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1. 发明授权

US08951551B2 Multiribbon nanocellulose as a matrix for wound healing 有权
标题翻译：多纤维纳米纤维素作为伤口愈合的基质
公开(公告)号：US08951551B2
公开(公告)日：2015-02-10
申请号：US11513564
申请日：2006-08-31
申请人： R. Malcolm Brown, Jr. , Wojciech Czaja , Marc Jeschke , David J. Young
发明人： R. Malcolm Brown, Jr. , Wojciech Czaja , Marc Jeschke , David J. Young
IPC分类号： A61K9/70 , A61K38/18 , A61K38/22 , A61L15/16 , A61K45/06 , A61K31/56 , A61L15/28 , A61L27/20 , A61L29/04 , A61L31/04 , A61K38/19
CPC分类号： A61K45/06 , A61K9/70 , A61K9/7007 , A61K31/56 , A61K38/18 , A61K38/191 , A61L15/16 , A61L15/28 , A61L27/20 , A61L29/043 , A61L31/042 , A61L2400/12 , Y02A50/481 , C08L1/00 , C08L1/28
摘要： The present invention includes compositions and methods for the integration of a non-allergenic nanocellulose into a wound bed. The composition may be formed into a wide variety of implants, e.g., a suture, a sheet, a compress, a bandage, a band, a prosthesis, a fiber, a woven fiber, a bead, a strip, a clasp, a prosthesis, a catheter, a screw, a bone plate, a pin, a bandage or combinations thereof.
摘要翻译：本发明包括将非过敏性纳米纤维素整合到伤口床中的组合物和方法。组合物可以形成多种植入物，例如缝合线，片，压片，绷带，带，假体，纤维，编织纤维，珠，条，扣，假体，导管，螺钉，骨板，针，绷带或其组合。

2. 发明授权

US07803601B2 Production and secretion of glucose in photosynthetic prokaryotes (cyanobacteria) 有权
标题翻译：光合原核生物（蓝细菌）中葡萄糖的产生和分泌
公开(公告)号：US07803601B2
公开(公告)日：2010-09-28
申请号：US11866872
申请日：2007-10-03
申请人： David R. Nobles, Jr. , R. Malcolm Brown, Jr.
发明人： David R. Nobles, Jr. , R. Malcolm Brown, Jr.
IPC分类号： C12N1/20 , C12N1/12 , C12N15/00 , C12N9/10 , C12P19/04 , C12P19/02 , C12Q1/68
CPC分类号： C12P7/10 , C12P19/02 , C12P19/04 , Y02E50/16 , Y02E50/17
摘要： The present invention includes compositions and methods for making and using an isolated cyanobacterium that includes a portion of an exogenous bacterial cellulose operon sufficient to express bacterial cellulose, whereby the cyanobacterium produces extracellular glucose. The compositions and methods of the present invention may be used as a new global crop for the manufacture of cellulose, CO2 fixation, for the production of alternative sources of conventional cellulose as well as a biofuel and precursors thereof.
摘要翻译：本发明包括用于制备和使用分离的蓝细菌的组合物和方法，其包括足以表达细菌纤维素的外源性细菌纤维素操纵子的一部分，由此所述蓝细菌产生细胞外葡萄糖。本发明的组合物和方法可以用作新的全球作物，用于制造纤维素，固定CO2，用于生产常规纤维素的替代来源以及生物燃料及其前体。

