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    • 7. 发明申请
    • METHOD FOR PRODUCTION OF ACETIC ACID BACTERIUM-TYPE CERAMIDE
    • 生产乙酸钙类陶瓷的方法
    • US20090209023A1
    • 2009-08-20
    • US12301241
    • 2007-05-17
    • Shin OgawaTakahiro Oda
    • Shin OgawaTakahiro Oda
    • C12N1/20
    • C12R1/02A61K31/164C12P13/02C12R1/01
    • [Problems] To provide a method for efficient production of an acetic acid bacterium-type ceramide which is expected to have physiological effects such as making skin beautiful, by increasing the content of ceramide contained in cells of an acetic acid bacterium.[Means for Solving the Problems] There has been developed a method for increasing the acetic acid bacterium-type ceramide where the content of the acetic acid bacterium-type ceramide in cells of the acetic acid bacterium is able to be made as high as to a level of 10 to 30 fold by such a manner that acetic acid bacterium after finishing the culture is kept at the pH of 2.0 to 8.0 and the temperature of 4 to 70° C. for 3 hours to 7 days. As to the acetic acid bacterium used, Acetobacter malorum NCI 1683 strain (FERM BP-10595) or Gluconacetobacteri hansenii NCI 1468 strain (FERM BP-10596) is preferred.
    • 本发明提供一种通过增加醋酸细菌细胞中所含的神经酰胺含量,有效生​​产乙酸细菌型神经酰胺的方法,该方法预期具有生理作用,例如使皮肤美观。 解决问题的手段已经开发了一种增加醋酸细菌型神经酰胺的方法,其中醋酸细菌的细胞中的乙酸细菌型神经酰胺的含量能够高达a 水平为10〜30倍,使得培养完成后的乙酸菌保持在2.0〜8.0的pH,4〜70℃的温度下保持3小时〜7天。 对于所用的乙酸细菌,优选醋酸醋杆菌NCI1683菌株(FERM BP-10595)或汉逊酵母(Nec)18号菌株(FERM BP-10596)。