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1. 发明申请

US20180323050A1 ION INTEGRATING AND COOLING CELL FOR MASS SPECTROMETER 审中-公开
公开(公告)号：US20180323050A1
公开(公告)日：2018-11-08
申请号：US15588158
申请日：2017-05-05
申请人： Thermo Finnigan LLC
发明人： Johnathan Wayne SMITH , John E. P. SYKA
IPC分类号： H01J49/04 , H01J49/00 , H01J49/42
CPC分类号： H01J49/4235 , H01J49/009 , H01J49/0481 , H01J49/065
摘要： A method for operating a mass spectrometer comprises: generating a stream of ions by an ion source; directing the stream of ions into a first one of a pair of ion storage locations and trapping a first portion of the ions therein; directing a packet of ions from the other one of the pair of ion storage locations into an ion cooling cell that damps the kinetic energy of the ions comprising the packet of ions; directing the packet of ions to a mass analyzer of the mass spectrometer for mass analysis thereby; directing the first portion of ions from the first one of the pair of ion storage locations into the ion cooling cell; and directing the first portion of ions to the mass analyzer for mass analysis thereby.

2. 发明申请

US20180144923A1 METHOD FOR CHARACTERISING IONS 审中-公开
公开(公告)号：US20180144923A1
公开(公告)日：2018-05-24
申请号：US15572063
申请日：2016-05-04
申请人： UNIVERSITE D'AIX MARSEILLE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： Géraldine FERAUD , Christophe JOUVET , Claude DEDONDER
IPC分类号： H01J49/42 , H01J49/00 , H01J49/04 , G01N33/68
CPC分类号： H01J49/427 , G01N33/6812 , G01N33/6848 , H01J49/0059 , H01J49/0468 , H01J49/0481
摘要： A method for characterising ions includes trapping a first-generation ions in an ion trap; cooling the plurality of first-generation ions; photo-fragmenting the plurality of cooled first generation ions to obtain a plurality of second-generation ions, the second-generation ions being different to the first-generation ions, the plurality of second-generation ions being at least of one first type; selecting the first type of second-generation ions in the ion trap by ejecting, out of the trap, any residual first-generation ion and any second-generation ion of a type different from the first type; cooling the second-generation ions of the first type selected and trapped in the trap; photo-fragmenting the cooled second-generation ions of the first type to obtain a plurality of third-generation ions, the plurality of third-generation ions being different from the plurality of second-generation ions, the plurality of third-generation ions being at least of one first type; detecting the plurality of last-generation ions.

3. 发明申请

US20170301529A1 HIGH DUTY CYCLE ION SPECTROMETER 审中-公开
公开(公告)号：US20170301529A1
公开(公告)日：2017-10-19
申请号：US15640129
申请日：2017-06-30
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander Alekseevich MAKAROV
IPC分类号： H01J49/10 , H01J49/42 , H01J49/40 , H01J49/06 , H01J49/04 , H01J49/00 , G01N27/62
CPC分类号： H01J49/10 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/0481 , H01J49/06 , H01J49/063 , H01J49/401 , H01J49/4215 , H01J49/423 , H01J49/425 , H01J49/426 , H01J49/427 , H01J49/4295
摘要： An ion spectrometer is provided, comprising: an ion source, arranged to generate ions continuously with a first range of mass to charge ratios; and an ion trap, arranged to receive ions from the ion source along an axis, and to eject ions with a second range of mass to charge ratios orthogonally to that axis, the second range of mass to charge ratios being narrower than the first range of mass to charge ratios. In some embodiments, ions generated by the ion source continuously flow into the ion trap. Additionally or alternatively, ion optics receive ions ejected from the ion trap and cool the ions without substantial fragmentation. An ion analyser receives ions ejected from the ion trap or ion optics and separates the ions in accordance with at least one characteristic of the ions.