3. 发明授权

US4950597A Modification of cellulose normally synthesizied by cellulose-producing microorganisms 失效
标题翻译：纤维素生产微生物通常合成的纤维素的改性
公开(公告)号：US4950597A
公开(公告)日：1990-08-21
申请号：US198784
申请日：1988-05-25
申请人： Inder M. Saxena , Eric M. Roberts , R. Malcolm Brown, Jr.
发明人： Inder M. Saxena , Eric M. Roberts , R. Malcolm Brown, Jr.
IPC分类号： C12P19/04
CPC分类号： C12R1/02 , C12P19/04 , Y10S435/822 , Y10S435/823
摘要： The present invention involves a process for screening for and isolating spontaneously occurring or induced cellulose II-producing microorganisms. The process comprises a series of steps in various embodiments. Initially, cellulose-producing microorganisms from a first culture are plated out on a nutrient agar plate. The nutrient agar plate is then incubated to facilitate formation of colonies from single microorganisms. Samples of liquid nutrient medium are then inoculated with microorganisms from colonies having a smooth configuration, as compared to the usual rough colony configuration. The inoculated samples are then aerobically incubated to facilitate microorganism proliferation and pellicle formation. From these incubated samples are selected microorganisms, which, after a cultivation period, have proliferated but not formed a pellicle. Said selected microorganisms produce cellulose II instead of the cellulose I produced by pellicle-forming organisms.
摘要翻译：本发明涉及用于筛选和分离自发产生或诱导的产生纤维素II的微生物的方法。该方法包括各种实施方案中的一系列步骤。最初，将来自第一培养物的产生纤维素的微生物铺在营养琼脂平板上。然后培养营养琼脂平板以促进从单一微生物形成菌落。与通常的粗殖群配置相比，液体营养培养基的样品接种具有平滑构型的菌落的微生物。然后将接种的样品有氧培养以促进微生物增殖和防护薄膜组织。从这些孵育的样品中选出微生物，其在培养期后已增殖但未形成防护薄膜。所述选择的微生物产生纤维素II，而不是由防护薄膜组织生物体产生的纤维素I。

4. 发明授权

US4891317A Magnetic alternation of cellulose during its biosynthesis 失效
标题翻译：纤维素在其生物合成过程中的磁性交替
公开(公告)号：US4891317A
公开(公告)日：1990-01-02
申请号：US719505
申请日：1985-04-03
申请人： R. Malcolm Brown, Jr. , Debra S. Brown , Michael R. Gretz
发明人： R. Malcolm Brown, Jr. , Debra S. Brown , Michael R. Gretz
IPC分类号： C08B15/00 , A01G7/04 , C08B1/00 , C12N13/00 , C12P19/04 , C12R1/01 , C12R1/02 , C12R1/05 , C12R1/38 , C12R1/41
CPC分类号： C12N13/00 , A01G7/04 , C08B1/00 , C12P19/04 , Y10S435/822
摘要： A method of producing cellulose of amorphous character by subjecting cellulose-producing organisms to a magnetic field substantially greater than 0.5 gauss and preferably at least about 500 gauss. The cellulose produced in the presence of a magnetic field is of an amorphous nature with increased water absorptivity and decreased crystallinity.
摘要翻译：通过使产生纤维素的生物体达到基本上大于0.5高斯，优选至少约500高斯的磁场，制备无定形特性的纤维素的方法。在磁场存在下产生的纤维素具有无定形性质，具有增加的吸水率和降低的结晶度。

5. 发明授权

US5472859A Enzymatic method for synthesis of cellulose 1 失效
标题翻译：纤维素合成酶的方法1
公开(公告)号：US5472859A
公开(公告)日：1995-12-05
申请号：US100868
申请日：1993-08-02
申请人： R. Malcolm Brown, Jr. , Shiro Kobayashi , Krystyna Kudlicka , Shigenori Kuga , Jong Lee , Likun Li , Kazuo Okuda , Shin-Ichiro Shoda
发明人： R. Malcolm Brown, Jr. , Shiro Kobayashi , Krystyna Kudlicka , Shigenori Kuga , Jong Lee , Likun Li , Kazuo Okuda , Shin-Ichiro Shoda
IPC分类号： C12N9/10 , C12N9/24 , C12N11/12 , C12P19/04 , C12P19/08 , C12N9/42 , C12P19/00 , C12P19/14
CPC分类号： C12P19/08 , C12N11/12 , C12N9/10 , C12N9/2437 , C12P19/04 , C12Y302/01004
摘要： The present invention discloses a method of synthesizing a novel form of cellulose I as well as methods of synthesizing a novel form of cellulose I in vitro. One method comprises contacting an activated saccharide substrate with an endoglucanase in an appropriate organic solvent/buffer ratio. The invention also encompasses a partially purified endoglucanase and a method of synthesizing cellooligosaccharides. A second method comprises contacting a nucleotide sugar with a purified glycosyl transferase in an appropriate buffer medium to insure polymerization and crystallization of parallel glucan chains from the enzyme/micelle complex to form cellulose I.
摘要翻译：本发明公开了一种合成纤维素I的新形式的方法以及在体外合成纤维素I的新形式的方法。一种方法包括使活化的糖基底与内切葡聚糖酶以合适的有机溶剂/缓冲液比接触。本发明还包括部分纯化的内切葡聚糖酶和合成纤维寡糖的方法。第二种方法包括将核苷酸糖与纯化的糖基转移酶在合适的缓冲介质中接触以确保来自酶/胶束复合物的平行葡聚糖链的聚合和结晶以形成纤维素I.

