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1. 发明授权

US07790109B2 Micro-fluid reaction vessel, method for manufacturing the same, and micro-fluid reaction method using the vessel 有权
标题翻译：微流体反应容器，其制造方法和使用该容器的微流体反应方法
公开(公告)号：US07790109B2
公开(公告)日：2010-09-07
申请号：US11625877
申请日：2007-01-23
申请人： Su-hyeon Kim , Jin-tae Kim , Kak Namkoong , In-ho Lee , Chin-sung Park , Young-sun Lee
发明人： Su-hyeon Kim , Jin-tae Kim , Kak Namkoong , In-ho Lee , Chin-sung Park , Young-sun Lee
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , B01J10/00 , B01J10/02 , B01J12/00 , B01J12/02 , F15C1/04 , F15C3/00 , F15C1/06
CPC分类号： B01L3/502738 , B01L7/52 , B01L2200/0689 , B01L2300/0816 , B01L2300/0825 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , B29C33/3857 , B29C33/60 , Y10T137/218 , Y10T137/2202 , Y10T137/2224
摘要： A micro-fluid reaction vessel includes an upper plate formed of an elastomer, a lower plate adhered to the upper plate, a micro-chamber and a micro-channel formed on an inner surface of the upper plate facing the lower plate and an inlet hole and an outlet hole formed in the upper plate and through which a fluid flows into or out of, respectively. The micro-channel is constructed to be closed by pressure applied to the upper plate and elastically restored when the pressure is not applied. A micro fluid reaction method uses the micro fluid reaction vessel and a method of manufacturing forms the microfluid reaction vessel.
摘要翻译：微流体反应容器包括由弹性体形成的上板，粘附到上板的下板，形成在面向下板的上板的内表面上的微室和微通道，以及入口孔以及形成在上板中并且流体分别流入或流出的出口孔。微通道被构造为通过施加到上板的压力而关闭，并且当不施加压力时弹性恢复。微流体反应方法使用微流体反应容器和制造方法形成微流体反应容器。

2. 发明申请

US20060183112A1 Method of separating biomolecules using nanopore 审中-公开
标题翻译：使用纳米孔分离生物分子的方法
公开(公告)号：US20060183112A1
公开(公告)日：2006-08-17
申请号：US11335246
申请日：2006-01-19
申请人： Jun-hong Min , Su-hyeon Kim , In-ho Lee , Kui-hyun Kim , Seung-yeon Yang
发明人： Jun-hong Min , Su-hyeon Kim , In-ho Lee , Kui-hyun Kim , Seung-yeon Yang
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： G01N33/5438 , G01N33/48721
摘要： Provided is a method of separating particles, the method comprising: forming a first chamber and a second chamber separated by an interface with a pore, wherein the first and second chambers have electrodes with different polarities; placing particles to which a target biomolecule is bound from particles to which the target biomolecule is not bound in the first chamber; applying a voltage which has the same polarity as that of the target biomolecule to the electrode of the first chamber, and a voltage which has an opposite charge to that of the target biomolecule to the electrode of the second chamber; and translocating only the particles to which the target biomolecule is bound from the first chamber to the second chamber through the pore. Conventionally, the size of a pore is used to separate biomolecules. However, effective separation is difficult to achieve because the manufacture of a pore with a diameter of less than 10 nm, small enough to separate biomolecule, is not easy. Therefore, signal separation and data analysis must be required. However, in the present method, physical movement induced by the charge of biomolecules is used to effectively separate the biomolecules, thus obtaining a high signal to noise ratio. As a result, additional data analysis is not required.
摘要翻译：提供了一种分离颗粒的方法，该方法包括：形成由与孔的界面分隔开的第一室和第二室，其中第一和第二室具有不同极性的电极; 在第一室中放置靶生物分子所结合的颗粒与目标生物分子不结合的颗粒; 将具有与目标生物分子相同极性的电压施加到第一室的电极，以及将具有与靶生物分子相反的电荷的电压施加到第二室的电极; 并且仅将来自第一室的目标生物分子结合的颗粒通过孔转移到第二室。通常，使用孔的大小来分离生物分子。然而，由于直径小于10nm的孔的制造足够小以分离生物分子，所以难以实现有效的分离，这是不容易的。因此，必须要求信号分离和数据分析。然而，在本方法中，由生物分子的电荷引起的身体运动用于有效分离生物分子，从而获得高的信噪比。因此，不需要额外的数据分析。