4. 发明授权

US09548195B2 Ion ejection from a quadrupole ion trap 有权
标题翻译：从四极离子阱离子喷射
公开(公告)号：US09548195B2
公开(公告)日：2017-01-17
申请号：US15093152
申请日：2016-04-07
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Christian Albrecht Hock , Dmitry Grinfeld , Richard Heming
IPC分类号： H01J49/00 , H01J49/42 , H01J49/04 , H01J49/06 , H01J49/28 , H01J49/40
CPC分类号： H01J49/427 , H01J49/0031 , H01J49/0481 , H01J49/063 , H01J49/282 , H01J49/40 , H01J49/4225 , H01J49/424 , H01J49/4245
摘要： A method of ejecting ions to be analyzed from a quadrupole ion trap in which a trapping field is created by one or more RF voltages applied to one or more electrodes of the trap, the method comprising the steps of cooling the ions to be analyzed within the quadrupole ion trap until the ions are thermalized, reducing the amplitude of one or more RF voltages applied to the quadrupole ion trap and applying the reduced amplitude RF voltages for one half cycle after the one or more RF voltages have reached a zero crossing point, turning off the RF voltages applied to the quadrupole ion trap, and ejecting the ions to be analyzed from the quadrupole ion trap.
摘要翻译：从四极离子阱中排出要分析的离子的方法，其中通过施加到阱的一个或多个电极的一个或多个RF电压产生捕获场，该方法包括以下步骤：将待分析的离子冷却在四极离子阱，直到离子被热化，减少施加到四极离子阱的一个或多个RF电压的幅度，并且在一个或多个RF电压已经达到过零点之后将减小幅度的RF电压施加一个半周期，转动关闭施加到四极离子阱的RF电压，并从四极离子阱中喷射待分析的离子。

5. 发明授权

US09293315B2 High duty cycle ion spectrometer 有权
公开(公告)号：US09293315B2
公开(公告)日：2016-03-22
申请号：US14746753
申请日：2015-06-22
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander Alekseevich Makarov
IPC分类号： B01D59/44 , H01J49/00 , H01J49/26 , H01J3/00 , H01J49/10 , H01J49/06 , H01J49/42 , H01J49/04 , H01J49/40 , G01N27/62
CPC分类号： H01J49/10 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/0481 , H01J49/06 , H01J49/063 , H01J49/401 , H01J49/4215 , H01J49/423 , H01J49/425 , H01J49/426 , H01J49/427 , H01J49/4295
摘要： An ion spectrometer is provided, comprising: an ion source, arranged to generate ions continuously with a first range of mass to charge ratios; and an ion trap, arranged to receive ions from the ion source along an axis, and to eject ions with a second range of mass to charge ratios orthogonally to that axis, the second range of mass to charge ratios being narrower than the first range of mass to charge ratios. In some embodiments, ions generated by the ion source continuously flow into the ion trap. Additionally or alternatively, ion optics receive ions ejected from the ion trap and cool the ions without substantial fragmentation. An ion analyzer receives ions ejected from the ion trap or ion optics and separates the ions in accordance with at least one characteristic of the ions.

6. 发明授权

US09064679B2 High duty cycle ion spectrometer 有权
标题翻译：高占空比离子光谱仪
公开(公告)号：US09064679B2
公开(公告)日：2015-06-23
申请号：US14360345
申请日：2012-11-26
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander Alekseevich Makarov
IPC分类号： H01J49/00 , H01J49/06 , H01J49/42 , H01J49/04 , G01N27/62
CPC分类号： H01J49/10 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/0481 , H01J49/06 , H01J49/063 , H01J49/401 , H01J49/4215 , H01J49/423 , H01J49/425 , H01J49/426 , H01J49/427 , H01J49/4295
摘要： An ion spectrometer is provided, comprising: an ion source, arranged to generate ions continuously with a first range of mass to charge ratios; and an ion trap, arranged to receive ions from the ion source along an axis, and to eject ions with a second range of mass to charge ratios orthogonally to that axis, the second range of mass to charge ratios being narrower than the first range of mass to charge ratios. In some embodiments, ions generated by the ion source continuously flow into the ion trap. Additionally or alternatively, ion optics receive ions ejected from the ion trap and cool the ions without substantial fragmentation. An ion analyzer receives ions ejected from the ion trap or ion optics and separates the ions in accordance with at least one characteristic of the ions.
摘要翻译：提供了一种离子光谱仪，包括：离子源，被布置成以第一质量与电荷比例连续地产生离子; 以及离子阱，被布置成沿着轴接收离子源的离子，并且以与该轴正交的质量与第二质量范围的质量与电荷的比率排出离子，质量与电荷比的第二范围比第一范围的质荷比。在一些实施例中，由离子源产生的离子连续地流入离子阱。另外或替代地，离子光学器件接收从离子阱排出的离子并且冷却离子而不会明显碎裂。离子分析仪接收从离子阱或离子光学器件喷出的离子，并根据离子的至少一种特性分离离子。

