey , Hassan Javaheri , Bradley B. Schneider
IPC分类号： H01J49/00 , H01J49/40 , B01D54/44
CPC分类号： H01J49/063 , H01J49/164
摘要： A laser desorption ion source provides enhanced ion sampling efficiency and measurement sensitivity by using one or more ion guides to effectively capture ions in a plume emitted from the ion target and guide the ions through an aperture into a downstream vacuum chamber. In one configuration using two RF multipole ion guides, a first RF multipole ion guide disposed next to the ion target is selected to be sufficiently large to capture a substantial portion of the plume, while the second RF multipole ion guide disposed between the first multipole ion guide and the aperture has a smaller dimension to assist focusing of ions into the aperture. The first RF multipole ion guides the ions in the plume into the second RF multipole ion guide, which then focuses the ions so that they pass through the aperture into the downstream vacuum chamber.
摘要翻译：激光解吸离子源通过使用一个或多个离子引导件有效地捕获从离子靶发射的羽流中的离子并将离子引导通过孔进入下游真空室来提供增强的离子采样效率和测量灵敏度。在使用两个RF多极离子引导件的一种配置中，选择邻近离子靶设置的第一RF多极离子导向器足够大以捕获大部分羽流，而第二射频多极离子导向器设置在第一多极离子导向件和孔径具有较小的尺寸以辅助将离子聚焦到孔中。第一RF多极离子将羽流中的离子引导到第二射频多极离子导向器中，然后将离子聚焦以使它们通过孔进入下游真空室。

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