3. 发明授权

US07572644B2 Hydrogel copolymer, substrate coated with the copolymer, method of producing microarray using the copolymer, and microarray produced by the method 有权
标题翻译：水凝胶共聚物，用共聚物涂布的基材，使用共聚物制备微阵列的方法，以及通过该方法制备的微阵列
公开(公告)号：US07572644B2
公开(公告)日：2009-08-11
申请号：US11334145
申请日：2006-01-17
申请人： In-ho Lee , Jun-hong Min , Su-hyeon Kim
发明人： In-ho Lee , Jun-hong Min , Su-hyeon Kim
IPC分类号： G01N33/547 , G01N33/544 , G01N33/53 , C12M1/34 , C07K1/14 , C07D207/00
CPC分类号： C12N11/06 , B82Y30/00 , B82Y40/00 , C08F220/28 , C08F220/56 , C08F220/60 , C08F230/08 , C12Q1/6837 , G01N2035/00158 , Y10S524/916
摘要： A novel hydrogel copolymer, a substrate coated with the copolymer, a method of producing a microarray using the copolymer, and a microarray produced by the method are provided. The use of the hydrogel copolymer makes efficient removal of protein and high integration of nucleic acid and protein on a substrate for a microarray possible.
摘要翻译：提供一种新型水凝胶共聚物，用共聚物涂布的基材，使用该共聚物制备微阵列的方法，以及通过该方法制备的微阵列。使用水凝胶共聚物可有效去除蛋白质，核基酸和蛋白质在基质上的高度整合可用于微阵列。

4. 发明申请

US20060188907A1 Patterning method, substrate for biomolecule immobilization using the patterning method, and biochip employing the substrate 审中-公开
标题翻译：图案化方法，使用图案化方法的生物分子固定用基材和使用该基材的生物芯片
公开(公告)号：US20060188907A1
公开(公告)日：2006-08-24
申请号：US11336294
申请日：2006-01-18
申请人： In-ho Lee , Jun-hong Min , Su-hyeon Kim , Kui-hyun Kim , Seung-yeon Yang
发明人： In-ho Lee , Jun-hong Min , Su-hyeon Kim , Kui-hyun Kim , Seung-yeon Yang
IPC分类号： C12Q1/68 , C12M1/34 , H01L21/00
CPC分类号： C23C18/1893 , B01J19/0046 , B01J2219/00527 , B01J2219/00596 , B01J2219/00603 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/00743 , C23C18/1608 , C23C18/2086 , C23C18/44 , C40B40/06 , C40B40/10 , G01N33/54353 , H05K3/389 , H05K2203/013
摘要： Provided is a linker functional group patterning method for biomolecule immobilization. The patterning method includes preparing a coating composition including a hydrophobic group-containing silane compound and a hydrophilic group-containing silane compound; forming a surface tension control layer by coating the coating composition on a substrate for biomoleucle immobilization; and forming a linker functional group pattern on the surface tension control layer using a coating composition including a linker functional group-containing compound followed by thermal treatment. The linker functional group pattern is formed in a uniform size and distribution and contains high-density linker functional groups.
摘要翻译：提供了用于生物分子固定的接头官能团图案化方法。图案化方法包括制备包含含疏水基的硅烷化合物和含亲水基团的硅烷化合物的涂料组合物; 通过将所述涂料组合物涂布在用于生物核固定的底物上来形成表面张力控制层; 以及使用包含连接官能团的化合物的涂层组合物在表面张力控制层上形成接头官能团图案，随后进行热处理。连接体官能团图案形成均匀的大小和分布，并含有高密度接头官能团。

