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1. 发明授权

US07405397B2 Laser desorption ion source with ion guide coupling for ion mass spectroscopy 有权
标题翻译：激光解吸离子源与离子导向耦合离子质谱法
公开(公告)号：US07405397B2
公开(公告)日：2008-07-29
申请号：US11317368
申请日：2005-12-22
申请人： Thomas R. Covey , Hassan Javaheri , Bradley B. Schneider
发明人： Thomas R. Covey , Hassan Javaheri , Bradley B. Schneider
IPC分类号： H01J49/00 , H01J49/40 , B01D54/44
CPC分类号： H01J49/063 , H01J49/164
摘要： A laser desorption ion source provides enhanced ion sampling efficiency and measurement sensitivity by using one or more ion guides to effectively capture ions in a plume emitted from the ion target and guide the ions through an aperture into a downstream vacuum chamber. In one configuration using two RF multipole ion guides, a first RF multipole ion guide disposed next to the ion target is selected to be sufficiently large to capture a substantial portion of the plume, while the second RF multipole ion guide disposed between the first multipole ion guide and the aperture has a smaller dimension to assist focusing of ions into the aperture. The first RF multipole ion guides the ions in the plume into the second RF multipole ion guide, which then focuses the ions so that they pass through the aperture into the downstream vacuum chamber.
摘要翻译：激光解吸离子源通过使用一个或多个离子引导件有效地捕获从离子靶发射的羽流中的离子并将离子引导通过孔进入下游真空室来提供增强的离子采样效率和测量灵敏度。在使用两个RF多极离子引导件的一种配置中，选择邻近离子靶设置的第一RF多极离子导向器足够大以捕获大部分羽流，而第二射频多极离子导向器设置在第一多极离子导向件和孔径具有较小的尺寸以辅助将离子聚焦到孔中。第一RF多极离子将羽流中的离子引导到第二射频多极离子导向器中，然后将离子聚焦以使它们通过孔进入下游真空室。

2. 发明授权

US06930305B2 Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring 有权
标题翻译：使用激光解吸和多反应监测对小分子进行高通量定量的方法和系统
公开(公告)号：US06930305B2
公开(公告)日：2005-08-16
申请号：US10400322
申请日：2003-03-27
申请人： Thomas R. Covey , John J. Corr , William H. Fisher , Chau Tung
发明人： Thomas R. Covey , John J. Corr , William H. Fisher , Chau Tung
IPC分类号： G01N27/62 , B01D59/44 , G01N21/00 , G01N27/64 , H01J49/00 , H01J49/10 , H01J49/16 , H01J49/40 , H01J49/42 , B01D54/44
CPC分类号： H01J49/4215 , H01J49/0031 , H01J49/004 , H01J49/0481 , H01J49/164
摘要： A mass spectrometry quantitation technique enables high-throughput quantitation of small molecules using a laser-desorption (e.g., MALDI) ion source coupled to a triple-quadrupole mass analyzer. The ions generated from the ion source are collisionally damped/cooled, and then quantitatively analyzed using the triple-quadrupole analyzer operated in the multiple-reaction-monitoring (MRM) mode. Significantly improved measurement sensitivity is obtained by applying laser pulses to the ion source at a high pulse rate of about 500 Hz or higher. This allows the data acquisition to be performed rapidly, and the speed of about one second for each sample point on the ion source target has been achieved.
摘要翻译：使用耦合到三重四极杆质谱仪的激光解吸（例如MALDI）离子源，质谱定量技术可实现小分子的高通量定量。从离子源产生的离子被碰撞阻尼/冷却，然后使用在多反应监测（MRM）模式中操作的三重四极杆分析器进行定量分析。通过以大约500Hz或更高的高脉冲速度向离子源施加激光脉冲，可以获得显着提高的测量灵敏度。这允许快速执行数据采集，并且已经实现了离子源目标上的每个采样点的约1秒的速度。

