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1. 发明授权

US07259371B2 Method and apparatus for improved sensitivity in a mass spectrometer 有权
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：US07259371B2
公开(公告)日：2007-08-21
申请号：US11315788
申请日：2005-12-22
申请人： Bruce A. Collings , Thomas R. Covey , Mircea Guna , Hassan Javaheri , Alexandre V. Loboda , Bradley B. Schneider , Bruce A. Thomson
发明人： Bruce A. Collings , Thomas R. Covey , Mircea Guna , Hassan Javaheri , Alexandre V. Loboda , Bradley B. Schneider , Bruce A. Thomson
IPC分类号： H01J49/00
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, at least one ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以至基本上径向限制超音速自由射流膨胀的至少一个离子导向器可以将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

2. 发明授权

US07256395B2 Method and apparatus for improved sensitivity in a mass spectrometer 有权
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：US07256395B2
公开(公告)日：2007-08-14
申请号：US11032376
申请日：2005-01-10
申请人： Bruce A. Collings , Mircea Guna , Hassan Javaheri , Alexandre V. Loboda , Bruce A. Thomson
发明人： Bruce A. Collings , Mircea Guna , Hassan Javaheri , Alexandre V. Loboda , Bruce A. Thomson
IPC分类号： H01J49/00
CPC分类号： H01J49/04 , H01J49/062
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, an ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以基本上径向地限制超音速自由射流膨胀的离子导向器可以将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

3. 发明授权

US07405397B2 Laser desorption ion source with ion guide coupling for ion mass spectroscopy 有权
标题翻译：激光解吸离子源与离子导向耦合离子质谱法
公开(公告)号：US07405397B2
公开(公告)日：2008-07-29
申请号：US11317368
申请日：2005-12-22
申请人： Thomas R. Covey , Hassan Javaheri , Bradley B. Schneider
发明人： Thomas R. Covey , Hassan Javaheri , Bradley B. Schneider
IPC分类号： H01J49/00 , H01J49/40 , B01D54/44
CPC分类号： H01J49/063 , H01J49/164
摘要： A laser desorption ion source provides enhanced ion sampling efficiency and measurement sensitivity by using one or more ion guides to effectively capture ions in a plume emitted from the ion target and guide the ions through an aperture into a downstream vacuum chamber. In one configuration using two RF multipole ion guides, a first RF multipole ion guide disposed next to the ion target is selected to be sufficiently large to capture a substantial portion of the plume, while the second RF multipole ion guide disposed between the first multipole ion guide and the aperture has a smaller dimension to assist focusing of ions into the aperture. The first RF multipole ion guides the ions in the plume into the second RF multipole ion guide, which then focuses the ions so that they pass through the aperture into the downstream vacuum chamber.
摘要翻译：激光解吸离子源通过使用一个或多个离子引导件有效地捕获从离子靶发射的羽流中的离子并将离子引导通过孔进入下游真空室来提供增强的离子采样效率和测量灵敏度。在使用两个RF多极离子引导件的一种配置中，选择邻近离子靶设置的第一RF多极离子导向器足够大以捕获大部分羽流，而第二射频多极离子导向器设置在第一多极离子导向件和孔径具有较小的尺寸以辅助将离子聚焦到孔中。第一RF多极离子将羽流中的离子引导到第二射频多极离子导向器中，然后将离子聚焦以使它们通过孔进入下游真空室。

4. 发明申请

US20060169891A1 Method and apparatus for improved sensitivity in a mass spectrometer 有权
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：US20060169891A1
公开(公告)日：2006-08-03
申请号：US11315788
申请日：2005-12-22
申请人： Bruce Collings , Thomas Covey , Mircea Guna , Hassan Javaheri , Alexandre Loboda , Bradley Schneider , Bruce Thomson
发明人： Bruce Collings , Thomas Covey , Mircea Guna , Hassan Javaheri , Alexandre Loboda , Bradley Schneider , Bruce Thomson
IPC分类号： B01D59/44
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, at least one ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以至基本上径向限制超音速自由射流膨胀的至少一个离子导向器可以将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

5. 发明申请

US20060151692A1 Method and apparatus for improved sensitivity in a mass spectrometer 有权
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：US20060151692A1
公开(公告)日：2006-07-13
申请号：US11032376
申请日：2005-01-10
申请人： Bruce Collings , Mircea Guna , Hassan Javaheri , Alexandre Loboda , Bruce Thomson
发明人： Bruce Collings , Mircea Guna , Hassan Javaheri , Alexandre Loboda , Bruce Thomson
IPC分类号： B01D59/44
CPC分类号： H01J49/04 , H01J49/062
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, an ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以基本上径向限制超音速自由射流膨胀的离子导向器可将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