5. 发明申请

US20060110760A1 Microarray using laminar flow and method of preparing the same 审中-公开
标题翻译：使用层流的微阵列及其制备方法
公开(公告)号：US20060110760A1
公开(公告)日：2006-05-25
申请号：US11269037
申请日：2005-11-07
申请人： Su-hyeon Kim , In-ho Lee , Jun-hong Min
发明人： Su-hyeon Kim , In-ho Lee , Jun-hong Min
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00369 , B01J2219/00432 , B01J2219/005 , B01J2219/0052 , B01J2219/00641 , B01J2219/00644 , B01J2219/00657 , B01J2219/00673 , B01J2219/00677 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00743
摘要： A microarray including hydrogel and a plurality of probes which are immobilized in discrete regions of the hydrogel, and a method of preparing the same are provided. When using the microarray and method, a solid substrate is not required and many biomolecules can be immobilized in a small volume, thereby obtaining high sensitivity. Since gel can be cut to obtain many pieces, many microarrays can be prepared at once.
摘要翻译：提供了包含水凝胶和固定在水凝胶的离散区域中的多个探针的微阵列及其制备方法。当使用微阵列和方法时，不需要固体底物，并且许多生物分子可以以小体积固定，从而获得高灵敏度。由于可以切割凝胶以获得许多片，因此可以一次制备许多微阵列。

6. 发明申请

US20060160120A1 Novel hydrogel copolymer, substrate coated with the copolymer, method of producing microarray using the copolymer, and microarray produced by the method 有权
标题翻译：新型水凝胶共聚物，用共聚物涂布的基材，使用该共聚物制造微阵列的方法，以及通过该方法制备的微阵列
公开(公告)号：US20060160120A1
公开(公告)日：2006-07-20
申请号：US11334145
申请日：2006-01-17
申请人： In-ho Lee , Jun-hong Min , Su-hyeon Kim
发明人： In-ho Lee , Jun-hong Min , Su-hyeon Kim
IPC分类号： G01N1/28 , C12Q1/68 , G01N33/53 , C12M1/34 , B05D3/02
CPC分类号： C12N11/06 , B82Y30/00 , B82Y40/00 , C08F220/28 , C08F220/56 , C08F220/60 , C08F230/08 , C12Q1/6837 , G01N2035/00158 , Y10S524/916
摘要： A novel hydrogel copolymer, a substrate coated with the copolymer, a method of producing a microarray using the copolymer, and a microarray produced by the method are provided. The use of the hydrogel copolymer makes efficient removal of protein and high integration of nucleic acid and protein on a substrate for a microarray possible.
摘要翻译：提供一种新型水凝胶共聚物，用共聚物涂布的基材，使用该共聚物制备微阵列的方法，以及通过该方法制备的微阵列。使用水凝胶共聚物可有效去除蛋白质，核基酸和蛋白质在基质上的高度整合可用于微阵列。

7. 发明授权

US07807360B2 Method and apparatus for concentrating and amplifying nucleic acid in single micro chamber 有权
标题翻译：在单微室中浓缩和扩增核酸的方法和装置
公开(公告)号：US07807360B2
公开(公告)日：2010-10-05
申请号：US11620961
申请日：2007-01-08
申请人： Young-rok Kim , Jun-hong Min , In-ho Lee , Young-sun Lee , Chang-eun Yoo , Ki-woong Han
发明人： Young-rok Kim , Jun-hong Min , In-ho Lee , Young-sun Lee , Chang-eun Yoo , Ki-woong Han
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , B01L3/5027 , B01L3/5088 , C12Q1/686 , C12Q2565/629 , C12Q2537/149 , C12Q2527/125
摘要： A method of sequentially performing concentration and amplification of nucleic acid in a single micro chamber includes: introducing a nucleic acid-containing sample and a solution including a kosmotropic salt to a micro chamber having a hydrophilic interior surface to concentrate the nucleic acid by binding the nucleic acid on the interior surface of the micro chamber; and performing a polymerase chain reaction (PCR) by adding a PCR mixture to the chamber. Since the nucleic acid is reversibly bound to the interior surface of the micro chamber, PCR yield is higher compared with a surface of aluminum oxide in which irreversible binding occurs. In addition, all processes are sequentially performed in a single micro chamber so that the number of samples, consumables, time, and labor for treatment and analysis can be reduced, detection sensitivity can be improved, and risk of sample cross contamination significantly reduced without sample loss by eliminating transporting of the sample. A complete automated system for concentration and amplification of nucleic acid is thus readily provided.
摘要翻译：在单个微室中依次进行核酸的浓缩和扩增的方法包括：将含核酸的样品和包含可染色盐的溶液引入具有亲水性内表面的微室中，以通过结合核酸来浓缩核酸酸在微室的内表面上; 并通过向该室加入PCR混合物进行聚合酶链式反应（PCR）。由于核酸可逆地结合到微室的内表面，与其中发生不可逆结合的氧化铝的表面相比，PCR产率更高。此外，所有过程都在单个微室中顺序进行，以便可以减少样品数量，消耗品，时间和处理和分析的劳动力，可以提高检测灵敏度，并且样品交叉污染的风险在没有样品时显着降低通过消除样品的运输而损失。因此容易提供用于浓缩和扩增核酸的完整的自动化系统。