3. 发明授权

US07105810B2 Electrospray emitter for microfluidic channel 有权
公开(公告)号：US07105810B2
公开(公告)日：2006-09-12
申请号：US10394757
申请日：2003-03-21
申请人： Jun Kameoka , Harold G. Craighead
发明人： Jun Kameoka , Harold G. Craighead
IPC分类号： H01J49/00 , B01D54/44
CPC分类号： H01J49/165 , G01N30/7266 , H01J49/0018 , G01N30/6095
摘要： An electrospray ionization device incorporates a shaped thin film with a microfluidic channel. The device may be interfaced to a time-of-flight mass spectrometer (TFOMS). In one embodiment, the shaped thin film has a polygonal-shaped or triangle-shaped thin polymer tip formed by lithography and etching. The microfluidic channel is approximately 20 micrometer wide and 10 micrometers deep, and embossed in a substrate using a silicon master. The shaped thin film is aligned with the channel and bonded between the channel substrate and a flat plate to create a microfluidic channel with a wicking tip protruding from the end of the channel. Application of a high voltage at one end of the channel creates an electrospray from the tip, which is provided to the TFOMS.

4. 发明授权

US06943346B2 Method and apparatus for mass spectrometry analysis of aerosol particles at atmospheric pressure 失效
公开(公告)号：US06943346B2
公开(公告)日：2005-09-13
申请号：US10639508
申请日：2003-08-13
申请人： Phillip V. Tan , Vladimir M. Doroshenko
发明人： Phillip V. Tan , Vladimir M. Doroshenko
IPC分类号： H01J49/04 , H01J49/16 , H01J49/40 , B01D54/44
CPC分类号： H01J49/164 , H01J49/0445
摘要： An apparatus and method for generating ions from an aerosol and transferring the ions into a mass analyzer. In the apparatus and method, an aerosol beam is generated, the aerosol beam is directed to a spatial volume outside the mass analyzer, particles in the aerosol beam are ionized to produce the ions, and the ions are collected into the mass analyzer. As such the apparatus includes respectively an aerosol beam generator, an ion source generator, and an ion collector.

5. 发明授权

US6002130A Mass spectrometry and mass spectrometer 失效
公开(公告)号：US6002130A
公开(公告)日：1999-12-14
申请号：US15322
申请日：1998-01-29
申请人： Yoshiaki Kato
发明人： Yoshiaki Kato
IPC分类号： H01J49/04 , B01D54/44 , H01J49/00
CPC分类号： H01J49/24 , H01J49/04
摘要： Ions generated under an atmospheric pressure pass through vacuum chambers partitioned through first, second and third fine holes. The ions are led to an MS part where the ions are mass-analyzed. A first vacuum chamber adjacent to an atmospheric pressure part has not vacuum pump for independently pumping this chamber. The first vacuum chamber is evacuated by a common pump together with a second vacuum chamber via a bypass hole formed in the wall having the second aperture. A pressure of the first vacuum chamber can be set to several 100 Pa, while a pressure of the second vacuum chamber can be set to several 10 Pa. Sufficient desolvation has been attained by an ion acceleration voltage of approximately 100 V in the first vacuum chamber, while a speed spread can be restrained. The ions are accelerated by approximately 10 V in the second vacuum chamber, and the speed can be restrained as low as possible.