6. 发明授权

US06759650B2 Method of and apparatus for ionizing an analyte and ion source probe for use therewith 有权
标题翻译：用于离子化分析物和离子源探针的方法和装置
公开(公告)号：US06759650B2
公开(公告)日：2004-07-06
申请号：US10118343
申请日：2002-04-09
申请人： Thomas R. Covey , Raymond Jong , Hassan Javaheri
发明人： Thomas R. Covey , Raymond Jong , Hassan Javaheri
IPC分类号： H01J4900
CPC分类号： H01J49/165 , H01J49/049
摘要： Ions for analysis are formed from a liquid sample comprising an analyte in a solvent liquid by directing the liquid sample through a capillary tube having a free end so as to form a first flow comprising a spray of droplets of the liquid sample, to promote vaporization of the solvent liquid. An orifice member is spaced from the free-end of the capillary tube and has an orifice therein. An electric field is generated between the free-end of the capillary and the orifice member, thereby causing the droplets to be charged, and the first flow is directed in a first direction along the axis of the capillary tube. Two gas sources, or an arc jet of gas, provide second and third flows, of a gas, and include heaters for heating the second and third flows. The second and third flows intersect with the first flow at a selected mixing region, to promote turbulent mixing of the first, second and third flows, the first, second and third directions being different from one another, and each of the second and third directions being selected to provide each of the second and third flows with a velocity component in the first direction and a velocity component towards the axis of the capillary tube, thereby to promote entrainment of the heated gas in the spray, with the heated gas acting to assist the evaporation of the droplets to release ions therefrom. At least some of the ions produced from the droplets are drawn through the orifice for analysis.
摘要翻译：用于分析的离子由包含溶剂液体中的分析物的液体样品形成，通过引导液体样品通过具有自由端的毛细管，以便形成包含液体样品的液滴的喷雾的第一流，以促进溶剂液体。孔部件与毛细管的自由端分开并且在其中具有孔口。在毛细管的自由端和孔口部件之间产生电场，从而使液滴被充电，并且第一流动沿着毛细管的轴线沿第一方向。两种气源或电弧射流提供气体的第二和第三流，并且包括用于加热第二和第三流量的加热器。第二和第三流在选定的混合区域与第一流相交，以促进第一，第二和第三流的湍流混合，第一，第二和第三方向彼此不同，第二和第三方向被选择为使第二和第三流中的每一个具有在第一方向上的速度分量和朝向毛细管的轴线的速度分量，从而促进加热的气体在喷雾中的夹带，加热的气体用于辅助液滴的蒸发从其中释放离子。从液滴产生的至少一些离子被吸入孔中进行分析。

7. 发明申请

US20060124846A1 Laser desorption ion source with ion guide coupling for ion mass spectroscopy 有权
标题翻译：激光解吸离子源与离子导向耦合离子质谱法
公开(公告)号：US20060124846A1
公开(公告)日：2006-06-15
申请号：US11317368
申请日：2005-12-22
申请人： Thomas Covey , Hassan Javaheri , Bradley Schneider
发明人： Thomas Covey , Hassan Javaheri , Bradley Schneider
IPC分类号： H01J49/00
CPC分类号： H01J49/063 , H01J49/164
摘要： A laser desorption ion source provides enhanced ion sampling efficiency and measurement sensitivity by using one or more ion guides to effectively capture ions in a plume emitted from the ion target and guide the ions through an aperture into a downstream vacuum chamber. In one configuration using two RF multipole ion guides, a first RF multipole ion guide disposed next to the ion target is selected to be sufficiently large to capture a substantial portion of the plume, while the second RF multipole ion guide disposed between the first multipole ion guide and the aperture has a smaller dimension to assist focusing of ions into the aperture. The first RF multipole ion guides the ions in the plume into the second RF multipole ion guide, which then focuses the ions so that they pass through the aperture into the downstream vacuum chamber.
摘要翻译：激光解吸离子源通过使用一个或多个离子引导件有效地捕获从离子靶发射的羽流中的离子并将离子引导通过孔进入下游真空室来提供增强的离子采样效率和测量灵敏度。在使用两个RF多极离子引导件的一种配置中，选择邻近离子靶设置的第一RF多极离子导向器足够大以捕获大部分羽流，而第二射频多极离子导向器设置在第一多极离子导向件和孔径具有较小的尺寸以辅助将离子聚焦到孔中。第一RF多极离子将羽流中的离子引导到第二射频多极离子导向器中，然后将离子聚焦以使它们通过孔进入下游真空室。

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