6. 发明授权

US4967825A High resolution replicas 失效
标题翻译：高分辨率副本
公开(公告)号：US4967825A
公开(公告)日：1990-11-06
申请号：US216762
申请日：1988-07-08
申请人： R. Malcolm Brown, Jr. , Shun Mizuta
发明人： R. Malcolm Brown, Jr. , Shun Mizuta
IPC分类号： B22D23/00
CPC分类号： B82Y30/00 , B22D23/00 , Y10S977/881 , Y10S977/89 , Y10S977/902
摘要： Disclosed are improved methods for preparing high resolution replicas for electron microscopic analysis. Replicas are prepared having a resolution capability less than ten angstroms, with structures of even less than five angstroms being readily discernible. Particular aspects of the invention concern the use of a platinum/carbon evaporant to prepare extremely thin replica surfaces which allow the visualization of structures heretofore unresolvable. The replication is performed at high vacuum, on the order of 10.sup.-5 Torr or better, with continuous rotation of the sample to allow for an even distribution of the evaporant. The resultant replica surfaces are on the order of no more than 5 to 10 angstroms thick. The replica technology disclosed herein is applicable to both biological as well as non-biological samples, including tissues, biochemicals, metals and polymers and even computer chips and superconductor surfaces.
摘要翻译：公开了用于制备用于电子显微镜分析的高分辨率复制品的改进方法。准备了具有小于10埃的分辨能力的复制品，其结构甚至小于5埃是易于识别的。本发明的特定方面涉及使用铂/碳蒸发器来制备极薄的复制表面，其允许可视化迄今为止尚未解决的结构。复制在高真空下进行，大约为10 -5 Torr或更好，样品连续旋转以允许蒸发剂的均匀分布。所得复制表面的厚度不超过5至10埃。本文公开的复制技术适用于生物和非生物样品，包括组织，生物化学物质，金属和聚合物，甚至计算机芯片和超导体表面。

7. 发明授权

US07335882B1 High resolution low dose transmission electron microscopy real-time imaging and manipulation of nano-scale objects in the electron beam 失效
标题翻译：高分辨率低剂量透射电子显微镜在电子束中实时成像和操纵纳米级物体
公开(公告)号：US07335882B1
公开(公告)日：2008-02-26
申请号：US11082239
申请日：2005-03-16
申请人： R. Malcolm Brown, Jr. , Zack Barnes , Chie Sawatari , Tetsuo Kondo
发明人： R. Malcolm Brown, Jr. , Zack Barnes , Chie Sawatari , Tetsuo Kondo
IPC分类号： G01N23/00
CPC分类号： B82B3/00 , B82Y30/00 , B82Y40/00
摘要： The present invention includes a method, apparatus and system for nanofabrication in which one or more target molecules are identified for manipulation with an electron beam and the one or more target molecules are manipulated with the electron beam to produce new useful materials.
摘要翻译：本发明包括一种用于纳米制造的方法，装置和系统，其中一个或多个目标分子被识别为用电子束进行操作，并且一个或多个目标分子被电子束操纵以产生新的有用材料。