7. 发明授权

US08629409B2 Ion interface device having multiple confinement cells and methods of use thereof 有权
标题翻译：具有多个限制电池的离子界面装置及其使用方法
公开(公告)号：US08629409B2
公开(公告)日：2014-01-14
申请号：US13363036
申请日：2012-01-31
申请人： Viatcheslav V. Kovtoun
发明人： Viatcheslav V. Kovtoun
IPC分类号： H01J49/26 , H01J49/40 , H01J49/06 , H01J49/00
CPC分类号： H01J49/063 , H01J49/0031 , H01J49/005 , H01J49/0481 , H01J49/062
摘要： A device and associated methods of operations are disclosed for interfacing on ion trap to a mass analyzer, such as a TOF mass analyzer. The device includes a plurality of sequentially arranged confinement cells having fixed locations. A group of ions, e.g., ions within a relatively narrow window of mass-to-charge ratio, is received by the device from the ion trap, undergoes fragmentation, and is transported through the device from a first to final confinement cell by a series of transfers between adjacent cells. The ion group is confined in each cell for a prescribed cooling period. By providing a suitable aggregate ion confinement time and by enabling concurrent transport and cooling of successively ejected ion groups, the ions are cooled sufficiently to enable the acquisition of mass spectra at high resolution, without having to substantially delay the ejection of a subsequent group of ions from the ion trap until cooling of the previous group is completed.
摘要翻译：公开了一种用于将离子阱连接到质量分析器（例如TOF质量分析器）上的装置和相关联的操作方法。该装置包括具有固定位置的多个顺序排列的约束单元。一组离子，例如在质荷比较窄的窗口内的离子被器件从离子阱接收，经历碎裂，并通过串联从第一至第一限制电池传输通过该装置的相邻单元之间的传输。离子组被限制在每个电池中规定的冷却时间。通过提供合适的聚集体离子限制时间并且通过使连续喷射的离子基团能够同时传输和冷却，离子被充分冷却以使得能够以高分辨率获取质谱，而不必基本上延迟随后的一组离子的喷射从离子阱直到前一组的冷却完成。

8. 发明授权

US08525106B2 Method and apparatus for transmitting ions in a mass spectrometer maintained in a sub-atmospheric pressure regime 有权
标题翻译：在保持在低于大气压的压力状态的质谱仪中传输离子的方法和装置
公开(公告)号：US08525106B2
公开(公告)日：2013-09-03
申请号：US13103415
申请日：2011-05-09
申请人： Felician Muntean
发明人： Felician Muntean
IPC分类号： H01J49/10 , H01J49/42
CPC分类号： H01J49/062 , H01J49/0481
摘要： A method and apparatus for transmitting ions in a mass spectrometer from an ion source to a mass analyzer extracts analyte ions from the ion source in such a manner that the number of extracted analyte ions is maximized. The ions are then transmitted through an ion guide to the mass analyzer. The ion guide is filled with an interaction gas and its operating parameters are adjusted so that, as the ions pass through the ion guide, the analyte ion energy distribution width is narrowed and the analyte ions are collimated within the ion guide to improve the resolution and sensitivity of the mass analyzer.
摘要翻译：用于将质谱仪中的离子从离子源传输到质量分析器的方法和装置以使提取的分析物离子的数量最大化的方式从离子源中提取分析物离子。然后离子通过离子导向器传输到质量分析器。离子导向器填充有相互作用气体，并且其操作参数被调节，使得当离子通过离子导向器时，分析物离子能量分布宽度变窄，并且分析物离子在离子导向器内准直以提高分辨率，质量分析仪的灵敏度。