6. 发明授权

US06987263B2 High throughput systems and methods for parallel sample analysis 有权
标题翻译：高通量系统和并行样本分析方法
公开(公告)号：US06987263B2
公开(公告)日：2006-01-17
申请号：US10736154
申请日：2003-12-13
申请人： Steven E. Hobbs , Stephen D. O'Connor , Ronald C. Gamble
发明人： Steven E. Hobbs , Stephen D. O'Connor , Ronald C. Gamble
IPC分类号： B01D54/44 , H01J49/00
CPC分类号： G01N30/6043 , B01L3/5027 , G01N30/6095 , G01N30/72 , H01J49/009 , H01J49/04
摘要： Systems for analyzing multiple samples in parallel using mass spectrometric preferably coupled with fluid phase separation techniques are provided. A multi-analyzer mass spectrometer includes multiple inlets, multiple mass analyzers, and multiple transducers to conduct mass analyses of multiple samples in parallel. A modular mass analyzer may include a vacuum enclosure, a chassis, and multiple mass analysis modules disposed within the chassis. Modules are preferably disposed in a spatially compact two-dimensional array. A common multi-stage vacuum system may be utilized in conjunction with baffles or partitions disposed within and between modules to maintain differential vacuum conditions within the spectrometer utilizing a minimum number of pumps. Common control inputs may be provided to multiple modules or other components within a multi-analyzer spectrometer. Fluid phase separation devices for use with a multi-analyzer spectrometer may be microfluidic devices utilizing chromatographic, electrophoretic, or other separation methods.
摘要翻译：提供了使用优选与流体相分离技术耦合的质谱分析多个样品的系统。多分析仪质谱仪包括多个入口，多个质量分析仪和多个换能器，用于并行进行多个样品的质量分析。模块化质量分析器可以包括真空外壳，底盘以及设置在底盘内的多个质量分析模块。模块优选地设置在空间紧凑的二维阵列中。共同的多级真空系统可以与设置在模块内和模块之间的挡板或隔板一起使用，以利用最少数量的泵来保持光谱仪内的差分真空条件。通常的控制输入可以提供给多分析仪光谱仪中的多个模块或其他组件。用于多分析仪光谱仪的流体相分离装置可以是利用色谱，电泳或其它分离方法的微流体装置。

7. 发明授权

US06967324B2 Micro matrix ion generator for analyzers 有权
标题翻译：用于分析仪的微型离子发生器
公开(公告)号：US06967324B2
公开(公告)日：2005-11-22
申请号：US10644463
申请日：2003-08-20
申请人： Paul C. Goodley , Jean-Luc Truche
发明人： Paul C. Goodley , Jean-Luc Truche
IPC分类号： H01J49/04 , H01J49/00 , H01J49/40 , B01D54/44
CPC分类号： H01J49/167 , H01J49/0018 , H01J49/04
摘要： A source of ions for an analyzer includes a reservoir for containing a liquid, a manifold having a plurality of nozzles, a conduit connecting the reservoir to the manifold and a counter electrode having a potential difference between the counter electrode and the nozzles to enable liquid to be ejected from the nozzles in droplets and to enable ions to be ejected from the droplets.
摘要翻译：用于分析器的离子源包括用于容纳液体的储存器，具有多个喷嘴的歧管，将储存器连接到歧管的导管和在对电极和喷嘴之间具有电位差的对电极，从喷嘴喷出液滴，并使离子从液滴中喷出。

8. 发明授权

US06903332B2 Pulsers for time-of-flight mass spectrometers with orthogonal ion injection 有权
标题翻译：具有正交离子注入的飞行时间质谱仪的脉冲器
公开(公告)号：US06903332B2
公开(公告)日：2005-06-07
申请号：US10303661
申请日：2002-11-25
申请人： Gerhard Weiss , Carsten Stoermer , Oliver Räther
发明人： Gerhard Weiss , Carsten Stoermer , Oliver Räther
IPC分类号： H01J49/16 , H01J49/40 , H01J49/00 , B01D54/44
CPC分类号： H01J49/401 , H01J49/06
摘要： The invention relates to the construction and operation of a slit diaphragm pulser for a time-of-flight mass spectrometer with orthogonal injection of the ions to be examined. The invention includes switching three diaphragm potentials during a transition from a filling phase to an acceleration phase in order to maintain a potential along the axis of the injected ion beam at a constant level, to prevent any penetration by the accelerating fields during the filling phase and to obtain extremely high mass resolution in the acceleration phase through a lens effect.
摘要翻译：本发明涉及正交注射待检离子的飞行时间质谱仪的狭缝隔膜脉冲发生器的结构和操作。本发明包括在从填充阶段到加速阶段的过渡期间切换三个隔膜电位，以便沿着注入的离子束的轴线保持恒定水平的电位，以防止在填充阶段期间加速场的任何穿透;以及通过透镜效应在加速阶段获得极高的质量分辨率。

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