8. 发明申请

US20070238114A1 Method and apparatus for disrupting cells and purifying nucleic acid using a single chip 有权
标题翻译：使用单个芯片破坏细胞并纯化核酸的方法和装置
公开(公告)号：US20070238114A1
公开(公告)日：2007-10-11
申请号：US11639794
申请日：2006-12-15
申请人： In-ho Lee , Jun-hong Min , Young-rok Kim , Jae-ho You , Chang-eun Yoo , Jeong-gun Lee , Ki-woong Han
发明人： In-ho Lee , Jun-hong Min , Young-rok Kim , Jae-ho You , Chang-eun Yoo , Jeong-gun Lee , Ki-woong Han
IPC分类号： C12Q1/68 , C12N1/08
CPC分类号： C12Q1/68 , C12M47/06 , C12N15/1006
摘要： Provided herein is a method and apparatus for disrupting cells and purifying nucleic acids in a single chip. The method comprises irradiating a chip with a laser beam, wherein the chip comprises a solid support on which a cell lysis enhancing metal oxide layer, and a cell binding metal oxide layer have been deposited.
摘要翻译：本文提供了在单个芯片中破坏细胞并纯化核酸的方法和装置。该方法包括用激光束照射芯片，其中芯片包括其上沉积有细胞裂解增强金属氧化物层和细胞结合金属氧化物层的固体支持物。

9. 发明授权

US08343325B2 Electrodialysis apparatus and electrodialysis method using the same 有权
标题翻译：电渗析装置及使用其的电渗析方法
公开(公告)号：US08343325B2
公开(公告)日：2013-01-01
申请号：US11737448
申请日：2007-04-19
申请人： Hun-joo Lee , Soo-suk Lee , Joon-ho Kim , Sung-ouk Jung , In-ho Lee
发明人： Hun-joo Lee , Soo-suk Lee , Joon-ho Kim , Sung-ouk Jung , In-ho Lee
IPC分类号： B01D61/44
CPC分类号： B01D61/422 , B01D2311/243 , B01D2313/02 , B01D2313/10 , B01D2313/26 , B01D2313/30 , B01D2313/50 , B01D2321/185
摘要： An electrodialysis apparatus includes a sample chamber including first and second dialysis membranes and filled with a sample between the first dialysis membrane and the second dialysis membrane, an anode chamber including an anode and filled with a first chamber solution between the anode and the first dialysis membrane, and a cathode chamber including a cathode and filled with a second chamber solution between the cathode and the second dialysis membrane. In particular, when a voltage is applied to the anode and the cathode, ionic materials of the sample move to the anode and cathode chambers.
摘要翻译：电渗透装置包括：样品室，包括第一和第二透析膜，并在第一透析膜和第二透析膜之间填充样品;阳极室，包括阳极，并在阳极和第一透析膜之间填充第一室溶液以及包括阴极并在阴极和第二透析膜之间填充有第二室溶液的阴极室。特别地，当向阳极和阴极施加电压时，样品的离子材料移动到阳极室和阴极室。

10. 发明授权

US07718577B2 Linker compound, substrate coated with the compound, method of producing microarray using the compound and microarray produced by the method 有权
标题翻译：接头化合物，用该化合物涂布的基质，使用该化合物制备微阵列的方法和通过该方法制备的微阵列
公开(公告)号：US07718577B2
公开(公告)日：2010-05-18
申请号：US11266710
申请日：2005-11-03
申请人： In-ho Lee , Bong-jin Moon , Jun-hong Min , Jang-seok Ma
发明人： In-ho Lee , Bong-jin Moon , Jun-hong Min , Jang-seok Ma
IPC分类号： C40B40/00
CPC分类号： C07F7/1804
摘要： A compound represented by formula (4), a substrate coated with the compound, a method of producing a microarray using the compound, and a microarray produced by the method are provided.
摘要翻译：提供由式（4）表示的化合物，用该化合物包被的底物，使用该化合物制备微阵列的方法和通过该方法制备的微阵列。

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