8. 发明授权

US4954439A Multiribbon microbial cellulose 失效
标题翻译：多纤维微生物纤维素
公开(公告)号：US4954439A
公开(公告)日：1990-09-04
申请号：US23336
申请日：1987-03-09
申请人： R. Malcolm Brown, Jr. , Fong C. Lin
发明人： R. Malcolm Brown, Jr. , Fong C. Lin
IPC分类号： C12N1/20 , C12P19/04 , C12Q1/02 , C12R1/01 , C12R1/02 , C12R1/05 , C12R1/38 , C12R1/41
CPC分类号： C12P19/04 , Y10S435/823 , Y10S435/829 , Y10S435/878
摘要： The present invention comprises a biologically pure culture of a cellulose-producing microorganism, preferably a prokaryote. This cellulose-producing microorganism is capable, during fermentation in an aqueous nutrient medium containing assimilable sources of carbon, nitrogen and inorganic substances, of reversal of direction of cellulose ribbon extrusion. This reversal of direction of cellulose ribbon extrusion results on the cellulose-producing microorganism shuttling, at least periodically, first in one direction and then in the other direction along a length of an earlier-deposited cellulose ribbon to add another cellulose ribbon thereto and produce a cellulose ribbon-bundle having a width of at least two cellulose ribbons.The cellulose-producing microorganism of the present invention may be of the genus Acetobacter, Agrobacterium, Rhizobium, Pseudomonas or Alcaligenes, preferably of the genus Acetobacter and more preferably of the species Acetobacter xylinum or Acetobacter pasteurianus. Among preferred Acetobacter xylinum strains are strain N05, H1A; H1B; H1C; H2A; H2B; H5C; H5D; H6C; H8C; H8G; H14B; H15A; and H15B. Acetobacter xylinum strain N05, the most preferred strain, has identifying characterisitcs of ATCC 53582 on deposit with the American Type Culture Collection, Rockville, MD.

9. 发明授权

US4942128A Microbial cellulose modified during synthesis 失效
标题翻译：合成过程中微生物纤维素修饰
公开(公告)号：US4942128A
公开(公告)日：1990-07-17
申请号：US22904
申请日：1987-03-06
申请人： R. Malcolm Brown, Jr.
发明人： R. Malcolm Brown, Jr.
IPC分类号： C08H99/00 , C08L1/02 , C12P19/04 , C12R1/02
CPC分类号： C08L1/02 , C12P19/04 , Y10S435/823
摘要： The present invention involves a method of producing cellulose. This method comprises inoculating a quantity of nutrient medium comprising a polysaccharide derivative such as carboxymethylcellulose (CMC) with a cellulose-producing microorganism. The inoculated medium is then aerobically incubated to facilitate the production of cellulose. The step of substantially drying the cellulose may be added for certain products. Substantially dried cellulose resulting from this procedure is highly absorbent, tending to retain its absorbent properties during repeated wetting and drying, and is usable where such absorbency is desired.A subject of the present invention is a composition of matter consisting essentially of such cellulose in a native or substantially dried form. Microbial cellulose produced in the presence of carboxymethyl cellulose may be substantially dried by many means known to those skilled in the art. This drying may be, for example, by washing with a non-aqueous hydrophilic solvent or by air-drying. Preferred non-aqueous solvents include alkyl alcohols or ketones having less than about six carbon atoms. When such non-aqueous solvents are used to dry the CMC-produced cellulose, the dried cellulose may have a resilient structure and possibly an elastic nature.
摘要翻译：本发明涉及一种生产纤维素的方法。该方法包括将一定量的包含多糖衍生物如羧甲基纤维素（CMC）的营养培养基与产生纤维素的微生物接种。然后将接种的培养基进行有氧培养以促进纤维素的生产。可以为某些产品添加基本干燥纤维素的步骤。由该方法得到的基本干燥的纤维素是高吸收性的，在反复润湿和干燥期间倾向于保持其吸收性能，并且在需要这种吸收性的情况下可使用。本发明的主题是基本上由天然或基本干燥形式的这种纤维素组成的物质组合物。在羧甲基纤维素存在下生产的微生物纤维素可以通过本领域技术人员已知的许多方法基本干燥。这种干燥可以是例如通过用非水亲水性溶剂洗涤或通过空气干燥。优选的非水溶剂包括具有小于约6个碳原子的烷基醇或酮。当使用这种非水溶剂干燥CMC-生产的纤维素时，干燥的纤维素可具有弹性结构并且可能具有弹性。

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