9. 发明授权

US08198582B2 Method and apparatus for thermalization of ions 有权
标题翻译：用于热离子化的方法和装置
公开(公告)号：US08198582B2
公开(公告)日：2012-06-12
申请号：US12308456
申请日：2007-06-14
申请人： Emmanuel Raptakis , Dimitris Papanastasiou , Andrew Bowdler
发明人： Emmanuel Raptakis , Dimitris Papanastasiou , Andrew Bowdler
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/424 , H01J49/0481 , H01J49/24
摘要： A method of pulsing gas in a quadrupole ion trap to reduce excess internal energy of ions formed externally to the trap at high-vacuum conditions by laser desoprtion is disclosed. With pulsed gas introduction, pressures greater than those under which traps are normally operated can be achieved over a few milliseconds. Under these elevated pressure transients, the process of translational cooling is accelerated and ions undergo thermalized collisions before dissociation occurs. Minimization of uncontrolled fragmentation (thermalization) and enhanced sensitivity are observed at pressures exceeding a threshold of about 1 mTorr.
摘要翻译：公开了一种在四极离子阱中脉冲气体的方法，以通过激光去除在高真空条件下减少在阱外部形成的离子的过量内部能量。在脉冲气体引入下，可以在几毫秒内实现大于陷阱正常工作的压力的压力。在这些升高的压力瞬变下，平移冷却过程加速，离子发生之前发生热化碰撞。在超过约1mTorr的压力的压力下观察到不受控制的碎裂（热化）和增强的灵敏度的最小化。

10. 发明申请

US20110095180A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20110095180A1
公开(公告)日：2011-04-28
申请号：US12999957
申请日：2008-06-20
申请人： Junichi Taniguchi
发明人： Junichi Taniguchi
IPC分类号： H01J49/40
CPC分类号： H01J49/36 , H01J49/004 , H01J49/0481 , H01J49/40 , H01J49/424 , H01J49/426 , H01J49/427
摘要： In performing an isolation of specific ions or performing a dissociation operation by CID, ions are captured by applying a radio-frequency high voltage to a ring electrode 31 as before. In a cooling operation which is performed immediately before target ions are ejected toward a TOFMS unit 4 with the ions stored in an ion trap 3, a radio-frequency high voltage is not applied to the ring electrode 31 but to end cap electrodes 32 and 34 to capture the ions. In this operation, the frequency thereof is set to be higher than that of the voltage applied to the ring electrode 31 and the amplitude is also increased in order to assure a large pseudopotential and keep the low mass cutoff (LMC). This narrows the spatial distribution of the cooled ions, reducing the variation of the initial positions of the ions at the point in time when they are ejected, which increases the mass resolution. In addition, since an isolation of ions having a large m/z can be performed with a great qz value as is conventionally done, a high mass selectivity can be assured.
摘要翻译：在执行特定离子的分离或通过CID进行解离操作时，如前所述通过向环形电极31施加射频高电压来捕获离子。在将离子存储在离子阱3内的目标离子朝向TOFMS单元4喷射之前执行的冷却操作中，高频高压不施加到环形电极31而是端盖电极32和34 捕获离子。在这种操作中，其频率被设置为高于施加到环形电极31的电压的频率，并且为了确保大的伪电位并保持低质量截止（LMC），振幅也增加。这减小了冷却的离子的空间分布，减少了它们在喷射时的时间点上离子的初始位置的变化，这增加了质量分辨率。此外，由于如以往那样以大的qz值进行具有大m / z的离子的分离，因此可以确保高的质量选择性。

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